-We are studying the relationship between hereditary and environmental factors and disease incidence, in an attempt to predict disease risk and determine the causes of diseases. To this end, cohort studies are being performed in Miyagi and Iwate Prefectures.
In addition, through analyses of the MRI images (brain and thigh) of some of the people taking part in the cohort studies, combined with analyses of their lifestyles, cognitive capacity, mental health status, and genome information, we are studying the effects that hereditary and environmental factors have on the brain and cognitive capacity, as well as the mechanisms of developing Posttraumatic Stress Reaction (PTSR), depression, and dementia.
-We are now developing a biobank which collects and stores blood, urine and other biological specimens of the 150,000 people who will be participating in the cohort studies, as well as their health information and data from analyses that utilized these biological specimens. To ensure that research using these biological specimens and information contributes to development of future medicine, practical studies are being implemented on biobank management approaches.
Key Word: cohort study, genome, population-based, three-generation, biobank, MRI
Health surveillance of the brain and psychological state program with MRI
Return of Genomic Results to Cohort Study Participants Publications
The Tohoku Medical Megabank Project: Design and Mission Shinichi Kuriyama, Nobuo Yaegashi, Fuji Nagami, Tomohiko Arai, Yoshio Kawaguchi, Noriko Osumi, Masaki Sakaida, Yoichi Suzuki, Keiko Nakayama, Hiroaki Hashizume, Gen Tamiya, Hiroshi Kawame, Kichiya Suzuki, Atsushi Hozawa, Naoki Nakaya, Masahiro Kikuya, Hirohito Metoki, Ichiro Tsuji, Nobuo Fuse, Hideyasu Kiyomoto, Junichi Sugawara, Akito Tsuboi, Shinichi Egawa, Kiyoshi Ito, Koichi Chida, Tadashi Ishii, Hiroaki Tomita, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Seizo Koshiba, Kengo Kinoshita, Soichi Ogishima, Takako Takai-Igarashi, Teiji Tominaga, Osamu Tanabe, Noriaki Ohuchi, Toru Shimosegawa, Shigeo Kure, Hiroshi Tanaka, Sadayoshi Ito, Jiro Hitomi, Kozo Tanno, Motoyuki Nakamura, Kuniaki Ogasawara, Seiichiro Kobayashi, Kiyomi Sakata, Mamoru Satoh, Atsushi Shimizu, Makoto Sasaki, Ryujin Endo, Kenji Sobue, the Tohoku Medical Megabank Project Study Group, Masayuki Yamamoto Journal of Epidemiology, Published online: 23 June 2016 DOI: 10.2188/jea.JE20150268 article
Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project Seizo Koshiba, Ikuko Motoike, Daisuke Saigusa, Jin Inoue, Matsuyuki Shirota, Yasutake Katoh, Fumiki Katsuoka, Inaho Danjoh, Atsushi Hozawa, Shinichi Kuriyama, Naoko Minegishi, Masao Nagasaki, Takako Takai‐Igarashi, Soichi Ogishima, Nobuo Fuse, Shigeo Kure, Gen Tamiya, Osamu Tanabe, Jun Yasuda, Kengo Kinoshita, Masayuki Yamamoto publication journal article
Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design Takako Takai-Igarashi, Kengo Kinoshita, Masao Nagasaki, Soichi Ogishima, Naoki Nakamura,Sachiko Nagase, Satoshi Nagaie, Tomo Saito, Fuji Nagami, Naoko Minegishi, Yoichi Suzuki, Kichiya Suzuki, Hiroaki Hashizume, Shinichi Kuriyama, Atsushi Hozawa, Nobuo Yaegashi, Shigeo Kure, Gen Tamiya, Yoshio Kawaguchi, Hiroshi Tanaka and Masayuki Yamamoto BMC Medical Informatics and Decision Making article
HERE for more publications related to cohort study and biobank in ToMMo. Interviews
Interview with Dr. Tomita from the Department of Disaster Psychiatry (Oct. 8, 2014) Movies
50,000 people have participated in the Tohoku Medical Megabank Project Community-Based Cohort Study in Miyagi Prefecture.
VIDEO Press Releases
ToMMo completed the ToMMo Child Health Study in Miyagi Prefecture during a period of four years after the Great East Earthquake (Apr. 5, 2016)
- Depressive symptoms continue to be higher in coastal areas than in inland areas 3 years after the Great East Japan Earthquake (Mar. 16, 2016)
- Psychological Consequences Remain Profound Among Coastal Communities Devastated by the Great East Japan Earthquake (Sep. 1, 2015)
- Findings from the FY2013 Long-term community child health study (Jan. 17, 2014)
- The first round of aggregate findings from the community resident cohort study in the first year-27% of study participants showed depressive tendencies, 5% showed signs of PTSD- (Feb. 27, 2014) News
50,000 people have participated in the Tohoku Medical Megabank Project Community-Based Cohort Study in Miyagi Prefecture (Nov. 4, 2015)
The number of participants for the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study reached to 70,000 (Jan. 26 2017)