Tohoku University Tohoku Medical Megabank Organization (Takafumi Suzuki)
2025.05.01

1.   Aoyama Yumi, Yamazaki Hiromi, Nishimura Koutarou, et al. Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages. Blood. 2025; 145 (11): 1149-1163. doi:10.1182/blood.2024025402  
2.   Iwasaki Tomoyuki, Shirota Hidekazu, Sasaki Keiju, et al. Specific cancer types and prognosis in patients with variations in the KEAP1NRF2 system: A retrospective cohort study. Cancer Science. 2024; 115 (12): 4034-4044. doi:10.1111/cas.16355  
3.   Takahashi Jun, Suzuki Takafumi, Sato Miu, et al. Differential squamous cell fates elicited by NRF2 gain of function versus KEAP1 loss of function. Cell Reports. 2024; 43 (4): 114104. doi:10.1016/j.celrep.2024.114104  
4.   Ikejiri Kazuaki, Suzuki Takafumi, Muto Satsuki, et al. Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study. Clinical and Experimental Nephrology. 2024; 28 (3): 225-234. doi:10.1007/s10157-023-02427-w  
5.   Sato Miu, Yaguchi Nahoko, Iijima Takuya, et al. Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo. Redox Biology. 2024; 77 : 103355. doi:10.1016/j.redox.2024.103355  
6.   Uruno Akira, Kadoguchi-Igarashi Shiori, Saito Ritsumi, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer’s disease model mice. The Journal of Biochemistry. 2024; 176 (5): 405-414. doi:10.1093/jb/mvae060  
7.   Aoki Yu-ichi, Taguchi Keiko, Anzawa Hayato, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. The Journal of Biochemistry. 2024; 175 (6): 611-627. doi:10.1093/jb/mvae008  
8.   Shimizu Ritsuko, Hirano Ikuo, Hasegawa Atsushi, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Communications Biology. 2023; 6 (1): 875. doi:10.1038/s42003-023-05251-w  
9.   Zhang Anqi, Suzuki Takafumi, Adachi Saki, et al. Nrf2 activation improves experimental rheumatoid arthritis. Free Radical Biology and Medicine. 2023; 207 : 279-295. doi:10.1016/j.freeradbiomed.2023.07.016  
10.   Suzuki Takafumi, Takahashi Jun, Yamamoto Masayuki. Molecular Basis of the KEAP1-NRF2 Signaling Pathway. Molecules and Cells. 2023; 46 (3): 133-141. doi:10.14348/molcells.2023.0028  
11.   Baird Liam, Taguchi Keiko, Zhang Anqi, et al. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023; 66 : 102845. doi:10.1016/j.redox.2023.102845  
12.   Suzuki Norio, Iwamura Yuma, Nakai Taku, et al. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International. 2022; 101 (1): 92-105. doi:10.1016/j.kint.2021.09.031  
13.   Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6  
14.   Yumoto Akane, Kokubo Toshiaki, Izumi Ryutaro, et al. Novel method for evaluating the health condition of mice in space through a video downlink. Experimental Animals. 2021; 70 (2): 236-244. doi:10.1538/expanim.20-0102