Tohoku University Tohoku Medical Megabank Organization (Tomohiro Nakamura)
2023.01.27

1.   Tatara Yota, Yamazaki Hiromi, Katsuoka Fumiki, et al. Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment. Current Research in Translational Medicine. 2023; 71 (1): 103367. doi:10.1016/j.retram.2022.103367  
2.   Kobayashi Tomoko, Kobayashi Mika, Minegishi Naoko, et al. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2023; 259 (2): 2022.J103. doi:10.1620/tjem.2022.J103  
3.   Akaishi Ryujiro, Fujishima Fumiyoshi, Ishida Hirotaka, et al. HO ‐1 in lymph node metastasis predicted overall survival in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiation therapy. Cancer Reports. 2022; 5 (3): . doi:10.1002/cnr2.1477  
4.   Watanabe Hirofumi, Fujishima Fumiyoshi, Komoto Izumi, et al. Somatostatin Receptor 2 Expression Profiles and Their Correlation with the Efficacy of Somatostatin Analogues in Gastrointestinal Neuroendocrine Tumors. Cancers. 2022; 14 (3): 775. doi:10.3390/cancers14030775  
5.   Takahashi So, Hatta Waku, Watanabe Kenta, et al. Prognostic Benefit of Additional Treatment After Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma. Digestive Diseases and Sciences. 2022; : . doi:10.1007/s10620-022-07746-8  
6.   Ogata Yohei, Hatta Waku, Ohara Yuki, et al. Predictors of early and late mortality after the treatment for early gastric cancers. Digestive Endoscopy. 2022; 34 (4): 816-825. doi:10.1111/den.14172  
7.   Akaishi Tetsuya, Suzuki Tomomi, Nemoto Harumi, et al. Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. Disaster Medicine and Public Health Preparedness. 2022; 16 (5): 1966-1974. doi:10.1017/dmp.2021.214  
8.   Akaishi Ryujiro, Fujishima Fumiyoshi, Ishida Hirotaka, et al. Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma. Esophagus. 2022; 19 (3): 436-443. doi:10.1007/s10388-021-00904-3  
9.   Munakata Masanori, Hattori Tomomi, Kubota-Nakayama Fumie, et al. Home Blood Pressure-based Guidance Did not Increase Anti-albuminuric Effects on Diagnostic Provision of Microalbuminuria in School Workers: A Miyagi Karoshi Prevention Study. Internal Medicine. 2022; : 0107-22. doi:10.2169/internalmedicine.0107-22  
10.   Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; 5 (2): . doi:10.31662/jmaj.2021-0156  
11.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2022; : 63523. doi:10.5551/jat.63523  
12.   Egawa Makiko, Kanda Eiichiro, Ohtsu Hiroshi, et al. Number of Children and Risk of Cardiovascular Disease in Japanese Women: Findings from the Tohoku Medical Megabank. Journal of Atherosclerosis and Thrombosis. 2022; : 63527. doi:10.5551/jat.63527  
13.   Takase Masato, Nakamura Tomohiro, Hirata Takumi, et al. Association between fat mass index, fat‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study. Journal of Diabetes Investigation. 2022; 13 (5): 858-867. doi:10.1111/jdi.13729  
14.   Itabashi Fumi, Hirata Takumi, Kogure Mana, et al. Combined Associations of Liver Enzymes and Obesity With Diabetes Mellitus Prevalence: The Tohoku Medical Megabank Community-based Cohort Study. Journal of Epidemiology. 2022; 32 (5): JE20200384. doi:10.2188/jea.JE20200384  
15.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2022; 67 (1): 9-17. doi:10.1038/s10038-021-00952-8  
16.   Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113  
17.   Akiyama Shizuko, Madan Neel, Graham George, et al. Regional brain development in fetuses with Dandy-Walker malformation: A volumetric fetal brain magnetic resonance imaging study. PLOS ONE. 2022; 17 (2): e0263535. doi:10.1371/journal.pone.0263535  
18.   Kanno I., Hasegawa K., Nakamura T., et al. Relationship between the housing coldness/warmth evaluation by CASBEE Housing Health Checklist and psychological distress based on TMM Community-Based Cohort Study: a cross-sectional analysis. Public Health. 2022; 208 : 98-104. doi:10.1016/j.puhe.2022.05.003  
19.   Liu Yexin, Uruno Akira, Saito Ritsumi, et al. Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice. Redox Biology. 2022; 58 : 102525. doi:10.1016/j.redox.2022.102525  
20.   Akaishi Tetsuya, Ishii Tadashi, Nakaya Naoki, et al. White blood cell count profile in patients with physical complaints without known causes. SAGE Open Medicine. 2022; 10 : 205031212211053. doi:10.1177/20503121221105328  
21.   Matsuyama Takashi, Narita Akira, Takanashi Masaki, et al. Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores. Scientific Reports. 2022; 12 (1): 17656. doi:10.1038/s41598-022-22266-1  
