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  • Cohort Study and Biobank

    Cohort Studies

    To study how genetic factors and environmental factors affect disease risk, two large-scale prospective studies, the Tohoku Medical Megabank Project Community-Based Cohort Study (TMM CommCohort Study) and the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study), are ongoing in Miyagi and Iwate Prefectures in Japan.
    Since the cohort studies started in 2013, we successfully recruited more than 150,000 participants for baseline assessment by 2017. We collected biospecimens including serum, plasma, mononuclear cells urine, and the answers to the questionnaires of their lifestyles and medical history. A part of participants took detailed health survey in assessment centers we established.

    After the baseline assessment was completed, we have started follow-up study “repeat assessment center-based survey during the second period” in which we ask participants to take a health survey similar to the base line assessment they did at the centers. We made plan for this repeat assessment survey which they take once a 3 to 5 years. We also collect postal or web annually questionnaire and information survey from publicly constructed database.

    Detail of cohort studies
    Name of cohort study Type Recruitment target
    TMM CommCohort Study Population-based cohort Local residents who are 20 years old or older
    TMM BirThree Cohort Study Family-based cohort,
    Birth and Three-generation cohort
    Expectant mothers and their family
    Number of cohort study participants

     

    Related information

    -TMM CommCohort Study (Japanese Only)

    -TMM BirThree Cohort Study (Japanese Only)

    -Return of Genomic Results to Cohort Study Participants

    -the ToMMo Child Health Study

     

    Additional Cohort Studies

    We also perform some additional cohort studies on participants of TMM CommCohort Study and TMM BirThree Cohort Study. For example, we are studying brain imaging data of over 4,000 subjects through “Health surveillance of the brain and psychological state program with MRI” (the Brain-MRI project). In another example, we are looking at lifelog data of mothers during pregnancy with a smartphone through Maternity Log Study (MLOG). By focusing on some specific topics in different areas, the studies make our biobank resources richer.

    The scheme of additional cohort studies

    The subjects of additional cohort studies are a part of cohort study participants.

    Related information

    -Health surveillance of the brain and psychological state program with MRI

     

    Biobank

    To achieve the next-generation medicine, such as personalized medicine and healthcare, we have been developing the biobank from the biological specimens of 150,000 cohort study participants. We store millions of biological specimens such as serum, plasma, mononuclear cells, DNA, health information, and genetic data from the cohort study participants.

    Biological specimens
    DNA, Plasma, Serum, Buffy coat cells, Peripheral blood mononuclear cells, Cord blood mononuclear cells,
    EBV-Transformed B cells, Stimulated T cells, Urine, Breast milk, Saliva

     

    Related information

    Specimen and Data Collection

     

    Publications

    • The Tohoku Medical Megabank Project: Design and Mission
    • Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project
    • Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design

    Click HERE for more publications related to cohort study and biobank in ToMMo.

     

    Press Releases

    -ToMMo completed the ToMMo Child Health Study in Miyagi Prefecture during a period of four years after the Great East Earthquake (Apr. 5, 2016)

    -Depressive symptoms continue to be higher in coastal areas than in inland areas 3 years after the Great East Japan Earthquake (Mar. 16, 2016)

    -Psychological Consequences Remain Profound Among Coastal Communities Devastated by the Great East Japan Earthquake(Sep. 1, 2015)

    -Findings from the FY2013 Long-term community child health study (Jan. 17, 2014)

    -The first round of aggregate findings from the community resident cohort study in the first year-27% of study participants showed depressive tendencies, 5% showed signs of PTSD- (Feb. 27, 2014)

     

    News

    50,000 people have participated in the Tohoku Medical Megabank Project Community-Based Cohort Study in Miyagi Prefecture (Nov. 4, 2015)

    The number of participants for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study reached to 70,000 (Jan. 26 2017)

     

    Interviews

    -Interview with Dr. Tomita from the Department of Disaster Psychiatry (Oct. 8, 2014)

    Movies

    50,000 people have participated in the Tohoku Medical Megabank Project Community-Based Cohort Study in Miyagi Prefecture.