Tohoku University Tohoku Medical Megabank Organization (Shigeo Kure)
2020.11.20

1.   Wada Yoichi, Arai-Ichinoi Natsuko, Kikuchi Atsuo, et al. Hypoketotic hypoglycemia in citrin deficiency: a case report. BMC Pediatrics. 2020; 20 (1): 444. doi:10.1186/s12887-020-02349-6  
2.   Kuniyoshi Yasutaka, Obara Taku, Ishikuro Mami, et al. Effectiveness of seasonal inactivated influenza vaccination in Japanese schoolchildren: an epidemiologic study at the community level. Human Vaccines & Immunotherapeutics. 2020; 16 (2): 295-300. doi:10.1080/21645515.2019.1655833  
3.   Wagata Maiko, Kogure Mana, Nakaya Naoki, et al. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. Hypertension Research. 2020; : . doi:10.1038/s41440-020-0463-8  
4.   Kogure Mana, Hirata Takumi, Nakaya Naoki, et al. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. Hypertension Research. 2020; 43 (1): 62-71. doi:10.1038/s41440-019-0335-2  
5.   Hirata Takumi, Nakamura Tomohiro, Kogure Mana, et al. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. Hypertension Research. 2020; 43 (1): 23-29. doi:10.1038/s41440-019-0329-0  
6.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
7.   Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Epidemiology. 2020; : . doi:10.2188/jea.JE20200338  
8.   Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Epidemiology. 2020; : . doi:10.2188/jea.JE20190271  
9.   Shirota Matsuyuki, Saigusa Daisuke, Yamashita Riu, et al. Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy. Medical Mass Spectrometry. 2020; 4 (1): 36-49. doi:10.24508/mms.2020.06.001  
10.   Wada Yoichi, Kikuchi Atsuo, Kaga Akimune, et al. Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice. PLOS Genetics. 2020; 16 (2): e1008628. doi:10.1371/journal.pgen.1008628  
11.   Wagata Maiko, Ishikuro Mami, Obara Taku, et al. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. Pregnancy Hypertension. 2020; 22 : 119-125. doi:10.1016/j.preghy.2020.08.001  
12.   Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97  
13.   Narita Akira, Nagai Masato, Mizuno Satoshi, et al. Clustering by phenotype and genome-wide association study in autism. Translational Psychiatry. 2020; 10 (1): 290. doi:10.1038/s41398-020-00951-x  
14.   Takahashi Yuta, Ueki Masao, Tamiya Gen, et al. Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes. Translational Psychiatry. 2020; 10 (1): 294. doi:10.1038/s41398-020-00957-5  
15.   Iwasawa Shinya, Yanagi Kumiko, Kikuchi Atsuo, et al. Recurrent de novo MAPK8IP3 variants cause neurological phenotypes. Annals of Neurology. 2019; 85 (6): 927-933. doi:10.1002/ana.25481  
16.   Isojima Tsuyoshi, Kato Noriko, Yokoya Susumu, et al. Early excessive growth with distinct seasonality in preschool obesity. Archives of Disease in Childhood. 2019; 104 (1): 53-57. doi:10.1136/archdischild-2018-314862  
17.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): e025939. doi:10.1136/bmjopen-2018-025939  
18.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. Disaster Medicine and Public Health Preparedness. 2019; 13 (5-6): 905-911. doi:10.1017/dmp.2019.8  
19.   Wada Yoichi, Kikuchi Atsuo, Arai-Ichinoi Natsuko, et al. Biallelic GALM pathogenic variants cause a novel type of galactosemia. Genetics in Medicine. 2019; 21 (6): 1286-1294. doi:10.1038/s41436-018-0340-x  
20.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
21.   Nagasaki Masao, Kuroki Yoko, Shibata Tomoko F., et al. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Human Genome Variation. 2019; 6 (1): 27. doi:10.1038/s41439-019-0057-7  
22.   Fuse Nobuo, Sakurai-Yageta Mika, Katsuoka Fumiki, et al. Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project. JMA Journal. 2019; 2 (2): 113-122. doi:10.31662/jmaj.2019-0014  
23.   Igarashi Ayaka, Aida Jun, Sairenchi Toshimi, et al. Does Cigarette Smoking Increase Traffic Accident Death During 20 Years Follow-up in Japan? The Ibaraki Prefectural Health Study. Journal of Epidemiology. 2019; 29 (5): 192-196. doi:10.2188/jea.JE20170330  