22.   Toda Shusuke, Hatta Waku, Asanuma Kiyotaka, et al. Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. The Tohoku Journal of Experimental Medicine. 2022; 258 (3): 2022.J077. doi:10.1620/tjem.2022.J077  
23.   Egi Moritoki, Ogura Hiroshi, Yatabe Tomoaki, et al. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020). Acute Medicine & Surgery. 2021; 8 (1): 21465. doi:10.1002/ams2.659  
24.   Nakaya Naoki, Xie Tian, Scheerder Bart, et al. Spousal similarities in cardiometabolic risk factors: A cross-sectional comparison between Dutch and Japanese data from two large biobank studies. Atherosclerosis. 2021; 334 : 85-92. doi:10.1016/j.atherosclerosis.2021.08.037  
25.   Kotozaki Yuka, Tanno Kozo, Sakata Kiyomi, et al. Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study. BMC Public Health. 2021; 21 (1): 925. doi:10.1186/s12889-021-10896-5  
26.   Nishimoto Yuka, Tsubono Yoshitaka, Kogure Mana, et al. The prevalence of current smokers and alcohol drinkers among cancer survivors and subjects with no history of cancer among participants in a community‐based cardiometabolic screening program in Miyagi prefecture, Japan: a comparison with nationally repres. Cancer Medicine. 2021; 10 (24): 9000-9011. doi:10.1002/cam4.4364  
27.   Yamauchi Takuro, Fujishima Fumiyoshi, Hashimoto Masatoshi, et al. Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes. Cancers. 2021; 13 (17): 4473. doi:10.3390/cancers13174473  
28.   Yamada Mitsuhiro, Motoike Ikuko N., Kojima Kaname, et al. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. Communications Biology. 2021; 4 (1): 1288. doi:10.1038/s42003-021-02813-8  
29.   Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6  
30.   Norita Kazuaki, Asanuma Kiyotaka, Koike Tomoyuki, et al. Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease. Digestion. 2021; 102 (3): 404-414. doi:10.1159/000508661  
31.   Saigusa Daisuke, Matsukawa Naomi, Hishinuma Eiji, Koshiba Seizo. Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics. Drug Metabolism and Pharmacokinetics. 2021; 37 (7): 100373. doi:10.1016/j.dmpk.2020.11.008  
32.   Hatta Waku, Tsuji Yosuke, Yoshio Toshiyuki, et al. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score. Gut. 2021; 70 (3): 476-484. doi:10.1136/gutjnl-2019-319926  
33.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
34.   Hirata Takumi, Kogure Mana, Tsuchiya Naho, et al. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. Hypertension Research. 2021; 44 (7): 858-865. doi:10.1038/s41440-021-00628-y  
35.   Kogure Mana, Nakaya Naoki, Hirata Takumi, et al. Sodium/potassium ratio change was associated with blood pressure change: possibility of population approach for sodium/potassium ratio reduction in health checkup. Hypertension Research. 2021; 44 (2): 225-231. doi:10.1038/s41440-020-00536-7  
36.   Kogure Mana, Tsuchiya Naho, Narita Akira, et al. Relationship Between Calcium Intake and Impaired Activities of Daily Living in a Japanese Population: NIPPON DATA90. Journal of Epidemiology. 2021; 31 (2): 119-124. doi:10.2188/jea.JE20190234  
37.   Abe Hiroko, Hatta Waku, Ogata Yohei, et al. Prevention of delayed bleeding with vonoprazan in upper gastrointestinal endoscopic treatment. Journal of Gastroenterology. 2021; 56 (7): 640-650. doi:10.1007/s00535-021-01781-4  
38.   Hatta Waku, Koike Tomoyuki, Takahashi So, et al. Risk of metastatic recurrence after endoscopic resection for esophageal squamous cell carcinoma invading into the muscularis mucosa or submucosa: a multicenter retrospective study. Journal of Gastroenterology. 2021; 56 (7): 620-632. doi:10.1007/s00535-021-01787-y  
39.   Ishikuro Mami, Murakami Keiko, Yokozeki Fumiya, et al. Hypertension in pregnancy as a possible factor for child autistic behavior at two years old. Pregnancy Hypertension. 2021; 25 (8): 88-90. doi:10.1016/j.preghy.2021.05.020  
40.   Akaishi Tetsuya, Misu Tatsuro, Fujihara Kazuo, et al. White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. Scientific Reports. 2021; 11 (1): 22357. doi:10.1038/s41598-021-01942-8  
41.   Ogata Yohei, Hatta Waku, Koike Tomoyuki, et al. Predictors of Early and Late Mortality after Endoscopic Resection for Esophageal Squamous Cell Carcinoma. The Tohoku Journal of Experimental Medicine. 2021; 253 (1): 29-39. doi:10.1620/tjem.253.29  
42.   髙瀬 雅仁, 五十嵐 有香, 中谷 直樹, et al. 東日本大震災に伴う災害による健康影響に関する文献レビュー. 日本循環器病予防学会誌. 2021; 56 (3): 244-257.  
