その他の主要な論文
主な英語原著論文
Differential squamous cell fates elicited by NRF2 gain-of-function versus KEAP1 loss-of-function
Jun Takahashi, Takafumi Suzuki, Miu Sato, Shuji Nitta, et al.
Cell Reports
Available online 10 April 2024
DOI : 10.1016/j.celrep.2024.114104
FeNO distribution and its relevant factors in the general adult population and its ‘healthy’ subpopulation
Mitsuhiro Yamada, Masato Takase, Kumi Nakaya, Tomohiro Nakamura, et al.
Journal of Allergy and Clinical Immunology: Global
Available online 8 April 2024
DOI : 10.1016/j.jacig.2024.100253
Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Aoi Noda, Taku Obara, Matsuyuki Shirota, Fumihiko Ueno, et al.
European Journal of Clinical Pharmacology
Published : 17 April 2024
DOI : 10.1007/s00228-024-03685-7
Factors Associated with the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-Based Cohort Study
Kumi Nakaya, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, et al.
Journal of Neurogastroenterology and Motility
Published : April 30, 2024
DOI : 10.5056/jnm23090
The Health History of First-Degree Relatives’ Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia
Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, et al.
Genes
Published : 21 March 2024
DOI : 10.3390/genes15030384
Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study
Yudai Yonezawa, Ippei Takahashi, Hisashi Ohseto, Fumihiko Ueno, et al.
BMC Pregnancy and Childbirth
Published : 20 March 2024
DOI : 10.1186/s12884-024-06376-4
Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women
Satoshi Mizuno, Maiko Wagata, Satoshi Nagaie, Mami Ishikuro, et al.
Scientific Reports
Published : 15 March 2024
DOI : 10.1038/s41598-024-55914-9
Risk Factors, Prognosis, Influence on the Offspring, and Genetic Architecture of Perinatal Depression Classified Based on the Depressive Symptom Trajectory
Hisashi Ohseto, Ippei Takahashi, Akira Narita, Taku Obara, et al.
Depression and Anxiety
Published : 15 March 2024
DOI : 10.1155/2024/6622666
Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study
Geng Chen, Mami Ishikuro, Hisashi Ohseto, Keiko Murakami, et al.
Acta Obstetricia et Gynecologica Scandinavica
Published : 07 March 2024
DOI : 10.1111/aogs.14820
Association of physiological factors with grip and leg extension strength: Tohoku Medical Megabank Community-based cohort study
Yoshiaki Noji, Rieko Hatanaka, Naoki Nakaya, Mana Kogure, et al.
BMC Public Health
Published : 05 March 2024
DOI : 10.1186/s12889-024-18244-z
Dietary habits and plasma lipid concentrations in a general Japanese population
Mitsuharu Sato, Eiji Hishinuma Naomi Matsukawa, Yoshiko Shima, et al.
Metabolomics
Published : 05 March 2024
DOI : 10.1007/s11306-024-02087-1
Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals
Aoki Y, Taguchi K, Anzawa H, Kawashima J, et al.
The Journal of Biochemistry
Published : 24 January 2024
DOI : 10.1093/jb/mvae008
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS, and impact on esophageal cancer risk in Japanese people
Yuriko N. Koyanagi, Masahiro Nakatochi, Shinichi Namba, Isao Oze, et al.
Science Advances
Published : 26 Jan 2024
DOI : 10.1126/sciadv.ade2780
Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study
Masato Takase, Naoki Nakaya, Kozo Tanno, Mana Kogure, et al.
Hypertension research
Published : 29 February 2024
DOI : 10.1038/s41440-024-01582-1
Genetic etiology of truncus arteriosus excluding 22q11.2 deletion syndrome and identification of c.1617del, a prevalent variant in TMEM260, in the Japanese population
Hisao Yaoita, Eiichiro Kawai, Jun Takayama, Shinya Iwasawa, et al.
Journal of Human Genetics
Published : 13 February 2024
DOI : 10.1038/s10038-024-01223-y
Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture
Atsushi Hozawa, Kumi Nakaya, Naoki Nakaya, Tomohiro Nakamura, et al.
Journal of Epidemiology
Advance online publication: February 24, 2024
DOI: 10.2188/jea.JE20230241
Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study
Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, et al.
Journal of Atherosclerosis and Thrombosis
Advance online publication: February 06, 2024
DOI: 10.5551/jat.64535
Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Yoshie Saito, Keigo Sato, Shinji Jinno, Yoshitaka Nakamura, et al.
Nutrients
Published: 31 December 2023
DOI: 10.3390/nu16010145
Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy
Aoi Noda, Taku Obara, Fumiko Matsuzaki, Satoko Suzuki, et al.
Drugs – Real World Outcomes
Published: 19 January 2024
DOI: 10.1007/s40801-023-00411-0
The association between blood pressure control in women during pregnancy and adverse perinatal outcomes: the TMM BirThree Cohort Study
Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, et al.
Hypertension Research
Published: 18 January 2024
DOI: 10.1038/s41440-023-01570-x
Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: A meta-analysis
Mami Ishikuro, Tomoko Nishimura, Hiroyoshi Iwata, Hirohito Metoki, et al.
Journal of Human Hypertension
Published: 10 January 2024
DOI: 10.1038/s41371-023-00890-2
Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information
Hisaaki Kudo, Noriko Ishida, Takahiro Nobukuni, Yuichi Aoki, et al.
Biopreservation and Biobanking
Published: 11 December 2023
DOI: 10.1089/bio.2022.0211
Stakeholder Perception of the Implementation of Genetic Risk Testing for Twelve Multifactorial Diseases
Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Fuji Nagami, et al.
Genes
Published: 28 December 2023
DOI: 10.3390/genes15010049
Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Misato Aizawa, Keiko Murakami, Ippei Takahashi, Hisashi Ohseto, et al.
Nutrition Journal
Published: 6 December 2023
DOI: 10.1186/s12937-023-00901-5
jMorp: Japanese Multi-Omics Reference Panel update report 2023
Shu Tadaka, Junko Kawashima, Eiji Hishinuma, Sakae Saito, et al.
Nucleic Acids Research
Published: 1 November 2023
DOI: 10.1093/nar/gkad978
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses
Kouya Shiraishi, Atsushi Takahashi, Yukihide Momozawa, Yataro Daigo, et al.
Cancer Communications
Published: 26 October 2023
DOI: 10.1002/cac2.12498.
The association between depressive symptoms and masked hypertension in participants with normotension measured at research center
Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Mana Kogure, et al.
Hypertension Research
Published: 31 October 2023
DOI: 10.1038/s41440-023-01484-8
The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study
Rieko Hatanaka, Naoki Nakaya, Mana Kogure, Kumi Nakaya, et al.
Hypertension Research
Published: 13 October 2023
DOI: 10.1038/s41440-023-01454-0
Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study
Satoshi Mizuno, Satoshi Nagaie, Gen Tamiya, Shinichi Kuriyama, et al.
BMC Pregnancy and Childbirth
Published: 31 August 2023
DOI: 10.1186/s12884-023-05919-5
Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Yoshiko Shima, et al.
Cancer & Metabolism
Published: 11 October 2023
DOI: 10.1186/s40170-023-00317-z
Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study
Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, et al.
Journal of Alzheimer’s Disease
Published: 10 October 2023
DOI: 10.3233/JAD-230318
Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study
Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, et al.
Journal of atheroslcoersis and thromobosis
Advance online publication: October 06, 2023
DOI: 10.5551/jat.64425
Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8,380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation
Yu Sato, Eiji Hishinuma, Shuki Yamazaki, Akiko Ueda, et al.
Drug Metabolism and Disposition
Published : Sep 29, 2023
DOI: 10.1124/dmd.123.001389
Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice
Ritsuko Shimizu, Ikuo Hirano, Atsushi Hasegawa, Mikiko Suzuki, et al.
Communications Biology
Published : 25 August 2023
DOI: 10.1038/s42003-023-05251-w
Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 years
Ippei Takahashi, Taku Obara, Mami Ishikuro, Keiko Murakami, et al.
