Tohoku University Tohoku Medical Megabank Organization (Masayuki Yamamoto)
2019.09.20

1.   Saigusa Daisuke, Saito Ritsumi, Kawamoto Komei, et al. Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry. 2019; : acs.analchem.9b01159. doi:10.1021/acs.analchem.9b01159  
2.   Keleku-Lukwete Nadine, Suzuki Mikiko, Panda Harit, et al. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood advances. 2019; 3 (8): 1285-1297. doi:10.1182/bloodadvances.2018017574  
3.   Sakurai-Yageta Mika, Kawame Hiroshi, Kuriyama Shinichi, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Medical Education. 2019; 19 (1): 297. doi:10.1186/s12909-019-1725-5  
4.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): bmjopen-2018-025939. doi:10.1136/bmjopen-2018-025939  
5.   Harada Nobuhiko, Hasegawa Atsushi, Hirano Ikuo, et al. GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice. Cancer science. 2019; 110 (4): 1183-1193. doi:10.1111/cas.13959  
6.   Suzuki Takafumi, Muramatsu Aki, Saito Ryota, et al. Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1. Cell Reports. 2019; 28 (3): 746-758.e4. doi:10.1016/j.celrep.2019.06.047  
7.   Kurosawa Ryo, Satoh Kimio, Kikuchi Nobuhiro, et al. Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds-. Circulation Research. 2019; : CIRCRESAHA.119.315229. doi:10.1161/CIRCRESAHA.119.315229  
8.   Wada Yoichi, Kikuchi Atsuo, Arai-Ichinoi Natsuko, et al. Biallelic GALM pathogenic variants cause a novel type of galactosemia. Genetics in Medicine. 2019; 21 (6): 1286-1294. doi:10.1038/s41436-018-0340-x  
9.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
10.   Tadaka Shu, Katsuoka Fumiki, Ueki Masao, et al. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. Human Genome Variation. 2019; 6 (1): 28. doi:10.1038/s41439-019-0059-5  
11.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective. International Journal of Epidemiology. 2019; : . doi:10.1093/ije/dyz169  
12.   Sakurai Rieko, Ueki Masao, Makino Satoshi, et al. Outlier detection for questionnaire data in biobanks. International Journal of Epidemiology. 2019; : . doi:10.1093/ije/dyz012  
13.   Kiniwa Yukiko, Yasuda Jun, Saito Sakae, et al. Identification of genetic alterations in extramammary Paget disease using whole exome analysis. Journal of Dermatological Science. 2019; 94 (1): 229-235. doi:10.1016/j.jdermsci.2019.03.006  
14.   Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4  
15.   Suzuki Ken, Akiyama Masato, Ishigaki Kazuyoshi, et al. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. Nature Genetics. 2019; 51 (3): 379-386. doi:10.1038/s41588-018-0332-4  
16.   Miura Emiri, Tsuchiya Naho, Igarashi Yu, et al. Respiratory resistance among adults in a population-based cohort study in Northern Japan. Respiratory Investigation. 2019; 57 (3): 274-281. doi:10.1016/j.resinv.2018.12.008  
17.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
18.   Mimori Takahiro, Yasuda Jun, Kuroki Yoko, et al. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing. The Pharmacogenomics Journal. 2019; 19 (2): 136-146. doi:10.1038/s41397-017-0010-4  
19.   Minegishi Naoko, Nishijima Ichiko, Nobukuni Takahiro, et al. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project. The Tohoku journal of experimental medicine. 2019; 248 (1): 45-55. doi:10.1620/tjem.248.45  
20.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. Allergology International. 2018; 67 (4): 481-486. doi:10.1016/j.alit.2018.02.009  
21.   Watanabe Takashi, Saito Takahiro, Rico Evelyn Marie Gutiérrez, et al. Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation. Biochemical Pharmacology. 2018; 156 : 420-430. doi:10.1016/j.bcp.2018.09.010  
