Tohoku University Tohoku Medical Megabank Organization (2016)

1.   Sakai Mai, Takahashi Yuta, Yu Zhiqian, Tomita Hiroaki. Microglial Gene Expression Alterations in the Brains of Patients with Psychiatric Disorders. Advances in Neuroimmune Biology. 2016; 6 (2): 83-93. doi:10.3233/NIB-160110  
2.   Matsuo Hirotaka, Yamamoto Ken, Nakaoka Hirofumi, et al. Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes. Annals of the Rheumatic Diseases. 2016; 75 (4): 652-659. doi:10.1136/annrheumdis-2014-206191  
3.   Zhang Qi, Matsui Hiroyuki, Horiuchi Hisanori, et al. A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation. Biochemical and Biophysical Research Communications. 2016; 476 (4): 438-444. doi:10.1016/j.bbrc.2016.05.141  
4.   Tadaka Shu, Kinoshita Kengo. NCMine: Core-peripheral based functional module detection using near-clique mining. Bioinformatics (Oxford, England). 2016; 32 (22): 3454-3460. doi:10.1093/bioinformatics/btw488  
5.   Kanoh Naoki, Mano Kosuke, Saigusa Daisuke, et al. Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate. Bioorganic & Medicinal Chemistry Letters. 2016; 26 (23): 5770-5772. doi:10.1016/j.bmcl.2016.10.046  
6.   Yamada Kazunori D, Nishi Hafumi, Nakata Junichi, Kinoshita Kengo. Structural characterization of single nucleotide variants at ligand binding sites and enzyme active sites of human proteins. Biophysics and physicobiology. 2016; 13 : 157-163. doi:10.2142/biophysico.13.0_157  
7.   Nariai Naoki, Kojima Kaname, Mimori Takahiro, et al. A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes. BMC Genomics. 2016; 17 (S1): 2. doi:10.1186/s12864-015-2295-5  
8.   Hasegawa Takanori, Kojima Kaname, Kawai Yosuke, et al. AP-SKAT: highly-efficient genome-wide rare variant association test. BMC genomics. 2016; 17 (1): 745. doi:10.1186/s12864-016-3094-3  
9.   Kojima Kaname, Kawai Yosuke, Nariai Naoki, et al. Short tandem repeat number estimation from paired-end reads for multiple individuals by considering coalescent tree. BMC genomics. 2016; 17 Suppl 5 : 494. doi:10.1186/s12864-016-2821-0  
10.   Kojima Kaname, Kawai Yosuke, Misawa Kazuharu, et al. STR-realigner: a realignment method for short tandem repeat regions. BMC genomics. 2016; 17 (1): 991. doi:10.1186/s12864-016-3294-x  
11.   Nishi Daisuke, Su Kuan-Pin, Usuda Kentaro, et al. The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol for a randomized controlled trial. BMC psychiatry. 2016; 16 (1): 321. doi:10.1186/s12888-016-1031-2  
12.   Akimoto Yoritaka, Nozawa Takayuki, Kanno Akitake, et al. High-gamma power changes after cognitive intervention: preliminary results from twenty-one senior adult subjects. Brain and Behavior. 2016; 6 (3): n/a-n/a. doi:10.1002/brb3.427  
13.   Satoh H., Moriguchi T., Saigusa D., et al. NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. Cancer Research. 2016; 76 (10): 3088-3096. doi:10.1158/0008-5472.CAN-15-1584  
14.   Hashimoto Teruo, Fukui Kento, Takeuchi Hikaru, et al. Effects of the BDNF Val66Met Polymorphism on Gray Matter Volume in Typically Developing Children and Adolescents. Cerebral Cortex. 2016; 26 (4): 1795-1803. doi:10.1093/cercor/bhw020  
