| 1. |
|
Kawaguchi Chikana, Ozawa Maki, Hidaka Takanori, et al. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Allergology International. 2025; 74 (2): 246-253. doi:10.1016/j.alit.2024.09.008 |
|
| 2. |
|
Aoyama Yumi, Yamazaki Hiromi, Nishimura Koutarou, et al. Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages. Blood. 2025; 145 (11): 1149-1163. doi:10.1182/blood.2024025402 |
|
| 3. |
|
ISHIDA Saeko, TAGUCHI Keiko, IIDA Ryuya, et al. Diverse Cre recombinase expression pattern in Albumin-Cre driver rats. Experimental Animals. 2025; : 24-0174. doi:10.1538/expanim.24-0174 |
|
| 4. |
|
Murakami Keiko, Ishihara Junko, Takachi Ribeka, et al. Validity and Reproducibility of Food Group Intakes in a Self-administered Food Frequency Questionnaire for Genomic and Omics Research: The Tohoku Medical Megabank Project. Journal of Epidemiology. 2025; 35 (3): JE20240064. doi:10.2188/jea.JE20240064 |
|
| 5. |
|
Ohneda Kinuko, Suzuki Yoichi, Hamanaka Yohei, et al. Returning genetic risk information for hereditary cancers to participants in a population-based cohort study in Japan. Journal of Human Genetics. 2025; 70 (3): 147-157. doi:10.1038/s10038-024-01314-w |
|
| 6. |
|
Oshikiri Hiroyuki, Taguchi Keiko, Hirose Wataru, et al. Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma. Molecular and Cellular Biology. 2025; 45 (2): 79-97. doi:10.1080/10985549.2024.2438817 |
|
| 7. |
|
Iwamura Yuma, Nakai Taku, Kato Koichiro, et al. Erythropoietin Production in Embryonic Neural Cells is Controlled by Hypoxia Signaling and Histone Deacetylases with an Undifferentiated Cellular State. Molecular and Cellular Biology. 2025; 45 (1): 32-45. doi:10.1080/10985549.2024.2428717 |
|
| 8. |
|
Hatzikotoulas Konstantinos, Southam Lorraine, Stefansdottir Lilja, et al. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature. 2025; : . doi:10.1038/s41586-025-08771-z |
|
| 9. |
|
Yamamoto Yuji, Shirai Yuya, Sonehara Kyuto, et al. Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases. Nature Communications. 2025; 16 (1): 3765. doi:10.1038/s41467-025-58149-y |
|
| 10. |
|
Fuse Nobuo, Anzawa Hayato, Sakurai Miyuki, et al. Genome-wide association study of intraocular pressure in population-based cohorts in Japan: The ToMMo Eye Study. Ophthalmology Science. 2025; : 100821. doi:10.1016/j.xops.2025.100821 |
|
| 11. |
|
Kodate Shun, Sato Mitsuharu, Hishinuma Eiji, et al. Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies. Scientific Reports. 2025; 15 (1): 17035. doi:10.1038/s41598-025-01634-7 |
|
| 12. |
|
Mori Naoko, Mugikura Shunji, Hozawa Atsushi, et al. Language Registration-Based Scoring System for Handwritten Logical Memory of Wechsler Memory Scale-Revised: Developed and Validated in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J006. doi:10.1620/tjem.2025.J006 |
|
| 13. |
|
Mizuno Satoshi, Nagaie Satoshi, Sugawara Junichi, et al. Early prediction of hypertensive disorders of pregnancy toward preventive early intervention. AJOG Global Reports. 2024; 4 (4): 100383. doi:10.1016/j.xagr.2024.100383 |
|
| 14. |
|
Chu Ching-Tung, Uruno Akira, Katsuoka Fumiki, Yamamoto Masayuki. Role of NRF2 in Pathogenesis of Alzheimer’s Disease. Antioxidants. 2024; 13 (12): 1529. doi:10.3390/antiox13121529 |
|
| 15. |
|
Kudo Hisaaki, Ishida Noriko, Nobukuni Takahiro, et al. Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information. Biopreservation and Biobanking. 2024; 22 (4): 373-382. doi:10.1089/bio.2022.0211 |
|
| 16. |
|
Shiraishi Kouya, Takahashi Atsushi, Momozawa Yukihide, et al. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses. Cancer Communications. 2024; 44 (2): 287-293. doi:10.1002/cac2.12498 |
|
| 17. |
|
Iwasaki Tomoyuki, Shirota Hidekazu, Sasaki Keiju, et al. Specific cancer types and prognosis in patients with variations in the KEAP1 ‐ NRF2 system: A retrospective cohort study. Cancer Science. 2024; 115 (12): 4034-4044. doi:10.1111/cas.16355 |
|
| 18. |
|
Takahashi Jun, Suzuki Takafumi, Sato Miu, et al. Differential squamous cell fates elicited by NRF2 gain of function versus KEAP1 loss of function. Cell Reports. 2024; 43 (4): 114104. doi:10.1016/j.celrep.2024.114104 |
|
| 19. |
|
Inose-Maruyama Atsushi, Irokawa Hayato, Takeda Kouki, et al. Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. Cell Stress and Chaperones. 2024; 29 (3): 497-509. doi:10.1016/j.cstres.2024.05.003 |
|
| 20. |
|
Ikejiri Kazuaki, Suzuki Takafumi, Muto Satsuki, et al. Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study. Clinical and Experimental Nephrology. 2024; 28 (3): 225-234. doi:10.1007/s10157-023-02427-w |
|
| 21. |
|
Takayama Jun, Makino Satoshi, Funayama Takamitsu, et al. A fine‐scale genetic map of the Japanese population. Clinical Genetics. 2024; 106 (3): 284-292. doi:10.1111/cge.14536 |
|
| 22. |
|
Tawarayama Hiroshi, Uchida Keiko, Hasegawa Hirokazu, et al. Estrogen, via ESR2 receptor, prevents oxidative stress-induced Müller cell death and stimulates FGF2 production independently of NRF2, attenuating retinal degeneration. Experimental Eye Research. 2024; 248 : 110103. doi:10.1016/j.exer.2024.110103 |
|
| 23. |
|
Hirano Ikuo, Abe Kanako, Engel James Douglas, et al. Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency. Experimental Hematology & Oncology. 2024; 13 (1): 23. doi:10.1186/s40164-024-00491-w |
|
| 24. |
|
Ishihara Daishi, Hasegawa Atsushi, Hirano Ikuo, et al. The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice. Experimental Hematology & Oncology. 2024; 13 (1): 24. doi:10.1186/s40164-024-00492-9 |
|
| 25. |
|
Ando Miki, Nagata Kazuki, Takeshita Ryuki, et al. The gut lactic acid bacteria metabolite, 10-oxo-cis-6,trans-11-octadecadienoic acid, suppresses inflammatory bowel disease in mice by modulating the NRF2 pathway and GPCR-signaling. Frontiers in Immunology. 2024; 15 : . doi:10.3389/fimmu.2024.1374425 |
|
| 26. |
|
Tokutomi Tomoharu, Yoshida Akiko, Fukushima Akimune, et al. The Health History of First-Degree Relatives’ Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia. Genes. 2024; 15 (3): 384. doi:10.3390/genes15030384 |
|
| 27. |
|
Suzuki Tomohisa, Ninomiya Kota, Funayama Takamitsu, et al. Next-generation sequencing analysis with a population-specific human reference genome. Genes & Genetic Systems. 2024; 99 : 24-00112. doi:10.1266/ggs.24-00112 |
|
| 28. |
|
Kowalik Marta Anna, Taguchi Keiko, Serra Marina, et al. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. Hepatology. 2024; 79 (4): 829-843. doi:10.1097/HEP.0000000000000568 |
|
| 29. |
|
Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8 |
|
| 30. |
|
Fuse Nobuo, Kimura Masae, Shimizu Ai, et al. Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals. Japanese Journal of Ophthalmology. 2024; 68 (6): 688-701. doi:10.1007/s10384-024-01103-0 |
|
| 31. |
|
Orui Masatsugu, Obara Taku, Ishikuro Mami. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. JMA Journal. 2024; 7 (3): 353-363. doi:10.31662/jmaj.2024-0043 |
|
| 32. |
|
