Tohoku University Tohoku Medical Megabank Organization (2019)

1.   Nakaya Naoki, Sone Toshimasa, Tomata Yasutake, et al. All-cause mortality among Japanese whose cohabiting partners are diagnosed with cancer: the Ohsaki Cohort 2006 study. Acta Oncologica. 2019; 58 (4): 425-431. doi:10.1080/0284186X.2018.1562208  
2.   Huang Cong, Kogure Mana, Tomata Yasutake, et al. Association of serum adiponectin levels and body mass index with worsening depressive symptoms in elderly individuals: a 10-year longitudinal study. Aging & Mental Health. 2019; : 1-7. doi:10.1080/13607863.2019.1584877  
3.   Watanabe Mari, Oe Yuji, Sato Emiko, et al. Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity. American journal of physiology. Renal physiology. 2019; 316 (4): F654-F659. doi:10.1152/ajprenal.00489.2018  
4.   Iwasawa Shinya, Yanagi Kumiko, Kikuchi Atsuo, et al. Recurrent de novo MAPK8IP3 variants cause neurological phenotypes. Annals of neurology. 2019; 85 (6): 927-933. doi:10.1002/ana.25481  
5.   Isojima Tsuyoshi, Kato Noriko, Yokoya Susumu, et al. Early excessive growth with distinct seasonality in preschool obesity. Archives of disease in childhood. 2019; 104 (1): 53-57. doi:10.1136/archdischild-2018-314862  
6.   Imaruoka Kenta, Oe Yuji, Fushima Tomofumi, et al. Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide. Biochemical and biophysical research communications. 2019; 510 (4): 587-593. doi:10.1016/j.bbrc.2019.01.110  
7.   Keleku-Lukwete Nadine, Suzuki Mikiko, Panda Harit, et al. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood advances. 2019; 3 (8): 1285-1297. doi:10.1182/bloodadvances.2018017574  
8.   Kubo Sachimi, Nishida Yoko, Kubota Yoshimi, et al. Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. BMC nephrology. 2019; 20 (1): 117. doi:10.1186/s12882-019-1291-4  
9.   Murakami Keiko, Hashimoto Hideki. Associations of education and income with heavy drinking and problem drinking among men: evidence from a population-based study in Japan. BMC public health. 2019; 19 (1): 420. doi:10.1186/s12889-019-6790-5  
10.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): bmjopen-2018-025939. doi:10.1136/bmjopen-2018-025939  
11.   Ikeda Shigeyuki, Takeuchi Hikaru, Taki Yasuyuki, et al. Neural substrates of self‐ and external‐preoccupation: A voxel‐based morphometry study. Brain and Behavior. 2019; : e01267. doi:10.1002/brb3.1267  
12.   Takeuchi Hikaru, Tomita Hiroaki, Taki Yasuyuki, et al. Effect of the interaction between BDNF Val66Met polymorphism and daily physical activity on mean diffusivity. Brain Imaging and Behavior. 2019; : . doi:10.1007/s11682-018-0025-8  
13.   Takeuchi Hikaru, Taki Yasuyuki, Nouchi Rui, et al. Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions. Brain structure & function. 2019; 224 (3): 1203-1217. doi:10.1007/s00429-019-01830-y  
14.   Kuniyoshi Yasutaka, Kikuya Masahiro, Matsubara Hiroko, et al. Association of Feeding Practice with Childhood Overweight and/or Obesity in Affected Areas Before and After the Great East Japan Earthquake. Breastfeeding Medicine. 2019; : bfm.2018.0254. doi:10.1089/bfm.2018.0254  
15.   Harada Nobuhiko, Hasegawa Atsushi, Hirano Ikuo, et al. GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. Cancer science. 2019; 110 (4): 1183-1193. doi:10.1111/cas.13959  
16.   Nishikawa Tomofumi, Miyamatsu Naomi, Higashiyama Aya, et al. Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study. Cerebrovascular Diseases. 2019; : 1-8. doi:10.1159/000500075  
17.   Kikuchi Haruhisa, Kawai Kosuke, Nakashiro Yota, et al. Construction of a Meroterpenoid-Like Compounds Library Based on Diversity-Enhanced Extracts. Chemistry (Weinheim an der Bergstrasse, Germany). 2019; 25 (4): 1106-1112. doi:10.1002/chem.201805417  
18.   Kurosawa Ryo, Satoh Kimio, Kikuchi Nobuhiro, et al. Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds-. Circulation Research. 2019; : CIRCRESAHA.119.315229. doi:10.1161/CIRCRESAHA.119.315229  
19.   Noda Aoi, Obara Taku, Abe Shinya, et al. The present situation of home blood pressure measurement among outpatients in Japan. Clinical and Experimental Hypertension. 2019; : 1-8. doi:10.1080/10641963.2019.1571601  
