Tohoku University Tohoku Medical Megabank Organization (Noriyuki Iwama)
2025.02.14

1.   Ishikuro Mami, Obara Taku, Hasegawa Mayu, et al. Subsequent high blood pressure and hypertension by hypertensive disorders of pregnancy: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Hypertension Research. 2025; 48 (1): 68-76. doi:10.1038/s41440-024-01936-9  
2.   Kawaguchi Chikana, Ishikuro Mami, Saito Ryota, et al. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. The Journal of Clinical Endocrinology & Metabolism. 2025; : . doi:10.1210/clinem/dgae825  
3.   Ishikawa Tomofumi, Sakai Takamasa, Iwama Noriyuki, et al. Association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. Acta Psychiatrica Scandinavica. 2024; 150 (6): 562-572. doi:10.1111/acps.13755  
4.   Takahashi Tsukasa, Tomita Hasumi, Hamada Hirotaka, et al. Transcatheter arterial embolization outperforms surgery in reducing blood transfusions for postpartum vulvovaginal hematoma. American Journal of Obstetrics and Gynecology. 2024; 231 (6): 653.e1-653.e8. doi:10.1016/j.ajog.2024.03.016  
5.   Wang Hongxin, Iwama Noriyuki, Yuwaki Keiichi, et al. Relationship between parity and the prevalence of chronic kidney disease in Japan considering hypertensive disorders of pregnancy and body mass index. BMC Nephrology. 2024; 25 (1): 166. doi:10.1186/s12882-024-03604-z  
6.   石黒 真美, 小原 拓, 黒田 真帆, et al. 東北メディカル・メガバンク計画三世代コホート調査:10年間の取り組みと周産期転帰のプロファイル. DOHaD研究. 2024; 12 (1): 11-17. doi:10.51067/dohad.12.1_11  
7.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Maternal social isolation and behavioral problems in preschool children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. European Child & Adolescent Psychiatry. 2024; 33 (3): 761-769. doi:10.1007/s00787-023-02199-4  
8.   Izumi Seiya, Iwama Noriyuki, Metoki Hirohito. Prediction of preterm preeclampsia risk in Asians using a simple two-item assessment in early pregnancy. Hypertension Research. 2024; 47 (5): 1231-1234. doi:10.1038/s41440-024-01590-1  
9.   Kudo Rie, Iwama Noriyuki, Hamada Hirotaka, et al. Maternal birth weight is an indicator of preterm delivery: the Japan environment and children’s study. Journal of Developmental Origins of Health and Disease. 2024; 15 : e11. doi:10.1017/S2040174424000126  
10.   Tagami Kazuma, Iwama Noriyuki, Hamada Hirotaka, et al. Maternal birth weight as an indicator of early and late gestational diabetes mellitus: The Japan Environment and Children's Study. Journal of Diabetes Investigation. 2024; 15 (6): 751-761. doi:10.1111/jdi.14159  
11.   Murakami Keiko, Nakadate Misako, Obara Taku, et al. Validity of a self-administered food frequency questionnaire for genomic and omics research among pregnant women: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Epidemiology. 2024; : JE20240293. doi:10.2188/jea.JE20240293  
12.   Ishikuro Mami, Nishimura Tomoko, Iwata Hiroyoshi, et al. Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis. Journal of Human Hypertension. 2024; 38 (2): 187-190. doi:10.1038/s41371-023-00890-2  
13.   Hamada Hirotaka, Iwama Noriyuki, Tomita Hasumi, et al. Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children’s Study. Nutrients. 2024; 16 (4): 531. doi:10.3390/nu16040531  
14.   Ishitsuka Kazue, Piedvache Aurélie, Kobayashi Sumitaka, et al. The Population-Attributable Fractions of Small-for-Gestational-Age Births: Results from the Japan Birth Cohort Consortium. Nutrients. 2024; 16 (2): 186. doi:10.3390/nu16020186  
15.   Orui Masatsugu, Obara Taku, Ishikuro Mami, et al. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (4): . doi:10.1002/pcn5.70025  
16.   Wang Hongxin, Iwama Noriyuki, Yuwaki Keiichi, et al. Association of parity with the prevalence of hypertension in Japan: The Tohoku Medical Megabank Community‐based cohort study. The Journal of Clinical Hypertension. 2024; 26 (2): 102-121. doi:10.1111/jch.14756  
