Tohoku University Tohoku Medical Megabank Organization (2019)
2020.05.29

1.   Oe Chihiro, Hayashi Hironori, Hirata Kazushige, et al. Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related Proteins. ACS Infectious Diseases. 2019; : acsinfecdis.9b00305. doi:10.1021/acsinfecdis.9b00305  
2.   Nakaya Naoki, Sone Toshimasa, Tomata Yasutake, et al. All-cause mortality among Japanese whose cohabiting partners are diagnosed with cancer: the Ohsaki Cohort 2006 study. Acta Oncologica. 2019; 58 (4): 425-431. doi:10.1080/0284186X.2018.1562208  
3.   Huang Cong, Kogure Mana, Tomata Yasutake, et al. Association of serum adiponectin levels and body mass index with worsening depressive symptoms in elderly individuals: a 10-year longitudinal study. Aging & Mental Health. 2019; : 1-7. doi:10.1080/13607863.2019.1584877  
4.   Huang Cong, Kogure Mana, Tomata Yasutake, et al. Association of serum adiponectin levels and body mass index with worsening depressive symptoms in elderly individuals: a 10-year longitudinal study. Aging & Mental Health. 2019; : 1-7. doi:10.1080/13607863.2019.1584877  
5.   Watanabe Mari, Oe Yuji, Sato Emiko, et al. Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity. American journal of physiology. Renal physiology. 2019; 316 (4): F654-F659. doi:10.1152/ajprenal.00489.2018  
6.   Saigusa Daisuke, Saito Ritsumi, Kawamoto Komei, et al. Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry. 2019; 91 (14): 8979-8986. doi:10.1021/acs.analchem.9b01159  
7.   Iwasawa Shinya, Yanagi Kumiko, Kikuchi Atsuo, et al. Recurrent de novo MAPK8IP3 variants cause neurological phenotypes. Annals of neurology. 2019; 85 (6): 927-933. doi:10.1002/ana.25481  
8.   Hatta Waku, Gotoda Takuji, Oyama Tsuneo, et al. Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer?. Annals of surgical oncology. 2019; 26 (11): 3636-3643. doi:10.1245/s10434-019-07579-2  
9.   Isojima Tsuyoshi, Kato Noriko, Yokoya Susumu, et al. Early excessive growth with distinct seasonality in preschool obesity. Archives of disease in childhood. 2019; 104 (1): 53-57. doi:10.1136/archdischild-2018-314862  
10.   Otsuki Akihito, Yamamoto Masayuki. Cis-element architecture of Nrf2-sMaf heterodimer binding sites and its relation to diseases. Archives of pharmacal research. 2019; : . doi:10.1007/s12272-019-01193-2  
11.   Imaruoka Kenta, Oe Yuji, Fushima Tomofumi, et al. Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide. Biochemical and biophysical research communications. 2019; 510 (4): 587-593. doi:10.1016/j.bbrc.2019.01.110  
12.   Akatsuka Jun, Yamamoto Yoichiro, Sekine Tetsuro, et al. Illuminating Clues of Cancer Buried in Prostate MR Image: Deep Learning and Expert Approaches. Biomolecules. 2019; 9 (11): . doi:10.3390/biom9110673  
13.   Keleku-Lukwete Nadine, Suzuki Mikiko, Panda Harit, et al. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood advances. 2019; 3 (8): 1285-1297. doi:10.1182/bloodadvances.2018017574  
14.   Miyahara Reiko, Piyaworawong Surachai, Naranbhai Vivek, et al. Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals. BMC infectious diseases. 2019; 19 (1): 667. doi:10.1186/s12879-019-4292-9  
15.   Sakurai-Yageta Mika, Kawame Hiroshi, Kuriyama Shinichi, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Medical Education. 2019; 19 (1): 297. doi:10.1186/s12909-019-1725-5  
16.   Kubo Sachimi, Nishida Yoko, Kubota Yoshimi, et al. Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. BMC nephrology. 2019; 20 (1): 117. doi:10.1186/s12882-019-1291-4  
17.   Higuchi Yuji, Fujiwara Masaki, Nakaya Naoki, et al. Change in smoking cessation stage over 1 year in patients with schizophrenia: a follow up study in Japan. BMC psychiatry. 2019; 19 (1): 367. doi:10.1186/s12888-019-2351-9  
18.   Nakagawa Seishu, Sugiura Motoaki, Sekiguchi Atsushi, et al. The pitfall of empathic concern with chronic fatigue after a disaster in young adults. BMC psychiatry. 2019; 19 (1): 338. doi:10.1186/s12888-019-2323-0  
19.   Murakami Keiko, Hashimoto Hideki. Associations of education and income with heavy drinking and problem drinking among men: evidence from a population-based study in Japan. BMC public health. 2019; 19 (1): 420. doi:10.1186/s12889-019-6790-5  
