Tohoku University Tohoku Medical Megabank Organization (Nobuo Yaegashi)
2022.05.17

1.   Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Epidemiology. 2022; 32 (2): JE20200338. doi:10.2188/jea.JE20200338  
2.   Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113  
3.   Ishikawa Tomofumi, Obara Taku, Akazawa Manabu, et al. Risk of major congenital malformations associated with first‐trimester exposure to propulsives: A health administrative database study in Japan. Pharmacoepidemiology and Drug Safety. 2022; 31 (2): 196-205. doi:10.1002/pds.5370  
4.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Scientific Reports. 2022; 12 (1): 6400. doi:10.1038/s41598-022-09944-w  
5.   Ishikuro Mami, Noda Aoii, Murakami Keiko, et al. Families’ Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Tohoku Journal of Experimental Medicine. 2022; 256 (2): 93-101. doi:10.1620/tjem.256.93  
6.   Uchida Yasuo, Higuchi Tomoya, Shirota Matsuyuki, et al. Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia. Biological and Pharmaceutical Bulletin. 2021; 44 (6): 804-815. doi:10.1248/bpb.b20-01043  
7.   Kikuchi Saya, Kobayashi Natsuko, Watanabe Zen, et al. The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms. Depression and Anxiety. 2021; 38 (4): 422-430. doi:10.1002/da.23134  
8.   Tanoue Kaou, Watanabe Zen, Nishigori Hidekazu, et al. The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake. Environmental Health and Preventive Medicine. 2021; 26 (1): 27. doi:10.1186/s12199-021-00944-2  
9.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
10.   Nagaoka Shinichi, Yamaguchi-Kabata Yumi, Shiga Naomi, et al. Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal recessive bone dysplasia using a whole-genome reference panel of Japanese individuals. Human Genome Variation. 2021; 8 (1): 2. doi:10.1038/s41439-020-00133-7  
11.   Kikuchi Saya, Murakami Keiko, Obara Taku, et al. One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Affective Disorders. 2021; 295 : 632-638. doi:10.1016/j.jad.2021.08.118  
12.   Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271  
13.   Tanoue Kaou, Nishigori Hidekazu, Watanabe Zen, et al. Interannual Changes in the Prevalence of Intimate Partner Violence Against Pregnant Women in Miyagi Prefecture After the Great East Japan Earthquake: The Japan Environment and Children’s Study. Journal of Interpersonal Violence. 2021; 36 (21-22): 10013-10028. doi:10.1177/0886260519881517  
14.   Yasuoka Toshiaki, Iwama Noriyuki, Ota Kuniaki, et al. Pregnancy outcomes in children, adolescents, and young adults that survived cancer: A nationwide survey in Japan. Journal of Obstetrics and Gynaecology Research. 2021; 47 (9): 3352-3361. doi:10.1111/jog.14909  
15.   Tokunaga Hideki, Iida Keita, Hozawa Atsushi, et al. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PLOS ONE. 2021; 16 (1): e0236907. doi:10.1371/journal.pone.0236907  
16.   Sasaki Satomi, Metoki Hirohito, Satoh Michihiro, et al. Association of subjective health and abnormal cervical cytology in Japanese pregnant women: An adjunct study of the Japan Environment and Children's Study. Preventive Medicine Reports. 2021; 24 : 101525. doi:10.1016/j.pmedr.2021.101525  
17.   Yamauchi Takafumi, Ochi Daisuke, Matsukawa Naomi, et al. Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. Scientific Reports. 2021; 11 (1): 17777. doi:10.1038/s41598-021-97342-z  
18.   Hishinuma Eiji, Shimada Muneaki, Matsukawa Naomi, et al. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. Toxins. 2021; 13 (7): 461. doi:10.3390/toxins13070461  
19.   Ishikawa Tomofumi, Obara Taku, Jin Kazutaka, et al. Folic acid prescribed to prenatal and postpartum women who are also prescribed antiepileptic drugs in Japan: Data from a health administrative database. Birth Defects Research. 2020; 112 (16): 1224-1233. doi:10.1002/bdr2.1748  
20.   Iwama Noriyuki, Sugiyama Takashi, Metoki Hirohito, et al. Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: The Japan Environment and Children’s Study (JECS). Diabetes Research and Clinical Practice. 2020; 169 : 108377. doi:10.1016/j.diabres.2020.108377  
21.   Iwama Noriyuki, Oba Mari S., Satoh Michihiro, et al. Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study. Hypertension Research. 2020; 43 (6): 550-559. doi:10.1038/s41440-020-0416-2  
22.   Wagata Maiko, Kogure Mana, Nakaya Naoki, et al. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. Hypertension Research. 2020; 43 (11): 1277-1283. doi:10.1038/s41440-020-0463-8  
23.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
24.   Ishikawa Tomofumi, Obara Taku, Kikuchi Saya, et al. Antidepressant prescriptions for prenatal and postpartum women in Japan: A health administrative database study. Journal of Affective Disorders. 2020; 264 : 295-303. doi:10.1016/j.jad.2020.01.016  
