Tohoku University Tohoku Medical Megabank Organization (Nobuo Yaegashi)
2019.09.20

1.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): bmjopen-2018-025939. doi:10.1136/bmjopen-2018-025939  
2.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. Disaster Medicine and Public Health Preparedness. 2019; : 1-7. doi:10.1017/dmp.2019.8  
3.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
4.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children’s Study. Hypertension Research. 2019; 42 (1): 85-94. doi:10.1038/s41440-018-0124-3  
5.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Association between alcohol consumption during pregnancy and hypertensive disorders of pregnancy in Japan: the Japan Environment and Children's Study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019; 42 (1): 85-94. doi:10.1038/s41440-018-0124-3  
6.   Tanaka Kosuke, Nishigori Hidekazu, Watanabe Zen, et al. Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children's study. Hypertension research : official journal of the Japanese Society of Hypertension. 2019; 42 (4): 558-566. doi:10.1038/s41440-019-0206-x  
7.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International Journal of Epidemiology. 2019; : . doi:10.1093/ije/dyz169  
8.   Watanabe Zen, Nishigori Hidekazu, Tanoue Kaou, et al. Preconception dysmenorrhea as a risk factor for psychological distress in pregnancy: The Japan Environment and Children's Study. Journal of affective disorders. 2019; 245 : 475-483. doi:10.1016/j.jad.2018.11.061  
9.   Iwama Noriyuki, Metoki Hirohito, Nishigori Hidekazu, et al. Blood pressure changes during twin pregnancies: the Japan Environment and Children's Study. Journal of hypertension. 2019; 37 (1): 206-215. doi:10.1097/HJH.0000000000001846  
10.   Ishikawa Tomofumi, Obara Taku, Jin Kazutaka, et al. Examination of the prescription of antiepileptic drugs to prenatal and postpartum women in Japan from a health administrative database. Pharmacoepidemiology and Drug Safety. 2019; : . doi:10.1002/pds.4749  
11.   Hattori Hiromitsu, Kitamura Akane, Takahashi Fumiaki, et al. The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. Reproductive biology and endocrinology : RB&E. 2019; 17 (1): 27. doi:10.1186/s12958-019-0471-1  
12.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
13.   Egiz Mahy, Usui Toshinori, Ishibashi Masumi, et al. La-Related Protein 4 as a Suppressor for Motility of Ovarian Cancer Cells. The Tohoku journal of experimental medicine. 2019; 247 (1): 59-67. doi:10.1620/tjem.247.59  
14.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. Allergology International. 2018; 67 (4): 481-486. doi:10.1016/j.alit.2018.02.009  
15.   Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, et al. Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing. Genes, Chromosomes and Cancer. 2018; 57 (2): 51-60. doi:10.1002/gcc.22507  
16.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
17.   Hasegawa-Minato Junko, Toyoshima Masafumi, Ishibashi Masumi, et al. Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers. Oncotarget. 2018; 9 (3): 3483-3496. doi:10.18632/oncotarget.23322  
18.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Antihypertensives prescribed for pregnant women in Japan: Prevalence and timing determined from a database of health insurance claims. Pharmacoepidemiology and Drug Safety. 2018; 27 (12): 1325-1334. doi:10.1002/pds.4654  
19.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Development of algorithms to determine the onset of pregnancy and delivery date using health care administrative data in a university hospital in Japan. Pharmacoepidemiology and drug safety. 2018; 27 (7): 751-762. doi:10.1002/pds.4444  
20.   Sugawara Junichi, Iwama Noriyuki, Hoshiai Tetsuro, et al. Regional Birth Outcomes after the 2011 Great East Japan Earthquake and Tsunami in Miyagi Prefecture. Prehospital and Disaster Medicine. 2018; 33 (02): 215-219. doi:10.1017/S1049023X18000183  
21.   Ishibashi Masumi, Toyoshima Masafumi, Zhang Xuewei, et al. Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancer. Scientific Reports. 2018; 8 (1): 13207. doi:10.1038/s41598-018-31069-2  
22.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Update on the prevalence and determinants of folic acid use in Japan evaluated with 91,538 pregnant women: the Japan Environment and Children's Study. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2018; : 1-10. doi:10.1080/14767058.2018.1494712  
23.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
24.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study. Congenital Anomalies. 2017; 57 (3): 72-78. doi:10.1111/cga.12202  
25.   Sakurai Kasumi, Nishigori Hidekazu, Nishigori Toshie, et al. Incidence of Domestic Violence Against Pregnant Females After the Great East Japan Earthquake in Miyagi Prefecture: The Japan Environment and Children’s Study. Disaster Medicine and Public Health Preparedness. 2017; 11 (02): 216-226. doi:10.1017/dmp.2016.109  
26.   Nishigori Hidekazu, Nishigori Toshie, Sakurai Kasumi, et al. Pregnant Women’s Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children’s Study. Disaster Medicine and Public Health Preparedness. 2017; 11 (03): 355-364. doi:10.1017/dmp.2016.150  