20.   Fujiwara Masaki, Inagaki Masatoshi, Shimazu Taichi, et al. A randomised controlled trial of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia in psychiatric outpatient clinics: study protocol for the J-SUPPORT 1901 (ACCESS) study. BMJ open. 2019; 9 (11): e032955. doi:10.1136/bmjopen-2019-032955  
21.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): bmjopen-2018-025939. doi:10.1136/bmjopen-2018-025939  
22.   Ikeda Shigeyuki, Takeuchi Hikaru, Taki Yasuyuki, et al. Neural substrates of self- and external-preoccupation: A voxel-based morphometry study. Brain and behavior. 2019; 9 (6): e01267. doi:10.1002/brb3.1267  
23.   Takeuchi Hikaru, Tomita Hiroaki, Taki Yasuyuki, et al. Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity. Brain imaging and behavior. 2019; 247 (1): 59-67. doi:10.1007/s11682-018-0025-8  
24.   Takeuchi Hikaru, Taki Yasuyuki, Nouchi Rui, et al. Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions. Brain structure & function. 2019; 224 (3): 1203-1217. doi:10.1007/s00429-019-01830-y  
25.   Kuniyoshi Yasutaka, Kikuya Masahiro, Matsubara Hiroko, et al. Association of Feeding Practice with Childhood Overweight and/or Obesity in Affected Areas Before and After the Great East Japan Earthquake. Breastfeeding Medicine. 2019; 14 (6): 382-389. doi:10.1089/bfm.2018.0254  
26.   Harada Nobuhiko, Hasegawa Atsushi, Hirano Ikuo, et al. GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. Cancer science. 2019; 110 (4): 1183-1193. doi:10.1111/cas.13959  
27.   Suzuki Takafumi, Muramatsu Aki, Saito Ryota, et al. Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1. Cell Reports. 2019; 28 (3): 746-758.e4. doi:10.1016/j.celrep.2019.06.047  
28.   Hitomi Yuki, Nakatani Ken, Kojima Kaname, et al. NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants. Cellular and molecular gastroenterology and hepatology. 2019; 7 (3): 515-532. doi:10.1016/j.jcmgh.2018.11.006  
29.   Takeuchi Hikaru, Tomita Hiroaki, Taki Yasuyuki, et al. A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity. Cerebral Cortex. 2019; 29 (8): 3211-3219. doi:10.1093/cercor/bhy189  
30.   Nishikawa Tomofumi, Miyamatsu Naomi, Higashiyama Aya, et al. Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study. Cerebrovascular Diseases. 2019; 47 (3-4): 143-150. doi:10.1159/000500075  
31.   Kikuchi Haruhisa, Kawai Kosuke, Nakashiro Yota, et al. Construction of a Meroterpenoid-Like Compounds Library Based on Diversity-Enhanced Extracts. Chemistry (Weinheim an der Bergstrasse, Germany). 2019; 25 (4): 1106-1112. doi:10.1002/chem.201805417  
32.   Kondo Keiko, Miura Katsuyuki, Tanaka-Mizuno Sachiko, et al. Cardiovascular Risk Assessment Chart by Dietary Factors in Japan ― NIPPON DATA80 ―. Circulation Journal. 2019; 83 (6): 1254-1260. doi:10.1253/circj.CJ-18-1002  
33.   Kurosawa Ryo, Satoh Kimio, Kikuchi Nobuhiro, et al. Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension. Circulation Research. 2019; 125 (3): 309-327. doi:10.1161/CIRCRESAHA.119.315229  
34.   Noda Aoi, Obara Taku, Takada Kazuki, et al. Changes in community pharmacists’ knowledge, attitudes, and practice regarding the management of hypertension before and after educational interventions. Clinical and Experimental Hypertension. 2019; : 1-6. doi:10.1080/10641963.2019.1652634  
35.   Doi A, Kano S, Asano M, et al. Autoantibodies to killer cell immunoglobulin-like receptor 3DL1 in patients with systemic lupus erythematosus. Clinical and experimental immunology. 2019; 195 (3): 358-363. doi:10.1111/cei.13235  
36.   Ishizawa Kota, Yamanaka Mie, Saiki Yuriko, et al. CD45+CD326+ Cells are Predictive of Poor Prognosis in Non-Small Cell Lung Cancer Patients. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019; 25 (22): 6756-6763. doi:10.1158/1078-0432.CCR-19-0545  
37.   Murakami Keiko, Aida Jun, Hashimoto Hideki. Associations of social relationships with curative and preventive dental care use among young and middle-aged adults: Evidence from a population-based study in Japan. Community dentistry and oral epidemiology. 2019; 47 (5): 389-397. doi:10.1111/cdoe.12487  
