その他の主要な論文

主な英語原著論文
Relationship between calcium intake and impaired activities of daily living in a Japanese population: NIPPON DATA90

Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, et al.
Published: February 08, 2020
Journal of Epidemiology
doi:10.2188/jea.JE20190234.

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Nrf2 contributes to the weight gain of mice during space travel

Takafumi Suzuki, Akira Uruno, Akane Yumoto, Keiko Taguchi, et al.
Published: 08 September 2020
Communications Biology
doi:10.1038/s42003-020-01227-2

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Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup

Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, et al.
Published: 17 August 2020
Hypertension Research
doi:10.1038/s41440-020-00536-7

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Clustering by phenotype and genome-wide association study in autism

Akira Narita, Masato Nagai, Satoshi Mizuno, Soichi Ogishima, et al.
Published: 17 August 2020
Translational Psychiatry
doi:10.1038/s41398-020-00951-x

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Heterologous expression of high-activity cytochrome P450 in mammalian cells

Masaki Kumondai, Eiji Hishinuma, Evelyn Marie Gutiérrez Rico, Akio Ito, et al.
Published: 25 August 2020
Scientific Reports
doi:10.1038/s41598-020-71035-5

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Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes

Yuta Takahashi, Masao Ueki, Gen Tamiya, Soichi Ogishima, et al.
Published: 17 August 2020
Translational Psychiatry
doi:10.1038/s41398-020-00957-5

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Fruit and vegetable consumption before and during pregnancy and birth weight of new-borns in Japan: the Tohoku medical megabank project birth and three-generation cohort study

Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Junichi Sugawara, et al.
Published: 3 August 2020
Nutrition Journal
doi:10.1186/s12937-020-00595-z

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In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase

Eiji Hishinuma, Evelyn Gutiérrez Rico, Masahiro Hiratsuka
Published: 22 July 2020
Journal of Clinical Medicine
doi:10.3390/jcm9082342

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Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy

Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, et al.
Published: June 2020
Medical Mass Spectrometry
doi:10.24508/mms.2020.06.001

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Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis

Matsuyuki Shirota, Daisuke Saigusa, Riu Yamashita, Yasutake Kato, et al.
Published: 13 May 2020
Cancer Research
doi:10.1038/s41440-020-0463-8

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Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors

Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, et al.
Published: July 8, 2020
Cancer Research
doi:10.1158/0008-5472.CAN-19-2888

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Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection

Yuta Takahashi, Masao Ueki, Makoto Yamada, Gen Tamiya, et al.
Published: May 19, 2020
Translational Psychiatry
doi:10.1038/s41398-020-0831-9

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Clusters of Coronavirus Disease in Communities, Japan, January–April 2020

Yuki Furuse, Eiichiro Sando, Naho Tsuchiya, Reiko Miyahara, et al.
Published: June 10, 2020
Emerging Infectious Diseases
doi:10.3201/eid2609.202272

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Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, et al.
Published: 08 June 2020
Nature Genetics
doi:10.1038/s41588-020-0640-3

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Genome-wide association study identifies new loci for albuminuria in the Japanese population

Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, et al.
Published: 10 April 2020
Clinical and Experimental Nephrology
doi:10.1007/s10157-020-01884-x

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Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.

Kento Tsukada, Shono Shinki, Akiho Kaneko, et al.
Published: 14 April 2020
Nature Communications
doi:10.1038/s41467-020-15664-4

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Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 μg per day: results from TMM BirThree Cohort Study.

