Tohoku University Tohoku Medical Megabank Organization (2026)
2026.03.09

1.   Fujiwara Masaki, Yamada Yuto, Ishii Taisuke, et al. Impact of Schizophrenia Spectrum Disorders on the Receipt of Invasive and Systemic Therapy for Colorectal Cancer: A Nationwide Multicenter Retrospective Cohort Study in Japan. Acta Psychiatrica Scandinavica. 2026; 153 (3): 191-199. doi:10.1111/acps.70065  
2.   Kanno Miyako, Sato Hiroko, Uemura Yuta, et al. Bleeding Diathesis in Hypotrichosis–Lymphedema–Telangiectasia Syndrome due to Decreased von Willebrand Factor. American Journal of Medical Genetics Part A. 2026; : . doi:10.1002/ajmga.70068  
3.   Yamamoto Naoki, Inoue Jin, Saito Ritsumi, et al. Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2026; 1874 (1): 141105. doi:10.1016/j.bbapap.2025.141105  
4.   Tsuchiya Masami, Funakoshi Ryohkan, Masuyama Koichi, et al. Comparative analysis of the characteristics and trends of adverse drug reaction reports from patients in Japan and the Japanese Adverse Drug Event Report database. British Journal of Clinical Pharmacology. 2026; 92 (2): 515-524. doi:10.1002/bcp.70291  
5.   Nishimura Takayuki, Kunikata Hiroshi, Takada Naoko, et al. Exploring risk factors for axial length elongation: a population-based cohort study of 9195 eyes in Japan. British Journal of Ophthalmology. 2026; 110 (3): 346-352. doi:10.1136/bjo-2025-327213  
6.   Kusano Keisuke, Uno Kaname, Tamahara Toru, et al. Metabolic Syndrome Develops Cardia Cancer via Nuclear Factor-E2-related Factor 2-Programmed Death-Ligand 1 Signaling. Cellular and Molecular Gastroenterology and Hepatology. 2026; 20 (1): 101629. doi:10.1016/j.jcmgh.2025.101629  
7.   Uematsu Ami, Orui Masatsugu, Ishikuro Mami, et al. Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study. Clinical and Experimental Pediatrics. 2026; 69 (1): 36-45. doi:10.3345/cep.2025.01165  
8.   Numazaki Kento, Tamahara Toru, Komiyama Takamasa, et al. Association of anterior crossbite and open bite with the number of remaining teeth: A cross-sectional study from the Tohoku medical megabank cohort. Clinical Oral Investigations. 2026; 30 (1): 43. doi:10.1007/s00784-025-06715-5  
9.   Yokokawa Yuta, Sakurai Rieko, Kudo Daisuke, et al. Clinical subphenotypes of sepsis based on mixed continuous and categorical data and differences in treatment effects: a cluster analysis of multicenter observational studies. Critical Care. 2026; 30 (1): 28. doi:10.1186/s13054-025-05819-4  
10.   Affricano Alex, Fukuuchi Tomoko, Kawamoto Komei, et al. Analysis of the distribution of adenosine and guanosine on fermented soybean cryosections by MALDI-MSI. Food Chemistry. 2026; 498 : 147217. doi:10.1016/j.foodchem.2025.147217  
11.   Chu Ching-Tung, Uruno Akira, Suzuki Takafumi, et al. NRF2 activation by CDDO-Im regulates inflammatory and autophagy pathways in human microglial cells. Free Radical Biology and Medicine. 2026; 243 : 318-337. doi:10.1016/j.freeradbiomed.2025.11.046  
12.   Mizuta Ikuko, Yamashita Fumio, Sutoh Yoichi, et al. Significant Correlation Between White Matter Hyperintensity Volume and Rare NOTCH3 Variants in the General Japanese Population. Geriatrics & Gerontology International. 2026; 26 (2): . doi:10.1111/ggi.70400  
13.   Iwama Noriyuki, Izumi Seiya, Nobayashi Hiroki, et al. Comparison of the associations between office and home BP with placenta-mediated pregnancy complications: the BOSHI study. Hypertension Research. 2026; 49 (3): 926-937. doi:10.1038/s41440-025-02439-x  
14.   Satoh Michihiro, Nakayama Shingo, Nobayashi Hiroki, et al. Current hypertension epidemiology and contemporary approaches using the “Real-World Evidence Cycle” framework. Hypertension Research. 2026; 49 (3): 756-767. doi:10.1038/s41440-025-02532-1  
15.   Satoh Michihiro, Ohkubo Takayoshi. Divergent recommendations for home blood pressure measurement in Japanese and international hypertension guidelines. Hypertension Research. 2026; 49 (3): 988-992. doi:10.1038/s41440-025-02526-z  
16.   Nobayashi Hiroki, Izumi Seiya, Satoh Michihiro, et al. Impact of cumulative blood pressure load during early pregnancy on the risk of low birth weight: the BOSHI study. Hypertension Research. 2026; 49 (2): 550-559. doi:10.1038/s41440-025-02421-7  
17.   Okumiyama Hiroshi, Fujii Ryosuke, Nagayoshi Mako, et al. Integration of polygenic risk score with measured blood pressure reveals hidden risks of cardiovascular disease mortality: A Japanese prospective cohort study. Hypertension Research. 2026; 49 (3): 585-595. doi:10.1038/s41440-025-02486-4  
18.   Hatanaka Rieko, Nakaya Naoki, Kogure Mana, et al. Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study. Hypertension Research. 2026; 49 (2): 303-314. doi:10.1038/s41440-025-02436-0  
19.   Iwabe Yutaro, Satoh Michihiro, Nobayashi Hiroki, et al. Regional disparities in blood pressure control after hypertension treatment initiation in Japan: a real-world data analysis. Hypertension Research. 2026; 49 (2): 328-339. doi:10.1038/s41440-025-02454-y  