38.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. Congenital anomalies. 2019; 59 (4): 110-117. doi:10.1111/cga.12293  
39.   Yamada Hiroyuki, Doi Kent, Tsukamoto Tatsuo, et al. Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis. Critical care (London, England). 2019; 23 (1): 41. doi:10.1186/s13054-019-2330-z  
40.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. Disaster Medicine and Public Health Preparedness. 2019; 13 (5-6): 905-911. doi:10.1017/dmp.2019.8  
41.   Shimizu Makiko, Yoda Hiromi, Nakakuki Komei, et al. Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database. Drug metabolism and pharmacokinetics. 2019; 34 (5): 334-339. doi:10.1016/j.dmpk.2019.06.001  
42.   Akiyama Tetsuya, Suzuki Naoki, Ishikawa Mitsuru, et al. Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons. EBioMedicine. 2019; 45 : 362-378. doi:10.1016/j.ebiom.2019.06.013  
43.   Itoi Keiichi, Motoike Ikuko, Liu Ying, et al. Genome-Wide Analysis of Glucocorticoid-Responsive Transcripts in the Hypothalamic Paraventricular Region of Male Rats. Endocrinology. 2019; 160 (1): 38-54. doi:10.1210/en.2018-00535  
44.   Nakamura Mieko, Ojima Toshiyuki, Nagahata Tomomi, et al. Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: findings from the NIPPON DATA2010. Environmental health and preventive medicine. 2019; 24 (1): 1. doi:10.1186/s12199-018-0752-x  
45.   Panda Harit, Keleku-Lukwete Nadine, Kuga Ayumi, et al. Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model. Experimental Hematology. 2019; 77 : 51-60.e1. doi:10.1016/j.exphem.2019.08.001  
46.   Akaishi Tetsuya, Onishi Eiko, Abe Michiaki, et al. The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid. Fluids and barriers of the CNS. 2019; 16 (1): 8. doi:10.1186/s12987-019-0128-7  
47.   Manome Ayumi, Abiko Yuki, Kawashima Junko, et al. Acidogenic Potential of Oral Bifidobacterium and Its High Fluoride Tolerance. Frontiers in microbiology. 2019; 10 : 1099. doi:10.3389/fmicb.2019.01099  
48.   Yamada Shinya, Hatta Waku, Shimosegawa Tooru, et al. Different risk factors between early and late cancer recurrences in patients without additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer. Gastrointestinal Endoscopy. 2019; 89 (5): 950-960. doi:10.1016/j.gie.2018.11.015  
49.   Shimanoe C, Hachiya T, Hara M, et al. A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression. Genes, brain, and behavior. 2019; 18 (2): e12481. doi:10.1111/gbb.12481  
50.   Wada Yoichi, Kikuchi Atsuo, Arai-Ichinoi Natsuko, et al. Biallelic GALM pathogenic variants cause a novel type of galactosemia. Genetics in Medicine. 2019; 21 (6): 1286-1294. doi:10.1038/s41436-018-0340-x  
51.   Sone Toshimasa, Nakaya Naoki, Tomata Yasutake, et al. Spouse's functional disability and mortality: The Ohsaki Cohort 2006 Study. Geriatrics & gerontology international. 2019; 19 (8): 774-779. doi:10.1111/ggi.13709  
52.   Mori Minako, Hira Asuka, Yoshida Kenichi, et al. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2019; 104 (10): 1962-1973. doi:10.3324/haematol.2018.207241  
53.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
54.   Tadaka Shu, Katsuoka Fumiki, Ueki Masao, et al. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. Human Genome Variation. 2019; 6 (1): 28. doi:10.1038/s41439-019-0059-5  
55.   Nagasaki Masao, Kuroki Yoko, Shibata Tomoko F., et al. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Human Genome Variation. 2019; 6 (1): 27. doi:10.1038/s41439-019-0057-7  
56.   Wang Yen-Yen, Mimori Takahiro, Khor Seik-Soon, et al. HLA-VBSeq v2: improved HLA calling accuracy with full-length Japanese class-I panel. Human Genome Variation. 2019; 6 (1): 29. doi:10.1038/s41439-019-0061-y  
57.   Misawa Kazuharu, Watanabe Hiroshi, Yokoseki Akio, et al. Is the population of Sado Island genetically close to the population of western Japan?. Human genome variation. 2019; 6 : 26. doi:10.1038/s41439-019-0058-6  
58.   Fukunaga Hisanori, Taki Yasuyuki, Prise Kevin M. Diversity of ATM gene variants: a population-based genome data analysis for precision medicine. Human genomics. 2019; 13 (1): 38. doi:10.1186/s40246-019-0234-2  