JAMA Pediatrics
Published Online: August 21, 2023
DOI: 10.1001/jamapediatrics.2023.3057
Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure
Sayuri Tokioka, Naoki Nakaya, Kumi Nakaya, Masato Takase, et al.
Journal of Atherosclerosis and Thrombosis
Advance online publication: July 05, 2023
DOI: 10.5551/jat.64151
Association between being Overweight in Young Childhood and during School Age and Puberty
Genki Shinoda, Yudai Nagaoka, Fumihiko Ueno, Naoyuki Kurokawa, et al.
MDPI Children
Published: 22 May 2023
DOI: 10.3390/children10050909
Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide-targeted metabolomics
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Bin Li, et al.
Journal of Obstetrics and Gynaecology Research
Published: 9 June 2023
DOI: 10.1111/jog.15709
Association between low levels of anti-inflammatory cytokines during pregnancy and a postpartum depression
Chiaki T. Ono, Zhiqian Yu, Taku Obara, Mami Ishikuro, et al.
Psychiatry and Clinical Neurosciences
Published: 15 June 2023
DOI：10.1111/pcn.13566
Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, et al.
Social Psychiatry and Psychiatric Epidemiology
Published: 03 June 2023
DOI：10.1007/s00127-023-02498-w
Prevalence, Associated Factors, and Inter-Eye Differences of Refractive Errors in a Population-Based Japanese Cohort: The Tohoku Medical Megabank Eye Study
Atsuya Miki, Nobuo Fuse, Satoko Fujimoto, Makiko Taira, et al.
Ophthalmic Epidemiology
Published: 24 April 2023
DOI：10.1080/09286586.2023.2203226
Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder
Masaki Nishioka, Jun Takayama, Naomi Sakai, An-a Kazuno, et al.
Molecular Psychiatry
Published: 30 May 2023
DOI：10.1038/s41380-023-02096-x
Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, et al.
BMC Pregnancy and Childbirth
Published: 19 April 2023
DOI：10.1186/s12884-023-05603-8
Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, et al.
Reproductive Medicine
Published: 18 April 2023
DOI：10.3390/reprodmed4020010
Associations of Education and Income with Secondhand Smoke Exposure Among Non-smoking Pregnant Women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, et al.
Maternal and Child Health Journal
Published: 29 March 2023
DOI：10.1007/s10995-023-03648-x
Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, et al.
European Child & Adolescent Psychiatry
Published: 30 March 2023
DOI：10.1007/s00787-023-02199-4
Combined fat mass and fat-free mass indices and lung function among Japanese population: The Tohoku Medical Megabank Community-based Cohort Study
Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, et al.
Journal of Epidemiology
Published: April 08, 2023
DOI：10.2188/jea.JE20220355
Associations between sugar-sweetened beverages before and during pregnancy and offspring overweight/obesity in Japanese women: The TMM BirThree Cohort Study
Misato Aizawa, Keiko Murakami, Yudai Yonezawa, Ippei Takahashi, et al.
Public Health Nutrition
Published: 9 February 2023
DOI：10.1017/S1368980023000307
Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Aoi Noda, Mami Ishikuro, Taku Obara, et al.
Archives of Women’s Mental Health
Published: 21 February 2023
DOI： 10.1007/s00737-023-01298-0
Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study
Masato Takase, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, et al.
Journal of atherosclerosis and thrombosis
Advance online publication: February 11, 2023
DOI：10.5551/jat.64039
Association between maternal psychological distress and children’s neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Ippei Takahashi, Taku Obara, Saya Kikuchi, Mika Kobayashi,, et al.
Journal of Paediatrics and Child Health
Published: 08 February 2023
DOI：10.1111/jpc.16353
A knowledge representation model for family relationship to three generation
Kazuro Shimokawa, Mami Ishikuro, Taku Obara, Hirohito Metoki, et al.
Bioinformation
Published: 31 December 2022
DOI：10.6026/973206300181166
Antihypertensive drug use during pregnancy in Japan
Obara Taku, Ishikuro Mami, Ueno Fumihiko, Noda Aoi, et al.
Hypertension Research
Published: 02 December 2022
DOI：10.1038/s41440-022-01101-0.
Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study
Takase Masato, Yamada Mitsuhiro, Nakamura Tomohiro, Nakaya Naoki, et al.
Journal of Hypertension
Available online: 4 january 2023
DOI：10.1097/HJH.0000000000003356
Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, et al.
Journal of Affective Disorders
Published: 15 march 2023
DOI：10.1016/j.jad.2023.01.044
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida Surakka, et al.
Genome Biology
Published: 27 December 2022
DOI：10.1186/s13059-022-02837-1
Dietary calcium intake was related to the onset of pre-eclampsia: the TMM BirThree Cohort Study
Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, et al.
Journal of Clinical Hypertension
Published: 28 December 2022
DOI：10.1111/jch.14606
Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1
Norihisa Shindo, Kazuki Kumada, Kenji Iemura, Jun Yasuda, et al.
Cell Reports
Published: November 29, 2022
DOI：10.1016/j.celrep.2022.111723
Real-Time Prediction of Medical Demand and Mental Health Status in Ukraine under Russian Invasion Using Tweet Analysis
Susumu Fujii, Yasuto Kunii, Sayuri Nonaka, Yumiko Hamaie, et al.
The Tohoku Journal of Experimental Medicine
Advance online publication: December 22, 2022
DOI：10.1620/tjem.2022.J111
Plasma metabolic disturbances during pregnancy and postpartum in women with depression
Zhiqian Yu, Naomi Matsukawa, Daisuke Saigusa, Ikuko N. Motoike,et al.
iScience
Available online：24 November 2022
DOI：10.1016/j.isci.2022.105666
Functional characterization of 12 dihydropyrimidinase allelic variants in Japanese individuals for the prediction of 5-fluorouracil treatment-related toxicity
Eiji Hishinuma, Yoko Narita, Evelyn Marie Gutiérrez Rico, Akiko Ueda, et al.
Drug Metabolism and Disposition
Published online: November 22, 2022.
DOI：10.1124/dmd.122.001045
Structural basis of transcription regulation by CNC family transcription factor, Nrf2
Toru Sengoku, Masaaki Shiina, Kae Suzuki, Keisuke Hamada, et al.
Nucleic Acids Research
Published: 1 December 2022
DOI：10.1093/nar/gkac1102
Genome-wide association study of the risk of chronic kidney disease and kidney-related traits in the Japanese population: J-Kidney-Biobank
Yuka Sugawara, Yosuke Hirakawa, Hajime Nagasu, Akira Narita, et al.
Journal of Human Genetics
Published: 21 November 2022
DOI：10.1038/s10038-022-01094-1
The Thing Metabolome Repository family (XMRs): comparable untargeted metabolome databases for analyzing sample-specific unknown metabolites
Nozomu Sakurai, Shinichi Yamazaki, Kunihiro Suda, Ai Hosoki, et al.
Nucleic Acids Research
Published 24 November 2022
DOI：10.1093/nar/gkac1058
Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study
Misato Aizawa, Keiko Murakami, Ippei Takahashi, Tomomi Onuma, et al.
Nutrition Journal
Published 17 November 2022
DOI：10.1186/s12937-022-00822-9
Association of maternal psychological distress and the use of childcare facilities with children’s behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Ippei Takahashi, Keiko Murakami, Mika Kobayashi, Saya Kikuchi, et al.
BMC Psychiatry
Published 11 November 2022.
DOI：10.1186/s12888-022-04330-2
Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice
Yexin Liu, Akira Uruno, Ritsumi Saito, Naomi Matsukawa, et al.
Redox Biology
Published 3 November 2022.
DOI：10.1016/j.redox.2022.102525
The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study
Masato Takase, Mitsuhiro Yamada, Tomohiro Nakamura, Naoki Nakaya, et al.
Journal of Atherosclerosis and Thrombosis
Advance online publication: November 04, 2022
DOI：10.5551/jat.63826
Similarities in cardiometabolic risk factors among random male-female pairs: a large observational study in Japan
Naoki nakaya, Kumi nakaya, Naho Tsuchiya, Toshimasa sone, et al.