20.   Tagami Kazuma, Iwama Noriyuki, Hamada Hirotaka, et al. Twin pregnancies are risk factors for both early- and late-onset hypertensive disorders of pregnancy: the Japan Environment and Children’s study. Hypertension Research. 2026; : . doi:10.1038/s41440-025-02502-7  
21.   Satoh Michihiro, Nobayashi Hiroki, Nakayama Shingo, et al. Visit-to-visit blood pressure variability and dementia risk after considering antihypertensive treatment: real-world data from the Japanese National Health Insurance. Hypertension Research. 2026; 49 (2): 372-383. doi:10.1038/s41440-025-02451-1  
22.   Suzuki Taeko, Nishigori Toshie, Obara Taku, et al. Trajectories of paternal depression symptoms from 1 to 6 months postpartum and associated factors: An Adjunct Study of the Japan Environment and Children's Study. Infant Mental Health Journal: Infancy and Early Childhood. 2026; 47 (1): . doi:10.1002/imhj.70047  
23.   Kanamori Masayuki, Sugawara Yumi, Shimoda Yoshiteru, et al. Long-term intelligence after high-dose radiotherapy to the primary site versus chemotherapy and whole-ventricle radiotherapy in patients with germinoma. International Journal of Clinical Oncology. 2026; : . doi:10.1007/s10147-026-02976-6  
24.   Nakashita Manami, Kamiya Hajime, Watanabe Reiji, et al. Estimated Number of Mumps Cases Based on Clinical and Laboratory Data from Sentinel Surveillance in Kanazawa, Japan. Japanese Journal of Infectious Diseases. 2026; 79 (1): JJID.2024.331. doi:10.7883/yoken.JJID.2024.331  
25.   Fujioka Shunsuke, Takada Naoko, Yoshida Sayaka, et al. Distribution of axial length in Japanese children and adolescents aged 4 to 19 years. Japanese Journal of Ophthalmology. 2026; : . doi:10.1007/s10384-026-01328-1  
26.   Orui Masatsugu, Kogure Mana, Kotozaki Yuka, et al. Screening for Psychological Distress, Disaster-Related Experiences, and Newly Developed Mental Disorders among Residents Affected by the Great East Japan Earthquake: Implications for Suicide Prevention. JMA Journal. 2026; 9 (1): . doi:10.31662/jmaj.2025-0257  
27.   Yoshida Akiko, Tokutomi Tomoharu, Suzumori Nobuhiro, et al. Study Profile of the Iwate PGS Assessment and Risk Communication (PARC) Study. Journal of Epidemiology. 2026; 36 (2): JE20250078. doi:10.2188/jea.JE20250078  
28.   Murakami Keiko, Yonezawa Yudai, Obara Taku, et al. Validity of a Self-administered Food Frequency Questionnaire for Assessing Carotenoid Intakes Using Serum Biomarkers in Japan: The Tohoku Medical Megabank Project. Journal of Epidemiology. 2026; 36 (2): JE20250074. doi:10.2188/jea.JE20250074  
29.   Arakawa Misaki, Takeuchi Tomoyo, Ebana Yusuke, et al. Press release guide for genomic research and medicine: a framework co-developed with public contributors in Japan. Journal of Human Genetics. 2026; 71 (3): 119-124. doi:10.1038/s10038-026-01452-3  
30.   Fukase Satoshi, Kouketsu Atsumu, Tamahara Toru, et al. Differences in the Oral Microbiome Between Patients With and Without Oral Squamous Cell Carcinoma. Journal of Oral Pathology & Medicine. 2026; 55 (3): 368-380. doi:10.1111/jop.70099  
31.   Duan Changrong, Yu Zhiqian, Li Xue, et al. Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study. Molecular Psychiatry. 2026; : . doi:10.1038/s41380-026-03456-z  
32.   Abe Michiaki, Kawaguchi Kazuhiko, Yamasaki Satomi, et al. Citrate supplement facilitated muscle growth and renal maturation. PLOS One. 2026; 21 (1): e0339198. doi:10.1371/journal.pone.0339198  
33.   Feng Jialin, Carreño Mara, Jung Hannah, et al. The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2. Redox Biology. 2026; 90 : 104009. doi:10.1016/j.redox.2026.104009  
34.   Iwasaki Chikashi, Nakaya Kumi, Yamada Mitsuhiro, et al. Age-related factors associated with preserved ratio impaired spirometry: The Tohoku medical Megabank project community-based cohort study. Respiratory Investigation. 2026; 64 (1): 101343. doi:10.1016/j.resinv.2025.101343  
35.   Li Bin, Kumada Kazuki, Shimada Muneaki, et al. Establishment and Operation of a New Style Clinical Biobank: The Tohoku University Clinical Biobank. The Tohoku Journal of Experimental Medicine. 2026; : 2025.J152. doi:10.1620/tjem.2025.J152  
36.   Hamada Nanako, Ito Yuri, Niimi Hinata, et al. Nrf2 contributes to the protective effect of iron overload on thioacetamide-induced chronic liver injury in rats. Toxicological Sciences. 2026; 209 (2): . doi:10.1093/toxsci/kfaf165  
37.   Ohseto Hisashi, Inoue Kosuke, Takahashi Ippei, et al. Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population. Translational Psychiatry. 2026; : . doi:10.1038/s41398-026-03896-9  
38.   Hishinuma Eiji. Characterization of Genetic Polymorphisms Related to 5-FU Metabolizing Enzymes in Japanese Populations. YAKUGAKU ZASSHI. 2026; 146 (1): 25-00124. doi:10.1248/yakushi.25-00124