Kodama Eiichi N, Taira Makiko, Kiyomoto Hideyasu. Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project. JMA Journal. 2024; 7 (3): 342-352. doi:10.31662/jmaj.2023-0215 |
|
| 33. |
|
Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906 |
|
| 34. |
|
Hishida Asahi, Nakatochi Masahiro, Sutoh Yoichi, et al. GWAS Meta-analysis of Kidney Function Traits in Japanese Populations. Journal of Epidemiology. 2024; 34 (11): JE20230281. doi:10.2188/jea.JE20230281 |
|
| 35. |
|
Hozawa Atsushi, Nakaya Kumi, Nakaya Naoki, et al. Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture. Journal of Epidemiology. 2024; 34 (9): JE20230241. doi:10.2188/jea.JE20230241 |
|
| 36. |
|
Murakami Keiko, Nakadate Misako, Obara Taku, et al. Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Among Pregnant Women: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Epidemiology. 2024; : JE20240293. doi:10.2188/jea.JE20240293 |
|
| 37. |
|
Nakai Taku, Saigusa Daisuke, Kato Koichiro, et al. The drug-specific properties of hypoxia-inducible factor-prolyl hydroxylase inhibitors in mice reveal a significant contribution of the kidney compared to the liver to erythropoietin induction. Life Sciences. 2024; 346 : 122641. doi:10.1016/j.lfs.2024.122641 |
|
| 38. |
|
Sato Mitsuharu, Hishinuma Eiji, Matsukawa Naomi, et al. Dietary habits and plasma lipid concentrations in a general Japanese population. Metabolomics. 2024; 20 (2): 34. doi:10.1007/s11306-024-02087-1 |
|
| 39. |
|
Siew Keith, Nestler Kevin A., Nelson Charlotte, et al. Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction. Nature Communications. 2024; 15 (1): 4923. doi:10.1038/s41467-024-49212-1 |
|
| 40. |
|
Ojima Takafumi, Namba Shinichi, Suzuki Ken, et al. Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses. Nature Genetics. 2024; 56 (6): 1100-1109. doi:10.1038/s41588-024-01782-y |
|
| 41. |
|
Sekine Hiroki, Takeda Haruna, Takeda Norihiko, et al. PNPO–PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nature Metabolism. 2024; 6 (6): 1108-1127. doi:10.1038/s42255-024-01053-4 |
|
| 42. |
|
Tadaka Shu, Kawashima Junko, Hishinuma Eiji, et al. jMorp: Japanese Multi-Omics Reference Panel update report 2023. Nucleic Acids Research. 2024; 52 (D1): D622-D632. doi:10.1093/nar/gkad978 |
|
| 43. |
|
Miki Atsuya, Fuse Nobuo, Fujimoto Satoko, et al. Prevalence, Associated Factors, and Inter-Eye Differences of Refractive Errors in a Population-Based Japanese Cohort: The Tohoku Medical Megabank Eye Study. Ophthalmic Epidemiology. 2024; 31 (1): 46-54. doi:10.1080/09286586.2023.2203226 |
|
| 44. |
|
Li Xue, Takahashi Nagahide, Narita Akira, et al. Identification of risk loci for postpartum depression in a genome‐wide association study. Psychiatry and Clinical Neurosciences. 2024; 78 (11): 712-720. doi:10.1111/pcn.13731 |
|
| 45. |
|
Sato Miu, Yaguchi Nahoko, Iijima Takuya, et al. Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo. Redox Biology. 2024; 77 : 103355. doi:10.1016/j.redox.2024.103355 |
|
| 46. |
|
Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2024; : . doi:10.1093/rheumatology/keae492 |
|
| 47. |
|
Koyanagi Yuriko N., Nakatochi Masahiro, Namba Shinichi, et al. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Science Advances. 2024; 10 (4): . doi:10.1126/sciadv.ade2780 |
|
| 48. |
|
Mizuno Satoshi, Wagata Maiko, Nagaie Satoshi, et al. Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. Scientific Reports. 2024; 14 (1): 6292. doi:10.1038/s41598-024-55914-9 |
|
| 49. |
|
Sakurai Miyuki, Motoike Ikuko N., Hishinuma Eiji, et al. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. Scientific Reports. 2024; 14 (1): 15681. doi:10.1038/s41598-024-66180-0 |
|
| 50. |
|
Uruno Akira, Kadoguchi-Igarashi Shiori, Saito Ritsumi, et al. The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer’s disease model mice. The Journal of Biochemistry. 2024; 176 (5): 405-414. doi:10.1093/jb/mvae060 |
|
| 51. |
|
Aoki Yu-ichi, Taguchi Keiko, Anzawa Hayato, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. The Journal of Biochemistry. 2024; 175 (6): 611-627. doi:10.1093/jb/mvae008 |
|
| 52. |
|
Hanyuda Akiko, Goto Atsushi, Nakatochi Masahiro, et al. Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population. American Journal of Ophthalmology. 2023; 245 : 193-201. doi:10.1016/j.ajo.2022.09.004 |
|
| 53. |
|
Uruno Akira, Yamamoto Masayuki. The KEAP1-NRF2 System and Neurodegenerative Diseases. Antioxidants & Redox Signaling. 2023; 38 (13-15): 974-988. doi:10.1089/ars.2023.0234 |
|
| 54. |
|
Nakai Taku, Iwamura Yuma, Kato Koichiro, et al. Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice. Blood Advances. 2023; 7 (15): 3793-3805. doi:10.1182/bloodadvances.2023009798 |
|
| 55. |
|
Mizuno Satoshi, Nagaie Satoshi, Tamiya Gen, et al. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. BMC Pregnancy and Childbirth. 2023; 23 (1): 628. doi:10.1186/s12884-023-05919-5 |
|
| 56. |
|
Ohneda Kinuko, Hamanaka Yohei, Kawame Hiroshi, et al. Returning individual genomic results to population-based cohort study participants with BRCA1/2 pathogenic variants. Breast Cancer. 2023; 30 (1): 110-120. doi:10.1007/s12282-022-01404-7 |
|
| 57. |
|
Hirose Wataru, Horiuchi Makoto, Li Donghan, et al. Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium. Cellular and Molecular Gastroenterology and Hepatology. 2023; 15 (1): 153-178. doi:10.1016/j.jcmgh.2022.09.004 |
|
| 58. |
|
Shimizu Ritsuko, Hirano Ikuo, Hasegawa Atsushi, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Communications Biology. 2023; 6 (1): 875. doi:10.1038/s42003-023-05251-w |
|
| 59. |
|
Tatara Yota, Yamazaki Hiromi, Katsuoka Fumiki, et al. Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment. Current Research in Translational Medicine. 2023; 71 (1): 103367. doi:10.1016/j.retram.2022.103367 |
|
| 60. |
|
Murakami Keiko, Kuriyama Shinichi, Hashimoto Hideki. Economic, cognitive, and social paths of education to health-related behaviors: evidence from a population-based study in Japan. Environmental Health and Preventive Medicine. 2023; 28 (1): 22-00178. doi:10.1265/ehpm.22-00178 |
|
| 61. |
|
Inoue-Yanagimachi Maki, Himori Noriko, Uchida Keiko, et al. Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice. Experimental Eye Research. 2023; 226 : 109314. doi:10.1016/j.exer.2022.109314 |
|
| 62. |
|
Zhang Anqi, Suzuki Takafumi, Adachi Saki, et al. Nrf2 activation improves experimental rheumatoid arthritis. Free Radical Biology and Medicine. 2023; 207 : 279-295. doi:10.1016/j.freeradbiomed.2023.07.016 |
|
| 63. |
|
Kodama Naoki, Okada Hikaru, Hachisu Masakazu, et al. A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice. Frontiers in Nutrition. 2023; 10 : 206-220. doi:10.3389/fnut.2023.1081263 |
|
| 64. |
|
Li Xue, Ono Chiaki, Warita Noriko, et al. Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability. Frontiers in Psychiatry. 2023; 14 : . doi:10.3389/fpsyt.2023.1104222 |
|
| 65. |
|