17.   Ishibashi Masumi, Niikura Hitoshi, Ishida Motoko, et al. Long-Term and Short-Interval Assessment of Self-Reported Urinary and Sexual Functions after Nerve-Sparing Radical Hysterectomy: A Prospective Cohort Study. The Tohoku Journal of Experimental Medicine. 2024; 263 (1): 2024.J014. doi:10.1620/tjem.2024.J014  
18.   Murakami Keiko, Noda Aoi, Ishikuro Mami, et al. Maternal postnatal bonding disorder and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Archives of Women's Mental Health. 2023; 26 (2): 219-226. doi:10.1007/s00737-023-01298-0  
19.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. BMC Pregnancy and Childbirth. 2023; 23 (1): 268. doi:10.1186/s12884-023-05603-8  
20.   Shimizu Takanori, Iwama Noriyuki, Tokunaga Hideki, et al. Precautions during Direct Oral Anticoagulant Introduction in Gynecologic Malignancies: A Single-Center Retrospective Cohort Study. Cancers. 2023; 15 (4): 1132. doi:10.3390/cancers15041132  
21.   Tanaka Kosuke, Nishigori Hidekazu, Watanabe Zen, et al. Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children’s Study. Hypertension Research. 2023; 46 (4): 834-844. doi:10.1038/s41440-022-01144-3  
22.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Maternal postnatal bonding disorder and emotional/behavioral problems in preschool children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Affective Disorders. 2023; 325 : 582-587. doi:10.1016/j.jad.2023.01.044  
23.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Traumatic experiences of the Great East Japan Earthquake and postpartum depressive symptoms: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Affective Disorders. 2023; 320 : 461-467. doi:10.1016/j.jad.2022.09.139  
24.   Tomita Hasumi, Iwama Noriyuki, Hamada Hirotaka, et al. The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children’s study. Journal of Developmental Origins of Health and Disease. 2023; 14 (6): 699-710. doi:10.1017/S2040174423000387  
25.   Takahashi Ippei, Obara Taku, Kikuchi Saya, et al. Association between maternal psychological distress and children's neurodevelopment in offspring aged 4 years in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Journal of Paediatrics and Child Health. 2023; 59 (3): 548-554. doi:10.1111/jpc.16353  
26.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Nutrition Journal. 2023; 22 (1): 66. doi:10.1186/s12937-023-00901-5  
27.   Tagami Kazuma, Iwama Noriyuki, Hamada Hirotaka, et al. Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children’s study. Pregnancy Hypertension. 2023; 34 : 159-168. doi:10.1016/j.preghy.2023.11.002  
28.   Ishikawa Tomofumi, Nishigori Hidekazu, Akazawa Manabu, et al. Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010–2019. Pregnancy Hypertension. 2023; 31 : 73-83. doi:10.1016/j.preghy.2023.01.001  
29.   Ishikuro Mami, Obara Taku, Murakami Keiko, et al. Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Reproductive Medicine. 2023; 4 (2): 89-99. doi:10.3390/reprodmed4020010  
30.   Murakami Keiko, Noda Aoi, Ishikuro Mami, et al. Maternal social isolation in the perinatal period and early childhood development: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Social Psychiatry and Psychiatric Epidemiology. 2023; 58 (11): 1593-1601. doi:10.1007/s00127-023-02498-w  
31.   Ohseto Hisashi, Ishikuro Mami, Obara Taku, et al. Dietary calcium intake was related to the onset of pre‐eclampsia: The TMM BirThree Cohort Study. The Journal of Clinical Hypertension. 2023; 25 (1): 61-70. doi:10.1111/jch.14606  
32.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Social isolation and postnatal bonding disorder in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Archives of Women's Mental Health. 2022; 25 (6): 1079-1086. doi:10.1007/s00737-022-01266-0  
33.   Takahashi Ippei, Murakami Keiko, Kobayashi Mika, et al. Association of maternal psychological distress and the use of childcare facilities with children's behavioral problems: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. BMC Psychiatry. 2022; 22 (1): 693. doi:10.1186/s12888-022-04330-2  