22.   Yasuda Jun, Katsuoka Fumiki, Danjoh Inaho, et al. Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project. BMC Genomics. 2018; 19 (1): 551. doi:10.1186/s12864-018-4942-0  
23.   Hishinuma Eiji, Narita Yoko, Saito Sakae, et al. Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals. Drug Metabolism and Disposition. 2018; 46 (8): 1083-1090. doi:10.1124/dmd.118.081737  
24.   Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003  
25.   Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug metabolism and pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003  
26.   Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588  
27.   Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, et al. Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing. Genes, chromosomes & cancer. 2018; 57 (2): 51-60. doi:10.1002/gcc.22507  
28.   Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, et al. Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing. Genes, Chromosomes and Cancer. 2018; 57 (2): 51-60. doi:10.1002/gcc.22507  
29.   Saigusa Daisuke, Suzuki Norio, Matsumoto Yotaro, et al. Detection of novel metabolite for roxadustat doping by global metabolomics. Journal of biochemistry. 2018; 163 (6): e1. doi:10.1093/jb/mvy036  
30.   Saigusa Daisuke, Suzuki Norio, Matsumoto Yotaro, et al. Detection of novel metabolite for Roxadustat doping by global metabolomics. Journal of biochemistry. 2018; : . doi:10.1093/jb/mvy028  
31.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
32.   Suzuki Norio, Matsuo-Tezuka Yukari, Sasaki Yusuke, et al. Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts. Kidney international. 2018; 94 (5): 900-911. doi:10.1016/j.kint.2018.06.028  
33.   Takeuchi Fumihiko, Akiyama Masato, Matoba Nana, et al. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications. 2018; 9 (1): 5052. doi:10.1038/s41467-018-07345-0  
34.   Takeuchi Fumihiko, Akiyama Masato, Matoba Nana, et al. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature communications. 2018; 9 (1): 5052. doi:10.1038/s41467-018-07345-0  
35.   Rashad Sherif, Niizuma Kuniyasu, Saigusa Daisuke, et al. Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia. Neuroscience. 2018; 384 : 188-202. doi:10.1016/j.neuroscience.2018.05.015  
36.   Tadaka Shu, Saigusa Daisuke, Motoike Ikuko N., et al. jMorp: Japanese Multi Omics Reference Panel. Nucleic Acids Research. 2018; 46 (D1): D551-D557. doi:10.1093/nar/gkx978  
37.   Tadaka Shu, Saigusa Daisuke, Motoike Ikuko N, et al. jMorp: Japanese Multi Omics Reference Panel. Nucleic acids research. 2018; 46 (D1): D551-D557. doi:10.1093/nar/gkx978  
38.   Hachiya Tsuyoshi, Narita Akira, Ohmomo Hideki, et al. Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus. Scientific Reports. 2018; 8 (1): 14162. doi:10.1038/s41598-018-32074-1  
39.   Hachiya Tsuyoshi, Narita Akira, Ohmomo Hideki, et al. Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3'-BCL11B gene desert locus. Scientific reports. 2018; 8 (1): 14162. doi:10.1038/s41598-018-32074-1  
40.   Sato Kota, Saigusa Daisuke, Saito Ritsumi, et al. Metabolomic changes in the mouse retina after optic nerve injury. Scientific Reports. 2018; 8 (1): 11930. doi:10.1038/s41598-018-30464-z  
41.   Sato Kota, Saigusa Daisuke, Saito Ritsumi, et al. Metabolomic changes in the mouse retina after optic nerve injury. Scientific reports. 2018; 8 (1): 11930. doi:10.1038/s41598-018-30464-z  
42.   Nezu Masahiro, Suzuki Norio, Yamamoto Masayuki. Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression. American Journal of Nephrology. 2017; 45 (6): 473-483. doi:10.1159/000475890  