59.   Yu Yujiao, Nakagawa Tadashi, Morohoshi Akane, et al. Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity. Human Molecular Genetics. 2019; 28 (20): 3486-3497. doi:10.1093/hmg/ddz119  
60.   Fujishima Fumiyoshi, Katsushima Hiroki, Fukuhara Noriko, et al. Immunohistochemical pattern of c-MYC protein judged as “+/(weak)+/−” by a new notation correlates with MYC gene nontranslocation in large B-cell lymphoma. Human Pathology. 2019; 85 : 112-118. doi:10.1016/j.humpath.2018.10.025  
61.   Kuniyoshi Yasutaka, Obara Taku, Ishikuro Mami, et al. Effectiveness of seasonal inactivated influenza vaccination in Japanese schoolchildren: an epidemiologic study at the community level. Human Vaccines & Immunotherapeutics. 2019; : 1-6. doi:10.1080/21645515.2019.1655833  
62.   Li Yan, Thijs Lutgarde, Zhang Zhen-Yu, et al. Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure. Hypertension (Dallas, Tex. : 1979). 2019; 74 (6): 1333-1342. doi:10.1161/HYPERTENSIONAHA.119.12958  
63.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019; 42 (1): 85-94. doi:10.1038/s41440-018-0124-3  
64.   Tanaka Kosuke, Nishigori Hidekazu, Watanabe Zen, et al. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019; 42 (4): 558-566. doi:10.1038/s41440-019-0206-x  
65.   Akaishi Tetsuya, Kiyomoto Hideyasu, Abe Michiaki, et al. A 29-year-old Woman with Recurrent Pregnancy-induced Hypertension Based on Vascular Compression of the Medulla Oblongata. Internal Medicine. 2019; 58 (15): 2257-2261. doi:10.2169/internalmedicine.2382-18  
66.   Dissanayake Eishika, Tani Yumi, Nagai Kazue, et al. Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial. International archives of allergy and immunology. 2019; 180 (3): 202-211. doi:10.1159/000501636  
67.   Sato Tomonori, Kawasaki Yoshihide, Maekawa Masamitsu, et al. Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma. International journal of cancer. 2019; 145 (2): 484-493. doi:10.1002/ijc.32115  
68.   Nishikawa Tomofumi, Miyamatsu Naomi, Higashiyama Aya, et al. Being Conscious of Water Intake Positively Associated with Sufficient Non-Alcohol Drink Intake Regardless of Seasons and Reasons in Healthy Japanese; the KOBE Study: A Cross Sectional Study. International journal of environmental research and public health. 2019; 16 (21): . doi:10.3390/ijerph16214151  
69.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International Journal of Epidemiology. 2019; : . doi:10.1093/ije/dyz169  
70.   Sakurai Rieko, Ueki Masao, Makino Satoshi, et al. Outlier detection for questionnaire data in biobanks. International journal of epidemiology. 2019; 48 (4): 1305-1315. doi:10.1093/ije/dyz012  
71.   Maekawa Masamitsu, Jinnoh Isamu, Matsumoto Yotaro, et al. Structural Determination of Lysosphingomyelin-509 and Discovery of Novel Class Lipids from Patients with Niemann-Pick Disease Type C. International journal of molecular sciences. 2019; 20 (20): . doi:10.3390/ijms20205018  
72.   Suzuki Hideaki, Venkataraman Ashwin V, Bai Wenjia, et al. Associations of Regional Brain Structural Differences With Aging, Modifiable Risk Factors for Dementia, and Cognitive Performance. JAMA network open. 2019; 2 (12): e1917257. doi:10.1001/jamanetworkopen.2019.17257  
73.   Fuse Nobuo, Sakurai-Yageta Mika, Katsuoka Fumiki, et al. Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project. JMA Journal. 2019; 2 (2): 113-122. doi:10.31662/jmaj.2019-0014  
74.   Tayama J, Ogawa S, Nakaya N, et al. Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial. Journal of affective disorders. 2019; 245 : 364-370. doi:10.1016/j.jad.2018.11.039  
75.   Watanabe Zen, Nishigori Hidekazu, Tanoue Kaou, et al. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. Journal of affective disorders. 2019; 245 : 475-483. doi:10.1016/j.jad.2018.11.061  
76.   Yoshida Makiko, Obara Taku, Kikuchi Saya, et al. Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015. Journal of Attention Disorders. 2019; : 108705471984317. doi:10.1177/1087054719843179  