Kikuchi D, Obara T, Usuzaki T, et al.
Published online: 13 March 2020
The Journal of Maternal-Fetal & Neonatal Medicine
doi:10.1080/14767058.2020.1739020

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A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

Toshiyuki Waki, Ryo Mameda, Takuya Nakano, Sayumi Yamada, et al.
Published: 13 February 2020
Nature Communications
doi:10.1038/s41467-020-14558-9

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Impacts of NRF2 Activation in Non-Small-Cell Lung Cancer Cell Lines on Extracellular Metabolites

Daisuke Saigusa, Ikuko N. Motoike, Sakae Saito, Michael Zorzi, et al.
Online Published:January 15th, 2020
Cancer Science
doi:10.1111/cas.14278

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A proposal on the first Japanese practical guidance for the return of individual genomic results in research settings

Yayoi Aizawa, Fuji Nagami, Noriko Ohashi, Kazuto Kato
Published online 23 December 2019
Journal of Human Genetics
doi:10.1038/s10038-019-0697-y

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Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-in Alzheimer’s Disease Model Mice

Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, et al.
Published online January 13, 2020.
Molecular and Cellular Biology
doi:10.1128/MCB.00467-19

邦題:Nrf2 はApp ノックインアルツハイマー病モデルマウスで酸化ストレスと炎症を抑制する

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Neuromyelitis optica spectrum disorders with unevenly clustered attack occurrence

Tetsuya Akaishi, Ichiro Nakashima, Toshiyuki Takahashi, Michiaki Abe, et al.
First published November 22, 2019
Neurology Neuroimmunology & Neuroinflammation
doi:10.1212/NXI.0000000000000640

邦題:視神経脊髄炎における発作の群発性

解説ページへ   原著論文へ

3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome

Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, et al.
Published: 18 June 2019
Human Genome Variation 6, Article number: 28 (2019)
doi:10.1038/s41439-019-0059-5

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Rare variant discovery by deep whole-genome sequencing of 1070 Japanese Individuals

Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, et al.
Published: 21 August 2015
Nature Communications 6, Article number: 8018
doi: 10.1038/ncomms9018

論文概要:東北メディカル・メガバンク計画のコホート調査に参加した健常な日本人1,070人分の全ゲノムを解析し、精度検証を進めることで、日本人の全ゲノムリファレンスパネル(1KJPN)を構築

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Japonica Array: Improved genotype imputation by designing a population-specific SNP array with 1,070 Japanese individuals

Yosuke Kawai, Takahiro Mimori, Kaname Kojima, Naoki Nariai, et al.
Advance online publication: 25 June 2015
Journal of Human Genetics
doi: 10.1038/jhg.2015.68

論文概要:ジャポニカアレイ®:1,070人の日本人の情報に基づく日本人集団に適したSNPアレイの設計によるインピュテーションの改良

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The structural origin of metabolic quantitative diversity

Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa, et al.
Scientific Reports 6, Article number: 31463 (2016)
Published online August 16, 2016
doi:10.1038/srep31463

邦題:代謝物の量的な多様性の構造的起源

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Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2,049 individuals

Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, et al.
Journal of Human Genetics 63, 213–230 (2018)
Published online: 01 December 2017
doi:10.1038/s10038-017-0347-1

邦題:日本人2,049人の全ゲノムリファレンスパネルを用いた、既報の疾患原因バリアントの頻度と精査

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12 New Susceptibility Loci for Prostate Cancer Identified by Genome-wide Association Study in Japanese Population

Ryo Takata, Atsushi Takahashi, Masashi Fujita, Yukihide Momozawa, et al.
Nature Communications
Published: 27 September 2019
DOI: 10.1038/s41467-019-12267-6

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Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells

Fumiki Katsuoka, Akihito Otsuki, Mizue Takahashi, Shin Ito, Masayuki Yamamoto
Molecular and Cellular Biology
Published: 2019-08-05
DOI: 10.1128/MCB.00273-19

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Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study

Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, et al.
Hypertension Research
Published: 27 Sep 2019
DOI: 10.1038/s41440-019-0335-2

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Effectiveness of Seasonal Inactivated Influenza Vaccination in Japanese Schoolchildren: An Epidemiologic Study at the Community Level

Yasutaka Kuniyoshi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, et al.
Human Vaccines & Immunotherapeutics
Accepted author version posted online: 19 Aug 2019
DOI: 10.1080/21645515.2019.1655833

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Molecular Mechanism of Cellular Oxidative Sensing by Keap1

Takafumi Suzuki, Aki Muramatsu, Ryota Saito, Tatsuro Iso, et al.
Cell Reports
Available online 16 July 2019.
DOI: 10.1016/j.celrep.2019.06.047

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Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Authors: Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, et al.
EBioMedicine
Published online:June 28, 2019
DOI: 10.1016/j.ebiom.2019.06.013

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Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.