15.   Hattori Motoshi, Iwano Masayuki, Sako Mayumi, et al. Transition of adolescent and young adult patients with childhood-onset chronic kidney disease from pediatric to adult renal services: a nationwide survey in Japan. Clinical and Experimental Nephrology. 2016; 20 (6): 918-925. doi:10.1007/s10157-016-1231-6  
16.   Nakamura Tomohiro, Yamamoto Yoshiro, Douke Hideyuki. Sequential Hypothesis Tests for Identifying the Minimum Dose with a Threshold Effect. Communications in Statistics - Simulation and Computation. 2016; 45 (6): 1950-1970. doi:10.1080/03610918.2014.884588  
17.   Shirota Matsuyuki, Kinoshita Kengo. Discrepancies between human DNA, mRNA and protein reference sequences and their relation to single nucleotide variants in the human population. Database. 2016; 2016 : baw124. doi:10.1093/database/baw124  
18.   Mizuno Satoshi, Nishigori Hidekazu, Sugiyama Takashi, et al. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study. Diabetes research and clinical practice. 2016; 120 : 132-41. doi:10.1016/j.diabres.2016.07.020  
19.   Mishima Eikan, Takeuchi Yoichi, Nagasawa Tasuku, Hashimoto Junichiro. Prelude to Takotsubo cardiomyopathy: subclinical progression of antecedent myocardial ischaemia prior to symptom onset. European Heart Journal. 2016; 37 (37): 2845-2845. doi:10.1093/eurheartj/ehw216  
20.   Kawabe Takeshi, Suzuki Nobu, Yamaki Satoshi, et al. Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice. European Journal of Immunology. 2016; 46 (5): 1119-1131. doi:10.1002/eji.201545907  
21.   Takahashi Yuta, Yu Zhiqian, Sakai Mai, Tomita Hiroaki. Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders. Frontiers in Cellular Neuroscience. 2016; 10 : . doi:10.3389/fncel.2016.00144  
22.   Nouchi Rui, Taki Yasuyuki, Takeuchi Hikaru, et al. Reading Aloud and Solving Simple Arithmetic Calculation Intervention (Learning Therapy) Improves Inhibition, Verbal Episodic Memory, Focus Attention and Processing Speed in Healthy Elderly People: Evidence from a Randomized Controlled Trial. Frontiers in Human Neuroscience. 2016; 10 : . doi:10.3389/fnhum.2016.00217  
23.   Nakagawa Seishu, Takeuchi Hikaru, Taki Yasuyuki, et al. Sex-Related Differences in the Effects of Sleep Habits on Verbal and Visuospatial Working Memory. Frontiers in psychology. 2016; 7 : 1128. doi:10.3389/fpsyg.2016.01128  
24.   Katsuoka Fumiki, Yamamoto Masayuki. Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 2016; 586 (2): 197-205. doi:10.1016/j.gene.2016.03.058  
25.   Katsuoka Fumiki, Yamazaki Hiromi, Yamamoto Masayuki. Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice. Genes to Cells. 2016; 21 (12): 1309-1319. doi:10.1111/gtc.12445  
26.   Ueki Masao, Tamiya Gen. Smooth-Threshold Multivariate Genetic Prediction with Unbiased Model Selection. Genetic Epidemiology. 2016; 40 (3): 233-243. doi:10.1002/gepi.21958  
27.   Koso Hideto, Tsuhako Asano, Lai Chen-Yi, et al. Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina. Glia. 2016; 64 (11): 2005-24. doi:10.1002/glia.23038  
28.   Ishikuro Mami, Ubeda Sergio Ramón Gutiérrez, Obara Taku, et al. Knowledge, Attitude, and Practices Toward Blood Pressure Measurement at Home Among Japanese Nurses. Home healthcare now. 2016; 34 (4): 210-7. doi:10.1097/NHH.0000000000000357  
29.   Arai-Ichinoi Natsuko, Uematsu Mitsugu, Sato Ryo, et al. Genetic heterogeneity in 26 infants with a hypomyelinating leukodystrophy. Human Genetics. 2016; 135 (1): 89-98. doi:10.1007/s00439-015-1617-7  