77.   Dodo Mina, Kitamura Hiroshi, Shima Hiroki, et al. Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A. Journal of biochemistry. 2019; 165 (4): 323-334. doi:10.1093/jb/mvy108  
78.   Kakuta Yoichi, Kawai Yosuke, Naito Takeo, et al. A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals. Journal of Crohn's and Colitis. 2019; 13 (5): 648-658. doi:10.1093/ecco-jcc/jjy197  
79.   Kiniwa Yukiko, Yasuda Jun, Saito Sakae, et al. Identification of genetic alterations in extramammary Paget disease using whole exome analysis. Journal of Dermatological Science. 2019; 94 (1): 229-235. doi:10.1016/j.jdermsci.2019.03.006  
80.   Takagi K, Iwama N, Metoki H, et al. Paternal height has an impact on birth weight of their offspring in a Japanese population: the Japan Environment and Children's Study. Journal of developmental origins of health and disease. 2019; 10 (5): 542-554. doi:10.1017/S2040174418001162  
81.   Hozawa Atsushi, Hirata Takumi, Yatsuya Hiroshi, et al. Association Between Body Mass Index and All-Cause Death in Japanese Population: Pooled Individual Participant Data Analysis of 13 Cohort Studies. Journal of Epidemiology. 2019; 29 (12): 457-463. doi:10.2188/jea.JE20180124  
82.   Sumi Masaki, Hisamatsu Takashi, Fujiyoshi Akira, et al. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). Journal of Epidemiology. 2019; 29 (6): 205-212. doi:10.2188/jea.JE20170191  
83.   Shibata Yosuke, Ojima Toshiyuki, Nakamura Mieko, et al. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010. Journal of Epidemiology. 2019; 29 (4): 133-138. doi:10.2188/jea.JE20170229  
84.   Igarashi Ayaka, Aida Jun, Sairenchi Toshimi, et al. Does Cigarette Smoking Increase Traffic Accident Death During 20 Years Follow-up in Japan? The Ibaraki Prefectural Health Study. Journal of epidemiology. 2019; 29 (5): 192-196. doi:10.2188/jea.JE20170330  
85.   Kusama Taro, Aida Jun, Sugiyama Kemmyo, et al. Does the Type of Temporary Housing Make a Difference in Social Participation and Health for Evacuees of the Great East Japan Earthquake and Tsunami? A Cross-Sectional Study. Journal of Epidemiology. 2019; 29 (10): 391-398. doi:10.2188/jea.JE20180080  
86.   Mizuguchi Takeshi, Suzuki Takeshi, Abe Chihiro, et al. A 12-kb structural variation in progressive myoclonic epilepsy was newly identified by long-read whole-genome sequencing. Journal of human genetics. 2019; 64 (5): 359-368. doi:10.1038/s10038-019-0569-5  
87.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. Journal of hypertension. 2019; 37 (1): 206-215. doi:10.1097/HJH.0000000000001846  
88.   Satoh Atsushi, Arima Hisatomi, Hozawa Atsushi, et al. The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. Journal of Hypertension. 2019; 37 (8): 1676-1681. doi:10.1097/HJH.0000000000002080  
89.   Numakura Chikahiko, Tamiya Gen, Ueki Masao, et al. Growth impairment in individuals with citrin deficiency. Journal of inherited metabolic disease. 2019; 42 (3): 501-508. doi:10.1002/jimd.12051  
90.   Tanoue Kaou, Nishigori Hidekazu, Watanabe Zen, et al. Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children’s Study. Journal of Interpersonal Violence. 2019; : 088626051988151. doi:10.1177/0886260519881517  
91.   Shido Kosuke, Kojima Kaname, Yamasaki Kenshi, et al. Susceptibility Loci for Tanning Ability in the Japanese Population Identified by a Genome-Wide Association Study from the Tohoku Medical Megabank Project Cohort Study. Journal of Investigative Dermatology. 2019; 139 (7): 1605-1608.e13. doi:10.1016/j.jid.2019.01.015  
92.   Maekawa Masamitsu, Jinnoh Isamu, Narita Aya, et al. Investigation of diagnostic performance of five urinary cholesterol metabolites for Niemann-Pick disease type C. Journal of lipid research. 2019; 60 (12): 2074-2081. doi:10.1194/jlr.M093971  
93.   Fujita Takaaki, Sato Atsushi, Narita Akira, et al. Use of a multilayer perceptron to create a prediction model for dressing independence in a small sample at a single facility. Journal of physical therapy science. 2019; 31 (1): 69-74. doi:10.1589/jpts.31.69  
94.   Nishi Yasuhiro, Nomura Taro, Murakami Mamoru, et al. Effect of denture adhesives on oral moisture: A multicenter randomized controlled trial. Journal of Prosthodontic Research. 2019; : . doi:10.1016/j.jpor.2019.08.004  
