Tohoku University Tohoku Medical Megabank Organization (Soichi Ogishima)
2024.03.28

1.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; : . doi:10.1038/s41440-024-01582-1  
2.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8  
3.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; : 64535. doi:10.5551/jat.64535  
4.   Hozawa Atsushi, Nakaya Kumi, Nakaya Naoki, et al. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture. Journal of Epidemiology. 2024; : JE20230241. doi:10.2188/jea.JE20230241  
5.   Harada Sei, Iida Miho, Miyagawa Naoko, et al. Study Profile of the Tsuruoka Metabolomics Cohort Study (TMCS). Journal of Epidemiology. 2024; : JE20230192. doi:10.2188/jea.JE20230192  
6.   Mizuno Satoshi, Wagata Maiko, Nagaie Satoshi, et al. Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. Scientific Reports. 2024; 14 (1): 6292. doi:10.1038/s41598-024-55914-9  
7.   Mizuno Satoshi, Nagaie Satoshi, Tamiya Gen, et al. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. BMC Pregnancy and Childbirth. 2023; 23 (1): 628. doi:10.1186/s12884-023-05919-5  
8.   Li Xue, Ono Chiaki, Warita Noriko, et al. Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability. Frontiers in Psychiatry. 2023; 14 : . doi:10.3389/fpsyt.2023.1104222  
9.   Taira Makiko, Mugikura Shunji, Mori Naoko, et al. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background. JMA Journal. 2023; 6 (3): 246-264. doi:10.31662/jmaj.2022-0220  
10.   Sato Shuichi, Imaeda Takao, Mugikura Shunji, et al. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. Journal of Alzheimer's Disease. 2023; 95 (4): 1469-1480. doi:10.3233/JAD-230318  
11.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64151. doi:10.5551/jat.64151  
12.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
13.   Saito Yoshie, Sato Keigo, Jinno Shinji, et al. Effect of Nicotinamide Mononucleotide Concentration in Human Milk on Neurodevelopmental Outcome: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Nutrients. 2023; 16 (1): 145. doi:10.3390/nu16010145  
14.   Ono Chiaki T., Yu Zhiqian, Obara Taku, et al. Association between low levels of anti‐inflammatory cytokines during pregnancy and postpartum depression. Psychiatry and Clinical Neurosciences. 2023; 77 (8): 434-441. doi:10.1111/pcn.13566  
15.   Shiga Hisashi, Takahashi Takahiro, Shiraki Manabu, et al. Reduced antiviral seropositivity among patients with inflammatory bowel disease treated with immunosuppressive agents. Scandinavian Journal of Gastroenterology. 2023; 58 (4): 360-367. doi:10.1080/00365521.2022.2132831  
16.   Kobayashi Tomoko, Kobayashi Mika, Minegishi Naoko, et al. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2023; 259 (2): 2022.J103. doi:10.1620/tjem.2022.J103  
17.   Shimokawa Kazuro. A knowledge representation model for family relationship to three generation. Bioinformation. 2022; 18 (12): 1166-1172. doi:10.6026/973206300181166  
18.   Li Xue, Ono Chiaki, Warita Noriko, et al. Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women. Frontiers in Psychiatry. 2022; 12 : . doi:10.3389/fpsyt.2021.799029  
19.   Yu Zhiqian, Matsukawa Naomi, Saigusa Daisuke, et al. Plasma metabolic disturbances during pregnancy and postpartum in women with depression. iScience. 2022; 25 (12): 105666. doi:10.1016/j.isci.2022.105666  
20.   Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; 5 (2): . doi:10.31662/jmaj.2021-0156  
21.   Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of epidemiology. 2022; 32 (2): 69-79. doi:10.2188/jea.JE20200338  
22.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2022; 67 (1): 9-17. doi:10.1038/s10038-021-00952-8  
23.   Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113  
24.   Matsuyama Takashi, Narita Akira, Takanashi Masaki, et al. Visualization of estimated prevalence of CES-D positivity accounting for background factors and AIS scores. Scientific Reports. 2022; 12 (1): 17656. doi:10.1038/s41598-022-22266-1  
25.   Rehm Heidi L., Page Angela J.H., Smith Lindsay, et al. GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genomics. 2021; 1 (2): 100029. doi:10.1016/j.xgen.2021.100029  
26.   Lawson Jonathan, Cabili Moran N., Kerry Giselle, et al. The Data Use Ontology to streamline responsible access to human biomedical datasets. Cell Genomics. 2021; 1 (2): 100028. doi:10.1016/j.xgen.2021.100028  
27.   Yamada Mitsuhiro, Motoike Ikuko N., Kojima Kaname, et al. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. Communications Biology. 2021; 4 (1): 1288. doi:10.1038/s42003-021-02813-8  