30.   Yaoita Masako, Niihori Tetsuya, Mizuno Seiji, et al. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Human genetics. 2016; 135 (2): 209-22. doi:10.1007/s00439-015-1627-5  
31.   Satoh Michihiro, Asayama Kei, Kikuya Masahiro, et al. Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study. Hypertension. 2016; 67 (1): 48-55. doi:10.1161/HYPERTENSIONAHA.115.06461  
32.   Iwama Noriyuki, Metoki Hirohito, Ohkubo Takayoshi, et al. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. Hypertension Research. 2016; 39 (3): 151-157. doi:10.1038/hr.2015.108  
33.   Ntineri Angeliki, Stergiou George S, Thijs Lutgarde, et al. Relationship between office and home blood pressure with increasing age: The International Database of HOme blood pressure in relation to Cardiovascular Outcome (IDHOCO). Hypertension Research. 2016; 39 (8): 612-617. doi:10.1038/hr.2016.32  
34.   Ishikura Kazuki, Obara Taku, Kikuya Masahiro, et al. Home blood pressure level and decline in renal function among treated hypertensive patients: the J-HOME-Morning Study. Hypertension research : official journal of the Japanese Society of Hypertension. 2016; 39 (2): 107-12. doi:10.1038/hr.2015.110  
35.   Watanabe Ko, Tanaka Hiroshi, Takahashi Kensho, et al. NIRS-Based Language Learning BCI System. IEEE Sensors Journal. 2016; 16 (8): 2726-2734. doi:10.1109/JSEN.2016.2519886  
36.   Matsubayashi Makoto, Kawahara Fumiya, Hatta Takeshi, et al. Transcriptional profiles of virulent and precocious strains of Eimeria tenella at sporozoite stage; novel biological insight into attenuated asexual development. Infection, Genetics and Evolution. 2016; 40 : 54-62. doi:10.1016/j.meegid.2016.02.021  
37.   Mashimo Yoichi, Sakurai-Yageta Mika, Watanabe Misa, et al. Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism. Inflammation. 2016; 39 (3): pp 949–962. doi:10.1007/s10753-015-0291-1  
38.   Chagan-Yasutan Haorile, Chen Yue, Lacuesta Talitha Lea, et al. Urine Levels of Defensin α1 Reflect Kidney Injury in Leptospirosis Patients. International journal of molecular sciences. 2016; 17 (10): . doi:10.3390/ijms17101637  
39.   Watanabe Zen, Iwama Noriyuki, Nishigori Hidekazu, et al. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study. Journal of Affective Disorders. 2016; 190 : 341-348. doi:10.1016/j.jad.2015.10.024  
40.   Hirata Aya, Okamura Tomonori, Sugiyama Daisuke, et al. The Relationship between Very High Levels of Serum High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in a 20-Year Follow-Up Study of Japanese General Population. Journal of Atherosclerosis and Thrombosis. 2016; 23 (7): 800-809. doi:10.5551/jat.33449  
41.   Araki Yuta, Okamura Ken, Munkhbat Batmunkh, et al. Whole-exome sequencing confirmation of multiple MC1R variants associated with extensive freckles and red hair: Analysis of a Mongolian family. Journal of dermatological science. 2016; 84 (2): 216-219. doi:10.1016/j.jdermsci.2016.08.009  
42.   Matsubara Hiroko, Ishikuro Mami, Kikuya Masahiro, et al. Design of the Nationwide Nursery School Survey on Child Health Throughout the Great East Japan Earthquake. Journal of Epidemiology. 2016; 26 (2): 98-104. doi:10.2188/jea.JE20150073  
43.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