Saigusa D, Saito R, Kawamoto K, Uruno A, et al.
Analytical Chemistry
Published online 28 June 2019
DOI: 10.1021/acs.analchem.9b01159

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Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension -High-throughput Screening of 5,562 Compounds-

Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Haruhisa Kikuchi, Daisuke Saigusa, et al.
Circulation Research
Originally published June 14, 2019
DOI: 10.1161/CIRCRESAHA.119.315229.

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Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, et al.
Disaster medicine and public health preparedness
Published online: 03 June 2019
DOI: 10.1017/dmp.2019.8

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Susceptibility loci for tanning ability in Japanese population identified by genome-wide association study from Tohoku Medical Megabank Project cohort study

Kosuke Shido, Kaname Kojima, Kenshi Yamasaki, Atsushi Hozawa, et al.
Journal of Investigative Dermatology
published online 25 January 2019
DOI: 10.1016/j.jid.2019.01.015

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Respiratory resistance among adults in a population-based cohort study in Northern Japan

Emiri Miura, NahoTsuchiya, Yu Igarashi, Ritsuko Arakawa, et al.
Respiratory Investigation
Available online 13 February 2019.
DOI: 10.1016/j.resinv.2018.12.008

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Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals

Yumi Yamaguchi-Kabata, Jun Yasuda, Akira Uruno, Kazuro Shimokawa, et al.
Human Genetics
First Online: 18 March 2019
DOI: 10.1007/s00439-019-01998-7

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Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.

Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, et al.
Nature Communications
Published: 23 April 2019
DOI: 10.1038/s41467-019-09735-4

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Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database

Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, et al.
Pharmacoepidemiology and Drug Safety
First published: 10 March 2019
DOI: 10.1002/pds.4749

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Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy

Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauch, et al.
BMJ
Open 2019 Feb 19;9(2):e025939
DOI: 10.1136/bmjopen-2018-025939.

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Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

Ken Suzuki, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kana, et al.
Nature Genetics
Published: 04 February 2019
DOI: 10.1038/s41588-018-0332-4

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Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study

Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, et al.
The Tohoku Journal of Experimental Medicine
Published: October 2018
DOI: https://doi.org/10.1620/tjem.246.97

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Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods

Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, et al.
Scientific Reports
Published: 4 October 2018
DOI: doi.org/10.1038/s41598-018-33110-w

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Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation

Takashi Watanabe, Takahiro Saito, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, et al.
Biochemical Pharmacology
Published: 8 September 2018
DOI: https://doi.org/ 10.1016/j.bcp.2018.09.010.

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Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS)

Masaki Kumondai, Akio Ito, Eiji Hishinuma, Aoi Kikuchi, et al.
Drug Metabolism and Pharmacokinetics
Available online 22 August 2018
DOI: 10.1016/j.dmpk.2018.08.003

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Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project

Jun Yasuda, Fumiki Katsuoka, Inaho Danjoh, Yosuke Kawai, et al.
BMC Genomics
Published: 24 July 2018
DOI: 10.1186/s12864-018-4942-0

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Strong Association of HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population

Xiaoyuan Jia, Tomoko Horinouchi, Yuki Hitomi, Akemi Shono, et al.
Journal of the American Society of Nephrology
Accepted for publication May 11, 2018.
DOI: 10.1681/ASN.2017080859

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NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

Yoichi Kakuta, Yosuke Kawai, Daisuke Okamoto, Tetsuya Takagawa, et al.
Journal of Gastroenterology
First Online: 19 June 2018
DOI: 10.1007/s00535-018-1486-7

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Functional characterization of 21 allelic variants of dihydropyrimidine dehydrogenase identified in 1,070 Japanese individuals