BMC Public Health
Published 28 October 2022
DOI: 10.1186/s12889-022-14348-6
Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores
Takashi Matsuyama, Akira Narita, Masaki Takanashi, Mana Kogure, et al.
Scientific Reports
Published 21 October 2022
DOI:10.1038/s41598-022-22266-1
Development of a method for walking step observation based on large-scale GPS data
Shohei Nagata, Tomoki Nakaya, Tomoya Hanibuchi, Naoki Nakaya, et al.
International Journal of Health Geographics
Published 07 September 2022
DOI:10.1186/s12942-022-00312-5
Reduced antiviral seropositivity among patients with inflammatory bowel disease treated with immunosuppressive agents
Hisashi Shiga, Takahiro Takahashi, Manabu Shiraki, Yasuhiro Kojima, et al.
Scandinavian Journal of Gastroenterology
Published online 12 October 2022
DOI:10.1080/00365521.2022.2132831
Liver steatosis and fibrosis markers’ association with cardiovascular and renal damage in Japanese adults: The TMM BirThree cohort study
Toshiya Machida, Taku Obara, Mami Ishikuro, Keiko Murakami, et al.
Annals of Hepatology
Available online 28 September 2022
DOI:10.1016/j.aohep.2022.100761
Social isolation and insomnia among pregnant women in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, et al.
Sleep Health
Available online 10 October 2022
DOI:10.1016/j.sleh.2022.08.007
Returning individual genomic results to population-based cohort study participants with BRCA1/2 pathogenic variants
Kinuko Ohneda, Yohei Hamanaka, Hiroshi Kawame, Nobuo Fuse, et al.
Breast Cancer
Published: 26 September 2022
DOI: 10.1007/s12282-022-01404-7
Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, et al.
Journal of Affective Disorders
Available online 30 September 2022
DOI: 10.1016/j.jad.2022.09.139
Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology
Akihito Otsuki, Yasunobu Okamura, Noriko Ishida, Shu Tadaka, et al.
Communications Biology
Published 20 September 2022
DOI: 10.1038/s42003-022-03953-1
Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study
Takahiro Yamashita, Taku Obara, Yudai Yonezawa, Ippei Takahashi, et al.
Nutrition Journal
Published online:16 September 2022
DOI: 10.1186/s12937-022-00808-7
Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, et al.
Archives of Women’s Mental Health
Published:17 September 2022
DOI: 10.1007/s00737-022-01266-0
Selective Elimination of NRF2-Activated Cells by Competition with Neighboring Cells in the Esophageal Epithelium
Wataru Hirose, Makoto Horiuchi, Donghan Li, Ikuko N. Motoike, et al.
Cellular and Molecular Gastroenterology and Hepatology
Published:September 14, 2022
DOI: 10.1016/j.jcmgh.2022.09.004
Omics profiles of fecal and oral microbiota change in irritable bowel syndrome patients with diarrhea and symptom exacerbation
Yukari Tanaka, Riu Yamashita, Junko Kawashima, Hiroshi Mori, et al.
Journal of Gastroenterology
Published: 30 July 2022
DOI: 10.1007/s00535-022-01888-2
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Shweta Ramdas, Jonathan Judd, Sarah E. Graham, Stavroula Kanoni, et al.
The American Journal of Human Genetics
Published: August 4, 2022
DOI: 10.1016/j.ajhg.2022.06.012
Association between smoking and hypertension in pregnancy among Japanese women: a meta-analysis of birth cohort studies in the Japan Birth Cohort Consortium (JBiCC) and JECS
Morisaki N, Obara T, Piedvache A, Kobayashi S, et al.
Journal of Epidemiology
Advance online publication: 8 August 2022
DOI: 10.2188/jea.JE20220076
Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis
Ikumi Kanno, Kenichi Hasegawa, Tomohiro Nakamura, Mana Kogure, et al.
Public Health
Published:20 june 2022
DOI:10.1016/j.puhe.2022.05.003
Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study
Masato Takase, Tomohiro Nakamura, Naoki Nakaya, Mana Kogure, et al.
Journal of Atherosclerosis and Thrombosis
Published:26 May 2022
DOI:10.5551/jat.63523
Preeclampsia prediction model using the dipstick test for proteinuria during early gestation
Hisashi Ohseto, Mami Ishikuro, Taku Obara, Keiko Murakami, et al.
Journal of Epidemiology
Published:24 June 2022
DOI: 10.14390/jsshp.HRP2022-002
Social Predictors of Continued and Indoor Smoking Among Partners of Non-smoking Pregnant Women: The TMM BirThree Cohort Study
Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, et al.
Journal of Epidemiology
DOI: 10.2188/jea.JE20200313
Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population
Eiji Hishinuma, Yoko Narita, Kai Obuchi, Akiko Ueda, et al.
Frontiers in Pharmacology
Published: 15 June 2022.
doi:10.1093/ije/dyz169
Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study
Noriyuki Iwama, Taku Obara, Mami Ishikuro, Keiko Murakami, et.al
Published online: 26 May 2022
Scientific Reports
doi：10.1038/s41598-022-12892-0
Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Taku Obara, Fumihiko Ueno, et.al
Published online: 16 April 2022
Scientific Reports
doi：10.1038/s41598-022-09944-w
A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants
Kinuko Ohneda, Masahiro Hiratsuka, Hiroshi Kawame, Fuji Nagami, et.al
Published online: March 11, 2022
JMA Journal
doi：10.31662/jmaj.2021-0156
Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: Findings from the TMM BirThree Cohort Study
Chikana Kawaguchi, Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, et.al
Published online: 24 March 2022
BMC Pregnancy and Childbirth
doi：10.1186/s12884-022-04556-8
Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer
Fumiki Katsuoka, Akihito Otsuki, Nozomi Hatanaka, Haruna Okuyama, Masayuki Yamamoto
Published online: 17 March 2022
Molecular and Cellular Biology
doi：10.1128/mcb.00520-21
Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study
Nobuo Fuse, Miyuki Sakurai, Ikuko N.Motoike, Kaname Kojima, et.al
Available online 22 January 2022
Ophthalmology Science
doi：10.1016/j.xops.2022.100113
Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements
Dieter M. Tourlousse, Koji Narita, Takamasa Miura, Akiko Ohashi, et.al
Published online: 02 March 2022
Microbiology Spectrum
doi：10.1128/spectrum.01915-21
Families’ Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Mami Ishikuro, Aoi Noda, Keiko Murakami, Tomomi Onuma, et.al
Published online: February 23, 2022
The Tohoku Journal of Experimental Medicine
doi：10.1620/tjem.256.93
Relationship between the combination of polyunsaturated fatty acids intake and psychological distress during pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Ippei Takahashi, Taku Obara, Misato Aizawa, Yudai Yonezawa, et.al
Available online 21 January 2022
Prostaglandins, Leukotrienes and Essential Fatty Acids
doi：10.1016/j.plefa.2022.102400
Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study
Mana Kogure, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, et.al
Published: 18 January 2022
Hypertension Research
doi：10.1038/s41440-021-00843-7
The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community-based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally representative surveys in other countries
Yuka Nishimoto, Yoshitaka Tsubono, Mana Kogure, Tomohiro Nakamura, et.al
Published: 01 December 2021
Cancer Medicine
doi：10.1002/cam4.4364
Living environments long-term after the Great East Japan Earthquake and nutritional intake among recent mothers
Takahiro Yamashita, Keiko Murakami, Taku Obara, Yudai Yonezawa, et.al
Published: 30 December 2021
Asia Pacific Journal of Clinical Nutrition
doi：10.6133/apjcn.202112_30(4).0012
A massive natural disaster, the Great East Japan Earthquake, and the incidence of dialysis due to end-stage kidney disease
Michiaki Abe, Tetsuya Akaishi, Koto Ishizawa, Hirohisa Shinano, et.al
Published: 12 October 2021
Journal of Nephrology
doi：10.1007/s40620-021-01140-9
Nrf2 plays a critical role in the metabolic response during and after spaceflight
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, et.al
Published: 09 December 2021
Communications Biology
doi：10.1038/s42003-021-02904-6
The power of genetic diversity in genome-wide association studies of lipids
Sarah E Graham, Shoa L Clarke, Kuan-Han H Wu, Stavroula Kanoni, et.al
Published: 9 December 2021
Nature
doi：10.1038/s41586-021-04064-3
Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel
Norio Suzuki, Yuma Iwamura, Taku Nakai, Koichiro Kato, et al.