Watarai Gosuke, Suzuki Jun, Motoike Ikuko N, et al. Relationship between age‐related hearing loss and consumption of coffee and tea. Geriatrics & Gerontology International. 2023; 23 (6): 453-456. doi:10.1111/ggi.14589 |
|
| 66. |
|
Taira Makiko, Mugikura Shunji, Mori Naoko, et al. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background. JMA Journal. 2023; 6 (3): 246-264. doi:10.31662/jmaj.2022-0220 |
|
| 67. |
|
Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425 |
|
| 68. |
|
Saito-Hakoda Akiko, Kikuchi Atsuo, Takahashi Tadahisa, et al. Familial Paget’s disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27). Journal of Bone and Mineral Metabolism. 2023; 41 (2): 193-202. doi:10.1007/s00774-022-01392-w |
|
| 69. |
|
Sugawara Yuka, Kato Hideki, Nagasaki Masao, et al. CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome. Journal of Human Genetics. 2023; 68 (6): 427-430. doi:10.1038/s10038-023-01129-1 |
|
| 70. |
|
Sugawara Yuka, Hirakawa Yosuke, Nagasu Hajime, et al. Genome-wide association study of the risk of chronic kidney disease and kidney-related traits in the Japanese population: J-Kidney-Biobank. Journal of Human Genetics. 2023; 68 (2): 55-64. doi:10.1038/s10038-022-01094-1 |
|
| 71. |
|
Saigusa Daisuke, Saito Ritsumi, Kawamoto Komei, et al. Improving the Signal Intensity of Cryosections Using a Conductive Adhesive Film in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Mass Spectrometry. 2023; 12 (1): A0137. doi:10.5702/massspectrometry.A0137 |
|
| 72. |
|
Suzuki Takafumi, Takahashi Jun, Yamamoto Masayuki. Molecular Basis of the KEAP1-NRF2 Signaling Pathway. Molecules and Cells. 2023; 46 (3): 133-141. doi:10.14348/molcells.2023.0028 |
|
| 73. |
|
Sato Kota, Saigusa Daisuke, Kokubun Taiki, et al. Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. npj Aging. 2023; 9 (1): 28. doi:10.1038/s41514-023-00124-2 |
|
| 74. |
|
Ono Chiaki T., Yu Zhiqian, Obara Taku, et al. Association between low levels of anti‐inflammatory cytokines during pregnancy and postpartum depression. Psychiatry and Clinical Neurosciences. 2023; 77 (8): 434-441. doi:10.1111/pcn.13566 |
|
| 75. |
|
Baird Liam, Taguchi Keiko, Zhang Anqi, et al. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023; 66 : 102845. doi:10.1016/j.redox.2023.102845 |
|
| 76. |
|
Ohe Takashi, Yamada Mitsuhiro, Hozawa Atsushi, et al. Associations between birth weight and lung function in a Japanese adult population: The tohoku medical megabank community-based cohort study. Respiratory Investigation. 2023; 61 (5): 588-600. doi:10.1016/j.resinv.2023.06.004 |
|
| 77. |
|
Furukawa Yoshihiro, Saigusa Daisuke, Kano Kuniyuki, et al. Distributions of CHN compounds in meteorites record organic syntheses in the early solar system. Scientific Reports. 2023; 13 (1): 6683. doi:10.1038/s41598-023-33595-0 |
|
| 78. |
|
Hanyuda Akiko, Goto Atsushi, Katagiri Ryoko, et al. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. Scientific Reports. 2023; 13 (1): 7052. doi:10.1038/s41598-023-33966-7 |
|
| 79. |
|
Kobayashi Tomoko, Kobayashi Mika, Minegishi Naoko, et al. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2023; 259 (2): 2022.J103. doi:10.1620/tjem.2022.J103 |
|
| 80. |
|
Edamitsu Tomohiro, Taguchi Keiko, Okuyama Ryuhei, Yamamoto Masayuki. AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis. Antioxidants. 2022; 11 (2): 227. doi:10.3390/antiox11020227 |
|
| 81. |
|
Nakai Taku, Saigusa Daisuke, Iwamura Yuma, et al. Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration. Biochemical Pharmacology. 2022; 197 : 114939. doi:10.1016/j.bcp.2022.114939 |
|
| 82. |
|
Shimokawa Kazuro. A knowledge representation model for family relationship to three generation. Bioinformation. 2022; 18 (12): 1166-1172. doi:10.6026/973206300181166 |
|
| 83. |
|
Hirose Wataru, Oshikiri Hiroyuki, Taguchi Keiko, Yamamoto Masayuki. The KEAP1-NRF2 System and Esophageal Cancer. Cancers. 2022; 14 (19): 4702. doi:10.3390/cancers14194702 |
|
| 84. |
|
Satoh Hironori, Arai Yasuhito, Furukawa Eisaku, et al. Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels. Carcinogenesis. 2022; 43 (7): 613-623. doi:10.1093/carcin/bgac041 |
|
| 85. |
|
Otsuki Akihito, Okamura Yasunobu, Ishida Noriko, et al. Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology. Communications Biology. 2022; 5 (1): 991. doi:10.1038/s42003-022-03953-1 |
|
| 86. |
|
Hasegawa Atsushi, Hayasaka Yuki, Morita Masanobu, et al. Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding. Communications Biology. 2022; 5 (1): 376. doi:10.1038/s42003-022-03316-w |
|
| 87. |
|
Wakamori Shun, Taguchi Keiko, Nakayama Yuki, et al. Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening. Free Radical Biology and Medicine. 2022; 188 : 206-220. doi:10.1016/j.freeradbiomed.2022.06.239 |
|
| 88. |
|
Li Xue, Ono Chiaki, Warita Noriko, et al. Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women. Frontiers in Psychiatry. 2022; 12 : . doi:10.3389/fpsyt.2021.799029 |
|
| 89. |
|
Kanoni Stavroula, Graham Sarah E., Wang Yuxuan, et al. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biology. 2022; 23 (1): 268. doi:10.1186/s13059-022-02837-1 |
|
| 90. |
|
Shiga Naomi, Yamaguchi-Kabata Yumi, Igeta Saori, et al. Pathological variants in genes associated with disorders of sex development and central causes of hypogonadism in a whole-genome reference panel of 8380 Japanese individuals. Human Genome Variation. 2022; 9 (1): 34. doi:10.1038/s41439-022-00213-w |
|
| 91. |
|
Zheng Jie, Zhang Yuemiao, Rasheed Humaira, et al. Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease. International Journal of Epidemiology. 2022; 50 (6): 1995-2010. doi:10.1093/ije/dyab203 |
|
| 92. |
|
Yu Zhiqian, Matsukawa Naomi, Saigusa Daisuke, et al. Plasma metabolic disturbances during pregnancy and postpartum in women with depression. iScience. 2022; 25 (12): 105666. doi:10.1016/j.isci.2022.105666 |
|
| 93. |
|
Baird Liam, Kensler Thomas W., Yamamoto Masayuki. Novel NRF2 ‐activated cancer treatments utilizing synthetic lethality. IUBMB Life. 2022; 74 (12): 1209-1231. doi:10.1002/iub.2680 |
|
| 94. |
|
Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; 5 (2): . doi:10.31662/jmaj.2021-0156 |
|
| 95. |
|
Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of epidemiology. 2022; 32 (2): 69-79. doi:10.2188/jea.JE20200338 |
|
| 96. |
|
Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2022; 67 (1): 9-17. doi:10.1038/s10038-021-00952-8 |
|
| 97. |
|
Suzuki Norio, Iwamura Yuma, Nakai Taku, et al. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International. 2022; 101 (1): 92-105. doi:10.1016/j.kint.2021.09.031 |
|
| 98. |
|
Katsuoka Fumiki, Otsuki Akihito, Hatanaka Nozomi, et al. Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer. Molecular and Cellular Biology. 2022; 42 (3): 1-18. doi:10.1128/mcb.00520-21 |
|
| 99. |
|
Kuga Ayumi, Tsuchida Kouhei, Panda Harit, et al. The β -TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo. Molecular and Cellular Biology. 2022; 42 (7): 1-22. doi:10.1128/mcb.00563-21 |
|
| 100. |
|