Eiji Hishinuma, Yoko Narita, Sakae Saito, Masamitsu Maekawa, et al.
Drug Metabolism and Disposition
Published online May 16, 2018.
DOI: 10.1124/dmd.118.081737

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Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study

Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, et al. 
Allergology International
Available online: 13 April 2018
DOI: 10.1016/j.alit.2018.02.009

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Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake

Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, et al.
International Journal of Disaster Risk Reduction誌2018年6月第28巻 206-213頁 
Available online: 22 February 2018
DOI: 10.1016/j.ijdrr.2018.02.037

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Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma

Yukihiro Shiga, Masato Akiyama, Koji M Nishiguchi, Kota Sato, et al.
Human Molecular Genetics
Published: 14 February 2018
DOI:https://doi.org/10.1093/hmg/ddy053

解説ページへ   原著論文へ

Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing

Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F. Shibata, et al.
The Pharmacogenomics Journal
Published:19 January 2018
DOI: 10.1016/j.alit.2018.02.009

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Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders

Masaki Nishioka, Miki Bundo, Junko Ueda, Fumiki Katsuoka, et al.
Accepted manuscript online: 28 December 2017
DOI: 10.1111/pcn.12632

邦題:全ゲノム解析による脳組織での体細胞変異の同定と精神神経疾患発症との関連

解説ページへ   原著論文へ

Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbA1c

Tsuyoshi Hachiya, Shohei Komaki, Yutaka Hasegawa, Hideki Ohmomo, et al.
Scientific Reports
Published online:23 November 2017
DOI: 10.1038/s41598-017-16493-0

邦題:日本人集団の全ゲノムメタ解析がHbA1cと関連するTMC6-TMC8 及び SIX3-SIX2座位の新規多型を同定

解説ページへ   原著論文へ

Genome-wide association study identifies 112 loci for body mass index in the Japanese population

Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, et al.
Nature genetics
Published: 11 September 2017
DOI: 10.1038/ng.3951

解説ページへ   原著論文へ

Population-based biobank participants’ preferences for receiving genetic test results

Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, et al.
Journal of Human Genetics
Published: 10 August 2017
doi:10.1016/j.mayocp.2014.03.015

邦題:住民バイオバンク参加者の遺伝学的検査結果回付への需要

解説ページへ   原著論文へ

Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren

Masako Miyashita, Mami Ishikuro, Masahiro Kikuya, Chizuru Yamanaka, et al.
Journal of Pediatrics and Congenital Disorders
Published: 10 July 2017
DOI: 10.1620/tjem.236.123

解説ページへ   原著論文へ

Detecting genetic association through shortest paths in a bi-directed graph

Masao Ueki, Yoshinori Kawasaki, Gen Tamiya
Genetic Epiemiology
First published: 19 June 2017
DOI: 10.1002/gepi.22051

解説ページへ   原著論文へ

A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients

Teruhiko Hamanaka, Masae Kimura, Tetsuro Sakurai, Nobuo Ishida, et al.
Published: May 2017
DOI: 10.1167/iovs.16-20646

解説ページへ   原著論文へ

Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies

Tsuyoshi Hachiya, Ryohei Furukawa, Yuh Shiwa, Hideki Ohmomo, et al.
npj Genomic Medicine 2, Article number: 11 (2017)
Published: 13 April 2017
doi:10.1038/s41525-017-0016-5

邦題:全ゲノム規模の個人毎のDNAメチル化部位の変動部位の同定はエピゲノム関連解析の有効性を改善できる

解説ページへ   原著論文へ

Drug Use before and during Pregnancy in Japan: The Japan Environment and Children’s Study

Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, et al.
Published: 10 April 2017
DOI: 10.3390/pharmacy5020021

邦題:日本人妊婦の医薬品・サプリメント使用:エコチル調査

解説ページへ   原著論文へ

Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens–Johnson syndrome with severe ocular complications

Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, et al.
Journal of Human Genetics
Published online:19 January 2017
DOI: 10.1038/jhg.2016.160