Published: 9 November 2021
Kidney International
doi：10.1016/j.kint.2021.09.031
Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator
Mitsuhiro Yamada, Ikuko N. Motoike, Kaname Kojima, Nobuo Fuse, et al.
Published: 15 November 2021
Communications Biology
doi：10.1038/s42003-021-02813-8
The Data Use Ontology to streamline responsible access to human biomedical datasets
Jonathan Lawson, Moran N. Cabili, Giselle Kerry, Tiffany Boughtwood, et al.
Published: 11 November 2021
Cell Genomics
doi：10.1016/j.xgen.2021.100028
GA4GH: International policies and standards for data sharing across genomic research and healthcare
Heidi L. Rehm, Angela J.H. Page, Lindsay Smith, Jeremy B. Adams, et al.
Published: 11 November 2021
Cell Genomics
doi：10.1016/j.xgen.2021.100029
A cross-population atlas of genetic associations for 220 human phenotypes
Saori Sakaue, Masahiro Kanai, Yosuke Tanigawa, Juha Karjalainen, et al.
Published: 30 September 2021
Nature Genetics
doi：10.1038/s41588-021-00931-x
Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies
Naoki Nakaya, Tian Xie, Bart Scheerder, Naho Tsuchiya, et al.
Available online 26 August 2021
Atherosclerosis
doi：10.1016/j.atherosclerosis.2021.08.037
One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Saya Kikuchi, Keiko Murakami, Taku Obara, Mami Ishikuro, et al.
Available online 4 September 2021
Journal of Affective Disorders
doi：10.1016/j.jad.2021.08.118
The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk
Katsuki Usami, Kanae Niimi, Ayumi Matsuo, Yoshihisa Suyama, et al.
Published: 7 September 2021
Cell Reports
doi：10.1016/j.celrep.2021.109655
Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis
Takafumi Yamauchi, Daisuke Ochi, Naomi Matsukawa, Daisuke Saigusa, et al.
Published: 7 September 2021
Scientific Reports
doi：10.1038/s41598-021-97342-z
Grain consumption before and during pregnancy and birth weight in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Mami Ishikuro, et al.
Published: 15 June 2021
European Journal of Clinical Nutrition
doi：10.1038/s41430-021-00939-w
Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan
Yudai Yonezawa, Fumihiko Ueno, Taku Obara, Takahiro Yamashita, et al.
Published: 14 June 2021
British Journal of Nutrition
doi：10.1017/S0007114521002154
Hypertension in pregnancy as a possible factor for child autistic behavior at two years old
Mami Ishikuro, Keiko Murakami, Fumiya Yokozeki, Tomomi Onuma, et al.
Available online 28 May 2021
Pregnancy Hypertension
doi：10.1016/j.preghy.2021.05.020
Limited consumption of 100% fruit juices and sugar sweetened beverages in Japanese toddler and preschool children
Janet M.Wojcicki, Kenji J.Tsuchiya, Keiko Murakami, Mami Ishikuro, et al.
Available online 30 May 2021
Preventive Medicine Reports
doi：10.1016/j.pmedr.2021.101409
Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-deethylation
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Yuya Nakanishi, et al.
Published: July 22, 2021
Journal of Personalized Medicine
doi：10.3390/jpm11080690
Associations of education and work status with alcohol use and cessation among pregnant women in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Taku Obara, Mami Ishikuro, Fumihiko Ueno, et al.
Published: 15 July 2021
BMC Public Health
doi：10.1186/s12889-021-11461-w
Associations of education and income with hazardous drinking among postpartum women in Japan: results from the TMM BirThree Cohort Study
Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, et al.
Published: 03 July 2021
Environmental Health and Preventive Medicine
doi：10.1186/s12199-021-00991-9
Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer
Eiji Hishinuma, Muneaki Shimada, Naomi Matsukawa, Daisuke Saigusa, et al.
Published: 30 June 2021
Toxins
doi：10.3390/toxins13070461
Relation between disaster exposure, maternal characteristics, and obstetric outcomes
Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, et al.
Advance online publication: July 03, 2021
Journal of Epidemiology
doi：10.2188/jea.JE20210052
Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs
Mika Sakurai-Yageta, Kazuki Kumada, Chinatsu Gocho, Satoshi Makino, et al.
Published: 13 May 2021
Journal of Biochemistry
doi：10.1093/jb/mvab060
Maternal personality and alcohol use during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, et al.
Available online 16 June 2021
Addictive Behaviors
doi：10.1016/j.addbeh.2021.107020
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, et al.
Published online 2021 May 14
Communications Biology
doi：10.1038/s42003-021-02100-6
Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-Eclampsia
Yasuo Uchida, Tomoya Higuchi, Matsuyuki Shirota, Satoshi Kagami, et al.
Published: June 01, 2021
Biological and Pharmaceutical Bulletin
doi：10.1248/bpb.b20-01043
GWAS identified IL4R and the major histocompatibility complex region as the associated loci of total serum IgE levels in 9,260 Japanese individuals
Kosuke Shido, Kaname Kojima, Matsuyuki Shirota, Kenshi Yamasaki, et al.
Available online 14 April 2021
Journal of Investigative Dermatology
doi：10.1016/j.jid.2021.02.762
The association betwen ERK inhibitor sensitivity and molecular characteristics in colorectal cancer
Hodaka Tayama, Hideaki Karasawa, Akihiro Yamamura, Yasunobu Okamura, et al.
Available online: 11 May 2021
Biochemical and Biophysical Research Communications
doi：10.1016/j.bbrc.2021.04.130
Body mass index and colorectal cancer risk: A Mendelian randomization study
Shiori Suzuki, Atsushi Goto, Masahiro Nakatochi, Akira Narita, et al.
Issue Online: 03 April 2021
Cancer Science
doi：10.1111/cas.14824
Factors associated with postpartum smoking relapse among women who quit in early pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Mami Ishikuro, Fumihiko Ueno, Aoi Noda, et al.
Advance online publication: April 28, 2021
Journal of Epidemiology
doi：10.2188/jea.JE20200609
Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.
Yu Nagayoshi, Takeshi Chujo, S. Hirata, H. Nakatsuka, et al.
Published：26 Mar 2021
Science Advances
doi：10.1126/sciadv.abf3072
Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk
Daichi Shigemizu, Risa Mitsumori, Shintaro Akiyama, Akinori Miyashita, et al.
Published：03 March 2021
Translational Psychiatry
doi：10.1038/s41398-021-01272-3
Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics
Daisuke Saigusa, Naomi Matsukawa, Eiji Hishinuma, Seizo Koshiba
Published：February 22nd, 2021
Drug Metabolism and Pharmacokinetics
doi：10.1016/j.dmpk.2020.11.008
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, et al.
Published: February 24, 2021
Nature Communications
doi：10.1038/s41467-020-20851-4
Functional assessment of 12 rare allelic CYP2C9 variants identified in a population of 4,773 Japanese individuals
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, et al.
Published：2 February 2021
Journal of Personalized Medicine
doi：10.3390/jpm11020094
Facial UV photo imaging for skin pigmentation assessment using conditional generative adversarial networks
Kaname Kojima, Kosuke Shido, Gen Tamiya, Kenshi Yamasaki, et al.
Published：13 January 2021
Scientific Reports
doi：10.1038/s41598-020-79995-4
Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal-recessive bone dysplasia using a whole-genome reference panel of Japanese individuals
Shinichi Nagaoka, Yumi Yamaguchi-Kabata, Naomi Shiga, Masahito Tachibana, et al.
Published：15 January 2021
Human Genome Variation
doi：10.1038/s41439-020-00133-7
Functional characterization of 40 CYP3A4 variants by assessing midazolam 1′-hydroxylation and testosterone 6β-hydroxylation
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, et al.