20.   Doi A, Kano S, Asano M, et al. Autoantibodies to killer cell immunoglobulin-like receptor 3DL1 in patients with systemic lupus erythematosus. Clinical and experimental immunology. 2019; 195 (3): 358-363. doi:10.1111/cei.13235  
21.   Yamada Hiroyuki, Doi Kent, Tsukamoto Tatsuo, et al. Low-dose atrial natriuretic peptide for prevention or treatment of acute kidney injury: a systematic review and meta-analysis. Critical care (London, England). 2019; 23 (1): 41. doi:10.1186/s13054-019-2330-z  
22.   Hatta Waku, Koike Tomoyuki, Okata Hideki, et al. Continuous liquid‐suction catheter attachment for endoscope reduces volume of liquid reflux to the mouth in esophageal endoscopic submucosal dissection. Digestive Endoscopy. 2019; : den.13392. doi:10.1111/den.13392  
23.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. Disaster Medicine and Public Health Preparedness. 2019; : 1-7. doi:10.1017/dmp.2019.8  
24.   Itoi Keiichi, Motoike Ikuko, Liu Ying, et al. Genome-Wide Analysis of Glucocorticoid-Responsive Transcripts in the Hypothalamic Paraventricular Region of Male Rats. Endocrinology. 2019; 160 (1): 38-54. doi:10.1210/en.2018-00535  
25.   Nakamura Mieko, Ojima Toshiyuki, Nagahata Tomomi, et al. Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: findings from the NIPPON DATA2010. Environmental health and preventive medicine. 2019; 24 (1): 1. doi:10.1186/s12199-018-0752-x  
26.   Miyazawa Itsuko, Miura Katsuyuki, Miyagawa Naoko, et al. Relationship between carbohydrate and dietary fibre intake and the risk of cardiovascular disease mortality in Japanese: 24-year follow-up of NIPPON DATA80. European Journal of Clinical Nutrition. 2019; : . doi:10.1038/s41430-019-0424-y  
27.   Akaishi Tetsuya, Onishi Eiko, Abe Michiaki, et al. The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid. Fluids and barriers of the CNS. 2019; 16 (1): 8. doi:10.1186/s12987-019-0128-7  
28.   Manome Ayumi, Abiko Yuki, Kawashima Junko, et al. Acidogenic Potential of Oral Bifidobacterium and Its High Fluoride Tolerance. Frontiers in microbiology. 2019; 10 : 1099. doi:10.3389/fmicb.2019.01099  
29.   Yamada Shinya, Hatta Waku, Shimosegawa Tooru, et al. Different risk factors between early and late cancer recurrences in patients without additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer. Gastrointestinal Endoscopy. 2019; 89 (5): 950-960. doi:10.1016/j.gie.2018.11.015  
30.   Shimanoe C, Hachiya T, Hara M, et al. A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression. Genes, brain, and behavior. 2019; 18 (2): e12481. doi:10.1111/gbb.12481  
31.   Wada Yoichi, Kikuchi Atsuo, Arai-Ichinoi Natsuko, et al. Biallelic GALM pathogenic variants cause a novel type of galactosemia. Genetics in Medicine. 2019; 21 (6): 1286-1294. doi:10.1038/s41436-018-0340-x  
32.   Mori Minako, Hira Asuka, Yoshida Kenichi, et al. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2019; : haematol.2018.207241. doi:10.3324/haematol.2018.207241  
33.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
34.   Fujishima Fumiyoshi, Katsushima Hiroki, Fukuhara Noriko, et al. Immunohistochemical pattern of c-MYC protein judged as “+/(weak)+/−” by a new notation correlates with MYC gene nontranslocation in large B-cell lymphoma. Human Pathology. 2019; 85 : 112-118. doi:10.1016/j.humpath.2018.10.025  
35.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study. Hypertension Research. 2019; 42 (1): 85-94. doi:10.1038/s41440-018-0124-3  
36.   Tanaka Kosuke, Nishigori Hidekazu, Watanabe Zen, et al. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019; 42 (4): 558-566. doi:10.1038/s41440-019-0206-x  
37.   Akaishi Tetsuya, Kiyomoto Hideyasu, Abe Michiaki, et al. A 29-year-old Woman with Recurrent Pregnancy-induced Hypertension Based on Vascular Compression of the Medulla Oblongata. Internal Medicine. 2019; : . doi:10.2169/internalmedicine.2382-18  
38.   Sato Tomonori, Kawasaki Yoshihide, Maekawa Masamitsu, et al. Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma. International journal of cancer. 2019; 145 (2): 484-493. doi:10.1002/ijc.32115  
39.   Sakurai Rieko, Ueki Masao, Makino Satoshi, et al. Outlier detection for questionnaire data in biobanks. International Journal of Epidemiology. 2019; : . doi:10.1093/ije/dyz012  