解説ページへ   原著論文へ

網羅的ゲノム解析における偶発的所見を含む遺伝情報の結果の返却に関する我が国の現状と課題の検討―米国臨床遺伝・ゲノム学会(ACMG)の偶発的所見取り扱いに関する推奨からの考察―

Review of present state and challenges regarding return of genomic results from genome-wide analysis in Japan: Consideration of American College of Medical Genetics and Genomics (ACMG) recommendation for reporting incidental findings 日本遺伝カウンセリング学会誌 37(3): 105-126 2016

解説ページへ

Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score

Tsuyoshi Hachiya; Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, et al.
Stroke Originally
published:December 29, 2016 doi:10.1161/STROKEAHA.116.014506

邦題:脳梗塞の遺伝的体質;多遺伝子リスク評価

解説ページへ   原著論文へ

Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011

Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, et al.
Psychiatry and Clinical Neurosciences First Published: 21 December 2016
DOI: 10.1111/pcn.12467

邦題:東日本大震災後の心理的苦痛に対するソーシャルキャピタルの影響、および家屋の損壊と転居の相互作用

解説ページへ   原著論文へ

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery

Daisuke Saigusa, Yasunobu Okamura, Ikuko N. Motoike, Yasutake Katoh, et al.
PLoS ONE 11(8): e0160555
Published: August 31, 2016
DOI: 10.1371/journal.pone.0160555

邦題:バイオマーカー探索を目的とした質量分析計によるヒト血漿中代謝物の網羅的メタボロミクス解析プロトコルの開発

解説ページへ   原著論文へ

Partners’ Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake

Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, et al.
The Tohoku Journal of Experimental Medicine Vol. 239 (2016) No. 4 August p. 307-314
Published online August 10, 2016
DOI: 10.1620/tjem.239.307

邦題:配偶者の慢性疾患治療と心理的苦痛リスク

解説ページへ   原著論文へ

Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, et al.
Disaster Medicine and Public Health Preparedness
Published online: 23 June 2016 
doi: 10.1017/dmp.2016.102

邦題:震災後の心理的苦痛と高血圧治療中断リスク

解説ページへ   原著論文へ

Comparison of Boiling and Robotics Automation Method in DNA Extraction for Metagenomic Sequencing of Human Oral Microbes

Junya Yamagishi, Yukuto Sato, Natsuko Shinozaki, Bin Ye, et al.
Published: April 22, 2016
PLoS One. 2016 Apr 22;11(4):e0154389.
doi: 10.1371/journal.pone.0154389.

解説ページへ   原著論文へ

Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area

Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, et al.
Prehospital and Disaster Medicine
Published online: 28 March 2016
DOI: 10.1017/S1049023X16000182

邦題:東日本大震災被災地域におけるゲノム解析を伴う疫学調査に対する人々の意識

解説ページへ   原著論文へ

A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies

Masakazu Kohda, Yoshimi Tokuzawa, Yoshihito Kishita, Hiromi Nyuzuki, et al.
PLOS Genetics
Published: January 7, 2016
DOI: 10.1371/journal.pgen.1005679

邦題:網羅的ゲノム解析によりミトコンドリア病の遺伝的背景の一端を明らかにした

解説ページへ   原著論文へ

Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing

Xiaoqing Pan, Naoki Nariai, Noriko Fukuhara, Sakae Saito, et al.
British Journal of Haematology
Published online: 29 JAN 2016
DOI: 10.1111/bjh.13948

邦題:次世代シークエンサーを用いた全ゲノム解析情報による初期前駆T細胞性急性リンパ芽球性白血病治療の効果判定

解説ページへ   原著論文へ

Prospect of the future housing and the risk of psychological distress at 1 year after an earthquake disaster

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, et al.
Psychiatry and Clinical Neurosciences
Accepted manuscript online: 11 DEC 2015
DOI: 10.1111/pcn.12377

論文概要:震災1年後の将来の住居の見通しと心理的苦痛リスクの関連

解説ページへ   原著論文へ

Periodontitis-associated septic pulmonary embolism caused by Actinomyces species identified by anaerobic culture of bronchoalveolar lavage fluid: a case report