95.   Ohi Takashi, Komiyama Takamasa, Miyoshi Yoshitada, et al. The association between bilateral maximum occlusal force and all-cause mortality among community-dwelling older adults: The Tsurugaya project. Journal of Prosthodontic Research. 2019; : . doi:10.1016/j.jpor.2019.08.005  
96.   Satoh Michihiro, Metoki Hirohito, Asayama Kei, et al. Age-Related Trends in Home Blood Pressure, Home Pulse Rate, and Day-to-Day Blood Pressure and Pulse Rate Variability Based on Longitudinal Cohort Data: The Ohasama Study. Journal of the American Heart Association. 2019; 8 (15): e012121. doi:10.1161/JAHA.119.012121  
97.   Tanikawa Chizu, Kamatani Yoichiro, Terao Chikashi, et al. Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. Journal of the American Society of Nephrology : JASN. 2019; 30 (5): 855-864. doi:10.1681/ASN.2018090942  
98.   Takeuchi Hikaru, Taki Yasuyuki, Nouchi Rui, et al. Association of iron levels in hair with brain structures and functions in young adults. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2019; 58 : 126436. doi:10.1016/j.jtemb.2019.126436  
99.   Hashimoto Taeko, Harita Yutaka, Takizawa Keiichi, et al. In Vivo Expression of NUP93 and Its Alteration by NUP93 Mutations Causing Focal Segmental Glomerulosclerosis. Kidney international reports. 2019; 4 (9): 1312-1322. doi:10.1016/j.ekir.2019.05.1157  
100.   Wang Jiao, Kano Kuniyuki, Saigusa Daisuke, Aoki Junken. Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection. Mass spectrometry (Tokyo, Japan). 2019; 8 (1): A0072. doi:10.5702/massspectrometry.A0072  
101.   Izumi Yoshihiro, Matsuda Fumio, Hirayama Akiyoshi, et al. Inter-Laboratory Comparison of Metabolite Measurements for Metabolomics Data Integration. Metabolites. 2019; 9 (11): . doi:10.3390/metabo9110257  
102.   Katsuoka Fumiki, Otsuki Akihito, Takahashi Mizue, et al. Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells. Molecular and Cellular Biology. 2019; 39 (20): . doi:10.1128/MCB.00273-19  
103.   Iwasawa Shinya, Kikuchi Atsuo, Wada Yoichi, et al. The prevalence of GALM mutations that cause galactosemia: A database of functionally evaluated variants. Molecular genetics and metabolism. 2019; 126 (4): 362-367. doi:10.1016/j.ymgme.2019.01.018  
104.   Takata Ryo, Takahashi Atsushi, Fujita Masashi, et al. 12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population. Nature Communications. 2019; 10 (1): 4422. doi:10.1038/s41467-019-12267-6  
105.   Nikopoulos Konstantinos, Cisarova Katarina, Quinodoz Mathieu, et al. A frequent variant in the Japanese population determines quasi-Mendelian inheritance of rare retinal ciliopathy. Nature communications. 2019; 10 (1): 2884. doi:10.1038/s41467-019-10746-4  
106.   Yamamoto Yoichiro, Tsuzuki Toyonori, Akatsuka Jun, et al. Automated acquisition of explainable knowledge from unannotated histopathology images. Nature Communications. 2019; 10 (1): 5642. doi:10.1038/s41467-019-13647-8  
107.   Akiyama Masato, Ishigaki Kazuyoshi, Sakaue Saori, et al. Characterizing rare and low-frequency height-associated variants in the Japanese population. Nature communications. 2019; 10 (1): 4393. doi:10.1038/s41467-019-12276-5  
108.   Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4  
109.   Suzuki Ken, Akiyama Masato, Ishigaki Kazuyoshi, et al. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. Nature Genetics. 2019; 51 (3): 379-386. doi:10.1038/s41588-018-0332-4  
110.   Ishiura Hiroyuki, Shibata Shota, Yoshimura Jun, et al. Noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and an overlapping disease. Nature Genetics. 2019; 51 (8): 1222-1232. doi:10.1038/s41588-019-0458-z  
111.   Evangelou Evangelos, Gao He, Chu Congying, et al. New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders. Nature human behaviour. 2019; 3 (9): 950-961. doi:10.1038/s41562-019-0653-z  
112.   Tanaka Asahi, Arai Yasumichi, Hirata Takumi, et al. [Effects of polypharmacy and anticholinergic/sedative drugs on the physical/cognitive/mental related outcomes of community-dwelling elderly people: The Kawasaki Wellbeing Project]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. 2019; 56 (4): 504-515. doi:10.3143/geriatrics.56.504  
