Tohoku University Tohoku Medical Megabank Organization (2025)
2025.05.01

1.   Ishikuro Mami, Fuse Nobuo, Obara Taku, et al. Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study. AJO International. 2025; 2 (1): 100088. doi:10.1016/j.ajoint.2024.100088  
2.   Kawaguchi Chikana, Ozawa Maki, Hidaka Takanori, et al. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Allergology International. 2025; 74 (2): 246-253. doi:10.1016/j.alit.2024.09.008  
3.   Yoshinaga Kenji, Matsushima Toma, Abe Mitsunari, et al. Age‐disproportionate atrophy in Alzheimer's disease and Parkinson's disease spectra. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2025; 17 (1): . doi:10.1002/dad2.70048  
4.   Saijo Naoya, Yaoita Hisao, Takayama Jun, et al. A Prevalent TMEM260 Deletion Causes Conotruncal Heart Defects, Including Truncus Arteriosus. American Journal of Medical Genetics Part A. 2025; 197 (3): . doi:10.1002/ajmg.a.63906  
5.   Hayashi Hironori, Hasegawa Kazuya, Saijo Erika, et al. Binding of a potential antibacterial drug, mangiferin, to serine hydroxymethyltransferase from Enterococcus faecium. Biochemical and Biophysical Research Communications. 2025; 743 : 151177. doi:10.1016/j.bbrc.2024.151177  
6.   Aoyama Yumi, Yamazaki Hiromi, Nishimura Koutarou, et al. Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages. Blood. 2025; 145 (11): 1149-1163. doi:10.1182/blood.2024025402  
7.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. BMJ Public Health. 2025; 3 (1): e001746. doi:10.1136/bmjph-2024-001746  
8.   Tojo Maki, Iwata Hiroyoshi, Tamura Naomi, et al. Association between small for gestational age and motor coordination difficulties in children aged 5–6 years: Insights from the Hokkaido Study on Environment and Children's Health. Brain and Development. 2025; 47 (1): 104296. doi:10.1016/j.braindev.2024.10.004  
9.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; : CJ-24-0780. doi:10.1253/circj.CJ-24-0780  
10.   Nakayama Shingo, Satoh Michihiro, Toyama Maya, et al. Comparison of the incidence of proteinuria and changes in eGFR among febuxostat and topiroxostat users. Clinical and Experimental Nephrology. 2025; : . doi:10.1007/s10157-025-02630-x  
11.   Iwafuchi Sota, Uchida Nao, Saijo Naoya, et al. Idiopathic infantile hypercalcemia with a CYP24A1 variant triggered by vitamin D supplementation in fortified milk: A case report. Clinical Pediatric Endocrinology. 2025; 34 (1): 2024-0049. doi:10.1297/cpe.2024-0049  
12.   Shima Hirohito, Miura Akinobu, Kawashima Sayaka, et al. Solitary median maxillary central incisor syndrome caused by 22q11.2 microdeletion. Clinical Pediatric Endocrinology. 2025; 34 (1): 2024-0024. doi:10.1297/cpe.2024-0024  
13.   Suzuki Nonoka, Kojima Kaname, Malvica Silvia, et al. Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases. Communications Medicine. 2025; 5 (1): 3. doi:10.1038/s43856-024-00708-3  
14.   Honma Mariko, Suzuki Naoto, Goto Mikako, et al. A case series study on the safety of cefditoren pivoxil use during the first trimester of pregnancy in Japan. Congenital Anomalies. 2025; 65 (1): . doi:10.1111/cga.12588  
15.   ISHIDA Saeko, TAGUCHI Keiko, IIDA Ryuya, et al. Diverse Cre recombinase expression pattern in Albumin-Cre driver rats. Experimental Animals. 2025; : 24-0174. doi:10.1538/expanim.24-0174  
16.   Komiyama Takamasa, Ohi Takashi, Miyoshi Yoshitada, et al. Number of teeth and functional disability in community‐dwelling older adults. Gerodontology. 2025; 42 (1): 86-92. doi:10.1111/ger.12775  
17.   Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974  