27.   Miyashita Masako, Ishikuro Mami, Kikuya Masahiro, et al. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren. Journal of Pediatrics and Congenital Disorders. 2017; 4 : . http://www.jscholaronline.org/articles/JPCD/Development-of-a-Questionnaire.pdf  
28.   Nishigori Hidekazu, Obara Taku, Nishigori Toshie, et al. Drug Use before and during Pregnancy in Japan: The Japan Environment and Children's Study. Pharmacy. 2017; 5 (2): 21. doi:10.3390/pharmacy5020021  
29.   Obara Taku, Nishigori Hidekazu, Nishigori Toshie, et al. Prevalence and determinants of inadequate use of folic acid supplementation in Japanese pregnant women: the Japan Environment and Children’s Study (JECS). The Journal of Maternal-Fetal & Neonatal Medicine. 2017; 30 (5): 588-593. doi:10.1080/14767058.2016.1179273  
30.   Mizuno Satoshi, Nishigori Hidekazu, Sugiyama Takashi, et al. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study. Diabetes research and clinical practice. 2016; 120 : 132-41. doi:10.1016/j.diabres.2016.07.020  
31.   Iwama Noriyuki, Metoki Hirohito, Ohkubo Takayoshi, et al. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. Hypertension Research. 2016; 39 (3): 151-157. doi:10.1038/hr.2015.108  
32.   Watanabe Zen, Iwama Noriyuki, Nishigori Hidekazu, et al. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study. Journal of Affective Disorders. 2016; 190 : 341-348. doi:10.1016/j.jad.2015.10.024  
33.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
34.   Shigeta S, Toyoshima M, Kitatani K, et al. Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer. Oncogene. 2016; 35 (27): 3577-86. doi:10.1038/onc.2015.425  
35.   Mizuno Satoshi, Ogishima Soichi, Kitatani Kazuyuki, et al. Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease. PloS one. 2016; 11 (2): e0148431. doi:10.1371/journal.pone.0148431  
36.   Mizuno Satoshi, Ogishima Soichi, Nishigori Hidekazu, et al. The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia. PLOS ONE. 2016; 11 (10): e0162828. doi:10.1371/journal.pone.0162828  
37.   Sugawara Junichi, Hoshiai Tetsuro, Sato Kazuyo, et al. Impact of the Great East Japan Earthquake on Regional Obstetrical Care in Miyagi Prefecture. Prehospital and Disaster Medicine. 2016; 31 (3): 255-258. doi:10.1017/S1049023X1600025X  
38.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
39.   Takahashi Fumiaki, Nishigori Hidekazu, Nishigori Toshie, et al. Fermented Food Consumption and Psychological Distress in Pregnant Women: A Nationwide Birth Cohort Study of the Japan Environment and Children’s Study. The Tohoku Journal of Experimental Medicine. 2016; 240 (4): 309-321. doi:10.1620/tjem.240.309  
40.   Mashiko Satsuki, Kitatani Kazuyuki, Toyoshima Masafumi, et al. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer biology & therapy. 2015; 16 (2): 253-60. doi:10.1080/15384047.2014.1001271  
41.   Nishigori Hidekazu, Sasaki Michiho, Obara Taku, et al. Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan. Disaster medicine and public health preparedness. 2015; 9 (3): 307-12. doi:0.1017/dmp.2015.51  
42.   Ishikuro Mami, Obara Taku, Metoki Hirohito, et al. Parity as a factor affecting the white-coat effect in pregnant women: the BOSHI study. Hypertension research : official journal of the Japanese Society of Hypertension. 2015; 38 (11): 770-5. doi:10.1038/hr.2015.97  
43.   Ishikuro Mami, Obara Taku, Metoki Hirohito, et al. Differences between clinic and home blood pressure measurements during pregnancy. Journal of hypertension. 2015; 33 (7): 1492-3. doi:10.1097/HJH.0000000000000608  
44.   Yamazaki Isao, Kimura Fumiko, Nakagawa Kiyotaka, et al. Heterogeneity of the Fatty Acid Composition of Japanese Placentae for Determining the Perinatal Fatty Acid Status: a Methodological Study. Journal of oleo science. 2015; 64 (8): 905-914. doi:10.5650/jos.ess15071  
45.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature communications. 2015; 6 : 8018. doi:10.1038/ncomms9018  
46.   Kitatani K, Usui T, Sriraman S K, et al. Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2015; 35 (21): 2801-2812. doi:10.1038/onc.2015.330  
47.   Kitatani Kazuyuki, Wada Masayuki, Perry David, et al. Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. PloS one. 2015; 10 (8): e0136633. doi:10.1371/journal.pone.0136633  
48.   Tadakawa Mari, Sugawara Junichi, Saito Masatoshi, et al. Fertility and pregnancy outcomes following B-Lynch sutures for post-partum hemorrhage. The journal of obstetrics and gynaecology research. 2015; 41 (4): 559-64. doi:10.1111/jog.12590  
49.   Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297  
50.   Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123  
51.   Nishigori Hidekazu, Sugawara Junichi, Obara Taku, et al. Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake. Archives of women's mental health. 2014; 17 (6): 579-81. doi:10.1007/s00737-014-0459-y  
52.   Suenaga Kaori, Kitahara Shuji, Suzuki Yasuhiro, et al. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PloS one. 2014; 9 (9): e104728. doi:10.1371/journal.pone.0104728