113.   Obayashi Takeshi, Kagaya Yuki, Aoki Yuichi, et al. COXPRESdb v7: a gene coexpression database for 11 animal species supported by 23 coexpression platforms for technical evaluation and evolutionary inference. Nucleic acids research. 2019; 47 (D1): D55-D62. doi:10.1093/nar/gky1155  
114.   Morita Masahiko, Shimokawa Kazuro, Nishimura Masaomi, et al. ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks. Nucleic Acids Research. 2019; 47 (D1): D859-D866. doi:10.1093/nar/gky951  
115.   Murakami Mamoru, Nishi Yasuhiro, Harada Kea, et al. Impact of Oral Intake of Glucosylceramide Extracted from Pineapple on Xerostomia: A Double-Blind Randomized Cross-Over Trial. Nutrients. 2019; 11 (9): . doi:10.3390/nu11092020  
116.   Nishi Daisuke, Su Kuan-Pin, Usuda Kentaro, et al. Differences between Japan and Taiwan in the treatment of pregnant women with depressive symptoms by omega-3 fatty acids: An open-label pilot study. Nutritional Neuroscience. 2019; 22 (1): 63-71. doi:10.1080/1028415X.2017.1354540  
117.   Amano Yuji, Akazawa Yohei, Yasuda Jun, et al. A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease. Pediatric rheumatology online journal. 2019; 17 (1): 34. doi:10.1186/s12969-019-0337-2  
118.   Ishikawa Tomofumi, Obara Taku, Jin Kazutaka, et al. Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. Pharmacoepidemiology and Drug Safety. 2019; 28 (6): 804-811. doi:10.1002/pds.4749  
119.   Okutani Fuki, Hamamoto Shoichiro, Aoki Yuichi, et al. Rhizosphere modelling reveals spatiotemporal distribution of daidzein shaping soybean rhizosphere bacterial community. Plant, cell & environment. 2019; 74 (1): pce.13708. doi:10.1111/pce.13708  
120.   Ueki Masao, Fujii Masahiro, Tamiya Gen, for Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer’s Disease Metabolomics Consortium. Quick assessment for systematic test statistic inflation/deflation due to null model misspecifications in genome-wide environment interaction studies. PloS one. 2019; 14 (7): e0219825. doi:10.1371/journal.pone.0219825  
121.   Matsudaira Izumi, Oba Kentaro, Takeuchi Hikaru, et al. rs1360780 of the FKBP5 gene modulates the association between maternal acceptance and regional gray matter volume in the thalamus in children and adolescents. PloS one. 2019; 14 (8): e0221768. doi:10.1371/journal.pone.0221768  
122.   Nishi Daisuke, Su Kuan-Pin, Usuda Kentaro, et al. The Efficacy of Omega-3 Fatty Acids for Depressive Symptoms among Pregnant Women in Japan and Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial (SYNCHRO; NCT01948596). Psychotherapy and Psychosomatics. 2019; 88 (2): 122-124. doi:10.1159/000495296  
123.   Kobayashi Satomi, Yuan Xiaoyi, Sasaki Satoshi, et al. Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years or older. Public Health Nutrition. 2019; 22 (2): 212-222. doi:10.1017/S1368980018002331  
124.   Nagai Koshi, Uranbileg Baasanjav, Chen Zhen, et al. Identification of novel biomarkers of hepatocellular carcinoma by high‐definition mass spectrometry: Ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging. Rapid Communications in Mass Spectrometry. 2019; : rcm.8551. doi:10.1002/rcm.8551  
125.   Hattori Hiromitsu, Kitamura Akane, Takahashi Fumiaki, et al. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. Reproductive biology and endocrinology : RB&E. 2019; 17 (1): 27. doi:10.1186/s12958-019-0471-1  
126.   Miura Emiri, Tsuchiya Naho, Igarashi Yu, et al. Respiratory resistance among adults in a population-based cohort study in Northern Japan. Respiratory Investigation. 2019; 57 (3): 274-281. doi:10.1016/j.resinv.2018.12.008  
127.   Uranbileg Baasanjav, Ito Nobuko, Kurano Makoto, et al. Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model. Scientific reports. 2019; 9 (1): 16578. doi:10.1038/s41598-019-52999-5  
128.   Sato Koji, Hirano Ikuo, Sekine Hiroki, et al. An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts. Scientific reports. 2019; 9 (1): 11254. doi:10.1038/s41598-019-47766-5  