44.   Ogino Daisuke, Hashimoto Taeko, Hattori Motoshi, et al. Analysis of the genes responsible for steroid-resistant nephrotic syndrome and/or focal segmental glomerulosclerosis in Japanese patients by whole-exome sequencing analysis. Journal of Human Genetics. 2016; 61 (2): 137-141. doi:10.1038/jhg.2015.122  
45.   Sato Emiko, Tsunokuni Yukako, Fushima Tomofumi, et al. OS 08-06 METABOLOMIC ANALYSIS OF A MOUSE MODEL OF PREECLAMPSIA INDUCED BY OVERPRODUCING sFlt-1. Journal of hypertension. 2016; 34 Suppl 1 : e69. doi:10.1097/01.hjh.0000500031.24401.46  
46.   Satoh Michihiro, Haga Toshikazu, Hosaka Miki, et al. The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements. Journal of Hypertension. 2016; 34 (6): 1218-1223. doi:10.1097/HJH.0000000000000902  
48.   Kakazu Eiji, Mauer Amy S., Yin Meng, Malhi Harmeet. Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. Journal of Lipid Research. 2016; 57 (2): 233-245. doi:10.1194/jlr.M063412  
49.   Kakazu Eiji, Mauer Amy S, Yin Meng, Malhi Harmeet. Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. Journal of lipid research. 2016; 57 (2): 233-45. doi:10.1194/jlr.M063412  
50.   Murakami Yoichi, Omori Satoshi, Kinoshita Kengo. NLDB: a database for 3D protein-ligand interactions in enzymatic reactions. Journal of structural and functional genomics. 2016; 17 (4): 101-110. doi:10.1007/s10969-016-9206-0  
51.   Gojobori Takashi, Ikeo Kazuho, Katayama Yukie, et al. VaProS: a database-integration approach for protein/genome information retrieval. Journal of structural and functional genomics. 2016; 17 (4): 69-81. doi:10.1007/s10969-016-9211-3  
52.   Komiyama Takamasa, Ohi Takashi, Miyoshi Yoshitada, et al. Association Between Tooth Loss, Receipt of Dental Care, and Functional Disability in an Elderly Japanese Population: The Tsurugaya Project. Journal of the American Geriatrics Society. 2016; 64 (12): 2495-2502. doi:10.1111/jgs.14390  
53.   Mishima Eikan, Nishimiya Kensuke, Fujiwara Yasushi, et al. Serious Hypocalcemia After Withdrawal of Vitamin D Analog in Bedridden Nonagenarians with Previous Thyroidectomy: A Report of Two Cases. Journal of the American Geriatrics Society. 2016; 64 (6): 1374-1376. doi:10.1111/jgs.14171  
54.   Suzuki T., Yamaguchi H., Kikusato M., et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. Journal of the American Society of Nephrology. 2016; 27 (7): 1925-1932. doi:10.1681/ASN.2015060623  
55.   Maekawa Masamitsu, Omura Kaoru, Sekiguchi Shoutaro, et al. Identification of Two Sulfated Cholesterol Metabolites Found in the Urine of a Patient with Niemann-Pick Disease Type C as Novel Candidate Diagnostic Markers. Mass spectrometry (Tokyo, Japan). 2016; 5 (2): S0053. doi:10.5702/massspectrometry.S0053  
56.   Kitatani Kazuyuki, Iwabuchi Kazuhisa, Snider Ashley, Riboni Laura. Sphingolipids in Inflammation: From Bench to Bedside. Mediators of Inflammation. 2016; 2016 : 1-2. doi:10.1155/2016/7602526  
57.   Ogishima Soichi, Mizuno Satoshi, Kikuchi Masataka, et al. AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer’s Disease Pathogenesis. Methods in molecular biology (Clifton, N.J.). 2016; 1303 : 423-432. doi:10.1007/978-1-4939-2627-5_25  
58.   Kikuchi Masataka, Ogishima Soichi, Mizuno Satoshi, et al. Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer’s Disease. Methods in molecular biology (Clifton, N.J.). 2016; 1303 : 479-491. doi:10.1007/978-1-4939-2627-5_29  
