The 61st In Silico Megabank Research Seminar will be held on Thursday, April 16 .

This Time, we will be welcoming Dr. Ichizo Kobayashi, Graduate School of Frontier Sciences, The University of Tokyo as our lecturer, and he will be speaking on “Epigenetics-driven Evolution: Demonstration through OMICS Comparison of Multiple Sequences within Bacterial Species.”

・Date: Thursday, April 16, 2015
・Time: 10:00 am‐11:00 am
・Venue : Small Conference Room 2(3rd Floor), Tohoku Medical Megabank Building

・Title:
“Epigenetics-driven Evolution: Demonstration through OMICS Comparison of Multiple Sequences within Bacterial Species.”
・Lecturer : Ichizo Kobayashi (Graduate School of Frontier Sciences, The University of Tokyo)

*This lecture is transferable as a class in the medical research-related lecture course.

・Abstract : Concerning the adaptive evolution, a theory on the unit of evolution based on “epigenetic state” was developed in contrast to the idea of “selection from various genomic sequencing.” The epigenetic state was demonstrated in the study with bacteria that can directly pass on to the next generation.

Many of DNA methylase of bacteria create restriction-modification system and restriction enzyme recognizes the same sequence. They are “selfish” epigenetics that destroy non-self epigenomes. Excluding cells from which restriction-modification system is excluded through chromosomal breaks forces host bacteria into the certain methylome.

In our study, it was demonstrated that the restriction-modification system modulates the recognition sequence, alter the creation of methylome in various ways, and leads changes in the patterns of gene expressions and various phenotypes.

Restriction of these restriction-modification systems from internal and external environment, a type of restriction enzyme that cuts bases out as is the case in demethylating enzyme of eukaryote, and degradation and alteration of rRNA genes used for metagenome analysis are also introduced; we would like to discuss the perception of microevolution of microbiome

・Organizer : Yoko Kuroki, Masao Nagasaki