43.   Katayama Saori, Suzuki Mikiko, Yamaoka Ayaka, et al. GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis. Blood. 2017; 130 (7): 908-919. doi:10.1182/blood-2016-12-756767  
44.   Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5  
45.   Pan Xiaoqing, Nariai Naoki, Fukuhara Noriko, et al. Monitoring of minimal residual disease in early T-cell precursor acute lymphoblastic leukaemia by next-generation sequencing. British Journal of Haematology. 2017; 176 (2): 318-321. doi:10.1111/bjh.13948  
46.   Yagishita Yoko, Uruno Akira, Fukutomi Toshiaki, et al. Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress. Cell reports. 2017; 18 (8): 2030-2044. doi:10.1016/j.celrep.2017.01.064  
47.   Tsuchida Kouhei, Tsujita Tadayuki, Hayashi Makiko, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free radical biology & medicine. 2017; 103 : 236-247. doi:10.1016/j.freeradbiomed.2016.12.041  
48.   Matsuura Kentaro, Sawai Hiromi, Ikeo Kazuho, et al. Genome-wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. Gastroenterology. 2017; 152 (6): 1383-1394. doi:10.1053/j.gastro.2017.01.041  
49.   Kaneko Hiroshi, Katoh Takehide, Hirano Ikuo, et al. Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes to cells : devoted to molecular & cellular mechanisms. 2017; 22 (11): 939-952. doi:10.1111/gtc.12537  
50.   Hamanaka Teruhiko, Kimura Masae, Sakurai Tetsuro, et al. A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients. Investigative Opthalmology & Visual Science. 2017; 58 (5): 2818. doi:10.1167/iovs.16-20646  
51.   Miyashita Masako, Ishikuro Mami, Kikuya Masahiro, et al. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren. Journal of Pediatrics and Congenital Disorders. 2017; 4 : . http://www.jscholaronline.org/articles/JPCD/Development-of-a-Questionnaire.pdf  
52.   Nezu Masahiro, Souma Tomokazu, Yu Lei, et al. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney International. 2017; 91 (2): 387-401. doi:10.1016/j.kint.2016.08.023  
53.   Baird Liam, Tsujita Tadayuki, Kobayashi Eri H, et al. A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways. Molecular and cellular biology. 2017; 37 (4): . doi:10.1128/MCB.00439-16  
54.   Yu Lei, Takai Jun, Otsuki Akihito, et al. Derepression of the DNA Methylation Machinery of the Gata1 Gene Triggers the Differentiation Cue for Erythropoiesis. Molecular and Cellular Biology. 2017; 37 (8): MCB.00592-16. doi:10.1128/MCB.00592-16  
55.   Yu Lei, Moriguchi Takashi, Kaneko Hiroshi, et al. Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury. Molecular and Cellular Biology. 2017; 37 (22): e00211-17. doi:10.1128/MCB.00211-17  
56.   Hirano Ikuo, Suzuki Norio, Yamazaki Shun, et al. Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements. Molecular and Cellular Biology. 2017; 37 (4): MCB.00451-16. doi:10.1128/MCB.00451-16  
57.   Suzuki Takafumi, Seki Shiori, Hiramoto Keiichiro, et al. Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus. Nature Communications. 2017; 8 : 14577. doi:10.1038/ncomms14577  
58.   Akiyama Masato, Okada Yukinori, Kanai Masahiro, et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nature Genetics. 2017; 49 (10): 1458-1467. doi:10.1038/ng.3951  
59.   Low Siew-Kee, Takahashi Atsushi, Ebana Yusuke, et al. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nature genetics. 2017; 49 (6): 953-958. doi:10.1038/ng.3842  
60.   Hachiya Tsuyoshi, Furukawa Ryohei, Shiwa Yuh, et al. Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies. npj Genomic Medicine. 2017; 2 (1): 11. doi:10.1038/s41525-017-0016-5  