Shun Endo, Eikan Mishima, Yoichi Takeuchi, Takashi Ohi, et al.
BMC Infectious Diseases 2015, 15:552
Published online: 1 December 2015
DOI: 10.1186/s12879-015-1286-0

論文概要:気管支肺胞洗浄液の嫌気培養により診断されたアクチノマイセスによる歯周炎関連ー敗血症性肺塞栓の1例

解説ページへ   原著論文へ

Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study

Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, et al.
The Tohoku Journal of Experimental Medicine, Vol. 237 (2015) No. 4 December p. 297-305
Published online December 02, 2015
doi: 10.1620/tjem.237.297

解説ページへ   原著論文へ

iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing

Yumi Yamaguchi-Kabata, Naoki Nariai, Yosuke Kawai, Yukuto Sato, et al.
Human Genome Variation 2, Article number: 15050 (2015)
Published online 26 November 2015
doi: 10.1038/hgv.2015.50

論文概要:iJGVD: 全ゲノム解析に基づく日本人ゲノム多様性情報の統合されたデータベース

解説ページへ    原著論文へ

Unemployment risk among individuals undergoing medical treatment for chronic diseases

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, et al.
Occup Med (Lond) (2015)
First published online: November 13, 2015
doi: 10.1093/occmed/kqv159

論文概要:東日本大震災の被災地の沿岸地域において慢性疾患の有無と無職リスクの関連性を検討した。慢性疾患治療者の無職リスクは高く、心理・身体面が不良な者は慢性疾患治療と無職リスクの有意な関連が示された。

解説ページへ    原著論文へ

Inter-individual differences in the oral bacteriome are greater than intra-day fluctuations in individuals

Yukuto Sato, Junya Yamagishi, Riu Yamashita, Natsuko Shinozaki, et al.
PLOS ONE. 2015, 10(6): e0131607.
Published online 2015 June 29.
doi: 10.1371/journal.pone.0131607

論文概要:個人の口腔内のバクテリア叢は比較的安定して存在しており、その日内の変動は個人間の差よりも小さい

解説ページへ    原著論文へ

Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake

Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, et al.
The Tohoku Journal of Experimental Medicine, Vol. 236 No. 2
Published: June 2015
doi: 0.1620/tjem.236.123

論文概要:地域子ども長期健康調査の研究デザインと2012年度に岩沼市・亘理町・山元町で実施した調査の結果

解説ページへ    原著論文へ(J-STAGE)

The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project.

Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, et al.
Disaster Medicine and Public Health Preparedness
online: 27 April 2015
doi: 10.1017/dmp.2015.52

論文概要:東日本大震災で甚大な被害を受けた沿岸地域における循環器疾患、がん、高脂血症、肝臓病、腎臓病、糖尿病などの疾患を治療している者と心理的苦痛の関連の検討

解説ページへ    原著論文へ

Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population

Ikuko N Motoike, Mitsuyo Matsumoto, Inaho Danjoh, Masayuki Yamamoto, et al.
BMC Genomics. 2014, 15: 673.
Published: 
doi: 10.1186/1471-2164-15-673

論文概要:複数の種類の次世代型シークエンサーによる一塩基置換の読み取りの精度向上について

解説ページへ    原著論文へ

An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer

Fumiki Katsuoka, Junji Yokozawa, Kaoru Tsuda, Shin Ito, et al.
Analytical Biochemistry, Volume 466, 1 December 2014, Pages 27-29
Available online 28 August 2014
doi: 10.1016/j.ab.2014.08.015

論文概要:ToMMoで開発した新しいライブラリ定量に関する方法の論文です。ToMMoでは、この新しい定量方法を採用することで、効率の良い安定した全ゲノム解析を実現しています。

解説ページへ    原著論文へ

HapMonster: A Statistically Unified Approach for Variant Calling and Haplotyping Based on Phase-Informative Reads

Kaname Kojima, Naoki Nariai, Takahiro Mimori, Yumi Yamaguchi-Kabata, et al.
Lecture Notes in Computer Science Volume 8542, 2014, pp 107-118