18.   Toyama Maya, Satoh Michihiro, Hashimoto Hideaki, et al. Association between equivalized annual household income and regular medical visits for hypertensive patients since the COVID-19 outbreak. Hypertension Research. 2025; 48 (2): 786-795. doi:10.1038/s41440-024-02067-x  
19.   Satoh Michihiro, Metoki Hirohito, Murakami Takahisa, et al. Home blood pressure control and prescribing patterns of anti-hypertensive medications in a home blood pressure-based hypertension-specialized clinic in Japan: a sub-analysis of the Ohasama study. Hypertension Research. 2025; 48 (1): 26-36. doi:10.1038/s41440-024-01954-7  
20.   Satoh Michihiro, Tatsumi Yukako, Nakayama Shingo, et al. Self-measurement of blood pressure at home using a cuff device for change in blood pressure levels: systematic review and meta-analysis. Hypertension Research. 2025; 48 (2): 574-591. doi:10.1038/s41440-024-01981-4  
21.   Ishikuro Mami, Obara Taku, Hasegawa Mayu, et al. Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Hypertension Research. 2025; 48 (1): 68-76. doi:10.1038/s41440-024-01936-9  
22.   Ishikawa Tomofumi, Sakai Takamasa, Noda Aoi, et al. Inclination of antidepressant medication continuation during pregnancy between 2012 and 2023 in Japan: A cohort study. Journal of Affective Disorders. 2025; 374 : 640-645. doi:10.1016/j.jad.2025.01.044  
23.   Satoh Michihiro, Nakayama Shingo, Hashimoto Hideaki, et al. Differential coronary heart disease risk among antihypertensive and lipid-lowering medication users versus non-users: A real-world data analysis. Journal of Clinical Lipidology. 2025; 19 (2): 294-302. doi:10.1016/j.jacl.2024.12.006  
24.   Tagami Kazuma, Iwama Noriyuki, Hamada Hirotaka, et al. Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study. Journal of Diabetes Investigation. 2025; 16 (4): 735-743. doi:10.1111/jdi.14400  
25.   Kiuchi Sakura, Nakaya Kumi, Cooray Upul, et al. A Principal Component Analysis of Metabolome and Cognitive Decline Among Japanese Older Adults: Cross-sectional Analysis Using Tohoku Medical Megabank Cohort Study Data. Journal of Epidemiology. 2025; 35 (1): JE20240099. doi:10.2188/jea.JE20240099  
26.   Murakami Keiko, Ishihara Junko, Takachi Ribeka, et al. Validity and Reproducibility of Food Group Intakes in a Self-administered Food Frequency Questionnaire for Genomic and Omics Research: The Tohoku Medical Megabank Project. Journal of Epidemiology. 2025; 35 (3): JE20240064. doi:10.2188/jea.JE20240064  
27.   Nakaya Naoki, Nakaya Kumi, Kogure Mana, et al. Degree of housing damage caused by the Great East Japan Earthquake and all-cause mortality in the community-based cohort study of the Tohoku Medical Megabank Project. Journal of Epidemiology and Community Health. 2025; : jech-2024-223084. doi:10.1136/jech-2024-223084  
28.   Minn Aye Ko Ko, Matsuzaki Motomichi, Narita Akira, et al. Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank. Journal of Human Genetics. 2025; : . doi:10.1038/s10038-025-01331-3  
29.   Ohneda Kinuko, Suzuki Yoichi, Hamanaka Yohei, et al. Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan. Journal of Human Genetics. 2025; 70 (3): 147-157. doi:10.1038/s10038-024-01314-w  
30.   Takahara Aoi, Nakatsu Toru, Hirata Kazushige, et al. Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors. Journal of Medicinal Chemistry. 2025; 68 (3): 3123-3133. doi:10.1021/acs.jmedchem.4c02337  
31.   Sone Toshimasa, Nakaya Naoki, Sugawara Yumi, et al. Effect of Social Support on Caregiver's Functional Disability Due to Spouse's Functional Disability. Journal of the American Medical Directors Association. 2025; 26 (1): 105324. doi:10.1016/j.jamda.2024.105324  