59.   Iso Tatsuro, Suzuki Takafumi, Baird Liam, Yamamoto Masayuki. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells. Molecular and Cellular Biology. 2016; 36 (24): 3100-3112. doi:10.1128/MCB.00389-16  
60.   Hasegawa Atsushi, Kaneko Hiroshi, Ishihara Daishi, et al. GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation. Molecular and Cellular Biology. 2016; 36 (16): 2151-2167. doi:10.1128/MCB.00017-16  
61.   Uruno Akira, Yagishita Yoko, Katsuoka Fumiki, et al. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Molecular and Cellular Biology. 2016; 36 (11): 1655-1672. doi:10.1128/MCB.01095-15  
62.   Sekine Hiroki, Okazaki Keito, Ota Nao, et al. The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Molecular and cellular biology. 2016; 36 (3): 407-20. doi:10.1128/MCB.00785-15  
63.   Shimada Makoto K., Sanbonmatsu Ryoko, Yamaguchi-Kabata Yumi, et al. Selection pressure on human STR loci and its relevance in repeat expansion disease. Molecular Genetics and Genomics. 2016; 291 (5): 1851-1869. doi:10.1007/s00438-016-1219-7  
64.   Takeuchi H, Taki Y, Hashizume H, et al. Impact of videogame play on the brain’s microstructural properties: cross-sectional and longitudinal analyses. Molecular Psychiatry. 2016; 21 (12): 1781-1789. doi:10.1038/mp.2015.193  
65.   Matsumoto Akinobu, Pasut Alessandra, Matsumoto Masaki, et al. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature. 2016; 541 (7636): 228-232. doi:10.1038/nature21034  
66.   Kobayashi Eri H., Suzuki Takafumi, Funayama Ryo, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Communications. 2016; 7 : 11624. doi:10.1038/ncomms11624  
67.   Hidaka Takanori, Ogawa Eisaku, Kobayashi Eri H, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature Immunology. 2016; 18 (1): 64-73. doi:10.1038/ni.3614  
68.   Murakami Keiko, Metoki Hirohito, Satoh Michihiro, et al. Menstrual Factors and Stroke Incidence in Japanese Postmenopausal Women: The Ohasama Study. Neuroepidemiology. 2016; 47 (2): 109-116. doi:10.1159/000452220  
69.   Takeuchi Hikaru, Taki Yasuyuki, Hashizume Hiroshi, et al. Impact of reading habit on white matter structure: Cross-sectional and longitudinal analyses. NeuroImage. 2016; 133 : 378-389. doi:10.1016/j.neuroimage.2016.03.037  
70.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Unemployment risk among individuals undergoing medical treatment for chronic diseases. Occupational Medicine. 2016; 66 (2): 143-149. doi:10.1093/occmed/kqv159  
71.   Shigeta S, Toyoshima M, Kitatani K, et al. Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer. Oncogene. 2016; 35 (27): 3577-86. doi:10.1038/onc.2015.425  
72.   Masamune Atsushi, Nakano Eriko, Niihori Tetsuya, et al. Variants in the UBR1 gene are not associated with chronic pancreatitis in Japan. Pancreatology. 2016; 16 (5): 814-818. doi:10.1016/j.pan.2016.06.662  
73.   Aoki Yuichi, Okamura Yasunobu, Ohta Hiroyuki, et al. ALCOdb: Gene Coexpression Database for Microalgae. Plant & cell physiology. 2016; 57 (1): e3. doi:10.1093/pcp/pcv190  
74.   Aoki Yuichi, Okamura Yasunobu, Tadaka Shu, et al. ATTED-II in 2016: A Plant Coexpression Database Towards Lineage-Specific Coexpression. Plant & cell physiology. 2016; 57 (1): e5. doi:10.1093/pcp/pcv165  