Sengoku Toru, Shiina Masaaki, Suzuki Kae, et al. Structural basis of transcription regulation by CNC family transcription factor, Nrf2. Nucleic Acids Research. 2022; 50 (21): 12543-12557. doi:10.1093/nar/gkac1102 |
|
| 101. |
|
Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113 |
|
| 102. |
|
Liu Yexin, Uruno Akira, Saito Ritsumi, et al. Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice. Redox Biology. 2022; 58 : 102525. doi:10.1016/j.redox.2022.102525 |
|
| 103. |
|
Ramdas Shweta, Judd Jonathan, Graham Sarah E., et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. The American Journal of Human Genetics. 2022; 109 (8): 1366-1387. doi:10.1016/j.ajhg.2022.06.012 |
|
| 104. |
|
Kittikulsuth Wararat, Nakano Daisuke, Kitada Kento, et al. Renal NG2-expressing cells have a macrophage-like phenotype and facilitate renal recovery after ischemic injury. American Journal of Physiology-Renal Physiology. 2021; 321 (2): F170-F178. doi:10.1152/ajprenal.00011.2021 |
|
| 105. |
|
Uchida Yasuo, Higuchi Tomoya, Shirota Matsuyuki, et al. Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia. Biological and Pharmaceutical Bulletin. 2021; 44 (6): 804-815. doi:10.1248/bpb.b20-01043 |
|
| 106. |
|
Yu Lei, Myers Greggory, Ku Chia-Jui, et al. An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation. Blood. 2021; 138 (18): 1691-1704. doi:10.1182/blood.2021011682 |
|
| 107. |
|
Suzuki Shiori, Goto Atsushi, Nakatochi Masahiro, et al. Body mass index and colorectal cancer risk: A Mendelian randomization study. Cancer Science. 2021; 112 (4): 1579-1588. doi:10.1111/cas.14824 |
|
| 108. |
|
von Scheidt Moritz, Zhao Yuqi, de Aguiar Vallim Thomas Q., et al. Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. 2021; 143 (18): 1809-1823. doi:10.1161/CIRCULATIONAHA.120.050186 |
|
| 109. |
|
Yamada Mitsuhiro, Motoike Ikuko N., Kojima Kaname, et al. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. Communications Biology. 2021; 4 (1): 1288. doi:10.1038/s42003-021-02813-8 |
|
| 110. |
|
Horie Yuta, Suzuki Takafumi, Inoue Jin, et al. Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism. Communications Biology. 2021; 4 (1): 576. doi:10.1038/s42003-021-02100-6 |
|
| 111. |
|
Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6 |
|
| 112. |
|
Miyauchi Kenichiro, Nakai Taku, Saito Sakae, et al. Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions. EBioMedicine. 2021; 64 : 103209. doi:10.1016/j.ebiom.2021.103209 |
|
| 113. |
|
Yumoto Akane, Kokubo Toshiaki, Izumi Ryutaro, et al. Novel method for evaluating the health condition of mice in space through a video downlink. Experimental Animals. 2021; 70 (2): 236-244. doi:10.1538/expanim.20-0102 |
|
| 114. |
|
Saito Sakae, Aoki Yuichi, Tamahara Toru, et al. Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. Frontiers in Cellular and Infection Microbiology. 2021; 10 : . doi:10.3389/fcimb.2020.604596 |
|
| 115. |
|
Yamaguchi Ayami, Hirano Ikuo, Narusawa Shiho, et al. Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice. Genes to Cells. 2021; 26 (10): 782-797. doi:10.1111/gtc.12887 |
|
| 116. |
|
Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5 |
|
| 117. |
|
Nagaoka Shinichi, Yamaguchi-Kabata Yumi, Shiga Naomi, et al. Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal recessive bone dysplasia using a whole-genome reference panel of Japanese individuals. Human Genome Variation. 2021; 8 (1): 2. doi:10.1038/s41439-020-00133-7 |
|
| 118. |
|
Cvetko Filip, Caldwell Stuart T., Higgins Maureen, et al. Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry. 2021; 296 : 100169. doi:10.1074/jbc.RA120.016551 |
|
| 119. |
|
Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271 |
|
| 120. |
|
Shido Kosuke, Kojima Kaname, Shirota Matsuyuki, et al. GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals. Journal of Investigative Dermatology. 2021; 141 (11): 2749-2752. doi:10.1016/j.jid.2021.02.762 |
|
| 121. |
|
Saigusa Daisuke, Hishinuma Eiji, Matsukawa Naomi, et al. Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values. Metabolites. 2021; 11 (10): 652. doi:10.3390/metabo11100652 |
|
| 122. |
|
Horiuchi Makoto, Taguchi Keiko, Hirose Wataru, et al. Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium. Molecular and Cellular Biology. 2021; 41 (2): 1-18. doi:10.1128/MCB.00536-20 |
|
| 123. |
|
Zhang Anqi, Suzuki Takafumi, Adachi Saki, et al. Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction. Molecular and Cellular Biology. 2021; 41 (11): 1-22. doi:10.1128/MCB.00236-21 |
|
| 124. |
|
Otsuki Akihito, Okamura Yasunobu, Aoki Yuichi, et al. Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis. Molecular and Cellular Biology. 2021; 41 (2): 1-18. doi:10.1128/MCB.00472-20 |
|
| 125. |
|
Graham Sarah E., Clarke Shoa L., Wu Kuan-Han H., et al. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021; 600 (7890): 675-679. doi:10.1038/s41586-021-04064-3 |
|
| 126. |
|
Takayama Jun, Tadaka Shu, Yano Kenji, et al. Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference. Nature Communications. 2021; 12 (1): 226. doi:10.1038/s41467-020-20146-8 |
|
| 127. |
|
Gharahkhani Puya, Jorgenson Eric, Hysi Pirro, et al. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature Communications. 2021; 12 (1): 1258. doi:10.1038/s41467-020-20851-4 |
|
| 128. |
|
Sakaue Saori, Kanai Masahiro, Tanigawa Yosuke, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nature Genetics. 2021; 53 (10): 1415-1424. doi:10.1038/s41588-021-00931-x |
|
| 129. |
|
Tadaka Shu, Hishinuma Eiji, Komaki Shohei, et al. jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population. Nucleic Acids Research. 2021; 49 (D1): D536-D544. doi:10.1093/nar/gkaa1034 |
|
| 130. |
|
Tokunaga Hideki, Iida Keita, Hozawa Atsushi, et al. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PLOS ONE. 2021; 16 (1): e0236907. doi:10.1371/journal.pone.0236907 |
|
| 131. |
|
Shoji Masaki, Esumi Tomoyuki, Tanaka Narue, et al. Organic synthesis and anti-influenza A virus activity of cyclobakuchiols A, B, C, and D. PLOS ONE. 2021; 16 (3): e0248960. doi:10.1371/journal.pone.0248960 |
|
| 132. |
|
Nagayoshi Y., Chujo T., Hirata S., et al. Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. Science Advances. 2021; 7 (13): eabf3072. doi:10.1126/sciadv.abf3072 |
|
| 133. |
|
Yamauchi Takafumi, Ochi Daisuke, Matsukawa Naomi, et al. Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. Scientific Reports. 2021; 11 (1): 17777. doi:10.1038/s41598-021-97342-z |
|
| 134. |
|
Sakurai-Yageta Mika, Kumada Kazuki, Gocho Chinatsu, et al. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs. The Journal of Biochemistry. 2021; 170 (3): 399-410. doi:10.1093/jb/mvab060 |
|
| 135. |
|
Hishinuma Eiji, Shimada Muneaki, Matsukawa Naomi, et al. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. Toxins. 2021; 13 (7): 461. doi:10.3390/toxins13070461 |
|
| 136. |
|
Yamaoka Ayaka, Suzuki Mikiko, Katayama Saori, et al. EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis. Blood Advances. 2020; 4 (8): 1722-1736. doi:10.1182/bloodadvances.2019000978 |