Available online: 31 December 2020
Drug Metabolism and Disposition
doi：10.1124/dmd.120.000261
Combined associations of liver enzymes and obesity with diabetes mellitus prevalence: The Tohoku Medical Megabank Community-based Cohort Study
Fumi Itabashi, Takumi Hirata, Mana Kogure, Akira Narita, et al.
Available online: 26 December 2020
Journal of Epidemiology
doi：10.2188/jea.JE20200384
Maternal personality and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Keiko Murakami, Fumihiko Ueno, Ibuki Nakamura, Mami Ishikuro, et al.
Published: 31 December 2020
Journal of Affective Disorders
doi：10.1016/j.jad.2020.12.187
Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2)
Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, et al.
Published: January 11, 2021
PLOS One
doi：10.1371/journal.pone.0236907
Indole-3-acetic acid synthesized through the indole-3-pyruvate pathway promotes Candida tropicalis biofilm formation
Masaru Miyagi, Rachel Wilson, Daisuke Saigusa, Keiko Umeda, et al.
Published: December 17, 2020
PLOS One
doi：10.1371/journal.pone.0244246
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
Keito Okazaki, Hayato Anzawa, Zun Liu, Nao Ota, et al.
Published: November 20, 2020
Nature Communications
doi：10.1038/s41467-020-19593-0
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration
Ebrahim Afshinnekoo, Ryan T. Scott, Matthew J. MacKay, Eloise Pariset, et al.
Published: November 25, 2020
Cell
doi：10.1016/j.cell.2020.10.050
Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia
Ayako Nishizawa, Kazuki Kumada, Keiko Tateno, Maiko Wagata, et al.
Published: 18 November 2020
Scientific Reports
doi：10.1038/s41598-020-77081-3
jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population
Shu Tadaka, Eiji Hishinuma, Shohei Komaki, Ikuko N Motoike, et al.
Published: 12 November 2020
Nucleic Acids Research
doi：10.1093/nar/gkaa1034
Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines
Noriko Ishida, Yuichi Aoki, Fumiki Katsuoka, Ichiko Nishijima, et al.
Available online: 2 October 2020.
Free Radical Biology and Medicine
doi：10.1016/j.freeradbiomed.2020.09.023
Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population
Seizo Koshiba, Ikuko N. Motoike, Daisuke Saigusa, Jin Inoue, et al.
Published: November 11, 2020
Communications Biology
doi：10.1038/s42003-020-01383-5
Identification of dominant transcripts in oxidative stress response by a full-length transcriptome analysis
Akihito Otsuki, Yasunobu Okamura, Yuichi Aoki, Noriko Ishida, et al.
Released: November 9, 2020
Molecular and Cellular Biology
doi：10.1128/MCB.00472-20
Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Junichi Sugawara, Mami Ishikuro, Taku Obara, Tomomi Onuma, et al.
[Advance Publication] Released: October 10, 2020
The Journal of Epidemiology
doi：10.2188/jea.JE20200338
Comparison among research, home, and office blood pressure measurements for pregnant women: The TMM BirThree Cohort Study
Takuma Usuzaki, Mami Ishikuro, Hirohito Metoki, Keiko Murakami, et al.
Published: September 2020
The Journal of Clinical Hypertension
doi：10.1111/jch.14050
A genotype imputation method for de-identified haplotype reference information by using recurrent neural network
Kaname Kojima, Shu Tadaka, Fumiki Katsuoka, Gen Tamiya, et al.
Published: October 1, 2020
PLOS Computational Biology
doi：10.1371/journal.pcbi.1008207
Relationship between calcium intake and impaired activities of daily living in a Japanese population: NIPPON DATA90
Mana Kogure, Naho Tsuchiya, Akira Narita, Takumi Hirata, et al.
Published: February 08, 2020
Journal of Epidemiology
doi：10.2188/jea.JE20190234
Nrf2 contributes to the weight gain of mice during space travel
Takafumi Suzuki, Akira Uruno, Akane Yumoto, Keiko Taguchi, et al.
Published: 08 September 2020
Communications Biology
doi：10.1038/s42003-020-01227-2
Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup
Mana Kogure, Naoki Nakaya, Takumi Hirata, Naho Tsuchiya, et al.
Published: 17 August 2020
Hypertension Research
doi：10.1038/s41440-020-00536-7
Clustering by phenotype and genome-wide association study in autism
Akira Narita, Masato Nagai, Satoshi Mizuno, Soichi Ogishima, et al.
Published: 17 August 2020
Translational Psychiatry
doi：10.1038/s41398-020-00951-x
Heterologous expression of high-activity cytochrome P450 in mammalian cells
Masaki Kumondai, Eiji Hishinuma, Evelyn Marie Gutiérrez Rico, Akio Ito, et al.
Published: 25 August 2020
Scientific Reports
doi：10.1038/s41598-020-71035-5
Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes
Yuta Takahashi, Masao Ueki, Gen Tamiya, Soichi Ogishima, et al.
Published: 17 August 2020
Translational Psychiatry
doi：10.1038/s41398-020-00957-5
Fruit and vegetable consumption before and during pregnancy and birth weight of new-borns in Japan: the Tohoku medical megabank project birth and three-generation cohort study
Yudai Yonezawa, Taku Obara, Takahiro Yamashita, Junichi Sugawara, et al.
Published: 3 August 2020
Nutrition Journal
doi：10.1186/s12937-020-00595-z
In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase
Eiji Hishinuma, Evelyn Gutiérrez Rico, Masahiro Hiratsuka
Published: 22 July 2020
Journal of Clinical Medicine
doi：10.3390/jcm9082342
Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy
Matsuyuki Shirota, Daisuke Saigusa, Riu Yamashita, Yasutake Kato, et al.
Published: June 2020
Medical Mass Spectrometry
doi：10.24508/mms.2020.06.001
Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis
Maiko Wagata, Mana Kogure, Naoki Nakaya, Naho Tsuchiya, et al.
Published: 13 May 2020
Hypertension Research
doi：10.1038/s41440-020-0463-8
Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors
Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, et al.
Published: July 7, 2020
Cancer Research
doi：10.1158/0008-5472.CAN-19-2888
Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection
Yuta Takahashi, Masao Ueki, Makoto Yamada, Gen Tamiya, et al.
Published: May 19, 2020
Translational Psychiatry
doi：10.1038/s41398-020-0831-9
Clusters of Coronavirus Disease in Communities, Japan, January–April 2020
Yuki Furuse, Eiichiro Sando, Naho Tsuchiya, Reiko Miyahara, et al.
Published: June 10, 2020
Emerging Infectious Diseases
doi：10.3201/eid2609.202272
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, et al.
Published: 08 June 2020
Nature Genetics
doi：10.1038/s41588-020-0640-3
Genome-wide association study identifies new loci for albuminuria in the Japanese population
Hiroshi Okuda, Koji Okamoto, Michiaki Abe, Kota Ishizawa, et al.
Published: 10 April 2020
Clinical and Experimental Nephrology
doi：10.1007/s10157-020-01884-x
Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.
Kento Tsukada, Shono Shinki, Akiho Kaneko, et al.
Published: 14 April 2020
Nature Communications
doi：10.1038/s41467-020-15664-4
Evaluating folic acid supplementation among Japanese pregnant women with dietary intake of folic acid lower than 480 μg per day: results from TMM BirThree Cohort Study.
Kikuchi D, Obara T, Usuzaki T, et al.
Published online: 13 March 2020
The Journal of Maternal-Fetal & Neonatal Medicine
doi：10.1080/14767058.2020.1739020
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity
Toshiyuki Waki, Ryo Mameda, Takuya Nakano, Sayumi Yamada, et al.
Published: 13 February 2020
Nature Communications
doi：10.1038/s41467-020-14558-9
Impacts of NRF2 Activation in Non-Small-Cell Lung Cancer Cell Lines on Extracellular Metabolites
Daisuke Saigusa, Ikuko N. Motoike, Sakae Saito, Michael Zorzi, et al.
