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    ToMMo Project Design Key Publications

    Project Overview and Design | Biobank | Cohort Study | Genome and Omics Analyses |

    Project Overview and Design
    Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project

    Nobuo Fuse, Mika Sakurai-Yageta, Fumiki Katsuoka, Inaho Danjoh, et al.
    JMA Journal
    Published online: August 6, 2019
    doi:10.31662/jmaj.2019-0014

    Original paper

    The Tohoku Medical Megabank Project: Design and Mission

    Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, et al.
    Published online: 23 June 2016
    Journal of Epidemiology, Vol. 26 (2016), No. 9 pp. 493-511
    doi:10.2188/jea.JE20150268

    Original paper

    Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project

    Fuji Nagami, Miho Kuriki, Sachie Koreeda, Maiko Kageyama, et al.
    Published online: 21 April 2020
    The Tohoku Journal of Experimental Medicine
    doi:10.1620/tjem.250.253

    Original paper

     

    Biobank
    dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

    Soichi Ogishima, Satoshi Nagaie, Satoshi Mizuno, Ryosuke Ishiwata, et al.
    Published: 10 December 2021
    Human Genome Variation
    doi:10.1038/s41439-021-00175-5Minegishi N, Nishijima I, Nobukuni T, Kudo H, et al.

    Original paper

    Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project

    Minegishi N, Nishijima I, Nobukuni T, Kudo H, et al.
    Published online: May 24, 2019
    The Tohoku Journal of Experimental Medicine, 2019 Volume 248 Issue 1 Pages 45-55
    doi:10.1620/tjem.248.45.

    Original paper

    Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design

    Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, et al.
    BMC Medical Informatics and Decision Making (2017) 17:100
    Published: 06 July 2017
    doi:10.1186/s12911-017-0494-5

    Original paper

     

    Cohort Study
    Study profile of The Tohoku Medical Megabank Community-Based Cohort Study

    Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, et al.
    Journal of Epidemiology
    Published online: July 30, 2020
    doi:10.2188/jea.JE20190271

    Original paper

    Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project

    Akito Tsuboi, Hiroyuki Matsui, Naru Shiraishi, Takahisa Murakami, et al.
    The Tohoku Journal of Experimental Medicine
    Published online: June 23, 2020
    doi:10.1620/tjem.251.97

    Original paper

    Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective

    Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, et al.
    International Journal of Epidemiology
    Published online: August 25, 2019
    doi:10.1093/ije/dyz169

    Original paper

    A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization

    Mika Sakurai-Yageta, Hiroshi Kawame, Shinichi Kuriyama, Atsushi Hozawa, et al.
    BMC Medical Education
    Published online: 02 August 2019
    doi:10.1186/s12909-019-1725-5

    Original paper

    The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project

    Hiroshi Kawame, Akimune Fukushima, Nobuo Fuse, Fuji Nagami, et al.
     Journal of Human Genetics
    Published online:08 July 2021
    doi:10.1038/s10038-021-00952-8

    Original paper

    Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project

    Tomoko Kobayashi, Mika Kobayashi, Naoko Minegishi, Masahiro Kikuya, et al.
    The Tohoku Journal of Experimental Medicine
    Advance online publication: 01 December 2022
    doi:10.1620/tjem.2022.J103

    Original paper

    Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background

    Makiko Taira, Shunji Mugikura, Naoko Mori, Atsushi Hozawa, et al.
    Journal of the Japan Medical Association
    Published: July 14, 2023
    doi:10.31662/jmaj.2022-0220

    Original paper

     

    Genome and Omics Analyses
    Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology

    Akihito Otsuki, Yasunobu Okamura, Noriko Ishida, Shu Tadaka, et al
    Communications Biology
    Published: 20 September 2022
    doi:10.1038/s42003-022-03953-1
    Original paper

    Oral microbiome analysis in prospective genome cohort studies of the Tohoku Medical Megabank Project

    Sakae Saito, Yuichi Aoki, Toru Tamahara, Maki Goto, et al
    Frontiers Cellular and Infection Microbiology
    Published: 29 January 2021
    doi:10.3389/fcimb.2020.604596

    Original paper

    Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference

    Jun Takayama, Shu Tadaka, Kenji Yano, Fumiki Katsuoka, et al
    Nature Communications
    Published: 11 January 2021
    doi:10.1038/s41467-020-20146-8

    Original paper

    Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare

    Jun Yasuda, Kengo Kinoshita, Fumiki Katsuoka, Inaho Danjoh, et al.
    The Journal of Biochemistry
    Published online: 19 November 2018
    doi:10.1093/jb/mvy096

    Original paper

    Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project

    Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, et al.
    First published: 27 April 2018
    Genes to Cells
    doi:10.1111/gtc.12588

    Original paper

    jMorp: Japanese Multi Omics Reference Panel

    Shu Tadaka, Daisuke Saigusa, Ikuko N. Motoike, Jin Inoue, et al.
    Nucleic Acids Research, Volume 46, Issue D1
    Published: 24 October 2017
    doi:10.1093/nar/gkx978

    Original paper

     

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