75.   Kohda Masakazu, Tokuzawa Yoshimi, Kishita Yoshihito, et al. A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies. PLOS Genetics. 2016; 12 (1): e1005679. doi:10.1371/journal.pgen.1005679  
76.   Watanabe Masahiro, Hashimoto Koichi, Abe Yusaku, et al. A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo. PLOS ONE. 2016; 11 (9): e0162823. doi:10.1371/journal.pone.0162823  
77.   Shiwa Yuh, Hachiya Tsuyoshi, Furukawa Ryohei, et al. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols. PLOS ONE. 2016; 11 (1): e0147519. doi:10.1371/journal.pone.0147519  
78.   Sasaki Ayaka, Sato Naoko, Suzuki Naoki, et al. Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. PLOS ONE. 2016; 11 (2): e0149322. doi:10.1371/journal.pone.0149322  
79.   Yamagishi Junya, Sato Yukuto, Shinozaki Natsuko, et al. Comparison of Boiling and Robotics Automation Method in DNA Extraction for Metagenomic Sequencing of Human Oral Microbes. PLOS ONE. 2016; 11 (4): e0154389. doi:10.1371/journal.pone.0154389  
80.   Komuro Hazuki, Sato Naoko, Sasaki Ayaka, et al. Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome. PLOS ONE. 2016; 11 (1): e0147817. doi:10.1371/journal.pone.0147817  
81.   Tanaka Yukari, Kanazawa Motoyori, Kano Michiko, et al. Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome. PLOS ONE. 2016; 11 (7): e0157347. doi:10.1371/journal.pone.0157347  
82.   Kimura Yasumasa, Soma Takahiro, Kasahara Naoko, et al. Edesign: Primer and Enhanced Internal Probe Design Tool for Quantitative PCR Experiments and Genotyping Assays. PLOS ONE. 2016; 11 (2): e0146950. doi:10.1371/journal.pone.0146950  
83.   Kuragano Takahiro, Kitamura Kenichiro, Matsumura Osamu, et al. ESA Hyporesponsiveness Is Associated with Adverse Events in Maintenance Hemodialysis (MHD) Patients, But Not with Iron Storage. PLOS ONE. 2016; 11 (3): e0147328. doi:10.1371/journal.pone.0147328  
84.   Saigusa Daisuke, Okamura Yasunobu, Motoike Ikuko N., et al. Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLOS ONE. 2016; 11 (8): e0160555. doi:10.1371/journal.pone.0160555  
85.   Kasahara Kota, Kinoshita Kengo, Schulz R, et al. IBiSA_Tools: A Computational Toolkit for Ion-Binding State Analysis in Molecular Dynamics Trajectories of Ion Channels. PloS one. 2016; 11 (12): e0167524. doi:10.1371/journal.pone.0167524  
86.   Uranbileg Baasanjav, Ikeda Hitoshi, Kurano Makoto, et al. Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. PLOS ONE. 2016; 11 (2): e0149462. doi:10.1371/journal.pone.0149462  
87.   Kasahara Kota, Shirota Matsuyuki, Kinoshita Kengo. Ion Concentration- and Voltage-Dependent Push and Pull Mechanisms of Potassium Channel Ion Conduction. PloS one. 2016; 11 (3): e0150716. doi:10.1371/journal.pone.0150716  
88.   Mizuno Satoshi, Ogishima Soichi, Kitatani Kazuyuki, et al. Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease. PloS one. 2016; 11 (2): e0148431. doi:10.1371/journal.pone.0148431  
89.   Matsudaira Izumi, Yokota Susumu, Hashimoto Teruo, et al. Parental Praise Correlates with Posterior Insular Cortex Gray Matter Volume in Children and Adolescents. PLOS ONE. 2016; 11 (4): e0154220. doi:10.1371/journal.pone.0154220  