28.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
29.   Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271  
30.   Shido Kosuke, Kojima Kaname, Shirota Matsuyuki, et al. GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals. Journal of Investigative Dermatology. 2021; 141 (11): 2749-2752. doi:10.1016/j.jid.2021.02.762  
31.   Tokunaga Hideki, Iida Keita, Hozawa Atsushi, et al. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PLOS ONE. 2021; 16 (1): e0236907. doi:10.1371/journal.pone.0236907  
32.   Matsunaga Hiroshi, Ito Kaoru, Akiyama Masato, et al. Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. Circulation: Genomic and Precision Medicine. 2020; 13 (3): . doi:10.1161/CIRCGEN.119.002670  
33.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
34.   Wagata Maiko, Ishikuro Mami, Obara Taku, et al. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. Pregnancy Hypertension. 2020; 22 : 119-125. doi:10.1016/j.preghy.2020.08.001  
35.   Nishizawa Ayako, Kumada Kazuki, Tateno Keiko, et al. Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia. Scientific Reports. 2020; 10 (1): 20027. doi:10.1038/s41598-020-77081-3  
36.   Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97  
37.   Narita Akira, Nagai Masato, Mizuno Satoshi, et al. Clustering by phenotype and genome-wide association study in autism. Translational Psychiatry. 2020; 10 (1): 290. doi:10.1038/s41398-020-00951-x  
38.   Takahashi Yuta, Ueki Masao, Yamada Makoto, et al. Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection. Translational Psychiatry. 2020; 10 (1): 157. doi:10.1038/s41398-020-0831-9  
39.   Takahashi Yuta, Ueki Masao, Tamiya Gen, et al. Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes. Translational Psychiatry. 2020; 10 (1): 294. doi:10.1038/s41398-020-00957-5  
40.   Sakurai-Yageta Mika, Kawame Hiroshi, Kuriyama Shinichi, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Medical Education. 2019; 19 (1): 297. doi:10.1186/s12909-019-1725-5  
41.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): e025939. doi:10.1136/bmjopen-2018-025939  
42.   Nagasaki Masao, Kuroki Yoko, Shibata Tomoko F., et al. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Human Genome Variation. 2019; 6 (1): 27. doi:10.1038/s41439-019-0057-7  
43.   Shido Kosuke, Kojima Kaname, Yamasaki Kenshi, et al. Susceptibility Loci for Tanning Ability in the Japanese Population Identified by a Genome-Wide Association Study from the Tohoku Medical Megabank Project Cohort Study. Journal of Investigative Dermatology. 2019; 139 (7): 1605-1608.e13. doi:10.1016/j.jid.2019.01.015  
44.   Tanikawa Chizu, Kamatani Yoichiro, Terao Chikashi, et al. Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. Journal of the American Society of Nephrology. 2019; 30 (5): 855-864. doi:10.1681/ASN.2018090942  
45.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
46.   Minegishi Naoko, Nishijima Ichiko, Nobukuni Takahiro, et al. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2019; 248 (1): 45-55. doi:10.1620/tjem.248.45  
47.   Fujiwara Masaki, Inagaki Masatoshi, Nakaya Naoki, et al. Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. Cancer. 2018; 124 (3): 555-562. doi:10.1002/cncr.31086  
48.   Kogetsu Atsushi, Ogishima Soichi, Kato Kazuto. Authentication of Patients and Participants in Health Information Exchange and Consent for Medical Research: A Key Step for Privacy Protection, Respect for Autonomy, and Trustworthiness. Frontiers in Genetics. 2018; 9 : 167. doi:10.3389/fgene.2018.00167  
49.   Ogishima Soichi. [Human Genome Data and Drug Development]. Gan to kagaku ryoho. Cancer & chemotherapy. 2018; 45 (4): 597-600. http://www.ncbi.nlm.nih.gov/pubmed/29650811  
50.   Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588  
51.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
52.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
53.   Shido K, Kojima K, Hozawa A, et al. 503 Genome-wide association study identifies novel susceptibility loci for tanning ability in Japanese population. Journal of Investigative Dermatology. 2017; 137 (5): S86. doi:10.1016/j.jid.2017.02.523  
54.   Low Siew-Kee, Takahashi Atsushi, Ebana Yusuke, et al. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nature Genetics. 2017; 49 (6): 953-958. doi:10.1038/ng.3842  
55.   Köhler Sebastian, Vasilevsky Nicole A, Engelstad Mark, et al. The Human Phenotype Ontology in 2017. Nucleic Acids Research. 2017; 45 (D1): D865-D876. doi:10.1093/nar/gkw1039  