|
| 137. |
|
Hayashi Makiko, Kuga Ayumi, Suzuki Mikiko, et al. Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors. Cancer Research. 2020; 80 (16): 3331-3344. doi:10.1158/0008-5472.CAN-19-2888 |
|
| 138. |
|
Saigusa Daisuke, Motoike Ikuko N., Saito Sakae, et al. Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites. Cancer Science. 2020; 111 (2): 667-678. doi:10.1111/cas.14278 |
|
| 139. |
|
Yokose Takahiro, Kabe Yasuaki, Matsuda Atsushi, et al. O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer. Cancers. 2020; 12 (9): 2469. doi:10.3390/cancers12092469 |
|
| 140. |
|
Taguchi Keiko, Yamamoto Masayuki. The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment. Cancers. 2020; 13 (1): 46. doi:10.3390/cancers13010046 |
|
| 141. |
|
Afshinnekoo Ebrahim, Scott Ryan T., MacKay Matthew J., et al. Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. Cell. 2020; 183 (5): 1162-1184. doi:10.1016/j.cell.2020.10.050 |
|
| 142. |
|
Matsunaga Hiroshi, Ito Kaoru, Akiyama Masato, et al. Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. Circulation: Genomic and Precision Medicine. 2020; 13 (3): . doi:10.1161/CIRCGEN.119.002670 |
|
| 143. |
|
Okuda Hiroshi, Okamoto Koji, Abe Michiaki, et al. Genome-wide association study identifies new loci for albuminuria in the Japanese population. Clinical and Experimental Nephrology. 2020; 24 (8): 1-9. doi:10.1007/s10157-020-01884-x |
|
| 144. |
|
Koshiba Seizo, Motoike Ikuko N., Saigusa Daisuke, et al. Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population. Communications Biology. 2020; 3 (1): 662. doi:10.1038/s42003-020-01383-5 |
|
| 145. |
|
Suzuki Takafumi, Uruno Akira, Yumoto Akane, et al. Nrf2 contributes to the weight gain of mice during space travel. Communications Biology. 2020; 3 (1): 496. doi:10.1038/s42003-020-01227-2 |
|
| 146. |
|
Ishida Noriko, Aoki Yuichi, Katsuoka Fumiki, et al. Landscape of electrophilic and inflammatory stress-mediated gene regulation in human lymphoblastoid cell lines. Free Radical Biology and Medicine. 2020; 161 : 71-83. doi:10.1016/j.freeradbiomed.2020.09.023 |
|
| 147. |
|
Wagata Maiko, Kogure Mana, Nakaya Naoki, et al. Hypertensive disorders of pregnancy, obesity, and hypertension in later life by age group: a cross-sectional analysis. Hypertension Research. 2020; 43 (11): 1277-1283. doi:10.1038/s41440-020-0463-8 |
|
| 148. |
|
Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169 |
|
| 149. |
|
Shimizu Ritsuko, Yamamoto Masayuki. Quantitative and qualitative impairments in GATA2 and myeloid neoplasms. IUBMB Life. 2020; 72 (1): 142-150. doi:10.1002/iub.2188 |
|
| 150. |
|
Kasai Takuma, Ono Shunsuke, Koshiba Seizo, et al. Amino-acid selective isotope labeling enables simultaneous overlapping signal decomposition and information extraction from NMR spectra. Journal of Biomolecular NMR. 2020; 74 (2-3): 125-137. doi:10.1007/s10858-019-00295-9 |
|
| 151. |
|
Li Lei, Nakano Daisuke, Zhang Anqi, et al. Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice. Journal of Pharmacological Sciences. 2020; 144 (4): 229-236. doi:10.1016/j.jphs.2020.09.004 |
|
| 152. |
|
Shirota Matsuyuki, Saigusa Daisuke, Yamashita Riu, et al. Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy. Medical Mass Spectrometry. 2020; 4 (1): 36-49. doi:10.24508/mms.2020.06.001 |
|
| 153. |
|
Baird Liam, Suzuki Takafumi, Takahashi Yushi, et al. Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2. Molecular and Cellular Biology. 2020; 40 (22): . doi:10.1128/MCB.00377-20 |
|
| 154. |
|
Uruno Akira, Matsumaru Daisuke, Ryoke Rie, et al. Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice. Molecular and Cellular Biology. 2020; 40 (6): . doi:10.1128/MCB.00467-19 |
|
| 155. |
|
Baird Liam, Yamamoto Masayuki. The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway. Molecular and Cellular Biology. 2020; 40 (13): . doi:10.1128/MCB.00099-20 |
|
| 156. |
|
Pradas-Juni Marta, Hansmeier Nils R., Link Jenny C., et al. A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism. Nature Communications. 2020; 11 (1): 644. doi:10.1038/s41467-020-14323-y |
|
| 157. |
|
Okazaki Keito, Anzawa Hayato, Liu Zun, et al. Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. Nature Communications. 2020; 11 (1): 5911. doi:10.1038/s41467-020-19593-0 |
|
| 158. |
|
Ishigaki Kazuyoshi, Akiyama Masato, Kanai Masahiro, et al. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature Genetics. 2020; 52 (7): 669-679. doi:10.1038/s41588-020-0640-3 |
|
| 159. |
|
Kojima Kaname, Tadaka Shu, Katsuoka Fumiki, et al. A genotype imputation method for de-identified haplotype reference information by using recurrent neural network. PLOS Computational Biology. 2020; 16 (10): e1008207. doi:10.1371/journal.pcbi.1008207 |
|
| 160. |
|
Shimizu Sunao, Mimura Junsei, Hasegawa Takanori, et al. Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging. PLOS ONE. 2020; 15 (8): e0236834. doi:10.1371/journal.pone.0236834 |
|
| 161. |
|
Wagata Maiko, Ishikuro Mami, Obara Taku, et al. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. Pregnancy Hypertension. 2020; 22 : 119-125. doi:10.1016/j.preghy.2020.08.001 |
|
| 162. |
|
Nishizawa Ayako, Kumada Kazuki, Tateno Keiko, et al. Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia. Scientific Reports. 2020; 10 (1): 20027. doi:10.1038/s41598-020-77081-3 |
|
| 163. |
|
Rashad Sherif, Saigusa Daisuke, Yamazaki Takahiro, et al. Metabolic basis of neuronal vulnerability to ischemia; an in vivo untargeted metabolomics approach. Scientific Reports. 2020; 10 (1): 6507. doi:10.1038/s41598-020-63483-w |
|
| 164. |
|
Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97 |
|
| 165. |
|
Nagami Fuji, Kuriki Miho, Koreeda Sachie, et al. Public Relations and Communication Strategies in Construction of Large-Scale Cohorts and Biobank: Practice in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 250 (4): 253-262. doi:10.1620/tjem.250.253 |
|
| 166. |
|
Narita Akira, Nagai Masato, Mizuno Satoshi, et al. Clustering by phenotype and genome-wide association study in autism. Translational Psychiatry. 2020; 10 (1): 290. doi:10.1038/s41398-020-00951-x |
|
| 167. |
|
Takahashi Yuta, Ueki Masao, Yamada Makoto, et al. Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection. Translational Psychiatry. 2020; 10 (1): 157. doi:10.1038/s41398-020-0831-9 |
|
| 168. |
|
Takahashi Yuta, Ueki Masao, Tamiya Gen, et al. Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes. Translational Psychiatry. 2020; 10 (1): 294. doi:10.1038/s41398-020-00957-5 |
|
| 169. |
|
Saigusa Daisuke, Saito Ritsumi, Kawamoto Komei, et al. Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry. 2019; 91 (14): 8979-8986. doi:10.1021/acs.analchem.9b01159 |
|
| 170. |
|
Keleku-Lukwete Nadine, Suzuki Mikiko, Panda Harit, et al. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood Advances. 2019; 3 (8): 1285-1297. doi:10.1182/bloodadvances.2018017574 |
|
| 171. |
|