61.   Shiga Yukihiro, Nishiguchi Koji M., Kawai Yosuke, et al. Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7. PLOS ONE. 2017; 12 (12): e0186678. doi:10.1371/journal.pone.0186678  
62.   Nezu Masahiro, Souma Tomokazu, Yu Lei, et al. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Science Signaling. 2017; 10 (479): eaam5711. doi:10.1126/scisignal.aam5711  
63.   Hachiya Tsuyoshi, Komaki Shohei, Hasegawa Yutaka, et al. Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6–TMC8 and SIX3–SIX2 loci associated with HbA1c. Scientific Reports. 2017; 7 (1): 16147. doi:10.1038/s41598-017-16493-0  
64.   Hachiya Tsuyoshi, Kamatani Yoichiro, Takahashi Atsushi, et al. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Stroke. 2017; 48 (2): 253-258. doi:10.1161/STROKEAHA.116.014506  
65.   Satoh H., Moriguchi T., Saigusa D., et al. NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. Cancer Research. 2016; 76 (10): 3088-3096. doi:10.1158/0008-5472.CAN-15-1584  
66.   Katsuoka Fumiki, Yamamoto Masayuki. Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 2016; 586 (2): 197-205. doi:10.1016/j.gene.2016.03.058  
67.   Katsuoka Fumiki, Yamazaki Hiromi, Yamamoto Masayuki. Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice. Genes to Cells. 2016; 21 (12): 1309-1319. doi:10.1111/gtc.12445  
68.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
69.   Iso Tatsuro, Suzuki Takafumi, Baird Liam, Yamamoto Masayuki. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells. Molecular and Cellular Biology. 2016; 36 (24): 3100-3112. doi:10.1128/MCB.00389-16  
70.   Hasegawa Atsushi, Kaneko Hiroshi, Ishihara Daishi, et al. GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation. Molecular and Cellular Biology. 2016; 36 (16): 2151-2167. doi:10.1128/MCB.00017-16  
71.   Uruno Akira, Yagishita Yoko, Katsuoka Fumiki, et al. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Molecular and Cellular Biology. 2016; 36 (11): 1655-1672. doi:10.1128/MCB.01095-15  
72.   Sekine Hiroki, Okazaki Keito, Ota Nao, et al. The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Molecular and cellular biology. 2016; 36 (3): 407-20. doi:10.1128/MCB.00785-15  
73.   Kobayashi Eri H., Suzuki Takafumi, Funayama Ryo, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Communications. 2016; 7 : 11624. doi:10.1038/ncomms11624  
74.   Hidaka Takanori, Ogawa Eisaku, Kobayashi Eri H, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature Immunology. 2016; 18 (1): 64-73. doi:10.1038/ni.3614  
75.   Kohda Masakazu, Tokuzawa Yoshimi, Kishita Yoshihito, et al. A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies. PLOS Genetics. 2016; 12 (1): e1005679. doi:10.1371/journal.pgen.1005679  
76.   Shiwa Yuh, Hachiya Tsuyoshi, Furukawa Ryohei, et al. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols. PLOS ONE. 2016; 11 (1): e0147519. doi:10.1371/journal.pone.0147519  
77.   Saigusa Daisuke, Okamura Yasunobu, Motoike Ikuko N., et al. Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLOS ONE. 2016; 11 (8): e0160555. doi:10.1371/journal.pone.0160555  
78.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
79.   de Aguiar Vallim Thomas Q., Tarling Elizabeth J., Ahn Hannah, et al. MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism. Cell Metabolism. 2015; 21 (2): 298-310. doi:10.1016/j.cmet.2015.01.007  
80.   Otsuki Akihito, Suzuki Mikiko, Katsuoka Fumiki, et al. Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection. Free radical biology & medicine. 2015; 91 : 45-57. doi:10.1016/j.freeradbiomed.2015.12.005  
