東北メディカル・メガバンク機構

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    The Tohoku Medical Megabank Project: Design and Mission

    Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, the Tohoku Medical Megabank Project Study Group, Masayuki Yamamoto
    Published online: 23 June 2016
    Journal of Epidemiology
    Vol. 26 (2016), No. 9 pp. 493-511
    http://doi.org/10.2188/jea.JE20150268

    邦題:東北メディカル・メガバンク計画:デザインとミッション

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    Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project

    Minegishi N, Nishijima I, Nobukuni T, Kudo H, Ishida N, Terakawa T, Kumada K, Yamashita R, Katsuoka F, Ogishima S, Suzuki K, Sasaki M, Satoh M, Tohoku Medical Megabank Project Study Group, Yamamoto M.
    Published online: May 24, 2019
    Journal of Epidemiology
    2019 Volume 248 Issue 1 Pages 45-55
    doi:10.1620/tjem.248.45.

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    3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome

    Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, Satoshi Makino, Sakae Saito, Akihito Otsuki, Chinatsu Gocho, Mika Sakurai-Yageta, Inaho Danjoh, Ikuko N. Motoike, Yumi Yamaguchi-Kabata, Matsuyuki Shirota, Seizo Koshiba, Masao Nagasaki, Naoko Minegishi, Atsushi Hozawa, Shinichi Kuriyama, Atsushi Shimizu, Jun Yasuda, Nobuo Fuse, the Tohoku Medical Megabank Project Study Group, Gen Tamiya, Masayuki Yamamoto & Kengo Kinoshita
    Published: 18 June 2019
    Human Genome Variation 6, Article number: 28 (2019) 
    doi:10.1038/s41439-019-0059-5

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    Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project

    Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai‐Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto
    First published: 27 April 2018
    Genes to Cells
    https://doi.org/10.1111/gtc.12588

    邦題:東北メディカル・メガバンク計画におけるオミックス研究のデザイン

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    Rare variant discovery by deep whole-genome sequencing of 1070 Japanese Individuals

    Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, Kaname Kojima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Junji Yokozawa, Inaho Danjoh, Sakae Saito, Yukuto Sato, Takahiro Mimori, Kaoru Tsuda, Rumiko Saito, Xiaoqing Pan, Satoshi Nishikawa, Shin Ito, Yoko Kuroki, Osamu Tanabe, Nobuo Fuse, Shinichi Kuriyama, Hideyasu Kiyomoto, Atsushi Hozawa, Naoko Minegishi, James Douglas Engel, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, ToMMo Japanese Reference Panel Project & Masayuki Yamamoto
    Nature Communications 6, Article number: 8018
    Published 21 August 2015
    doi: 10.1038/ncomms9018
    PMID: 26292667

    論文概要:東北メディカル・メガバンク計画のコホート調査に参加した健常な日本人1,070人分の全ゲノムを解析し、精度検証を進めることで、日本人の全ゲノムリファレンスパネル(1KJPN)を構築

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    Japonica Array: Improved genotype imputation by designing a population-specific SNP array with 1,070 Japanese individuals

    Yosuke Kawai, Takahiro Mimori, Kaname Kojima, Naoki Nariai, Inaho Danjoh, Rumiko Saito, Jun Yasuda, Masayuki Yamamoto, Masao Nagasaki
    Journal of Human Genetics advance online publication 25 June 2015
    doi: 10.1038/jhg.2015.68

    論文概要:ジャポニカアレイ®:1,070人の日本人の情報に基づく日本人集団に適したSNPアレイの設計によるインピュテーションの改良

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    The structural origin of metabolic quantitative diversity

    Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa,Matsuyuki Shirota, Tomo Saito, Daisuke Saigusa, Inaho Danjoh, Fumiki Katsuoka, Soichi Ogishima, Yosuke Kawai, Yumi Yamaguchi-Kabata, Miyuki Sakurai, Sachiko Hirano, Junichi Nakata, Hozumi Motohashi, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai-Igarashi, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Yoichi Suzuki, Shigeo Kure, Nobuo Yaegashi, Osamu Tanabe, Kengo Kinoshita, Jun Yasuda & Masayuki Yamamoto
    Scientific Reports 6, Article number: 31463 (2016)
    Published online August 16, 2016
    doi:10.1038/srep31463

    邦題:代謝物の量的な多様性の構造的起源

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    Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design

    Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura,Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka and Masayuki Yamamoto
    BMC Medical Informatics and Decision Making (2017) 17:100
    Published: 06 July 2017
    doi:10.1186/s12911-017-0494-5

    邦題:複合バイオバンクでのデータシェアリングにおけるプライバシー保護のためのセキュリティコントロール:根拠と研究デザイン

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    jMorp: Japanese Multi Omics Reference Panel

    Shu Tadaka, Daisuke Saigusa, Ikuko N. Motoike, Jin Inoue, Yuichi Aoki, Matsuyuki Shirota, Seizo Koshiba, Masayuki Yamamoto, Kengo Kinoshita
    Nucleic Acids Research, Volume 46, Issue D1
    Published: 24 October 2017
    doi:10.1093/nar/gkx978

    邦題:jMorp: 日本人多層オミックス参照パネル

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    Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2,049 individuals

    Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, Hiroshi Kawame, Nobuo Fuse, Masao Nagasaki, Yosuke Kawai, Kaname Kojima, Fumiki Katsuoka, Sakae Saito, Inaho Danjoh, Ikuko Motoike, Riu Yamashita, Seizo Koshiba, Daisuke Saigusa, Gen Tamiya, Shigeo Kure, Nobuo Yaegashi, Yoshio Kawaguchi, Fuji Nagami, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Atsushi Hozawa, Soichi Ogishima, Hideyasu Kiyomoto, Takako Takai-Igarashi, ToMMo Study Group, Kengo Kinoshita, Masayuki Yamamoto
    Journal of Human Genetics 63, 213–230 (2018)
    Published online: 01 December 2017
    doi:10.1038/s10038-017-0347-1

    邦題:日本人2,049人の全ゲノムリファレンスパネルを用いた、既報の疾患原因バリアントの頻度と精査

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    Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare

    Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, Mika Sakurai-Yageta, Ikuko N Motoike, Yoko Kuroki, Sakae Saito, Kaname Kojima, Matsuyuki Shirota, Daisuke Saigusa, Akihito Otsuki, Junko Kawashima, Yumi Yamaguchi-Kabata, Shu Tadaka, Yuichi Aoki, Takahiro Mimori, Kazuki Kumada, Jin Inoue, Satoshi Makino, Miho Kuriki, Nobuo Fuse, Seizo Koshiba, Osamu Tanabe, Masao Nagasaki, Gen Tamiya, Ritsuko Shimizu, Takako Takai-Igarashi, Soichi Ogishima, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Akito Tsuboi, Hideyasu Kiyomoto, Tadashi Ishii, Hiroaki Tomita, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroshi Kawame, Hiroshi Tanaka, Yasuyuki Taki, Nobuo Yaegashi, Shigeo Kure, Fuji Nagami, Kenjiro Kosaki, Yoichi Sutoh, Tsuyoshi Hachiya, Atsushi Shimizu, Makoto Sasaki, Masayuki Yamamoto
    The Journal of Biochemistry
    Published online: 19 November 2018
    doi:10.1093/jb/mvy096

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