Tohoku University Tohoku Medical Megabank Organization (Takako Takai-Igarashi)
2021.09.17

1.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2021; : . doi:10.1038/s10038-021-00952-8  
2.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
3.   Sakai Kensuke, Tanikawa Chizu, Hirasawa Akira, et al. Identification of a novel uterine leiomyoma GWAS locus in a Japanese population. Scientific Reports. 2020; 10 (1): 1197. doi:10.1038/s41598-020-58066-8  
4.   Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97  
5.   Sakurai-Yageta Mika, Kawame Hiroshi, Kuriyama Shinichi, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Medical Education. 2019; 19 (1): 297. doi:10.1186/s12909-019-1725-5  
6.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): e025939. doi:10.1136/bmjopen-2018-025939  
7.   Nagasaki Masao, Kuroki Yoko, Shibata Tomoko F., et al. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Human Genome Variation. 2019; 6 (1): 27. doi:10.1038/s41439-019-0057-7  
8.   Sakurai Rieko, Ueki Masao, Makino Satoshi, et al. Outlier detection for questionnaire data in biobanks. International Journal of Epidemiology. 2019; 48 (4): 1305-1315. doi:10.1093/ije/dyz012  
9.   Miura Emiri, Tsuchiya Naho, Igarashi Yu, et al. Respiratory resistance among adults in a population-based cohort study in Northern Japan. Respiratory Investigation. 2019; 57 (3): 274-281. doi:10.1016/j.resinv.2018.12.008  
10.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
11.   Tanikawa Chizu, Kamatani Yoichiro, Toyoshima Osamu, et al. Genome‐wide association study identifies gastric cancer susceptibility loci at 12q24.11‐12 and 20q11.21. Cancer Science. 2018; 109 (12): 4015-4024. doi:10.1111/cas.13815  
12.   Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588  
13.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
14.   Yuan Xunmei, Tsujimoto Kazutaka, Hashimoto Koshi, et al. Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood. Nature Communications. 2018; 9 (1): 636. doi:10.1038/s41467-018-03038-w  
15.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
16.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
17.   Sawai Hashime, Takai-Igarashi Takako, Tanaka Hiroshi. Identification of collaborative activities with oxidative phosphorylation in bipolar disorder. Bioinformation. 2015; 11 (4): 207-216. doi:10.6026/97320630011207  
18.   Ehara Tatsuya, Kamei Yasutomi, Yuan Xunmei, et al. Ligand-Activated PPARα-Dependent DNA Demethylation Regulates the Fatty Acid β-Oxidation Genes in the Postnatal Liver. Diabetes. 2015; 64 (3): 775-784. doi:10.2337/db14-0158  
19.   Suzuki Asami, Takai-Igarashi Takako, Nakaya Jun, Tanaka Hiroshi. Development of an Ontology for Periodontitis. Journal of Biomedical Semantics. 2015; 6 (1): 30. doi:10.1186/s13326-015-0028-y  
20.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018  
21.   Hori-Tanaka Yasuha, Yura Kei, Takai-Igarashi Takako, Tanaka Hiroshi. Structural classification of steroid-binding sites on proteins by coarse-grained atomic environment and its correlation with their biological function. Steroids. 2015; 96 : 81-88. doi:10.1016/j.steroids.2015.01.015  
22.   Ogishima Soichi, Takai Takako, Shimokawa Kazuro, et al. Integrated Database And Knowledge Base For Genomic Prospective Cohort Study In Tohoku Medical Megabank Toward Personalized Prevention And Medicine. Studies in health technology and informatics. 2015; 216 : 1057. doi:10.3233/978-1-61499-564-7-1057  
23.   Iwasaki Y., Suganami T., Hachiya R., et al. Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages. Diabetes. 2014; 63 (1): 152-161. doi:10.2337/db13-0757  
24.   Hatazawa Yukino, Tadaishi Miki, Nagaike Yuta, et al. PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle. PLoS ONE. 2014; 9 (3): e91006. doi:10.1371/journal.pone.0091006  
25.   Suzuki Satoru, Takai-Igarashi Takako, Fukuoka Yutaka, et al. Systems analysis of inflammatory bowel disease based on comprehensive gene information. BMC Medical Genetics. 2012; 13 (1): 25. doi:10.1186/1471-2350-13-25