81.   Tsujita Tadayuki, Baird Liam, Furusawa Yuki, et al. Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system. Genes to cells : devoted to molecular & cellular mechanisms. 2015; 20 (7): 563-77. doi:10.1111/gtc.12248  
82.   Yamaguchi-Kabata Yumi, Nariai Naoki, Kawai Yosuke, et al. iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing. Human Genome Variation. 2015; 2 : 15050. doi:10.1038/hgv.2015.50  
83.   Kawai Yosuke, Mimori Takahiro, Kojima Kaname, et al. Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals. Journal of Human Genetics. 2015; 60 (10): 581-587. doi:10.1038/jhg.2015.68  
84.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature communications. 2015; 6 : 8018. doi:10.1038/ncomms9018  
85.   Nishikawa Keizo, Iwamoto Yoriko, Kobayashi Yasuhiro, et al. DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway. Nature medicine. 2015; 21 (3): 281-7. doi:10.1038/nm.3774  
86.   Sato Yukuto, Yamagishi Junya, Yamashita Riu, et al. Inter-Individual Differences in the Oral Bacteriome Are Greater than Intra-Day Fluctuations in Individuals. PLOS ONE. 2015; 10 (6): e0131607. doi:10.1371/journal.pone.0131607  
87.   Keleku-Lukwete Nadine, Suzuki Mikiko, Otsuki Akihito, et al. Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. Proceedings of the National Academy of Sciences. 2015; 112 (39): 12169-12174. doi:10.1073/pnas.1509158112  
88.   Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297  
89.   Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123  
90.   Katsuoka Fumiki, Yokozawa Junji, Tsuda Kaoru, et al. An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer. Analytical Biochemistry. 2014; 466 (466C): 27-29. doi:10.1016/j.ab.2014.08.015  
91.   Motoike Ikuko N, Matsumoto Mitsuyo, Danjoh Inaho, et al. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population. BMC genomics. 2014; 15 : 673. doi:10.1186/1471-2164-15-673  
92.   Yamazaki Hiromi, Suzuki Mikiko, Otsuki Akihito, et al. A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression. Cancer Cell. 2014; 25 (4): 415-427. doi:10.1016/j.ccr.2014.02.008  
93.   Yagishita Yoko, Fukutomi Toshiaki, Sugawara Akira, et al. Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice. Diabetes. 2014; 63 (2): 605-18. doi:10.2337/db13-0909  
94.   Hirotsu Yosuke, Higashi Chika, Fukutomi Toshiaki, et al. Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. Genes to Cells. 2014; 19 (8): 650-665. doi:10.1111/gtc.12165  
95.   Suzuki Mikiko, Yamamoto Masayuki, Engel James Douglas. Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies. Molecular and cellular biology. 2014; 34 (19): 3560-9. doi:10.1128/MCB.00714-14  
96.   鈴木 洋一, 山本 雅之. ゲノムコホート研究とバイオバンク. 医学のあゆみ. 2014; 250巻5号 : 321-325. http://www.ishiyaku.co.jp/magazines/ayumi/AyumiArticleDetail.aspx?BC=925005&AC=14110  
97.   Mukai Harumi Y., Suzuki Mikiko, Nagano Masumi, et al. Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain. Genes to Cells. 2013; 18 (10): n/a-n/a. doi:10.1111/gtc.12084  
98.   Suzuki Mikiko, Kobayashi-Osaki Maki, Tsutsumi Shuichi, et al. GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. Genes to Cells. 2013; 18 (11): 921-933. doi:10.1111/gtc.12086  
99.   Muramatsu Hiroyuki, Katsuoka Fumiki, Toide Katsuo, et al. Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice. Genes to Cells. 2013; 18 (10): n/a-n/a. doi:10.1111/gtc.12083  
100.   Shimizu Ritsuko, Hasegawa Atsushi, Ottolenghi Sergio, et al. Verification of the in vivo activity of three distinct cis -acting elements within the Gata1 gene promoter-proximal enhancer in mice. Genes to Cells. 2013; 18 (11): 1032-1041. doi:10.1111/gtc.12096  
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