32.   Narita Daisuke, Hishinuma Eiji, Ebina-Shibuya Risa, et al. Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile. Lung Cancer. 2025; 200 : 108082. doi:10.1016/j.lungcan.2025.108082  
33.   Oshikiri Hiroyuki, Taguchi Keiko, Hirose Wataru, et al. Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma. Molecular and Cellular Biology. 2025; 45 (2): 79-97. doi:10.1080/10985549.2024.2438817  
34.   Iwamura Yuma, Nakai Taku, Kato Koichiro, et al. Erythropoietin Production in Embryonic Neural Cells is Controlled by Hypoxia Signaling and Histone Deacetylases with an Undifferentiated Cellular State. Molecular and Cellular Biology. 2025; 45 (1): 32-45. doi:10.1080/10985549.2024.2428717  
35.   Yamamoto Yuji, Shirai Yuya, Sonehara Kyuto, et al. Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases. Nature Communications. 2025; 16 (1): 3765. doi:10.1038/s41467-025-58149-y  
36.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. Nutrition. 2025; 135 : 112739. doi:10.1016/j.nut.2025.112739  
37.   Nakatochi Masahiro, Kushima Itaru, Aleksic Branko, et al. Copy number variations in RNF216 and postsynaptic membrane–associated genes are associated with bipolar disorder: a case‐control study in the Japanese population. Psychiatry and Clinical Neurosciences. 2025; 79 (1): 12-20. doi:10.1111/pcn.13752  
38.   Yamada Yuto, Fujiwara Masaki, Nakaya Naoki, et al. Trends in uptake of cancer screening among people with severe mental illness before and after the COVID‐19 pandemic in Japan: A repeated cross‐sectional study. Psychiatry and Clinical Neurosciences Reports. 2025; 4 (1): . doi:10.1002/pcn5.70062  
39.   Nakaya Naoki, Nakaya Kumi, Sone Toshimasa, et al. Concordance of Cancer Screening Attendance Among Spouse Couples: A Cross‐Sectional Survey of the Tohoku Medical Megabank Project. Psycho-Oncology. 2025; 34 (5): . doi:10.1002/pon.70158  
40.   Wang Hongxin, Iwama Noriyuki, Yuwaki Keiichi, et al. Association of Parity with Type 2 Diabetes Mellitus in Japan. Reproductive Sciences. 2025; 32 (2): 366-381. doi:10.1007/s43032-024-01752-z  
41.   Kawaguchi Chikana, Ishikuro Mami, Saito Ryota, et al. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. The Journal of Clinical Endocrinology & Metabolism. 2025; : . doi:10.1210/clinem/dgae825  
42.   Izumi Seiya, Nishimura Misato, Iwama Noriyuki, et al. Pregnancy and Postpartum Trends in Self‐Measured Blood Pressure and Derived Indices: The BOSHI Study. The Journal of Clinical Hypertension. 2025; 27 (1): . doi:10.1111/jch.14949  
43.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Journal of Nutrition. 2025; : . doi:10.1016/j.tjnut.2025.02.024  
44.   Shinoda Genki, Matsuzaki Fumiko, Ueno Fumihiko, et al. Impact of Telework on Health and Lifestyle Changes During the COVID-19 Pandemic in Japan. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J014. doi:10.1620/tjem.2025.J014  
45.   Mori Naoko, Mugikura Shunji, Hozawa Atsushi, et al. Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J006. doi:10.1620/tjem.2025.J006  
46.   Shimoda Yoshiteru, Shibahara Ichiyo, Kanamori Masayuki, et al. Clinical Effect of Ventricular Entry During Resection of Isocitrate Dehydrogenase-Wildtype Glioblastoma: A Multi-Institutional Analysis. World Neurosurgery. 2025; 195 : 123643. doi:10.1016/j.wneu.2024.123643  
47.   Shimoda Yoshiteru, Kanamori Masayuki, Yamashita Shota, et al. Residual Pattern of the Hyperintense Area on T2-Weighted Magnetic Resonance Imaging After Initial Treatment Predicts the Pattern and Location of Recurrence in Patients with Newly Diagnosed Glioblastoma. World Neurosurgery. 2025; 193 : 517-532. doi:10.1016/j.wneu.2024.10.012