Online Published：January 15th, 2020
Cancer Science
doi：10.1111/cas.14278
A proposal on the first Japanese practical guidance for the return of individual genomic results in research settings
Yayoi Aizawa, Fuji Nagami, Noriko Ohashi, Kazuto Kato
Published online 23 December 2019
Journal of Human Genetics
doi：10.1038/s10038-019-0697-y
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-in Alzheimer’s Disease Model Mice
Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, et al.
Published online January 13, 2020.
Molecular and Cellular Biology
doi：10.1128/MCB.00467-19
邦題：Nrf2 はApp ノックインアルツハイマー病モデルマウスで酸化ストレスと炎症を抑制する
Neuromyelitis optica spectrum disorders with unevenly clustered attack occurrence
Tetsuya Akaishi, Ichiro Nakashima, Toshiyuki Takahashi, Michiaki Abe, et al.
First published November 22, 2019
Neurology Neuroimmunology & Neuroinflammation
doi：10.1212/NXI.0000000000000640
邦題：視神経脊髄炎における発作の群発性
3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome
Shu Tadaka, Fumiki Katsuoka, Masao Ueki, Kaname Kojima, et al.
Published: 18 June 2019
Human Genome Variation 6, Article number: 28 (2019)
doi：10.1038/s41439-019-0059-5
Rare variant discovery by deep whole-genome sequencing of 1070 Japanese Individuals
Masao Nagasaki, Jun Yasuda, Fumiki Katsuoka, Naoki Nariai, et al.
Published: 21 August 2015
Nature Communications 6, Article number: 8018
doi: 10.1038/ncomms9018
論文概要：東北メディカル・メガバンク計画のコホート調査に参加した健常な日本人1,070人分の全ゲノムを解析し、精度検証を進めることで、日本人の全ゲノムリファレンスパネル（1KJPN）を構築
Japonica Array: Improved genotype imputation by designing a population-specific SNP array with 1,070 Japanese individuals
Yosuke Kawai, Takahiro Mimori, Kaname Kojima, Naoki Nariai, et al.
Advance online publication: 25 June 2015
Journal of Human Genetics
doi: 10.1038/jhg.2015.68
論文概要：ジャポニカアレイ®：1,070人の日本人の情報に基づく日本人集団に適したSNPアレイの設計によるインピュテーションの改良
The structural origin of metabolic quantitative diversity
Seizo Koshiba, Ikuko Motoike, Kaname Kojima, Takanori Hasegawa, et al.
Scientific Reports 6, Article number: 31463 (2016)
Published online August 16, 2016
doi:10.1038/srep31463
邦題：代謝物の量的な多様性の構造的起源
Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2,049 individuals
Yumi Yamaguchi-Kabata, Jun Yasuda, Osamu Tanabe, Yoichi Suzuki, et al.
Journal of Human Genetics 63, 213–230 (2018)
Published online: 01 December 2017
doi:10.1038/s10038-017-0347-1
邦題：日本人2,049人の全ゲノムリファレンスパネルを用いた、既報の疾患原因バリアントの頻度と精査
12 New Susceptibility Loci for Prostate Cancer Identified by Genome-wide Association Study in Japanese Population
Ryo Takata, Atsushi Takahashi, Masashi Fujita, Yukihide Momozawa, et al.
Nature Communications
Published: 27 September 2019
DOI: 10.1038/s41467-019-12267-6
Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells
Fumiki Katsuoka, Akihito Otsuki, Mizue Takahashi, Shin Ito, Masayuki Yamamoto
Molecular and Cellular Biology
Published: 2019-08-05
DOI: 10.1128/MCB.00273-19
Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study
Mana Kogure, Takumi Hirata, Naoki Nakaya, Naho Tsuchiya, et al.
Hypertension Research
Published: 27 Sep 2019
DOI: 10.1038/s41440-019-0335-2
Effectiveness of Seasonal Inactivated Influenza Vaccination in Japanese Schoolchildren: An Epidemiologic Study at the Community Level
Yasutaka Kuniyoshi, Taku Obara, Mami Ishikuro, Hiroko Matsubara, et al.
Human Vaccines & Immunotherapeutics
Accepted author version posted online: 19 Aug 2019
DOI: 10.1080/21645515.2019.1655833
Molecular Mechanism of Cellular Oxidative Sensing by Keap1
Takafumi Suzuki, Aki Muramatsu, Ryota Saito, Tatsuro Iso, et al.
Cell Reports
Available online 16 July 2019.
DOI: 10.1016/j.celrep.2019.06.047
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons
Authors: Tetsuya Akiyama, Naoki Suzuki, Mitsuru Ishikawa, Koki Fujimori, et al.
EBioMedicine
Published online:June 28, 2019
DOI: 10.1016/j.ebiom.2019.06.013
Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging.
Saigusa D, Saito R, Kawamoto K, Uruno A, et al.
Analytical Chemistry
Published online 28 June 2019
DOI: 10.1021/acs.analchem.9b01159
Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension -High-throughput Screening of 5,562 Compounds-
Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Haruhisa Kikuchi, Daisuke Saigusa, et al.
Circulation Research
Originally published June 14, 2019
DOI: 10.1161/CIRCRESAHA.119.315229.
Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study
Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, et al.
Disaster medicine and public health preparedness
Published online: 03 June 2019
DOI: 10.1017/dmp.2019.8
Susceptibility loci for tanning ability in Japanese population identified by genome-wide association study from Tohoku Medical Megabank Project cohort study
Kosuke Shido, Kaname Kojima, Kenshi Yamasaki, Atsushi Hozawa, et al.
Journal of Investigative Dermatology
published online 25 January 2019
DOI: 10.1016/j.jid.2019.01.015
Respiratory resistance among adults in a population-based cohort study in Northern Japan
Emiri Miura, NahoTsuchiya, Yu Igarashi, Ritsuko Arakawa, et al.
Respiratory Investigation
Available online 13 February 2019.
DOI: 10.1016/j.resinv.2018.12.008
Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals
Yumi Yamaguchi-Kabata, Jun Yasuda, Akira Uruno, Kazuro Shimokawa, et al.
Human Genetics
First Online: 18 March 2019
DOI: 10.1007/s00439-019-01998-7
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, et al.
Nature Communications
Published: 23 April 2019
DOI: 10.1038/s41467-019-09735-4
Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database
Tomofumi Ishikawa, Taku Obara, Kazutaka Jin, Hidekazu Nishigori, et al.
Pharmacoepidemiology and Drug Safety
First published: 10 March 2019
DOI: 10.1002/pds.4749
Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy
Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauch, et al.
BMJ
Open 2019 Feb 19;9(2):e025939
DOI: 10.1136/bmjopen-2018-025939.
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population
Ken Suzuki, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kana, et al.
Nature Genetics
Published: 04 February 2019
DOI: 10.1038/s41588-018-0332-4
Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study
Mami Ishikuro, Taku Obara, Tamae Osanai, Chizuru Yamanaka, et al.
The Tohoku Journal of Experimental Medicine
Published: October 2018
DOI: https://doi.org/10.1620/tjem.246.97
Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods
Taku Obara, Mami Ishikuro, Gen Tamiya, Masao Ueki, et al.
Scientific Reports
Published: 4 October 2018
DOI: doi.org/10.1038/s41598-018-33110-w
Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation
Takashi Watanabe, Takahiro Saito, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, et al.
Biochemical Pharmacology
Published: 8 September 2018
DOI: https://doi.org/ 10.1016/j.bcp.2018.09.010.
Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS)
Masaki Kumondai, Akio Ito, Eiji Hishinuma, Aoi Kikuchi, et al.
Drug Metabolism and Pharmacokinetics
Available online 22 August 2018
DOI: 10.1016/j.dmpk.2018.08.003
Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project
Jun Yasuda, Fumiki Katsuoka, Inaho Danjoh, Yosuke Kawai, et al.
BMC Genomics
Published: 24 July 2018
DOI: 10.1186/s12864-018-4942-0
Strong Association of HLA-DR/DQ Locus with Childhood Steroid-Sensitive Nephrotic Syndrome in the Japanese Population
Xiaoyuan Jia, Tomoko Horinouchi, Yuki Hitomi, Akemi Shono, et al.