56.   Noguchi Shuhei, Arakawa Takahiro, Fukuda Shiro, et al. FANTOM5 CAGE profiles of human and mouse samples. Scientific Data. 2017; 4 (1): 170112. doi:10.1038/sdata.2017.112  
57.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
58.   Ogishima Soichi, Mizuno Satoshi, Kikuchi Masataka, et al. AlzPathway, an Updated Map of Curated Signaling Pathways: Towards Deciphering Alzheimer’s Disease Pathogenesis. Methods in molecular biology (Clifton, N.J.). 2016; 1303 : 423-432. doi:10.1007/978-1-4939-2627-5_25  
59.   Kikuchi Masataka, Ogishima Soichi, Mizuno Satoshi, et al. Network-Based Analysis for Uncovering Mechanisms Underlying Alzheimer’s Disease. Methods in molecular biology (Clifton, N.J.). 2016; 1303 : 479-491. doi:10.1007/978-1-4939-2627-5_29  
60.   Mizuno Satoshi, Ogishima Soichi, Kitatani Kazuyuki, et al. Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer’s Disease. PLOS ONE. 2016; 11 (2): e0148431. doi:10.1371/journal.pone.0148431  
61.   Mizuno Satoshi, Ogishima Soichi, Nishigori Hidekazu, et al. The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia. PLOS ONE. 2016; 11 (10): e0162828. doi:10.1371/journal.pone.0162828  
62.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
63.   Nagaie Satoshi, Ogishima Soichi, Nakaya Jun, Tanaka Hiroshi. A method to associate all possible combinations of genetic and environmental factors using GxE landscape plot. Bioinformation. 2015; 11 (3): 161-164. doi:10.6026/97320630011161  
64.   Ogishima Soichi, Tanaka Hiroshi, Nakaya Jun. Modularity in the evolution of yeast protein interaction network. Bioinformation. 2015; 11 (3): 127-130. doi:10.6026/97320630011127  
65.   Aoki-Kinoshita Kiyoko F, Kinjo Akira R, Morita Mizuki, et al. Implementation of linked data in the life sciences at BioHackathon 2011. Journal of Biomedical Semantics. 2015; 6 (1): 3. doi:10.1186/2041-1480-6-3  
66.   Tanaka Hiroshi, Ogishima Soichi. Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory. Journal of Molecular Cell Biology. 2015; 7 (3): 253-266. doi:10.1093/jmcb/mjv035  
67.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018  
68.   Arner Erik, Daub Carsten O, Vitting-Seerup Kristoffer, et al. Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science. 2015; 347 (6225): 1010-1014. doi:10.1126/science.1259418  
69.   Ogishima Soichi, Takai Takako, Shimokawa Kazuro, et al. Integrated Database And Knowledge Base For Genomic Prospective Cohort Study In Tohoku Medical Megabank Toward Personalized Prevention And Medicine. Studies in health technology and informatics. 2015; 216 : 1057. doi:10.3233/978-1-61499-564-7-1057  
70.   Katayama Toshiaki, Wilkinson Mark D, Aoki-Kinoshita Kiyoko F, et al. BioHackathon series in 2011 and 2012: penetration of ontology and linked data in life science domains. Journal of Biomedical Semantics. 2014; 5 (1): 5. doi:10.1186/2041-1480-5-5  
71.   FANTOM Consortium and the RIKEN PMI and CLST (DGT) The FANTOM Consortium and the RIKEN PMI and CLST, Forrest Alistair R R, Kawaji Hideya, et al. A promoter-level mammalian expression atlas. Nature. 2014; 507 (7493): 462-70. doi:10.1038/nature13182  
72.   Miyashita A, Hatsuta H, Kikuchi M, et al. Genes associated with the progression of neurofibrillary tangles in Alzheimer’s disease. Translational Psychiatry. 2014; 4 (6): e396-e396. doi:10.1038/tp.2014.35  
73.   Nakaya J., Kimura M., Ogishima S., et al. Future Direction of IMIA Standardization. Yearbook of Medical Informatics. 2014; 23 (01): 105-109. doi:10.15265/IY-2014-0010  
74.   Nishio Yousuke, Ogishima Soichi, Ichikawa Masao, et al. Analysis of l-glutamic acid fermentation by using a dynamic metabolic simulation model of Escherichia coli. BMC Systems Biology. 2013; 7 (1): 92. doi:10.1186/1752-0509-7-92  
75.   Ogishima S, Mizuno S, Kikuchi M, et al. A Map of Alzheimer’s Disease–Signaling Pathways: A Hope for Drug Target Discovery. Clinical Pharmacology & Therapeutics. 2013; 93 (5): 399-401. doi:10.1038/clpt.2013.37  
76.   Kikuchi Masataka, Ogishima Soichi, Miyamoto Tadashi, et al. Identification of Unstable Network Modules Reveals Disease Modules Associated with the Progression of Alzheimer’s Disease. PLoS ONE. 2013; 8 (11): e76162. doi:10.1371/journal.pone.0076162  
77.   Böck Matthias, Ogishima Soichi, Tanaka Hiroshi, et al. Hub-Centered Gene Network Reconstruction Using Automatic Relevance Determination. PLoS ONE. 2012; 7 (5): e35077. doi:10.1371/journal.pone.0035077