Sakurai-Yageta Mika, Kawame Hiroshi, Kuriyama Shinichi, et al. A training and education program for genome medical research coordinators in the genome cohort study of the Tohoku Medical Megabank Organization. BMC Medical Education. 2019; 19 (1): 297. doi:10.1186/s12909-019-1725-5 |
|
| 172. |
|
Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): e025939. doi:10.1136/bmjopen-2018-025939 |
|
| 173. |
|
Harada Nobuhiko, Hasegawa Atsushi, Hirano Ikuo, et al. GATA 2 hypomorphism induces chronic myelomonocytic leukemia in mice. Cancer Science. 2019; 110 (4): 1183-1193. doi:10.1111/cas.13959 |
|
| 174. |
|
Suzuki Takafumi, Muramatsu Aki, Saito Ryota, et al. Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1. Cell Reports. 2019; 28 (3): 746-758.e4. doi:10.1016/j.celrep.2019.06.047 |
|
| 175. |
|
Kurosawa Ryo, Satoh Kimio, Kikuchi Nobuhiro, et al. Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension: High-Throughput Screening of 5562 Compounds. Circulation Research. 2019; 125 (3): 309-327. doi:10.1161/CIRCRESAHA.119.315229 |
|
| 176. |
|
Panda Harit, Keleku-Lukwete Nadine, Kuga Ayumi, et al. Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model. Experimental Hematology. 2019; 77 : 51-60.e1. doi:10.1016/j.exphem.2019.08.001 |
|
| 177. |
|
Wada Yoichi, Kikuchi Atsuo, Arai-Ichinoi Natsuko, et al. Biallelic GALM pathogenic variants cause a novel type of galactosemia. Genetics in Medicine. 2019; 21 (6): 1286-1294. doi:10.1038/s41436-018-0340-x |
|
| 178. |
|
Mori Minako, Hira Asuka, Yoshida Kenichi, et al. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 2019; 104 (10): 1962-1973. doi:10.3324/haematol.2018.207241 |
|
| 179. |
|
Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7 |
|
| 180. |
|
Tadaka Shu, Katsuoka Fumiki, Ueki Masao, et al. 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome. Human Genome Variation. 2019; 6 (1): 28. doi:10.1038/s41439-019-0059-5 |
|
| 181. |
|
Nagasaki Masao, Kuroki Yoko, Shibata Tomoko F., et al. Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing. Human Genome Variation. 2019; 6 (1): 27. doi:10.1038/s41439-019-0057-7 |
|
| 182. |
|
Fujishima Fumiyoshi, Katsushima Hiroki, Fukuhara Noriko, et al. Immunohistochemical pattern of c-MYC protein judged as “+/(weak)+/−” by a new notation correlates with MYC gene nontranslocation in large B-cell lymphoma. Human Pathology. 2019; 85 (3): 112-118. doi:10.1016/j.humpath.2018.10.025 |
|
| 183. |
|
Sakurai Rieko, Ueki Masao, Makino Satoshi, et al. Outlier detection for questionnaire data in biobanks. International Journal of Epidemiology. 2019; 48 (4): 1305-1315. doi:10.1093/ije/dyz012 |
|
| 184. |
|
Fuse Nobuo, Sakurai-Yageta Mika, Katsuoka Fumiki, et al. Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project. JMA Journal. 2019; 2 (2): 113-122. doi:10.31662/jmaj.2019-0014 |
|
| 185. |
|
Kiniwa Yukiko, Yasuda Jun, Saito Sakae, et al. Identification of genetic alterations in extramammary Paget disease using whole exome analysis. Journal of Dermatological Science. 2019; 94 (1): 229-235. doi:10.1016/j.jdermsci.2019.03.006 |
|
| 186. |
|
Katsuoka Fumiki, Otsuki Akihito, Takahashi Mizue, et al. Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells. Molecular and Cellular Biology. 2019; 39 (20): . doi:10.1128/MCB.00273-19 |
|
| 187. |
|
Akiyama Masato, Ishigaki Kazuyoshi, Sakaue Saori, et al. Characterizing rare and low-frequency height-associated variants in the Japanese population. Nature Communications. 2019; 10 (1): 4393. doi:10.1038/s41467-019-12276-5 |
|
| 188. |
|
Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4 |
|
| 189. |
|
Suzuki Ken, Akiyama Masato, Ishigaki Kazuyoshi, et al. Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. Nature Genetics. 2019; 51 (3): 379-386. http://www.nature.com/articles/s41588-018-0332-4 |
|
| 190. |
|
Amano Yuji, Akazawa Yohei, Yasuda Jun, et al. A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease. Pediatric Rheumatology. 2019; 17 (1): 34. doi:10.1186/s12969-019-0337-2 |
|
| 191. |
|
Miura Emiri, Tsuchiya Naho, Igarashi Yu, et al. Respiratory resistance among adults in a population-based cohort study in Northern Japan. Respiratory Investigation. 2019; 57 (3): 274-281. doi:10.1016/j.resinv.2018.12.008 |
|
| 192. |
|
Sato Koji, Hirano Ikuo, Sekine Hiroki, et al. An immortalized cell line derived from renal erythropoietin-producing (REP) cells demonstrates their potential to transform into myofibroblasts. Scientific Reports. 2019; 9 (1): 11254. doi:10.1038/s41598-019-47766-5 |
|
| 193. |
|
Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096 |
|
| 194. |
|
Mimori Takahiro, Yasuda Jun, Kuroki Yoko, et al. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing. The Pharmacogenomics Journal. 2019; 19 (2): 136-146. doi:10.1038/s41397-017-0010-4 |
|
| 195. |
|
Minegishi Naoko, Nishijima Ichiko, Nobukuni Takahiro, et al. Biobank Establishment and Sample Management in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2019; 248 (1): 45-55. doi:10.1620/tjem.248.45 |
|
| 196. |
|
Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. Allergology International. 2018; 67 (4): 481-486. doi:10.1016/j.alit.2018.02.009 |
|
| 197. |
|
Watanabe Takashi, Saito Takahiro, Rico Evelyn Marie Gutiérrez, et al. Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation. Biochemical Pharmacology. 2018; 156 : 420-430. doi:10.1016/j.bcp.2018.09.010 |
|
| 198. |
|
Yasuda Jun, Katsuoka Fumiki, Danjoh Inaho, et al. Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project. BMC Genomics. 2018; 19 (1): 551. doi:10.1186/s12864-018-4942-0 |
|
| 199. |
|
Fujiwara Masaki, Inagaki Masatoshi, Nakaya Naoki, et al. Association between serious psychological distress and nonparticipation in cancer screening and the modifying effect of socioeconomic status: Analysis of anonymized data from a national cross-sectional survey in Japan. Cancer. 2018; 124 (3): 555-562. doi:10.1002/cncr.31086 |
|
| 200. |
|
Hishinuma Eiji, Narita Yoko, Saito Sakae, et al. Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals. Drug Metabolism and Disposition. 2018; 46 (8): 1083-1090. doi:10.1124/dmd.118.081737 |
|
| 201. |
|
Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003 |
|
| 202. |
|
Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588 |
|
| 203. |
|
Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, et al. Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing. Genes, Chromosomes and Cancer. 2018; 57 (2): 51-60. doi:10.1002/gcc.22507 |
|
| 204. |
|
Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1 |
|
| 205. |
|
Suzuki Norio, Matsuo-Tezuka Yukari, Sasaki Yusuke, et al. Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts. Kidney International. 2018; 94 (5): 900-911. doi:10.1016/j.kint.2018.06.028 |
|
| 206. |
|
Takeuchi Fumihiko, Akiyama Masato, Matoba Nana, et al. Interethnic analyses of blood pressure loci in populations of East Asian and European descent. Nature Communications. 2018; 9 (1): 5052. doi:10.1038/s41467-018-07345-0 |