25.   Shirota Matsuyuki, Saigusa Daisuke, Yamashita Riu, et al. Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy. Medical Mass Spectrometry. 2020; 4 (1): 36-49. doi:10.24508/mms.2020.06.001  
26.   Wagata Maiko, Ishikuro Mami, Obara Taku, et al. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. Pregnancy Hypertension. 2020; 22 : 119-125. doi:10.1016/j.preghy.2020.08.001  
27.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children’s Study. The Journal of Maternal-Fetal & Neonatal Medicine. 2020; 33 (3): 427-436. doi:10.1080/14767058.2018.1494712  
28.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): e025939. doi:10.1136/bmjopen-2018-025939  
29.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. Disaster Medicine and Public Health Preparedness. 2019; 13 (5-6): 905-911. doi:10.1017/dmp.2019.8  
30.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
31.   Nagasaki Masao, Kuroki Yoko, Shibata Tomoko F., et al. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Human Genome Variation. 2019; 6 (1): 27. doi:10.1038/s41439-019-0057-7  
32.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study. Hypertension Research. 2019; 42 (1): 85-94. doi:10.1038/s41440-018-0124-3  
33.   Tanaka Kosuke, Nishigori Hidekazu, Watanabe Zen, et al. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children’s study. Hypertension Research. 2019; 42 (4): 558-566. doi:10.1038/s41440-019-0206-x  
34.   Watanabe Zen, Nishigori Hidekazu, Tanoue Kaou, et al. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. Journal of Affective Disorders. 2019; 245 : 475-483. doi:10.1016/j.jad.2018.11.061  
35.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Blood pressure changes during twin pregnancies. Journal of Hypertension. 2019; 37 (1): 206-215. doi:10.1097/HJH.0000000000001846  
36.   Ishikawa Tomofumi, Obara Taku, Jin Kazutaka, et al. Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. Pharmacoepidemiology and Drug Safety. 2019; 28 (6): 804-811. doi:10.1002/pds.4749  
37.   Hattori Hiromitsu, Kitamura Akane, Takahashi Fumiaki, et al. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study. Reproductive Biology and Endocrinology. 2019; 17 (1): 27. doi:10.1186/s12958-019-0471-1  
38.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
39.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. Allergology International. 2018; 67 (4): 481-486. doi:10.1016/j.alit.2018.02.009  
40.   Fujiwara Masaki, Inagaki Masatoshi, Nakaya Naoki, et al. Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. Cancer. 2018; 124 (3): 555-562. doi:10.1002/cncr.31086  
41.   Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, et al. Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing. Genes, Chromosomes and Cancer. 2018; 57 (2): 51-60. doi:10.1002/gcc.22507  
42.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
43.   Zhang Xuewei, Kitatani Kazuyuki, Toyoshima Masafumi, et al. Ceramide nanoliposomes as a MLKL-dependent, necroptosis-inducing, chemotherapeutic reagent in ovarian cancer. Molecular Cancer Therapeutics. 2018; 17 (1): 50-59. doi:10.1158/1535-7163.MCT-17-0173  
44.   Hasegawa-Minato Junko, Toyoshima Masafumi, Ishibashi Masumi, et al. Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers. Oncotarget. 2018; 9 (3): 3483-3496. doi:10.18632/oncotarget.23322  
45.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Antihypertensives prescribed for pregnant women in Japan: Prevalence and timing determined from a database of health insurance claims. Pharmacoepidemiology and Drug Safety. 2018; 27 (12): 1325-1334. doi:10.1002/pds.4654  
46.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Development of algorithms to determine the onset of pregnancy and delivery date using health care administrative data in a university hospital in Japan. Pharmacoepidemiology and Drug Safety. 2018; 27 (7): 751-762. doi:10.1002/pds.4444  
47.   Sugawara Junichi, Iwama Noriyuki, Hoshiai Tetsuro, et al. Regional Birth Outcomes after the 2011 Great East Japan Earthquake and Tsunami in Miyagi Prefecture. Prehospital and Disaster Medicine. 2018; 33 (2): 215-219. doi:10.1017/S1049023X18000183  
48.   Ishibashi Masumi, Toyoshima Masafumi, Zhang Xuewei, et al. Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancer. Scientific Reports. 2018; 8 (1): 13207. doi:10.1038/s41598-018-31069-2  
49.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
50.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. Congenital Anomalies. 2017; 57 (3): 72-78. doi:10.1111/cga.12202  
51.   Sakurai Kasumi, Nishigori Hidekazu, Nishigori Toshie, et al. Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children’s Study. Disaster Medicine and Public Health Preparedness. 2017; 11 (2): 216-226. doi:10.1017/dmp.2016.109  