43.   Wagata Maiko, Kogure Mana, Nakaya Naoki, et al. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. Hypertension Research. 2020; 43 (11): 1277-1283. doi:10.1038/s41440-020-0463-8  
44.   Kogure Mana, Hirata Takumi, Nakaya Naoki, et al. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. Hypertension Research. 2020; 43 (1): 62-71. doi:10.1038/s41440-019-0335-2  
45.   Hirata Takumi, Nakamura Tomohiro, Kogure Mana, et al. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. Hypertension Research. 2020; 43 (1): 23-29. doi:10.1038/s41440-019-0329-0  
46.   Katayanagi Mitsuaki, Seto Moe, Nakaya Naoki, et al. Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities. International Journal of Environmental Research and Public Health. 2020; 17 (21): 8130. doi:10.3390/ijerph17218130  
47.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
48.   Yang Yunqing, Hozawa Atsushi, Kogure Mana, et al. Dietary inflammatory index positively associated with high-sensitivity C-reactive protein level in Japanese from NIPPON data2010. Journal of Epidemiology. 2020; 30 (2): 98-107. doi:10.2188/jea.JE20180156  
49.   Wagata Maiko, Ishikuro Mami, Obara Taku, et al. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. Pregnancy Hypertension. 2020; 22 : 119-125. doi:10.1016/j.preghy.2020.08.001  
50.   Utsumi Yusuke, Nemoto Harumi, Nakaya Naoki, et al. The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. Sports Medicine - Open. 2020; 6 (1): 30. doi:10.1186/s40798-020-00259-6  
51.   Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97  
52.   Hatta Waku, Gotoda Takuji, Oyama Tsuneo, et al. Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer?. Annals of Surgical Oncology. 2019; 26 (11): 3636-3643. doi:10.1245/s10434-019-07579-2  
53.   Hatta Waku, Koike Tomoyuki, Okata Hideki, et al. Continuous liquid‐suction catheter attachment for endoscope reduces volume of liquid reflux to the mouth in esophageal endoscopic submucosal dissection. Digestive Endoscopy. 2019; 31 (5): 527-534. doi:10.1111/den.13392  
54.   Fujishima Fumiyoshi, Katsushima Hiroki, Fukuhara Noriko, et al. Immunohistochemical pattern of c-MYC protein judged as “+/(weak)+/−” by a new notation correlates with MYC gene nontranslocation in large B-cell lymphoma. Human Pathology. 2019; 85 (3): 112-118. doi:10.1016/j.humpath.2018.10.025  
55.   Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4  
56.   Narita Akira, Nakaya Naoki, Nakamura Tomohiro, et al. [Association between mild physical injury and psychological distress: Shichigahama Health Promotion Project]. [Nihon koshu eisei zasshi] Japanese journal of public health. 2018; 65 (4): 157-163. doi:10.11236/jph.65.4_157  
57.   Hatta Waku, Gotoda Takuji, Oyama Tsuneo, et al. Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study. Gastric Cancer. 2018; 21 (3): 481-489. doi:10.1007/s10120-017-0769-7  
58.   Nakaya Naoki, Nemoto Harumi, Yi Carine, et al. Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake. International Journal of Disaster Risk Reduction. 2018; 28 : 206-213. doi:10.1016/j.ijdrr.2018.02.037  
59.   Ito Hirotaka, Gotoda Takuji, Oyama Tsuneo, et al. Long-term oncological outcomes of submucosal manipulation during non-curative endoscopic submucosal dissection for submucosal invasive gastric cancer: a multicenter retrospective study in Japan. Surgical Endoscopy. 2018; 32 (1): 196-203. doi:10.1007/s00464-017-5659-x  
60.   Hatta Waku, Gotoda Takuji, Oyama Tsuneo, et al. A Scoring System to Stratify Curability after Endoscopic Submucosal Dissection for Early Gastric Cancer: “eCura system”. American Journal of Gastroenterology. 2017; 112 (6): 874-881. doi:10.1038/ajg.2017.95  