|
| 207. |
|
Rashad Sherif, Niizuma Kuniyasu, Saigusa Daisuke, et al. Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia. Neuroscience. 2018; 384 : 188-202. doi:10.1016/j.neuroscience.2018.05.015 |
|
| 208. |
|
Tadaka Shu, Saigusa Daisuke, Motoike Ikuko N., et al. jMorp: Japanese Multi Omics Reference Panel. Nucleic Acids Research. 2018; 46 (D1): D551-D557. doi:10.1093/nar/gkx978 |
|
| 209. |
|
Hachiya Tsuyoshi, Narita Akira, Ohmomo Hideki, et al. Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus. Scientific Reports. 2018; 8 (1): 14162. doi:10.1038/s41598-018-32074-1 |
|
| 210. |
|
Sato Kota, Saigusa Daisuke, Saito Ritsumi, et al. Metabolomic changes in the mouse retina after optic nerve injury. Scientific Reports. 2018; 8 (1): 11930. doi:10.1038/s41598-018-30464-z |
|
| 211. |
|
山本 雅之, 勝岡 史城. 東北メディカル・メガバンク計画が実施するゲノムコホート研究. 医学のあゆみ. 2018; 266 ((5)): 370-376. |
|
| 212. |
|
Nezu Masahiro, Suzuki Norio, Yamamoto Masayuki. Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression. American Journal of Nephrology. 2017; 45 (6): 473-483. doi:10.1159/000475890 |
|
| 213. |
|
Katayama Saori, Suzuki Mikiko, Yamaoka Ayaka, et al. GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis. Blood. 2017; 130 (7): 908-919. doi:10.1182/blood-2016-12-756767 |
|
| 214. |
|
Takai-Igarashi Takako, Kinoshita Kengo, Nagasaki Masao, et al. Security controls in an integrated Biobank to protect privacy in data sharing: rationale and study design. BMC Medical Informatics and Decision Making. 2017; 17 (1): 100. doi:10.1186/s12911-017-0494-5 |
|
| 215. |
|
Pan Xiaoqing, Nariai Naoki, Fukuhara Noriko, et al. Monitoring of minimal residual disease in early T‐cell precursor acute lymphoblastic leukaemia by next‐generation sequencing. British Journal of Haematology. 2017; 176 (2): 318-321. doi:10.1111/bjh.13948 |
|
| 216. |
|
Yagishita Yoko, Uruno Akira, Fukutomi Toshiaki, et al. Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress. Cell Reports. 2017; 18 (8): 2030-2044. doi:10.1016/j.celrep.2017.01.064 |
|
| 217. |
|
Tsuchida Kouhei, Tsujita Tadayuki, Hayashi Makiko, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radical Biology and Medicine. 2017; 103 : 236-247. doi:10.1016/j.freeradbiomed.2016.12.041 |
|
| 218. |
|
Matsuura Kentaro, Sawai Hiromi, Ikeo Kazuho, et al. Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. Gastroenterology. 2017; 152 (6): 1383-1394. doi:10.1053/j.gastro.2017.01.041 |
|
| 219. |
|
Kaneko Hiroshi, Katoh Takehide, Hirano Ikuo, et al. Induction of erythropoietin gene expression in epithelial cells by chemicals identified in GATA inhibitor screenings. Genes to Cells. 2017; 22 (11): 939-952. doi:10.1111/gtc.12537 |
|
| 220. |
|
Hamanaka Teruhiko, Kimura Masae, Sakurai Tetsuro, et al. A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients. Investigative Opthalmology & Visual Science. 2017; 58 (5): 2818. doi:10.1167/iovs.16-20646 |
|
| 221. |
|
Kikuya Masahiro. Development of a Questionnaire Method of Screening for Citrin Deficiency in Schoolchildren. JPCD. 2017; 4 : 1-4. doi:10.17303/jpcd.2017.4.101 |
|
| 222. |
|
Nezu Masahiro, Souma Tomokazu, Yu Lei, et al. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney International. 2017; 91 (2): 387-401. doi:10.1016/j.kint.2016.08.023 |
|
| 223. |
|
Baird Liam, Tsujita Tadayuki, Kobayashi Eri H, et al. A Homeostatic Shift Facilitates Endoplasmic Reticulum Proteostasis through Transcriptional Integration of Proteostatic Stress Response Pathways. Molecular and Cellular Biology. 2017; 37 (4): . doi:10.1128/MCB.00439-16 |
|
| 224. |
|
Yu Lei, Takai Jun, Otsuki Akihito, et al. Derepression of the DNA Methylation Machinery of the Gata1 Gene Triggers the Differentiation Cue for Erythropoiesis. Molecular and Cellular Biology. 2017; 37 (8): MCB.00592-16. doi:10.1128/MCB.00592-16 |
|
| 225. |
|
Yu Lei, Moriguchi Takashi, Kaneko Hiroshi, et al. Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury. Molecular and Cellular Biology. 2017; 37 (22): e00211–17. doi:10.1128/MCB.00211-17 |
|
| 226. |
|
Hirano Ikuo, Suzuki Norio, Yamazaki Shun, et al. Renal Anemia Model Mouse Established by Transgenic Rescue with an Erythropoietin Gene Lacking Kidney-Specific Regulatory Elements. Molecular and Cellular Biology. 2017; 37 (4): MCB.00451-16. doi:10.1128/MCB.00451-16 |
|
| 227. |
|
Suzuki Takafumi, Seki Shiori, Hiramoto Keiichiro, et al. Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus. Nature Communications. 2017; 8 (1): 14577. doi:10.1038/ncomms14577 |
|
| 228. |
|
Akiyama Masato, Okada Yukinori, Kanai Masahiro, et al. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nature Genetics. 2017; 49 (10): 1458-1467. doi:10.1038/ng.3951 |
|
| 229. |
|
Low Siew-Kee, Takahashi Atsushi, Ebana Yusuke, et al. Identification of six new genetic loci associated with atrial fibrillation in the Japanese population. Nature Genetics. 2017; 49 (6): 953-958. doi:10.1038/ng.3842 |
|
| 230. |
|
Hidaka Takanori, Ogawa Eisaku, Kobayashi Eri H, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nature Immunology. 2017; 18 (1): 64-73. doi:10.1038/ni.3614 |
|
| 231. |
|
Hachiya Tsuyoshi, Furukawa Ryohei, Shiwa Yuh, et al. Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies. npj Genomic Medicine. 2017; 2 (1): 11. doi:10.1038/s41525-017-0016-5 |
|
| 232. |
|
Shiga Yukihiro, Nishiguchi Koji M., Kawai Yosuke, et al. Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7. PLOS ONE. 2017; 12 (12): e0186678. doi:10.1371/journal.pone.0186678 |
|
| 233. |
|
Nezu Masahiro, Souma Tomokazu, Yu Lei, et al. Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Science Signaling. 2017; 10 (479): eaam5711. doi:10.1126/scisignal.aam5711 |
|
| 234. |
|
Hachiya Tsuyoshi, Komaki Shohei, Hasegawa Yutaka, et al. Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6–TMC8 and SIX3–SIX2 loci associated with HbA1c. Scientific Reports. 2017; 7 (1): 16147. doi:10.1038/s41598-017-16493-0 |
|
| 235. |
|
Hachiya Tsuyoshi, Kamatani Yoichiro, Takahashi Atsushi, et al. Genetic Predisposition to Ischemic Stroke. Stroke. 2017; 48 (2): 253-258. doi:10.1161/STROKEAHA.116.014506 |
|
| 236. |
|
Satoh Hironori, Moriguchi Takashi, Saigusa Daisuke, et al. NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. Cancer Research. 2016; 76 (10): 3088-3096. doi:10.1158/0008-5472.CAN-15-1584 |
|
| 237. |
|
Otsuki Akihito, Suzuki Mikiko, Katsuoka Fumiki, et al. Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection. Free Radical Biology and Medicine. 2016; 91 : 45-57. doi:10.1016/j.freeradbiomed.2015.12.005 |
|
| 238. |
|
Katsuoka Fumiki, Yamamoto Masayuki. Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 2016; 586 (2): 197-205. doi:10.1016/j.gene.2016.03.058 |
|
| 239. |
|
Katsuoka Fumiki, Yamazaki Hiromi, Yamamoto Masayuki. Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice. Genes to Cells. 2016; 21 (12): 1309-1319. doi:10.1111/gtc.12445 |
|
| 240. |
|
Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268 |
|
| 241. |
|