Journal of the American Society of Nephrology
Accepted for publication May 11, 2018.
DOI: 10.1681/ASN.2017080859
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study
Yoichi Kakuta, Yosuke Kawai, Daisuke Okamoto, Tetsuya Takagawa, et al.
Journal of Gastroenterology
First Online: 19 June 2018
DOI: 10.1007/s00535-018-1486-7
Functional characterization of 21 allelic variants of dihydropyrimidine dehydrogenase identified in 1,070 Japanese individuals
Eiji Hishinuma, Yoko Narita, Sakae Saito, Masamitsu Maekawa, et al.
Drug Metabolism and Disposition
Published online May 16, 2018.
DOI: 10.1124/dmd.118.081737
Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study
Yasutaka Kuniyoshi, Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, et al.
Allergology International
Available online: 13 April 2018
DOI: 10.1016/j.alit.2018.02.009
Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake
Naoki Nakaya, Harumi Nemoto, Carine Yi, Ayako Sato, et al.
International Journal of Disaster Risk Reduction誌2018年6月第28巻 206-213頁
Available online: 22 February 2018
DOI: 10.1016/j.ijdrr.2018.02.037
Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma
Yukihiro Shiga, Masato Akiyama, Koji M Nishiguchi, Kota Sato, et al.
Human Molecular Genetics
Published: 14 February 2018
DOI:https://doi.org/10.1093/hmg/ddy053
Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing
Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F. Shibata, et al.
The Pharmacogenomics Journal
Published:19 January 2018
DOI: 10.1016/j.alit.2018.02.009
Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders
Masaki Nishioka, Miki Bundo, Junko Ueda, Fumiki Katsuoka, et al.
Accepted manuscript online: 28 December 2017
DOI: 10.1111/pcn.12632
邦題：全ゲノム解析による脳組織での体細胞変異の同定と精神神経疾患発症との関連
Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6-TMC8 and SIX3-SIX2 loci associated with HbA1c
Tsuyoshi Hachiya, Shohei Komaki, Yutaka Hasegawa, Hideki Ohmomo, et al.
Scientific Reports
Published online:23 November 2017
DOI: 10.1038/s41598-017-16493-0
邦題：日本人集団の全ゲノムメタ解析がHbA1cと関連するTMC6-TMC8 及び SIX3-SIX2座位の新規多型を同定
Genome-wide association study identifies 112 loci for body mass index in the Japanese population
Masato Akiyama, Yukinori Okada, Masahiro Kanai, Atsushi Takahashi, et al.
Nature genetics
Published: 11 September 2017
DOI: 10.1038/ng.3951
Population-based biobank participants’ preferences for receiving genetic test results
Kayono Yamamoto, Tsuyoshi Hachiya, Akimune Fukushima, Naoki Nakaya, et al.
Journal of Human Genetics
Published: 10 August 2017
doi：10.1016/j.mayocp.2014.03.015
邦題：住民バイオバンク参加者の遺伝学的検査結果回付への需要
Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren
Masako Miyashita, Mami Ishikuro, Masahiro Kikuya, Chizuru Yamanaka, et al.
Journal of Pediatrics and Congenital Disorders
Published: 10 July 2017
DOI: 10.1620/tjem.236.123
Detecting genetic association through shortest paths in a bi-directed graph
Masao Ueki, Yoshinori Kawasaki, Gen Tamiya
Genetic Epiemiology
First published: 19 June 2017
DOI: 10.1002/gepi.22051
A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients
Teruhiko Hamanaka, Masae Kimura, Tetsuro Sakurai, Nobuo Ishida, et al.
Published: May 2017
DOI: 10.1167/iovs.16-20646
Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies
Tsuyoshi Hachiya, Ryohei Furukawa, Yuh Shiwa, Hideki Ohmomo, et al.
npj Genomic Medicine 2, Article number: 11 (2017)
Published: 13 April 2017
doi:10.1038/s41525-017-0016-5
邦題：全ゲノム規模の個人毎のDNAメチル化部位の変動部位の同定はエピゲノム関連解析の有効性を改善できる
Drug Use before and during Pregnancy in Japan: The Japan Environment and Children’s Study
Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, et al.
Published: 10 April 2017
DOI: 10.3390/pharmacy5020021
邦題：日本人妊婦の医薬品・サプリメント使用：エコチル調査
Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens–Johnson syndrome with severe ocular complications
Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, et al.
Journal of Human Genetics
Published online:19 January 2017
DOI: 10.1038/jhg.2016.160
網羅的ゲノム解析における偶発的所見を含む遺伝情報の結果の返却に関する我が国の現状と課題の検討―米国臨床遺伝・ゲノム学会（ACMG）の偶発的所見取り扱いに関する推奨からの考察―
Review of present state and challenges regarding return of genomic results from genome-wide analysis in Japan: Consideration of American College of Medical Genetics and Genomics (ACMG) recommendation for reporting incidental findings 日本遺伝カウンセリング学会誌 37(3): 105-126 2016
Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score
Tsuyoshi Hachiya; Yoichiro Kamatani, Atsushi Takahashi, Jun Hata, et al.
Stroke Originally
published：December 29, 2016 doi：10.1161/STROKEAHA.116.014506
邦題：脳梗塞の遺伝的体質；多遺伝子リスク評価
Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011
Naho Tsuchiya, Naoki Nakaya, Tomohiro Nakamura, Akira Narita, et al.
Psychiatry and Clinical Neurosciences First Published: 21 December 2016
DOI: 10.1111/pcn.12467
邦題：東日本大震災後の心理的苦痛に対するソーシャルキャピタルの影響、および家屋の損壊と転居の相互作用
Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery
Daisuke Saigusa, Yasunobu Okamura, Ikuko N. Motoike, Yasutake Katoh, et al.
PLoS ONE 11(8): e0160555
Published: August 31, 2016
DOI: 10.1371/journal.pone.0160555
邦題：バイオマーカー探索を目的とした質量分析計によるヒト血漿中代謝物の網羅的メタボロミクス解析プロトコルの開発
Partners’ Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake
Naoki Nakaya, Akira Narita, Naho Tsuchiya, Tomohiro Nakamura, et al.
The Tohoku Journal of Experimental Medicine Vol. 239 (2016) No. 4 August p. 307-314
Published online August 10, 2016
DOI: 10.1620/tjem.239.307
邦題：配偶者の慢性疾患治療と心理的苦痛リスク
Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster
Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, et al.
Disaster Medicine and Public Health Preparedness
Published online: 23 June 2016
doi: 10.1017/dmp.2016.102
邦題：震災後の心理的苦痛と高血圧治療中断リスク
Comparison of Boiling and Robotics Automation Method in DNA Extraction for Metagenomic Sequencing of Human Oral Microbes
Junya Yamagishi, Yukuto Sato, Natsuko Shinozaki, Bin Ye, et al.
Published: April 22, 2016
PLoS One. 2016 Apr 22;11(4):e0154389.
doi: 10.1371/journal.pone.0154389.
Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area
Mami Ishikuro, Naoki Nakaya, Taku Obara, Yuki Sato, et al.
Prehospital and Disaster Medicine
Published online: 28 March 2016
DOI: 10.1017/S1049023X16000182
邦題：東日本大震災被災地域におけるゲノム解析を伴う疫学調査に対する人々の意識
A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies
Masakazu Kohda, Yoshimi Tokuzawa, Yoshihito Kishita, Hiromi Nyuzuki, et al.
PLOS Genetics
Published: January 7, 2016
DOI: 10.1371/journal.pgen.1005679
邦題：網羅的ゲノム解析によりミトコンドリア病の遺伝的背景の一端を明らかにした
Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing
Xiaoqing Pan, Naoki Nariai, Noriko Fukuhara, Sakae Saito, et al.
British Journal of Haematology
Published online: 29 JAN 2016
DOI: 10.1111/bjh.13948
邦題：次世代シークエンサーを用いた全ゲノム解析情報による初期前駆T細胞性急性リンパ芽球性白血病治療の効果判定
Prospect of the future housing and the risk of psychological distress at 1 year after an earthquake disaster
Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Akira Narita, et al.