61.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster. Disaster Medicine and Public Health Preparedness. 2017; 11 (2): 179-182. doi:10.1017/dmp.2016.102  
62.   Hatta Waku, Gotoda Takuji, Oyama Tsuneo, et al. Is radical surgery necessary in all patients who do not meet the curative criteria for endoscopic submucosal dissection in early gastric cancer? A multi-center retrospective study in Japan. Journal of Gastroenterology. 2017; 52 (2): 175-184. doi:10.1007/s00535-016-1210-4  
63.   Tsuchiya Naho, Nakaya Naoki, Nakamura Tomohiro, et al. Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011. Psychiatry and Clinical Neurosciences. 2017; 71 (1): 52-60. doi:10.1111/pcn.12467  
64.   Nezu Masahiro, Souma Tomokazu, Yu Lei, et al. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Science Signaling. 2017; 10 (479): eaam5711. doi:10.1126/scisignal.aam5711  
65.   Nakamura Tomohiro, Yamamoto Yoshiro, Douke Hideyuki. Sequential Hypothesis Tests for Identifying the Minimum Dose with a Threshold Effect. Communications in Statistics - Simulation and Computation. 2016; 45 (6): 1950-1970. doi:10.1080/03610918.2014.884588  
66.   Kogure Mana, Tsuchiya Naho, Hozawa Atsushi, et al. Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010. Hypertension Research. 2016; 39 (9): 670-679. doi:10.1038/hr.2016.46  
67.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Unemployment risk among individuals undergoing medical treatment for chronic diseases. Occupational Medicine. 2016; 66 (2): 143-149. doi:10.1093/occmed/kqv159  
68.   Ishikuro Mami, Nakaya Naoki, Obara Taku, et al. Public Attitudes toward an Epidemiological Study with Genomic Analysis in the Great East Japan Earthquake Disaster Area. Prehospital and Disaster Medicine. 2016; 31 (3): 330-334. doi:10.1017/S1049023X16000182  
69.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Prospect of future housing and risk of psychological distress at 1 year after an earthquake disaster. Psychiatry and Clinical Neurosciences. 2016; 70 (4): 182-189. doi:10.1111/pcn.12377  
70.   Nakaya Naoki, Narita Akira, Tsuchiya Naho, et al. Partners’ Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2016; 239 (4): 307-314. doi:10.1620/tjem.239.307  
71.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project. Disaster Medicine and Public Health Preparedness. 2015; 9 (4): 374-381. doi:10.1017/dmp.2015.52  
72.   Sato Hiroko, Uchida Toshihiko, Toyota Kentaro, et al. Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms. Journal of Human Genetics. 2015; 60 (1): 35-40. doi:10.1038/jhg.2014.98  
73.   Hori-Tanaka Yasuha, Yura Kei, Takai-Igarashi Takako, Tanaka Hiroshi. Structural classification of steroid-binding sites on proteins by coarse-grained atomic environment and its correlation with their biological function. Steroids. 2015; 96 (1): 81-88. doi:10.1016/j.steroids.2015.01.015  
74.   中村 智洋, 八木 圭太, 山本 義郎, 道家 暎幸. 用量反応試験における交互作用検出のための逐次型多重比較法について. 日本統計学会和文誌. 2015; 40 (2): 315-339. http://ci.nii.ac.jp/naid/110009828419  
75.   Felizola Saulo J.A., Nakamura Yasuhiro, Satoh Fumitoshi, et al. Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway. Molecular and Cellular Endocrinology. 2014; 382 (1): 170-177. doi:10.1016/j.mce.2013.09.025  
76.   Yoshizawa Junko, Abe Yuko, Oiso Naoki, et al. Variants in melanogenesis-related genes associate with skin cancer risk among Japanese populations. The Journal of Dermatology. 2014; 41 (4): 296-302. doi:10.1111/1346-8138.12432  
77.   Shibata Kyoko, Hozawa Atsushi, Tamiya Gen, et al. The confounding effect of cryptic relatedness for environmental risks of systolic blood pressure on cohort studies. Molecular Genetics & Genomic Medicine. 2013; 1 (1): 45-53. doi:10.1002/mgg3.4