24.   Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4  
25.   Nanto-Hara Fumika, Kanemitsu Yoshitomi, Fukuda Shinji, et al. The guanylate cyclase C agonist linaclotide ameliorates the gut–cardio–renal axis in an adenine-induced mouse model of chronic kidney disease. Nephrology Dialysis Transplantation. 2019; : . doi:10.1093/ndt/gfz126  
26.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
27.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. Allergology International. 2018; 67 (4): 481-486. doi:10.1016/j.alit.2018.02.009  
28.   Ono Atsushi, Isojima Tsuyoshi, Yokoya Susumu, et al. Effect of the Fukushima earthquake on weight in early childhood: a retrospective analysis. BMJ Paediatrics Open. 2018; 2 (1): e000229. doi:10.1136/bmjpo-2017-000229  
29.   Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588  
30.   Kato N, Isojima T, Yokoya S, et al. Earlier BMI rebound and lower pre-rebound BMI as risk of obesity among Japanese preschool children. International Journal of Obesity. 2018; 42 (1): 52-58. doi:10.1038/ijo.2017.242  
31.   Yokomichi Hiroshi, Matsubara Hiroko, Ishikuro Mami, et al. Impact of the Great East Japan Earthquake on Body Mass Index, Weight, and Height of Infants and Toddlers: An Infant Survey. Journal of Epidemiology. 2018; 28 (5): 237-244. doi:10.2188/jea.JE20170006  
32.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
33.   Ashraf Shazia, Kudo Hiroki, Rao Jia, et al. Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment. Nature Communications. 2018; 9 (1): 1960. doi:10.1038/s41467-018-04193-w  
34.   Obara Taku, Ishikuro Mami, Tamiya Gen, et al. Potential identification of vitamin B6 responsiveness in autism spectrum disorder utilizing phenotype variables and machine learning methods. Scientific Reports. 2018; 8 (1): 14840. doi:10.1038/s41598-018-33110-w  
35.   Katayama Saori, Suzuki Mikiko, Yamaoka Ayaka, et al. GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis. Blood. 2017; 130 (7): 908-919. doi:10.1182/blood-2016-12-756767  
36.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
37.   Ishikuro Mami, Matsubara Hiroko, Kikuya Masahiro, et al. Disease prevalence among nursery school children after the Great East Japan earthquake. BMJ Global Health. 2017; 2 (2): e000127. doi:10.1136/bmjgh-2016-000127  
38.   Kikuya Masahiro, Matsubara Hiroko, Ishikuro Mami, et al. Alterations in physique among young children after the Great East Japan Earthquake: Results from a nationwide survey. Journal of Epidemiology. 2017; 27 (10): 462-468. doi:10.1016/j.je.2016.09.012  
39.   Matsubara Hiroko, Ishikuro Mami, Kikuya Masahiro, et al. Design of the health examination survey on early childhood physical growth in the Great East Japan Earthquake affected areas. Journal of Epidemiology. 2017; 27 (3): 135-142. doi:10.1016/j.je.2016.03.001  
40.   Miyashita Masako, Ishikuro Mami, Kikuya Masahiro, et al. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren. JPCD. 2017; 4 : 1-4. doi:10.17303/jpcd.2017.4.101  
41.   Isojima Tsuyoshi, Yokoya Susumu, Ono Atsushi, et al. Prolonged elevated body mass index in preschool children after the Great East Japan Earthquake. Pediatrics International. 2017; 59 (9): 1002-1009. doi:10.1111/ped.13340  
42.   Matsubara Hiroko, Ishikuro Mami, Kikuya Masahiro, et al. Design of the Nationwide Nursery School Survey on Child Health Throughout the Great East Japan Earthquake. Journal of Epidemiology. 2016; 26 (2): 98-104. doi:10.2188/jea.JE20150073  
43.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
44.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
45.   Hino-Fukuyo Naomi, Kikuchi Atsuo, Arai-Ichinoi Natsuko, et al. Genomic analysis identifies candidate pathogenic variants in 9 of 18 patients with unexplained West syndrome. Human Genetics. 2015; 134 (6): 649-658. doi:10.1007/s00439-015-1553-6  
46.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018  
47.   Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297  
48.   Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123