Tohoku University Tohoku Medical Megabank Organization (Satoshi Nagaie)
2026.01.09

1.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. BMJ Public Health. 2025; 3 (1): e001746. doi:10.1136/bmjph-2024-001746  
2.   Nishimura Takayuki, Kunikata Hiroshi, Takada Naoko, et al. Exploring risk factors for axial length elongation: a population-based cohort study of 9195 eyes in Japan. British Journal of Ophthalmology. 2025; : bjo-2025-327213. doi:10.1136/bjo-2025-327213  
3.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. Cardiovascular Diabetology. 2025; 24 (1): 335. doi:10.1186/s12933-025-02849-8  
4.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; 89 (6): CJ-24-0780. doi:10.1253/circj.CJ-24-0780  
5.   Hatanaka Rieko, Nakaya Naoki, Tokioka Sayuri, et al. Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization. Circulation Reports. 2025; : CR-25-0263. doi:10.1253/circrep.CR-25-0263  
6.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. Clinical Kidney Journal. 2025; 18 (10): . doi:10.1093/ckj/sfaf275  
7.   Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974  
8.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. Hypertension Research. 2025; 48 (10): 2606-2617. doi:10.1038/s41440-025-02314-9  
9.   Obara Taku, Ishikuro Mami, Noda Aoi, et al. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International Journal of Epidemiology. 2025; 54 (5): . doi:10.1093/ije/dyaf148  
10.   Nagino Ken, Akasaki Yasutsugu, Fuse Nobuo, et al. Integration of Digital Phenotyping and Genomics for Dry Eye Disease: Protocol for a Prospective Cohort Study. JMIR Research Protocols. 2025; 14 : e67862. doi:10.2196/67862  
11.   Sakakibara Koichi, Kawahara Tomoki, Nawa Nobutoshi, et al. Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study. Journal of Diabetes Investigation. 2025; 16 (10): 1900-1909. doi:10.1111/jdi.70101  
12.   Yoshida Akiko, Tokutomi Tomoharu, Suzumori Nobuhiro, et al. Study Profile of the Iwate PGS Assessment and Risk Communication (PARC) Study. Journal of Epidemiology. 2025; : JE20250078. doi:10.2188/jea.JE20250078  
13.   Nakaya Naoki, Nakaya Kumi, Kogure Mana, et al. Degree of housing damage caused by the Great East Japan Earthquake and all-cause mortality in the community-based cohort study of the Tohoku Medical Megabank Project. Journal of Epidemiology and Community Health. 2025; 79 (6): 451-458. doi:10.1136/jech-2024-223084  
14.   Kawahara Tomoki, Nawa Nobutoshi, Murakami Keiko, et al. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. Journal of Human Genetics. 2025; 70 (5): 265-273. doi:10.1038/s10038-025-01330-4  
15.   Fuse Nobuo, Anzawa Hayato, Sakurai Miyuki, et al. Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. Ophthalmology Science. 2025; 5 (5): 100821. doi:10.1016/j.xops.2025.100821  
16.   Takahashi Ippei, Shinoda Genki, Ueno Fumihiko, et al. Respiratory syncytial virus infection, non‐respiratory syncytial virus respiratory infections, and later wheezing. Pediatrics International. 2025; 67 (1): . doi:10.1111/ped.70050  
17.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2025; 64 (5): 2591-2600. doi:10.1093/rheumatology/keae492  
18.   Mizuno Satoshi, Nagaie Satoshi, Sugawara Junichi, et al. Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. AJOG Global Reports. 2024; 4 (4): 100383. doi:10.1016/j.xagr.2024.100383  
19.   Chiba Ippei, Nakaya Naoki, Kogure Mana, et al. Associations between leisure time, non-leisure time physical activity, and kidney function in Japanese adults: a cross-sectional study. BMC Nephrology. 2024; 25 (1): 354. doi:10.1186/s12882-024-03813-6  
20.   Akaishi Tetsuya, Nakaya Kumi, Nakaya Naoki, et al. Low Hemoglobin Level and Elevated Inflammatory Hematological Ratios Associated With Depression and Sleep Disturbance. Cureus. 2024; : . doi:10.7759/cureus.56621  
21.   Chiba Ippei, Nakaya Naoki, Kogure Mana, et al. Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community‐based cohort study. Geriatrics & Gerontology International. 2024; 24 (6): 509-516. doi:10.1111/ggi.14867  
22.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8  
23.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; 47 (6): 1533-1545. doi:10.1038/s41440-024-01582-1  
24.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8  
25.   Himuro Hiromi, Kogure Mana, Nakaya Naoki, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension Research. 2024; 47 (11): 3025-3034. doi:10.1038/s41440-024-01827-z  
26.   Kodama Eiichi N, Taira Makiko, Kiyomoto Hideyasu. Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project. JMA Journal. 2024; 7 (3): 342-352. doi:10.31662/jmaj.2023-0215  
27.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906  
28.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; 31 (6): 64535. doi:10.5551/jat.64535  
29.   Hozawa Atsushi, Nakaya Kumi, Nakaya Naoki, et al. Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture. Journal of Epidemiology. 2024; 34 (9): JE20230241. doi:10.2188/jea.JE20230241  
30.   Nakaya Kumi, Nakaya Naoki, Kogure Mana, et al. Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study. Journal of Neurogastroenterology and Motility. 2024; 30 (2): 208-219. doi:10.5056/jnm23090  
31.   Mizuno Satoshi, Wagata Maiko, Nagaie Satoshi, et al. Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. Scientific Reports. 2024; 14 (1): 6292. doi:10.1038/s41598-024-55914-9  
32.   Mizuno Satoshi, Nagaie Satoshi, Tamiya Gen, et al. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. BMC Pregnancy and Childbirth. 2023; 23 (1): 628. doi:10.1186/s12884-023-05919-5  
33.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
34.   Shiga Hisashi, Takahashi Takahiro, Shiraki Manabu, et al. Reduced antiviral seropositivity among patients with inflammatory bowel disease treated with immunosuppressive agents. Scandinavian Journal of Gastroenterology. 2023; 58 (4): 360-367. doi:10.1080/00365521.2022.2132831  
35.   Shimokawa Kazuro, Ishikuro Mami, Obara Taku, et al. A knowledge representation model for family relationship to three generation. Bioinformation. 2022; 18 (12): 1166-1172. doi:10.6026/973206300181166  
36.   Lawson Jonathan, Cabili Moran N., Kerry Giselle, et al. The Data Use Ontology to streamline responsible access to human biomedical datasets. Cell Genomics. 2021; 1 (2): 100028. doi:10.1016/j.xgen.2021.100028  
37.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
38.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
39.   Nagaie Satoshi, Ogishima Soichi, Nakaya Jun, Tanaka Hiroshi. A method to associate all possible combinations of genetic and environmental factors using GxE landscape plot. Bioinformation. 2015; 11 (3): 161-164. doi:10.6026/97320630011161  
40.   Ogishima Soichi, Takai Takako, Shimokawa Kazuro, et al. Integrated Database And Knowledge Base For Genomic Prospective Cohort Study In Tohoku Medical Megabank Toward Personalized Prevention And Medicine. Studies in health technology and informatics. 2015; 216 : 1057. doi:10.3233/978-1-61499-564-7-1057