129.   Kanemitsu Yoshitomi, Mishima Eikan, Maekawa Masamitsu, et al. Comprehensive and semi-quantitative analysis of carboxyl-containing metabolites related to gut microbiota on chronic kidney disease using 2-picolylamine isotopic labeling LC-MS/MS. Scientific reports. 2019; 9 (1): 19075. doi:10.1038/s41598-019-55600-1  
130.   Low Siew-Kee, Chin Yoon Ming, Ito Hidemi, et al. Identification of two novel breast cancer loci through large-scale genome-wide association study in the Japanese population. Scientific reports. 2019; 9 (1): 17332. doi:10.1038/s41598-019-53654-9  
131.   Ikeda-Sakai Yasuko, Saito Yoshiyuki, Obara Taku, et al. Inadequate Folic Acid Intake Among Women Taking Antiepileptic Drugs During Pregnancy in Japan: A Cross-Sectional Study. Scientific Reports. 2019; 9 (1): 13497. doi:10.1038/s41598-019-49782-x  
132.   Nakagawa Seishu, Takeuchi Hikaru, Taki Yasuyuki, et al. Mean diffusivity related to collectivism among university students in Japan. Scientific reports. 2019; 9 (1): 1338. doi:10.1038/s41598-018-37995-5  
133.   Nakagawa Seishu, Takeuchi Hikaru, Taki Yasuyuki, et al. Mean diffusivity related to rule-breaking guilt: the Macbeth effect in the sensorimotor regions. Scientific reports. 2019; 9 (1): 12227. doi:10.1038/s41598-019-48654-8  
134.   Hitomi Yuki, Ueno Kazuko, Kawai Yosuke, et al. POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33. Scientific reports. 2019; 9 (1): 102. doi:10.1038/s41598-018-36490-1  
135.   Oe Yuji, Fushima Tomofumi, Sato Emiko, et al. Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury. Scientific reports. 2019; 9 (1): 2986. doi:10.1038/s41598-019-39914-8  
136.   Ishimaru Kazuhiro, Yoshioka Kazuaki, Kano Kuniyuki, et al. Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation. Scientific reports. 2019; 9 (1): 18329. doi:10.1038/s41598-019-54877-6  
137.   Nishiyama Takeshi, Nakatochi Masahiro, Goto Atsushi, et al. Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population. Sleep. 2019; 42 (6): . doi:10.1093/sleep/zsz046  
138.   Takeuchi Hikaru, Taki Yasuyuki, Nouchi Rui, et al. Mean diffusivity associated with trait emotional intelligence. Social cognitive and affective neuroscience. 2019; 14 (8): 871-883. doi:10.1093/scan/nsz059  
139.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
140.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children’s Study. The Journal of Maternal-Fetal & Neonatal Medicine. 2019; : 1-8. doi:10.1080/14767058.2018.1560414  
141.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children's Study. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2019; : 1-8. doi:10.1080/14767058.2018.1560415  
142.   Mimori Takahiro, Yasuda Jun, Kuroki Yoko, et al. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing. The Pharmacogenomics Journal. 2019; 19 (2): 136-146. doi:10.1038/s41397-017-0010-4  
143.   Ishii Tadashi, Akaishi Tetsuya, Fujimori Kenji, et al. Application of Large Electronic Medical Database for Detecting Undiagnosed Patients in the General Population. The Tohoku journal of experimental medicine. 2019; 249 (2): 113-119. doi:10.1620/tjem.249.113  
144.   Minegishi Naoko, Nishijima Ichiko, Nobukuni Takahiro, et al. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project. The Tohoku journal of experimental medicine. 2019; 248 (1): 45-55. doi:10.1620/tjem.248.45  
145.   Itto Rina, Oe Yuji, Imaruoka Kenta, et al. Glomerular Injury Is Exacerbated in Lupus-Prone MRL/lpr Mice Treated with a Protease-Activated Receptor 2 Antagonist. The Tohoku journal of experimental medicine. 2019; 249 (2): 127-133. doi:10.1620/tjem.249.127  
146.   Sakama Reiko, Yokokawa Hirohide, Fujibayashi Kazutoshi, et al. Psychological Characteristics of Children at Two Years after the Great East Japan Earthquake: Analyses of Telephone Consultation Records. The Tohoku journal of experimental medicine. 2019; 249 (2): 85-92. doi:10.1620/tjem.249.85  
147.   Oe Yuji, Sato Emiko, Sato Hiroshi, et al. Uremic toxins alter coagulation and fibrinolysis-related genes expression in human endothelial cells. Thrombosis research. 2019; 186 : 75-77. doi:10.1016/j.thromres.2019.12.017