52.   Nishigori Hidekazu, Nishigori Toshie, Sakurai Kasumi, et al. Pregnant Women’s Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children’s Study. Disaster Medicine and Public Health Preparedness. 2017; 11 (3): 355-364. doi:10.1017/dmp.2016.150  
53.   Kikuya Masahiro. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren. JPCD. 2017; 4 : 1-4. doi:10.17303/jpcd.2017.4.101  
54.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Drug Use before and during Pregnancy in Japan: The Japan Environment and Children’s Study. Pharmacy. 2017; 5 (4): 21. doi:10.3390/pharmacy5020021  
55.   Obara Taku, Nishigori Hidekazu, Nishigori Toshie, et al. Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children’s Study (JECS). The Journal of Maternal-Fetal & Neonatal Medicine. 2017; 30 (5): 588-593. doi:10.1080/14767058.2016.1179273  
56.   Mizuno Satoshi, Nishigori Hidekazu, Sugiyama Takashi, et al. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children’s Study. Diabetes Research and Clinical Practice. 2016; 120 : 132-141. doi:10.1016/j.diabres.2016.07.020  
57.   Iwama Noriyuki, Metoki Hirohito, Ohkubo Takayoshi, et al. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. Hypertension Research. 2016; 39 (3): 151-157. doi:10.1038/hr.2015.108  
58.   Watanabe Zen, Iwama Noriyuki, Nishigori Hidekazu, et al. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study. Journal of Affective Disorders. 2016; 190 : 341-348. doi:10.1016/j.jad.2015.10.024  
59.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
60.   Kitatani K, Usui T, Sriraman S K, et al. Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016; 35 (21): 2801-2812. doi:10.1038/onc.2015.330  
61.   Shigeta S, Toyoshima M, Kitatani K, et al. Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer. Oncogene. 2016; 35 (27): 3577-86. doi:10.1038/onc.2015.425  
62.   Mizuno Satoshi, Ogishima Soichi, Kitatani Kazuyuki, et al. Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer’s Disease. PLOS ONE. 2016; 11 (2): e0148431. doi:10.1371/journal.pone.0148431  
63.   Mizuno Satoshi, Ogishima Soichi, Nishigori Hidekazu, et al. The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia. PLOS ONE. 2016; 11 (10): e0162828. doi:10.1371/journal.pone.0162828  
64.   Sugawara Junichi, Hoshiai Tetsuro, Sato Kazuyo, et al. Impact of the Great East Japan Earthquake on Regional Obstetrical Care in Miyagi Prefecture. Prehospital and Disaster Medicine. 2016; 31 (3): 255-258. doi:10.1017/S1049023X1600025X  
65.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
66.   Takahashi Fumiaki, Nishigori Hidekazu, Nishigori Toshie, et al. Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children’s Study. The Tohoku Journal of Experimental Medicine. 2016; 240 (4): 309-321. doi:10.1620/tjem.240.309  
67.   Mashiko Satsuki, Kitatani Kazuyuki, Toyoshima Masafumi, et al. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biology & Therapy. 2015; 16 (2): 253-260. doi:10.1080/15384047.2014.1001271  
68.   Nishigori Hidekazu, Sasaki Michiho, Obara Taku, et al. Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan. Disaster medicine and public health preparedness. 2015; 9 (3): 307-12. doi:0.1017/dmp.2015.51  
69.   Ishikuro Mami, Obara Taku, Metoki Hirohito, et al. Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. Hypertension Research. 2015; 38 (11): 770-775. doi:10.1038/hr.2015.97  
70.   Ishikuro Mami, Obara Taku, Metoki Hirohito, et al. Differences between clinic and home blood pressure measurements during pregnancy. Journal of Hypertension. 2015; 33 (7): 1492-1493. doi:10.1097/HJH.0000000000000608  
71.   Tadakawa Mari, Sugawara Junichi, Saito Masatoshi, et al. Fertility and pregnancy outcomes following B-Lynch sutures for post-partum hemorrhage. Journal of Obstetrics and Gynaecology Research. 2015; 41 (4): 559-564. doi:10.1111/jog.12590  
72.   Yamazaki Isao, Kimura Fumiko, Nakagawa Kiyotaka, et al. Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study. Journal of Oleo Science. 2015; 64 (8): 905-914. doi:10.5650/jos.ess15071  
73.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018  
74.   Kitatani Kazuyuki, Wada Masayuki, Perry David, et al. Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease. PLOS ONE. 2015; 10 (8): e0136633. doi:10.1371/journal.pone.0136633  
75.   Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297  
76.   Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123  
77.   Nishigori Hidekazu, Sugawara Junichi, Obara Taku, et al. Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake. Archives of Women's Mental Health. 2014; 17 (6): 579-581. doi:10.1007/s00737-014-0459-y  
78.   Suenaga Kaori, Kitahara Shuji, Suzuki Yasuhiro, et al. Role of the Vasohibin Family in the Regulation of Fetoplacental Vascularization and Syncytiotrophoblast Formation. PLoS ONE. 2014; 9 (9): e104728. doi:10.1371/journal.pone.0104728