34.   Noda Aoi, Ishikuro Mami, Obara Taku, et al. Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi and Iwate Prefectures, Japan. BMJ Open. 2022; 12 (6): e060944. doi:10.1136/bmjopen-2022-060944  
35.   Tajima Kentaro, Ishikawa Tomofumi, Noda Aoi, et al. Development and validation of claims-based algorithms to identify pregnancy based on data from a university hospital in Japan. Current Medical Research and Opinion. 2022; 38 (9): 1651-1654. doi:10.1080/03007995.2022.2101817  
36.   Tatsuta Nozomi, Iwai-Shimada Miyuki, Nakayama Shoji F., et al. Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women: The Japan environment and Children's study. Environmental Research. 2022; 212 : 113231. doi:10.1016/j.envres.2022.113231  
37.   Metoki Hirohito, Iwama Noriyuki, Hamada Hirotaka, et al. Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement. Hypertension Research. 2022; 45 (8): 1298-1309. doi:10.1038/s41440-022-00965-6  
38.   Ohseto Hisashi, Ishikuro Mami, Obara Taku, et al. Preeclampsia prediction model using the dipstick test for proteinuria during early gestation. Hypertension Research in Pregnancy. 2022; 10 (3): HRP2022-002. doi:10.14390/jsshp.HRP2022-002  
39.   Tajima Kentaro, Ishikawa Tomofumi, Matsuzaki Fumiko, et al. Validity of Administrative Data for Identifying Birth-Related Outcomes with the End Date of Pregnancy in a Japanese University Hospital. International Journal of Environmental Research and Public Health. 2022; 19 (8): 4864. doi:10.3390/ijerph19084864  
40.   Yamashita Takahiro, Obara Taku, Yonezawa Yudai, et al. Dietary patterns before and during pregnancy and small for gestational age in Japan: a prospective birth cohort study. Nutrition Journal. 2022; 21 (1): 57. doi:10.1186/s12937-022-00808-7  
41.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Skipping breakfast during pregnancy and hypertensive disorders of pregnancy in Japanese women: the Tohoku medical megabank project birth and three-generation cohort study. Nutrition Journal. 2022; 21 (1): 71. doi:10.1186/s12937-022-00822-9  
42.   Yokoyama Emi, Takeda Takashi, Watanabe Zen, et al. Association of fish intake with menstrual pain: A cross-sectional study of the Japan Environment and Children’s Study. PLOS ONE. 2022; 17 (7): e0269042. doi:10.1371/journal.pone.0269042  
43.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Scientific Reports. 2022; 12 (1): 6400. doi:10.1038/s41598-022-09944-w  
44.   Iwama Noriyuki, Obara Taku, Ishikuro Mami, et al. Risk scores for predicting small for gestational age infants in Japan: The TMM birthree cohort study. Scientific Reports. 2022; 12 (1): 8921. doi:10.1038/s41598-022-12892-0  
45.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Social isolation and insomnia among pregnant women in Japan: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Sleep Health. 2022; 8 (6): 714-720. doi:10.1016/j.sleh.2022.08.007  
46.   Yasuoka Toshiaki, Iwama Noriyuki, Ota Kuniaki, et al. Pregnancy outcomes among female childhood, adolescent, and young adult cancer survivors assessed using internet-based nationwide questionnaire surveys in Japan. The Journal of Maternal-Fetal & Neonatal Medicine. 2022; 35 (26): 10667-10675. doi:10.1080/14767058.2022.2155037  
47.   Tanoue Kaou, Watanabe Zen, Nishigori Hidekazu, et al. The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake. Environmental Health and Preventive Medicine. 2021; 26 (1): 27. doi:10.1186/s12199-021-00944-2  
48.   Iwama Noriyuki, Sugiyama Takashi, Metoki Hirohito, et al. Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children’s Study (JECS). Diabetes Research and Clinical Practice. 2020; 169 : 108377. doi:10.1016/j.diabres.2020.108377  
49.   Iwama Noriyuki, Oba Mari S., Satoh Michihiro, et al. Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. Hypertension Research. 2020; 43 (6): 550-559. doi:10.1038/s41440-020-0416-2  
50.   Iwama Noriyuki, Ishikuro Mami, Tanaka Kosuke, et al. Epidemiological studies regarding hypertensive disorders of pregnancy: A review. Journal of Obstetrics and Gynaecology Research. 2020; 46 (9): 1672-1677. doi:10.1111/jog.14383