Tohoku University Tohoku Medical Megabank Organization (Naoko Minegishi)
2019.09.20

1.   Sakurai-Yageta Mika, Kawame Hiroshi, Kuriyama Shinichi, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Medical Education. 2019; 19 (1): 297. doi:10.1186/s12909-019-1725-5  
2.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): bmjopen-2018-025939. doi:10.1136/bmjopen-2018-025939  
3.   Tadaka Shu, Katsuoka Fumiki, Ueki Masao, et al. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. Human Genome Variation. 2019; 6 (1): 28. doi:10.1038/s41439-019-0059-5  
4.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International Journal of Epidemiology. 2019; : . doi:10.1093/ije/dyz169  
5.   Shido Kosuke, Kojima Kaname, Yamasaki Kenshi, et al. Susceptibility Loci for Tanning Ability in the Japanese Population Identified by a Genome-Wide Association Study from the Tohoku Medical Megabank Project Cohort Study. Journal of Investigative Dermatology. 2019; 139 (7): 1605-1608.e13. doi:10.1016/j.jid.2019.01.015  
6.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
7.   Mimori Takahiro, Yasuda Jun, Kuroki Yoko, et al. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing. The Pharmacogenomics Journal. 2019; 19 (2): 136-146. doi:10.1038/s41397-017-0010-4  
8.   Minegishi Naoko, Nishijima Ichiko, Nobukuni Takahiro, et al. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project. The Tohoku journal of experimental medicine. 2019; 248 (1): 45-55. doi:10.1620/tjem.248.45  
9.   Watanabe Takashi, Saito Takahiro, Rico Evelyn Marie Gutiérrez, et al. Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation. Biochemical Pharmacology. 2018; 156 : 420-430. doi:10.1016/j.bcp.2018.09.010  
10.   Kabe Yasuaki, Suematsu Makoto, Sakamoto Satoshi, et al. Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera. Clinical chemistry. 2018; 64 (10): 1463-1473. doi:10.1373/clinchem.2018.291963  
11.   Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003  
12.   Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug metabolism and pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003  
13.   Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588  
14.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
15.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
16.   Shido K., Kojima K., Hozawa A., et al. 503 Genome-wide association study identifies novel susceptibility loci for tanning ability in Japanese population. Journal of Investigative Dermatology. 2017; 137 (5): S86. doi:10.1016/j.jid.2017.02.523  
17.   Hirano Ikuo, Suzuki Norio, Yamazaki Shun, et al. Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements. Molecular and Cellular Biology. 2017; 37 (4): MCB.00451-16. doi:10.1128/MCB.00451-16  
18.   Akiyama Masato, Okada Yukinori, Kanai Masahiro, et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nature Genetics. 2017; 49 (10): 1458-1467. doi:10.1038/ng.3951  
19.   Hachiya Tsuyoshi, Kamatani Yoichiro, Takahashi Atsushi, et al. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Stroke. 2017; 48 (2): 253-258. doi:10.1161/STROKEAHA.116.014506  
20.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
21.   Shiwa Yuh, Hachiya Tsuyoshi, Furukawa Ryohei, et al. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols. PLOS ONE. 2016; 11 (1): e0147519. doi:10.1371/journal.pone.0147519  
22.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
23.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature communications. 2015; 6 : 8018. doi:10.1038/ncomms9018  
24.   Nakajima Tomomi, Kitagawa Kyoko, Ohhata Tatsuya, et al. Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. The Journal of biological chemistry. 2015; 290 (16): 10368-81. doi:10.1074/jbc.M114.613018  
25.   Motoike Ikuko N, Matsumoto Mitsuyo, Danjoh Inaho, et al. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population. BMC genomics. 2014; 15 : 673. doi:10.1186/1471-2164-15-673  
26.   Souma T., Yamazaki S., Moriguchi T., et al. Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis. Journal of the American Society of Nephrology. 2013; 24 (10): 1599-1616. doi:10.1681/ASN.2013010030  
27.   Yamazaki Shun, Souma Tomokazu, Hirano Ikuo, et al. A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nature communications. 2013; 4 : 1950. doi:10.1038/ncomms2950  
28.   Suzuki Norio, Hirano Ikuo, Pan Xiaoqing, et al. Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis. Nature communications. 2013; 4 : 2902. doi:10.1038/ncomms3902  
29.   Kon Shunsuke, Minegishi Naoko, Tanabe Kenji, et al. Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. The Journal of clinical investigation. 2013; 123 (3): 1123-37. doi:10.1172/JCI63711