90.   Mizuno Satoshi, Ogishima Soichi, Nishigori Hidekazu, et al. The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia. PLOS ONE. 2016; 11 (10): e0162828. doi:10.1371/journal.pone.0162828  
91.   Sugawara Junichi, Hoshiai Tetsuro, Sato Kazuyo, et al. Impact of the Great East Japan Earthquake on Regional Obstetrical Care in Miyagi Prefecture. Prehospital and Disaster Medicine. 2016; 31 (3): 255-258. doi:10.1017/S1049023X1600025X  
92.   Ishikuro Mami, Nakaya Naoki, Obara Taku, et al. Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area. Prehospital and Disaster Medicine. 2016; 31 (3): 330-334. doi:10.1017/S1049023X16000182  
93.   Li Feng, Fushima Tomofumi, Oyanagi Gen, et al. Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia. Proceedings of the National Academy of Sciences. 2016; 113 (47): 13450-13455. doi:10.1073/pnas.1614947113  
94.   Salie Zhe Li, Kirby Karen A., Michailidis Eleftherios, et al. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA). Proceedings of the National Academy of Sciences. 2016; 113 (33): 9274-9279. doi:10.1073/pnas.1605223113  
95.   Kasahara Kota, Kinoshita Kengo. Landscape of protein-small ligand binding modes. Protein Science. 2016; 25 (9): 1659-1671. doi:10.1002/pro.2971  
96.   Nishi Hafumi, Nakata Junichi, Kinoshita Kengo. Distribution of single-nucleotide variants on protein-protein interaction sites and its relationship with minor allele frequency. Protein science : a publication of the Protein Society. 2016; 25 (2): 316-21. doi:10.1002/pro.2845  
97.   Nishi Daisuke, Su Kuan-Pin, Usuda Kentaro, et al. Omega-3 fatty acid supplementation for expectant mothers with depressive symptoms in Japan and Taiwan: An open-label trial. Psychiatry and Clinical Neurosciences. 2016; 70 (6): 253-254. doi:10.1111/pcn.12388  
98.   Yoshida Hirokazu, Kobayashi Natsuko, Honda Nami, et al. Posttraumatic growth of children affected by the Great East Japan Earthquake and their attitudes to memorial services and media coverage. Psychiatry and Clinical Neurosciences. 2016; 70 (5): n/a-n/a. doi:10.1111/pcn.12379  
99.   Nakagawa Seishu, Takeuchi Hikaru, Taki Yasuyuki, et al. Basal ganglia correlates of fatigue in young adults. Scientific Reports. 2016; 6 (1): 21386. doi:10.1038/srep21386  
100.   Takeuchi Hikaru, Taki Yasuyuki, Sekiguchi Atsushi, et al. Differences in gray matter structure correlated to nationalism and patriotism. Scientific Reports. 2016; 6 (1): 29912. doi:10.1038/srep29912  
101.   Nakagawa Seishu, Sugiura Motoaki, Sekiguchi Atsushi, et al. Effects of post-traumatic growth on the dorsolateral prefrontal cortex after a disaster. Scientific reports. 2016; 6 : 34364. doi:10.1038/srep34364  
102.   Sun Yonghu, Irwanto Astrid, Toyo-oka Licht, et al. Fine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn’s disease and leprosy. Scientific Reports. 2016; 6 (1): 31429. doi:10.1038/srep31429  
103.   Sato Emiko, Mori Takefumi, Mishima Eikan, et al. Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease. Scientific Reports. 2016; 6 (1): 36618. doi:10.1038/srep36618  
104.   Nouchi Rui, Takeuchi Hikaru, Taki Yasuyuki, et al. Neuroanatomical bases of effortful control: evidence from a large sample of young healthy adults using voxel-based morphometry. Scientific reports. 2016; 6 : 31231. doi:10.1038/srep31231  