原著論文へ

SVEM: a Structural Variant Estimation Method using Multi-Mapped Reads on Breakpoints

Tomohiko Ohtsuki, Naoki Nariai, Kaname Kojima, Takahiro Mimori, et al.
Lecture Notes in Computer Science Volume 8542, 2014, pp 208-219

原著論文へ

A statistical variant calling approach from pedigree information and local haplotyping with phase informative reads

Kaname Kojima, Naoki Nariai, Takahiro Mimori, Mamoru Takahashi, et al.
Bioinformatics. 2013 Nov 15;29(22):2835-43.
Epub 2013 Sep 3
doi: 10.1093/bioinformatics/btt503.

原著論文へ

TIGAR: transcript isoform abundance estimation method with gapped alignment of RNA-Seq data by variational Bayesian inference

Naoki Nariai, Osamu Hirose, Kaname Kojima and Masao Nagasaki
Bioinformatics. 2013 Sep 15;29(18):2292-9.
Epub 2013 Jul 2
doi: 10.1093/bioinformatics/btt381.

原著論文へ

主な査読付き国際学会proceedingsなど
A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes

Naoki Nariai, Kaname Kojima, Takahiro Mimori, Yosuke Kawai and Masao Nagasaki
BMC Genomics201617(Suppl 1):2 
Published: 11 January 2016
DOI: 10.1186/s12864-015-2295-5
Selected articles from the Fourteenth Asia Pacific Bioinformatics Conference (APBC 2016): Genomics

邦題:RNAシークエンスデータと全ゲノムデータから、アレル特異的な遺伝子発現量を推定するベイズ理論を用いた手法を開発

解説ページへ   原著論文へ

HLA-VBSeq: accurate HLA typing at full resolution from whole-genome sequencing data

Naoki Nariai, Kaname Kojima, Sakae Saito, Takahiro Mimori, et al.
BMC Genomics, 16(Suppl 2):S7 (2015)
doi: 10.1186/1471-2164-16-S2-S7

論文概要:HLAの型を全ゲノムシークエンスデータから高精度で推定することができる統計手法の開発とソフトウェアHLA-VBSeqの実装

原著論文へ

Estimating copy numbers of alleles from population-scale high-throughput sequencing data

Takahiro Mimori, Naoki Nariai, Kaname Kojima, Yukuto Sato, et al.
BMC Bioinformatics, 16(Suppl 1):S4 (2015)
doi: 10.1186/1471-2105-16-S1-S4

論文概要:集団の全ゲノムシークエンスデータから、コピー数変異 (CNV) の塩基配列を推定する統計手法の開発と実装

原著論文へ

TIGAR2: sensitive and accurate estimation of transcript isoform expression with longer RNA-Seq reads

Naoki Nariai, Kaname Kojima, Takahiro Mimori, Yukuto Sato, et al.
BMC Genomics, 15(Suppl 10):S5 (2014)
doi: 10.1186/1471-2164-15-S10-S5

論文概要:既報のTIGARをさらに改良しより長い次世代シークエンサに転写産物の発現量を推定する手法の開発とソフトウェアTIGAR2の実装

原著論文へ

SUGAR: graphical user interface-based data refiner for high-throughput DNA sequencing

Yukuto Sato, Kaname Kojima, Naoki Nariai, Yumi Yamaguchi-Kabata, et al.
BMC Genomics. 2014 Aug 8;15:664.
doi: 10.1186/1471-2164-15-664.

論文概要:大量DNAシークエンスデータのクオリティ・コントロールを行うためのグラフィカルユーザーインターフェースソフトウェアSUGAR

解説ページへ    原著論文へ

iSVP: an integrated structural variant calling pipeline from high-throughput sequencing data

Takahiro Mimori, Naoki Nariai, Kaname Kojima, Mamoru Takahashi, et al.
BMC Syst Biol. 2013;7 Suppl 6:S8.
Epub 2013 Dec 13.
doi: 10.1186/1752-0509-7-S6-S8.

原著論文へ