40.   Ohwada G, Minakuchi S, Sato Y, et al. Subjective Evaluation of Denture Adhesives: A Multicenter Randomized Controlled Trial. JDR Clinical & Translational Research. 2019; : 238008441983760. doi:10.1177/2380084419837607  
41.   Tayama J, Ogawa S, Nakaya N, et al. Omega-3 polyunsaturated fatty acids and psychological intervention for workers with mild to moderate depression: A double-blind randomized controlled trial. Journal of affective disorders. 2019; 245 : 364-370. doi:10.1016/j.jad.2018.11.039  
42.   Watanabe Zen, Nishigori Hidekazu, Tanoue Kaou, et al. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. Journal of affective disorders. 2019; 245 : 475-483. doi:10.1016/j.jad.2018.11.061  
43.   Yoshida Makiko, Obara Taku, Kikuchi Saya, et al. Drug Prescriptions for Children With ADHD in Japan: A Study Based on Health Insurance Claims Data Between 2005 and 2015. Journal of Attention Disorders. 2019; : 108705471984317. doi:10.1177/1087054719843179  
44.   Dodo Mina, Kitamura Hiroshi, Shima Hiroki, et al. Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A. Journal of biochemistry. 2019; 165 (4): 323-334. doi:10.1093/jb/mvy108  
45.   Kakuta Yoichi, Kawai Yosuke, Naito Takeo, et al. A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals. Journal of Crohn's and Colitis. 2019; 13 (5): 648-658. doi:10.1093/ecco-jcc/jjy197  
46.   Kiniwa Yukiko, Yasuda Jun, Saito Sakae, et al. Identification of genetic alterations in extramammary Paget disease using whole exome analysis. Journal of Dermatological Science. 2019; 94 (1): 229-235. doi:10.1016/j.jdermsci.2019.03.006  
47.   Yang Yunqing, Hozawa Atsushi, Kogure Mana, et al. Dietary inflammatory index positively associated with high-sensitivity C-reactive protein level in Japanese from NIPPON DATA2010. Journal of epidemiology. 2019; : . doi:10.2188/jea.JE20180156  
48.   Igarashi Ayaka, Aida Jun, Sairenchi Toshimi, et al. Does Cigarette Smoking Increase Traffic Accident Death During 20 Years Follow-up in Japan? The Ibaraki Prefectural Health Study. Journal of epidemiology. 2019; 29 (5): 192-196. doi:10.2188/jea.JE20170330  
49.   Mizuguchi Takeshi, Suzuki Takeshi, Abe Chihiro, et al. A 12-kb structural variation in progressive myoclonic epilepsy was newly identified by long-read whole-genome sequencing. Journal of human genetics. 2019; 64 (5): 359-368. doi:10.1038/s10038-019-0569-5  
50.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. Journal of hypertension. 2019; 37 (1): 206-215. doi:10.1097/HJH.0000000000001846  
51.   Satoh Atsushi, Arima Hisatomi, Hozawa Atsushi, et al. The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men. Journal of Hypertension. 2019; : 1. doi:10.1097/HJH.0000000000002080  
52.   Numakura Chikahiko, Tamiya Gen, Ueki Masao, et al. Growth impairment in individuals with citrin deficiency. Journal of inherited metabolic disease. 2019; 42 (3): 501-508. doi:10.1002/jimd.12051  
53.   Shido Kosuke, Kojima Kaname, Yamasaki Kenshi, et al. Susceptibility Loci for Tanning Ability in the Japanese Population Identified by a Genome-Wide Association Study from the Tohoku Medical Megabank Project Cohort Study. Journal of Investigative Dermatology. 2019; : . doi:10.1016/j.jid.2019.01.015  
54.   Fujita Takaaki, Sato Atsushi, Narita Akira, et al. Use of a multilayer perceptron to create a prediction model for dressing independence in a small sample at a single facility. Journal of physical therapy science. 2019; 31 (1): 69-74. doi:10.1589/jpts.31.69  
55.   Tanikawa Chizu, Kamatani Yoichiro, Terao Chikashi, et al. Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. Journal of the American Society of Nephrology : JASN. 2019; 30 (5): 855-864. doi:10.1681/ASN.2018090942  
56.   Wang Jiao, Kano Kuniyuki, Saigusa Daisuke, Aoki Junken. Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection. Mass spectrometry (Tokyo, Japan). 2019; 8 (1): A0072. doi:10.5702/massspectrometry.A0072  
57.   Iwasawa Shinya, Kikuchi Atsuo, Wada Yoichi, et al. The prevalence of GALM mutations that cause galactosemia: A database of functionally evaluated variants. Molecular genetics and metabolism. 2019; 126 (4): 362-367. doi:10.1016/j.ymgme.2019.01.018  
