デザイン論文
本事業のデザイン論文
全体計画 | バイオバンク事業関連 | コホート事業関連 | ゲノム・オミックス解析事業関連 |
全体計画
Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project
Nobuo Fuse, Mika Sakurai-Yageta, Fumiki Katsuoka, Inaho Danjoh, et al.
JMA Journal
Published online: August 6, 2019
doi:10.31662/jmaj.2019-0014
The Tohoku Medical Megabank Project: Design and Mission
Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, et al.
Published online: 23 June 2016
Journal of Epidemiology, Vol. 26 (2016), No. 9 pp. 493-511
doi：10.2188/jea.JE20150268
邦題：東北メディカル・メガバンク計画：デザインとミッション
Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project
Fuji Nagami, Miho Kuriki, Sachie Koreeda, Maiko Kageyama, et al.
Published online: 21 April 2020
The Tohoku Journal of Experimental Medicine
doi：10.1620/tjem.250.253
バイオバンク事業関連
dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, et al.
Published: 10 December 2021
Human Genome Variation
doi：10.1038/s41439-021-00175-5
Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project
Minegishi N, Nishijima I, Nobukuni T, Kudo H, et al.
Published online: May 24, 2019
The Tohoku Journal of Experimental Medicine, 2019 Volume 248 Issue 1 Pages 45-55
doi：10.1620/tjem.248.45.
Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design
Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, et al.
BMC Medical Informatics and Decision Making (2017) 17:100
Published: 06 July 2017
doi:10.1186/s12911-017-0494-5
邦題：複合バイオバンクでのデータシェアリングにおけるプライバシー保護のためのセキュリティコントロール：根拠と研究デザイン
コホート事業関連
Study profile of The Tohoku Medical Megabank Community-Based Cohort Study
Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, et al.
Journal of Epidemiology
Published: January 05, 2021
doi:10.2188/jea.JE20190271
Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture
Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, et al.
Journal of Epidemiology
Published: February 24, 2024
doi:10.2188/jea.JE20230241
Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective
Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, et al.
International Journal of Epidemiology
Published: February 2020
doi:10.1093/ije/dyz169
Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update
Taku Obara, Mami Ishikuro, Aoi Noda, Keiko Murakami, et al.
International Journal of Epidemiology
Published: September 2025
doi:10.1093/ije/dyaf148
Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project
Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, et al.
The Tohoku Journal of Experimental Medicine
Advance online publication: 01 December 2022
doi:10.1620/tjem.2022.J103
Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project
Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, et al.
The Tohoku Journal of Experimental Medicine
Published online: June 23, 2020
doi:10.1620/tjem.251.97
Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background
Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, et al.
Journal of the Japan Medical Association
Published: July 14, 2023
doi:10.31662/jmaj.2022-0220
A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization
Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, et al.
BMC Medical Education
Published online: 02 August 2019
doi:10.1186/s12909-019-1725-5
The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project
Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, et al.
Journal of Human Genetics
Published online: 08 July 2021
doi:10.1038/s10038-021-00952-8
ゲノム・オミックス解析事業関連
Advancements in Whole Genome Sequencing Protocols: A Decade of In-House Operations and Quality Controls at the Tohoku Medical Megabank
Fumiki Katsuoka, Junko Kawashima, Shu Tadaka, Akihito Otsuki, et al.
JMA Journal
Published: October 15, 2025
doi:10.31662/jmaj.2025-0159
Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology
Akihito Otsuki, Yasunobu Okamura, Noriko Ishida, Shu Tadaka, et al.
Communications Biology
Published: 20 September 2022
doi:10.1038/s42003-022-03953-1
Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs
Mika Sakurai-Yageta, Kazuki Kumada, Chinatsu Gocho, Satoshi Makino, et al.
Journal of Biochemistry
Published: 13 May 2021
doi:10.1093/jb/mvab060
Oral microbiome analysis in prospective genome cohort studies of the Tohoku Medical Megabank Project
Sakae Saito, Yuichi Aoki, Toru Tamahara, Maki Goto, et al.
Frontiers Cellular and Infection Microbiology
Published: 29 January 2021
doi:10.3389/fcimb.2020.604596
Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference
Jun Takayama, Shu Tadaka, Kenji Yano, Fumiki Katsuoka, et al.
Nature Communications
Published: 11 January 2021
doi:10.1038/s41467-020-20146-8
Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare
Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, et al.
The Journal of Biochemistry
Published online: 19 November 2018
doi:10.1093/jb/mvy096
Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project
Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, et al.
First published: 27 April 2018
Genes to Cells
doi：10.1111/gtc.12588
邦題：東北メディカル・メガバンク計画におけるオミックス研究のデザイン
jMorp: Japanese Multi Omics Reference Panel
Shu Tadaka, Daisuke Saigusa, Ikuko N. Motoike, Jin Inoue, et al.
Nucleic Acids Research, Volume 46, Issue D1
Published: 24 October 2017
doi:10.1093/nar/gkx978
邦題：jMorp: 日本人多層オミックス参照パネル
jMorp: Japanese Multi-Omics Reference Panel update report 2023
Shu Tadaka, Junko Kawashima, Eiji Hishinuma, Sakae Saito, et al.
Nucleic Acids Research
Published: 1 November 2023
doi:10.1093/nar/gkad978