Psychiatry and Clinical Neurosciences
Accepted manuscript online: 11 DEC 2015
DOI: 10.1111/pcn.12377
論文概要：震災１年後の将来の住居の見通しと心理的苦痛リスクの関連
Periodontitis-associated septic pulmonary embolism caused by Actinomyces species identified by anaerobic culture of bronchoalveolar lavage fluid: a case report
Shun Endo, Eikan Mishima, Yoichi Takeuchi, Takashi Ohi, et al.
BMC Infectious Diseases 2015, 15:552
Published online: 1 December 2015
DOI: 10.1186/s12879-015-1286-0
論文概要：気管支肺胞洗浄液の嫌気培養により診断されたアクチノマイセスによる歯周炎関連ー敗血症性肺塞栓の１例
Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study
Masako Miyashita, Masahiro Kikuya, Chizuru Yamanaka, Mami Ishikuro, et al.
The Tohoku Journal of Experimental Medicine, Vol. 237 (2015) No. 4 December p. 297-305
Published online December 02, 2015
doi: 10.1620/tjem.237.297
iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing
Yumi Yamaguchi-Kabata, Naoki Nariai, Yosuke Kawai, Yukuto Sato, et al.
Human Genome Variation 2, Article number: 15050 (2015)
Published online 26 November 2015
doi: 10.1038/hgv.2015.50
論文概要：iJGVD: 全ゲノム解析に基づく日本人ゲノム多様性情報の統合されたデータベース
Unemployment risk among individuals undergoing medical treatment for chronic diseases
Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, et al.
Occup Med (Lond) (2015)
First published online: November 13, 2015
doi: 10.1093/occmed/kqv159
論文概要：東日本大震災の被災地の沿岸地域において慢性疾患の有無と無職リスクの関連性を検討した。慢性疾患治療者の無職リスクは高く、心理・身体面が不良な者は慢性疾患治療と無職リスクの有意な関連が示された。
Inter-individual differences in the oral bacteriome are greater than intra-day fluctuations in individuals
Yukuto Sato, Junya Yamagishi, Riu Yamashita, Natsuko Shinozaki, et al.
PLOS ONE. 2015, 10(6): e0131607.
Published online 2015 June 29.
doi: 10.1371/journal.pone.0131607
論文概要：個人の口腔内のバクテリア叢は比較的安定して存在しており、その日内の変動は個人間の差よりも小さい
Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake
Masahiro Kikuya, Masako Miyashita, Chizuru Yamanaka, Mami Ishikuro, et al.
The Tohoku Journal of Experimental Medicine, Vol. 236 No. 2
Published: June 2015
doi: 0.1620/tjem.236.123
論文概要：地域子ども長期健康調査の研究デザインと2012年度に岩沼市・亘理町・山元町で実施した調査の結果
The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project.
Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Ichiro Tsuji, et al.
Disaster Medicine and Public Health Preparedness
online: 27 April 2015
doi: 10.1017/dmp.2015.52
論文概要：東日本大震災で甚大な被害を受けた沿岸地域における循環器疾患、がん、高脂血症、肝臓病、腎臓病、糖尿病などの疾患を治療している者と心理的苦痛の関連の検討
Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population
Ikuko N Motoike, Mitsuyo Matsumoto, Inaho Danjoh, Masayuki Yamamoto, et al.
BMC Genomics. 2014, 15: 673.
Published:
doi: 10.1186/1471-2164-15-673
論文概要：複数の種類の次世代型シークエンサーによる一塩基置換の読み取りの精度向上について
An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer
Fumiki Katsuoka, Junji Yokozawa, Kaoru Tsuda, Shin Ito, et al.
Analytical Biochemistry, Volume 466, 1 December 2014, Pages 27-29
Available online 28 August 2014
doi: 10.1016/j.ab.2014.08.015
論文概要：ToMMoで開発した新しいライブラリ定量に関する方法の論文です。ToMMoでは、この新しい定量方法を採用することで、効率の良い安定した全ゲノム解析を実現しています。
HapMonster: A Statistically Unified Approach for Variant Calling and Haplotyping Based on Phase-Informative Reads
Kaname Kojima, Naoki Nariai, Takahiro Mimori, Yumi Yamaguchi-Kabata, et al.
Lecture Notes in Computer Science Volume 8542, 2014, pp 107-118
SVEM: a Structural Variant Estimation Method using Multi-Mapped Reads on Breakpoints
Tomohiko Ohtsuki, Naoki Nariai, Kaname Kojima, Takahiro Mimori, et al.
Lecture Notes in Computer Science Volume 8542, 2014, pp 208-219
A statistical variant calling approach from pedigree information and local haplotyping with phase informative reads
Kaname Kojima, Naoki Nariai, Takahiro Mimori, Mamoru Takahashi, et al.
Bioinformatics. 2013 Nov 15;29(22):2835-43.
Epub 2013 Sep 3
doi: 10.1093/bioinformatics/btt503.
TIGAR: transcript isoform abundance estimation method with gapped alignment of RNA-Seq data by variational Bayesian inference
Naoki Nariai, Osamu Hirose, Kaname Kojima and Masao Nagasaki
Bioinformatics. 2013 Sep 15;29(18):2292-9.
Epub 2013 Jul 2
doi: 10.1093/bioinformatics/btt381.
主な査読付き国際学会proceedingsなど
A Bayesian approach for estimating allele-specific expression from RNA-Seq data with diploid genomes
Naoki Nariai, Kaname Kojima, Takahiro Mimori, Yosuke Kawai and Masao Nagasaki
BMC Genomics201617(Suppl 1):2
Published: 11 January 2016
DOI: 10.1186/s12864-015-2295-5
Selected articles from the Fourteenth Asia Pacific Bioinformatics Conference (APBC 2016): Genomics
邦題：RNAシークエンスデータと全ゲノムデータから、アレル特異的な遺伝子発現量を推定するベイズ理論を用いた手法を開発
HLA-VBSeq: accurate HLA typing at full resolution from whole-genome sequencing data
Naoki Nariai, Kaname Kojima, Sakae Saito, Takahiro Mimori, et al.
BMC Genomics, 16(Suppl 2):S7 (2015)
doi: 10.1186/1471-2164-16-S2-S7
論文概要：HLAの型を全ゲノムシークエンスデータから高精度で推定することができる統計手法の開発とソフトウェアHLA-VBSeqの実装
Estimating copy numbers of alleles from population-scale high-throughput sequencing data
Takahiro Mimori, Naoki Nariai, Kaname Kojima, Yukuto Sato, et al.
BMC Bioinformatics, 16(Suppl 1):S4 (2015)
doi: 10.1186/1471-2105-16-S1-S4
論文概要：集団の全ゲノムシークエンスデータから、コピー数変異 (CNV) の塩基配列を推定する統計手法の開発と実装
TIGAR2: sensitive and accurate estimation of transcript isoform expression with longer RNA-Seq reads
Naoki Nariai, Kaname Kojima, Takahiro Mimori, Yukuto Sato, et al.
BMC Genomics, 15(Suppl 10):S5 (2014)
doi: 10.1186/1471-2164-15-S10-S5
論文概要：既報のTIGARをさらに改良しより長い次世代シークエンサに転写産物の発現量を推定する手法の開発とソフトウェアTIGAR2の実装
SUGAR: graphical user interface-based data refiner for high-throughput DNA sequencing
Yukuto Sato, Kaname Kojima, Naoki Nariai, Yumi Yamaguchi-Kabata, et al.
BMC Genomics. 2014 Aug 8;15:664.
doi: 10.1186/1471-2164-15-664.
論文概要：大量DNAシークエンスデータのクオリティ・コントロールを行うためのグラフィカルユーザーインターフェースソフトウェアSUGAR
iSVP: an integrated structural variant calling pipeline from high-throughput sequencing data
Takahiro Mimori, Naoki Nariai, Kaname Kojima, Mamoru Takahashi, et al.
BMC Syst Biol. 2013;7 Suppl 6:S8.
Epub 2013 Dec 13.
doi: 10.1186/1752-0509-7-S6-S8.