58.   Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4  
59.   Suzuki Ken, Akiyama Masato, Ishigaki Kazuyoshi, et al. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. Nature Genetics. 2019; 51 (3): 379-386. doi:10.1038/s41588-018-0332-4  
60.   Obayashi Takeshi, Kagaya Yuki, Aoki Yuichi, et al. COXPRESdb v7: a gene coexpression database for 11 animal species supported by 23 coexpression platforms for technical evaluation and evolutionary inference. Nucleic acids research. 2019; 47 (D1): D55-D62. doi:10.1093/nar/gky1155  
61.   Morita Masahiko, Shimokawa Kazuro, Nishimura Masaomi, et al. ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks. Nucleic Acids Research. 2019; 47 (D1): D859-D866. doi:10.1093/nar/gky951  
62.   Nishi Daisuke, Su Kuan-Pin, Usuda Kentaro, et al. Differences between Japan and Taiwan in the treatment of pregnant women with depressive symptoms by omega-3 fatty acids: An open-label pilot study. Nutritional Neuroscience. 2019; 22 (1): 63-71. doi:10.1080/1028415X.2017.1354540  
63.   Ishikawa Tomofumi, Obara Taku, Jin Kazutaka, et al. Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. Pharmacoepidemiology and Drug Safety. 2019; : . doi:10.1002/pds.4749  
64.   Nishi Daisuke, Su Kuan-Pin, Usuda Kentaro, et al. The Efficacy of Omega-3 Fatty Acids for Depressive Symptoms among Pregnant Women in Japan and Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial (SYNCHRO; NCT01948596). Psychotherapy and Psychosomatics. 2019; 88 (2): 122-124. doi:10.1159/000495296  
65.   Hattori Hiromitsu, Kitamura Akane, Takahashi Fumiaki, et al. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. Reproductive biology and endocrinology : RB&E. 2019; 17 (1): 27. doi:10.1186/s12958-019-0471-1  
66.   Miura Emiri, Tsuchiya Naho, Igarashi Yu, et al. Respiratory resistance among adults in a population-based cohort study in Northern Japan. Respiratory Investigation. 2019; 57 (3): 274-281. doi:10.1016/j.resinv.2018.12.008  
67.   Nakagawa Seishu, Takeuchi Hikaru, Taki Yasuyuki, et al. Mean diffusivity related to collectivism among university students in Japan. Scientific reports. 2019; 9 (1): 1338. doi:10.1038/s41598-018-37995-5  
68.   Hitomi Yuki, Ueno Kazuko, Kawai Yosuke, et al. POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33. Scientific reports. 2019; 9 (1): 102. doi:10.1038/s41598-018-36490-1  
69.   Oe Yuji, Fushima Tomofumi, Sato Emiko, et al. Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury. Scientific reports. 2019; 9 (1): 2986. doi:10.1038/s41598-019-39914-8  
70.   Nishiyama Takeshi, Nakatochi Masahiro, Goto Atsushi, et al. Genome-wide association meta-analysis and Mendelian randomization analysis confirm ALDH2 influencing on sleep duration in the Japanese population. Sleep. 2019; : . doi:10.1093/sleep/zsz046  
71.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
72.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Mother-to-infant bonding failure and intimate partner violence during pregnancy as risk factors for father-to-infant bonding failure at 1 month postpartum: an adjunct study of the Japan Environment and Children’s Study. The Journal of Maternal-Fetal & Neonatal Medicine. 2019; : 1-8. doi:10.1080/14767058.2018.1560414  
73.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. The prevalence and risk factors for postpartum depression symptoms of fathers at one and 6 months postpartum: an adjunct study of the Japan Environment & Children’s Study. The Journal of Maternal-Fetal & Neonatal Medicine. 2019; : 1-8. doi:10.1080/14767058.2018.1560415  
74.   Mimori Takahiro, Yasuda Jun, Kuroki Yoko, et al. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing. The Pharmacogenomics Journal. 2019; 19 (2): 136-146. doi:10.1038/s41397-017-0010-4  
75.   Minegishi Naoko, Nishijima Ichiko, Nobukuni Takahiro, et al. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project. The Tohoku journal of experimental medicine. 2019; 248 (1): 45-55. doi:10.1620/tjem.248.45  
76.   Egiz Mahy, Usui Toshinori, Ishibashi Masumi, et al. La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells. The Tohoku journal of experimental medicine. 2019; 247 (1): 59-67. doi:10.1620/tjem.247.59