105.   Sekiguchi Atsushi, Sato Chiho, Matsudaira Izumi, et al. Postoperative hormonal therapy prevents recovery of neurological damage after surgery in patients with breast cancer. Scientific reports. 2016; 6 : 34671. doi:10.1038/srep34671  
106.   Sato Masaya, Ikeda Hitoshi, Uranbileg Baasanjav, et al. Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human. Scientific reports. 2016; 6 : 32119. doi:10.1038/srep32119  
107.   Fujiwara Yuichiro, Kondo Hiroko X., Shirota Matsuyuki, et al. Structural basis for the membrane association of ankyrinG via palmitoylation. Scientific Reports. 2016; 6 (1): 23981. doi:10.1038/srep23981  
108.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
109.   Ueno Kazuko, Iwagawa Toshiro, Kuribayashi Hiroshi, et al. Transition of differential histone H3 methylation in photoreceptors and other retinal cells during retinal differentiation. Scientific Reports. 2016; 6 (1): 29264. doi:10.1038/srep29264  
110.   Oba Kentaro, Noriuchi Madoka, Atomi Tomoaki, et al. Memory and reward systems coproduce ‘nostalgic’ experiences in the brain. Social Cognitive and Affective Neuroscience. 2016; 11 (7): 1069-1077. doi:10.1093/scan/nsv073  
111.   Hanawa Sugiko, Sugiura Motoaki, Nozawa Takayuki, et al. The neural basis of the imitation drive. Social cognitive and affective neuroscience. 2016; 11 (1): 66-77. doi:10.1093/scan/nsv089  
112.   Sone Toshimasa, Nakaya Naoki, Sugawara Yumi, et al. Longitudinal association between time-varying social isolation and psychological distress after the Great East Japan Earthquake. Social Science & Medicine. 2016; 152 : 96-101. doi:10.1016/j.socscimed.2016.01.037  
113.   Murakami Keiko, Tsubota-Utsugi Megumi, Satoh Michihiro, et al. Impaired Higher-Level Functional Capacity as a Predictor of Stroke in Community-Dwelling Older Adults: The Ohasama Study. Stroke; a journal of cerebral circulation. 2016; 47 (2): 323-8. doi:10.1161/STROKEAHA.115.011131  
114.   Kubota Yoshiko, Nomura Kazumi, Katoh Yasutake, et al. Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis. The Journal of biological chemistry. 2016; 291 (39): 20516-29. doi:10.1074/jbc.M116.719161  
115.   Takahashi Fumiaki, Nishigori Hidekazu, Nishigori Toshie, et al. Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children’s Study. The Tohoku Journal of Experimental Medicine. 2016; 240 (4): 309-321. doi:10.1620/tjem.240.309  
116.   Nakaya Naoki, Narita Akira, Tsuchiya Naho, et al. Partners’ Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2016; 239 (4): 307-314. doi:10.1620/tjem.239.307  
117.   Stagg H R, Harris R J, Hatherell H-A, et al. What are the most efficacious treatment regimens for isoniazid-resistant tuberculosis? A systematic review and network meta-analysis. Thorax. 2016; 71 (10): 940-949. doi:10.1136/thoraxjnl-2015-208262  
118.   Satoh Michihiro, Obara Taku, Nishigori Hidekazu, et al. Prescription trends in children with pervasive developmental disorders: a claims data-based study in Japan. World journal of pediatrics : WJP. 2016; 12 (4): 443-449. doi:10.1007/s12519-016-0036-8  
119.   相澤 弥生, 川目 裕. 遺伝カウンセラーにおける共感疲労、バーンアウトと共感満足 系統的レビュー. 日本遺伝カウンセリング学会誌. 2016; 37 : 21--30.  
120.   相澤 弥生, 小林 朋子, 川目 裕. 網羅的ゲノム解析における偶発的所見を含む遺伝情報の結果の返却に関する我が国の現状と課題の検討 - 米国臨床遺伝・ゲノム学会 (ACMG) の偶発的所見取り扱いに関する推奨からの考察 -. 日本遺伝カウンセリング学会誌. 2016; 37 : 105 - 126.