Iso Tatsuro, Suzuki Takafumi, Baird Liam, Yamamoto Masayuki. Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells. Molecular and Cellular Biology. 2016; 36 (24): 3100-3112. doi:10.1128/MCB.00389-16 |
|
| 242. |
|
Hasegawa Atsushi, Kaneko Hiroshi, Ishihara Daishi, et al. GATA1 Binding Kinetics on Conformation-Specific Binding Sites Elicit Differential Transcriptional Regulation. Molecular and Cellular Biology. 2016; 36 (16): 2151-2167. doi:10.1128/MCB.00017-16 |
|
| 243. |
|
Uruno Akira, Yagishita Yoko, Katsuoka Fumiki, et al. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Molecular and Cellular Biology. 2016; 36 (11): 1655-1672. doi:10.1128/MCB.01095-15 |
|
| 244. |
|
Sekine Hiroki, Okazaki Keito, Ota Nao, et al. The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Molecular and Cellular Biology. 2016; 36 (3): 407-420. doi:10.1128/MCB.00785-15 |
|
| 245. |
|
Kobayashi Eri H., Suzuki Takafumi, Funayama Ryo, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Communications. 2016; 7 (1): 11624. doi:10.1038/ncomms11624 |
|
| 246. |
|
Kohda Masakazu, Tokuzawa Yoshimi, Kishita Yoshihito, et al. A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies. PLOS Genetics. 2016; 12 (1): e1005679. doi:10.1371/journal.pgen.1005679 |
|
| 247. |
|
Shiwa Yuh, Hachiya Tsuyoshi, Furukawa Ryohei, et al. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols. PloS one. 2016; 11 (1): e0147519. doi:10.1371/journal.pone.0147519 |
|
| 248. |
|
Saigusa Daisuke, Okamura Yasunobu, Motoike Ikuko N., et al. Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLOS ONE. 2016; 11 (8): e0160555. doi:10.1371/journal.pone.0160555 |
|
| 249. |
|
Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463 |
|
| 250. |
|
de Aguiar Vallim Thomas Q., Tarling Elizabeth J., Ahn Hannah, et al. MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism. Cell Metabolism. 2015; 21 (2): 298-311. doi:10.1016/j.cmet.2015.01.007 |
|
| 251. |
|
Tsujita Tadayuki, Baird Liam, Furusawa Yuki, et al. Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system. Genes to Cells. 2015; 20 (7): 563-577. doi:10.1111/gtc.12248 |
|
| 252. |
|
Yamaguchi-Kabata Yumi, Nariai Naoki, Kawai Yosuke, et al. iJGVD: an integrative Japanese genome variation database based on whole-genome sequencing. Human Genome Variation. 2015; 2 (1): 15050. doi:10.1038/hgv.2015.50 |
|
| 253. |
|
Kawai Yosuke, Mimori Takahiro, Kojima Kaname, et al. Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals. Journal of Human Genetics. 2015; 60 (10): 581-587. doi:10.1038/jhg.2015.68 |
|
| 254. |
|
Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018 |
|
| 255. |
|
Nishikawa Keizo, Iwamoto Yoriko, Kobayashi Yasuhiro, et al. DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway. Nature Medicine. 2015; 21 (3): 281-287. doi:10.1038/nm.3774 |
|
| 256. |
|
Sato Yukuto, Yamagishi Junya, Yamashita Riu, et al. Inter-Individual Differences in the Oral Bacteriome Are Greater than Intra-Day Fluctuations in Individuals. PLOS ONE. 2015; 10 (6): e0131607. doi:10.1371/journal.pone.0131607 |
|
| 257. |
|
Keleku-Lukwete Nadine, Suzuki Mikiko, Otsuki Akihito, et al. Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation. Proceedings of the National Academy of Sciences. 2015; 112 (39): 12169-12174. doi:10.1073/pnas.1509158112 |
|
| 258. |
|
Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297 |
|
| 259. |
|
Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123 |
|
| 260. |
|
Katsuoka Fumiki, Yokozawa Junji, Tsuda Kaoru, et al. An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer. Analytical Biochemistry. 2014; 466 (466C): 27-29. doi:10.1016/j.ab.2014.08.015 |
|
| 261. |
|
Motoike Ikuko N, Matsumoto Mitsuyo, Danjoh Inaho, et al. Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population. BMC Genomics. 2014; 15 (1): 673. doi:10.1186/1471-2164-15-673 |
|
| 262. |
|
Yamazaki Hiromi, Suzuki Mikiko, Otsuki Akihito, et al. A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression. Cancer Cell. 2014; 25 (4): 415-427. doi:10.1016/j.ccr.2014.02.008 |
|
| 263. |
|
Yagishita Yoko, Fukutomi Toshiaki, Sugawara Akira, et al. Nrf2 Protects Pancreatic -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice. Diabetes. 2014; 63 (2): 605-618. doi:10.2337/db13-0909 |
|
| 264. |
|
Hirotsu Yosuke, Higashi Chika, Fukutomi Toshiaki, et al. Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. Genes to Cells. 2014; 19 (8): 650-665. doi:10.1111/gtc.12165 |
|
| 265. |
|
Suzuki Mikiko, Yamamoto Masayuki, Engel James Douglas. Fetal Globin Gene Repressors as Drug Targets for Molecular Therapies To Treat the -Globinopathies. Molecular and Cellular Biology. 2014; 34 (19): 3560-3569. doi:10.1128/MCB.00714-14 |
|
| 266. |
|
Mukai Harumi Y., Suzuki Mikiko, Nagano Masumi, et al. Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain. Genes to Cells. 2013; 18 (10): 886-898. doi:10.1111/gtc.12084 |
|
| 267. |
|
Suzuki Mikiko, Kobayashi-Osaki Maki, Tsutsumi Shuichi, et al. GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation. Genes to Cells. 2013; 18 (11): 921-933. doi:10.1111/gtc.12086 |
|
| 268. |
|
Shimizu Ritsuko, Hasegawa Atsushi, Ottolenghi Sergio, et al. Verification of the in vivo activity of three distinct cis -acting elements within the Gata1 gene promoter-proximal enhancer in mice. Genes to Cells. 2013; 18 (11): 1032-1041. doi:10.1111/gtc.12096 |
|
| 269. |
|
Souma Tomokazu, Yamazaki Shun, Moriguchi Takashi, et al. Plasticity of Renal Erythropoietin-Producing Cells Governs Fibrosis. Journal of the American Society of Nephrology. 2013; 24 (10): 1599-1616. doi:10.1681/ASN.2013010030 |
|
| 270. |
|
Suzuki Mikiko, Yamazaki Hiromi, Mukai Harumi Y., et al. Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model. Molecular and Cellular Biology. 2013; 33 (8): 1687-1695. doi:10.1128/MCB.01617-12 |
|
| 271. |
|
Suzuki Takafumi, Shibata Tatsuhiro, Takaya Kai, et al. Regulatory Nexus of Synthesis and Degradation Deciphers Cellular Nrf2 Expression Levels. Molecular and Cellular Biology. 2013; 33 (12): 2402-2412. doi:10.1128/MCB.00065-13 |
|
| 272. |
|
Yamazaki Shun, Souma Tomokazu, Hirano Ikuo, et al. A mouse model of adult-onset anaemia due to erythropoietin deficiency. Nature Communications. 2013; 4 (1): 1950. doi:10.1038/ncomms2950 |
|
| 273. |
|
Suzuki Norio, Hirano Ikuo, Pan Xiaoqing, et al. Erythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis. Nature Communications. 2013; 4 (1): 2902. doi:10.1038/ncomms3902 |
|
| 274. |
|
布施 昇男、清水 愛、木村 雅恵、高野 良真、石 棟、宮澤 晃子、国松 志保、劉 孟林、渡邊 亮、安田 正幸、横山 悠、檜森 紀子、津田 聡、山本 耕太郎、中澤 徹、安田 純、勝岡 史城、小島 要、成相 直樹、松本 光代、元池 育子、長崎 正朗、木下 賢吾、五十嵐 和彦、山本 雅之、新堀 哲也、青木 洋子、松原 洋一、舟山 亮、長嶋 剛史、中山 啓子、眞島 行彦、舟山 智代、田中 光一、原田 高幸、阿部 春樹、福地 健郎、安田 典子、出田 秀尚、鄭 暁東、白石 敦、大橋 祐一、石田 誠夫、原 岳、金森 章. 緑内障のゲノム解析―次世代医療•個別化医療に向けて. 日本眼科学会雑誌. 2013; 118 ((3)): 216-240. |
|
| 275. |
|
Hirotsu Yosuke, Katsuoka Fumiki, Funayama Ryo, et al. Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks. Nucleic Acids Research. 2012; 40 (20): 10228-10239. doi:10.1093/nar/gks827 |
|