Tohoku University Tohoku Medical Megabank Organization (Takafumi Suzuki)
2026.06.25

1.   Chu Ching-Tung, Uruno Akira, Suzuki Takafumi, et al. NRF2 activation by CDDO-Im regulates inflammatory and autophagy pathways in human microglial cells. Free Radical Biology and Medicine. 2026; 243 : 318-337. doi:10.1016/j.freeradbiomed.2025.11.046  
2.   Ang Abel D, Dayalan Naidu Sharadha, Read Oliver J, et al. The CNC-bZIP transcription factor Nrf2 controls expression of matrix metalloproteases in murine macrophages. Journal of Leukocyte Biology. 2026; 118 (3): . doi:10.1093/jleuko/qiag021  
3.   Feng Jialin, Carreño Mara, Jung Hannah, et al. The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2. Redox Biology. 2026; 90 : 104009. doi:10.1016/j.redox.2026.104009  
4.   Dayalan Naidu Sharadha, Dikovskaya Dina, Walker Jasmine M., et al. Keap1-Kelch-targeting protein–protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment. RSC Chemical Biology. 2026; 7 (5): 906-922. doi:10.1039/D6CB00045B  
5.   Tsuji Ryosuke, Fujita Ryo, Hayashi Takuto, et al. 0.33 g mitigates muscle atrophy while 0.67 g preserves muscle function and myofiber type composition in mice during spaceflight. Science Advances. 2026; 12 (11): . doi:10.1126/sciadv.aed2258  
6.   Dayalan Naidu Sharadha, Ang Abel D., Jia Yee Charlotte Lim, et al. CD5L is a target of transcription factor Nrf2. Biochemical and Biophysical Research Communications. 2025; 776 : 152225. doi:10.1016/j.bbrc.2025.152225  
7.   Aoyama Yumi, Yamazaki Hiromi, Nishimura Koutarou, et al. Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages. Blood. 2025; 145 (11): 1149-1163. doi:10.1182/blood.2024025402  
8.   Baird Liam, Zhang Lin, Hidaka Takanori, et al. Systemic activation of NRF2 contributes to the therapeutic efficacy of clinically-approved KRAS-G12C anti-cancer drugs. British Journal of Cancer. 2025; 133 (9): 1377-1390. doi:10.1038/s41416-025-03162-7  
9.   Wen Huaichun, Suzuki Takafumi, Zhang Anqi, et al. NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment. iScience. 2025; 28 (10): 113519. doi:10.1016/j.isci.2025.113519  
10.   Katsuoka Fumiki, Kawashima Junko, Tadaka Shu, et al. Advancements in Whole-Genome Sequencing Protocols: A Decade of In-House Operations and Quality Controls at the Tohoku Medical Megabank. JMA Journal. 2025; 8 (4): . doi:10.31662/jmaj.2025-0159  
11.   Suzuki Takafumi, Takagi Kenji, Iso Tatsuro, et al. Bidirectional regulation of KEAP1 BTB domain-based sensor activity. Redox Biology. 2025; 87 : 103885. doi:10.1016/j.redox.2025.103885  
12.   Iwasaki Tomoyuki, Shirota Hidekazu, Sasaki Keiju, et al. Specific cancer types and prognosis in patients with variations in the KEAP1NRF2 system: A retrospective cohort study. Cancer Science. 2024; 115 (12): 4034-4044. doi:10.1111/cas.16355  
13.   Takahashi Jun, Suzuki Takafumi, Sato Miu, et al. Differential squamous cell fates elicited by NRF2 gain of function versus KEAP1 loss of function. Cell Reports. 2024; 43 (4): 114104. doi:10.1016/j.celrep.2024.114104  
14.   Ikejiri Kazuaki, Suzuki Takafumi, Muto Satsuki, et al. Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study. Clinical and Experimental Nephrology. 2024; 28 (3): 225-234. doi:10.1007/s10157-023-02427-w  
15.   Sato Miu, Yaguchi Nahoko, Iijima Takuya, et al. Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo. Redox Biology. 2024; 77 : 103355. doi:10.1016/j.redox.2024.103355  
16.   Uruno Akira, Kadoguchi-Igarashi Shiori, Saito Ritsumi, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer’s disease model mice. The Journal of Biochemistry. 2024; 176 (5): 405-414. doi:10.1093/jb/mvae060  
17.   Aoki Yu-ichi, Taguchi Keiko, Anzawa Hayato, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. The Journal of Biochemistry. 2024; 175 (6): 611-627. doi:10.1093/jb/mvae008  
18.   Shimizu Ritsuko, Hirano Ikuo, Hasegawa Atsushi, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Communications Biology. 2023; 6 (1): 875. doi:10.1038/s42003-023-05251-w  
19.   Zhang Anqi, Suzuki Takafumi, Adachi Saki, et al. Nrf2 activation improves experimental rheumatoid arthritis. Free Radical Biology and Medicine. 2023; 207 : 279-295. doi:10.1016/j.freeradbiomed.2023.07.016  
20.   Suzuki Takafumi, Takahashi Jun, Yamamoto Masayuki. Molecular Basis of the KEAP1-NRF2 Signaling Pathway. Molecules and Cells. 2023; 46 (3): 133-141. doi:10.14348/molcells.2023.0028  
21.   Baird Liam, Taguchi Keiko, Zhang Anqi, et al. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023; 66 : 102845. doi:10.1016/j.redox.2023.102845  
22.   Suzuki Norio, Iwamura Yuma, Nakai Taku, et al. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International. 2022; 101 (1): 92-105. doi:10.1016/j.kint.2021.09.031  
23.   Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6  
24.   Yumoto Akane, Kokubo Toshiaki, Izumi Ryutaro, et al. Novel method for evaluating the health condition of mice in space through a video downlink. Experimental Animals. 2021; 70 (2): 236-244. doi:10.1538/expanim.20-0102