To study how genetic factors and environmental factors affect disease risk, two large-scale prospective studies, the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study) and the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), are ongoing in Miyagi and Iwate Prefectures in Japan.
Since the cohort studies started in 2013, we successfully recruited more than 150,000 participants for baseline assessment by 2017. We collected biospecimens including serum, plasma, mononuclear cells, urine, and the answers to the questionnaires of their lifestyles and medical history. A part of participants took detailed health survey in assessment centers we established.
After the baseline assessment was completed, we have started follow-up study “repeat assessment center-based survey during the second period” in which we ask participants to take a health survey similar to the baseline assessment they did at the centers. We made plan for this repeat assessment survey which they take once a 3 to 5 years. We also collect postal or web annually questionnaire and information survey from publicly constructed database.
Detail of cohort studies
Name of cohort study
TMM CommCohort Study
Local residents who are 20 years old or older
TMM BirThree Cohort Study
Birth and Three-generation cohort
We also perform some additional cohort studies on participants of TMM CommCohort Study and TMM BirThree Cohort Study. For example, we are studying brain imaging data of over 4,000 subjects through “Health surveillance of the brain and psychological state program with MRI” (the Brain-MRI project). In another example, we are looking at lifelog data of mothers during pregnancy with a smartphone through Maternity Log Study (MLOG). By focusing on some specific topics in different areas, the studies make our biobank resources richer.
The scheme of additional cohort studies
The subjects of additional cohort studies are a part of cohort study participants.
To achieve next-generation medicine, such as personalized medicine and healthcare, we have been developing the biobank from the biological specimens of 150,000 cohort study participants. We store millions of biological specimens such as serum, plasma, mononuclear cells, DNA, health information, and genetic data from the cohort study participants.
DNA, Plasma, Serum, Buffy coat cells, Peripheral blood mononuclear cells, Cord blood mononuclear cells, EBV-Transformed B cells, Stimulated T cells, Urine, Breast milk, Saliva