Tohoku University Tohoku Medical Megabank Organization (Masayuki Yamamoto)
2024.04.24

1.   Shiraishi Kouya, Takahashi Atsushi, Momozawa Yukihide, et al. Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses. Cancer Communications. 2024; 44 (2): 287-293. doi:10.1002/cac2.12498  
2.   Ikejiri Kazuaki, Suzuki Takafumi, Muto Satsuki, et al. Effects of NRF2 polymorphisms on safety and efficacy of bardoxolone methyl: subanalysis of TSUBAKI study. Clinical and Experimental Nephrology. 2024; 28 (3): 225-234. doi:10.1007/s10157-023-02427-w  
3.   Tokutomi Tomoharu, Yoshida Akiko, Fukushima Akimune, et al. The Health History of First-Degree Relatives’ Dyslipidemia Can Affect Preferences and Intentions following the Return of Genomic Results for Monogenic Familial Hypercholesterolemia. Genes. 2024; 15 (3): 384. doi:10.3390/genes15030384  
4.   Kowalik Marta Anna, Taguchi Keiko, Serra Marina, et al. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. Hepatology. 2024; 79 (4): 829-843. doi:10.1097/HEP.0000000000000568  
5.   Hozawa Atsushi, Nakaya Kumi, Nakaya Naoki, et al. Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture. Journal of Epidemiology. 2024; : JE20230241. doi:10.2188/jea.JE20230241  
6.   Sato Mitsuharu, Hishinuma Eiji, Matsukawa Naomi, et al. Dietary habits and plasma lipid concentrations in a general Japanese population. Metabolomics. 2024; 20 (2): 34. doi:10.1007/s11306-024-02087-1  
7.   Tadaka Shu, Kawashima Junko, Hishinuma Eiji, et al. jMorp: Japanese Multi-Omics Reference Panel update report 2023. Nucleic Acids Research. 2024; 52 (D1): D622-D632. doi:10.1093/nar/gkad978  
8.   Miki Atsuya, Fuse Nobuo, Fujimoto Satoko, et al. Prevalence, Associated Factors, and Inter-Eye Differences of Refractive Errors in a Population-Based Japanese Cohort: The Tohoku Medical Megabank Eye Study. Ophthalmic Epidemiology. 2024; 31 (1): 46-54. doi:10.1080/09286586.2023.2203226  
9.   Koyanagi Yuriko N., Nakatochi Masahiro, Namba Shinichi, et al. Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. Science Advances. 2024; 10 (4): . doi:10.1126/sciadv.ade2780  
10.   Mizuno Satoshi, Wagata Maiko, Nagaie Satoshi, et al. Development of phenotyping algorithms for hypertensive disorders of pregnancy (HDP) and their application in more than 22,000 pregnant women. Scientific Reports. 2024; 14 (1): 6292. doi:10.1038/s41598-024-55914-9  
11.   Aoki Yu-ichi, Taguchi Keiko, Anzawa Hayato, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. The Journal of Biochemistry. 2024; : . doi:10.1093/jb/mvae008  
12.   Hanyuda Akiko, Goto Atsushi, Nakatochi Masahiro, et al. Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population. American Journal of Ophthalmology. 2023; 245 : 193-201. doi:10.1016/j.ajo.2022.09.004  
13.   Uruno Akira, Yamamoto Masayuki. The KEAP1-NRF2 System and Neurodegenerative Diseases. Antioxidants & Redox Signaling. 2023; 38 (13-15): 974-988. doi:10.1089/ars.2023.0234  
14.   Kudo Hisaaki, Ishida Noriko, Nobukuni Takahiro, et al. Detection and Correction of Sample Misidentifications in a Biobank Using the MassARRAY System and Genomic Information. Biopreservation and Biobanking. 2023; : . doi:10.1089/bio.2022.0211  
15.   Nakai Taku, Iwamura Yuma, Kato Koichiro, et al. Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice. Blood Advances. 2023; 7 (15): 3793-3805. doi:10.1182/bloodadvances.2023009798  
16.   Mizuno Satoshi, Nagaie Satoshi, Tamiya Gen, et al. Establishment of the early prediction models of low-birth-weight reveals influential genetic and environmental factors: a prospective cohort study. BMC Pregnancy and Childbirth. 2023; 23 (1): 628. doi:10.1186/s12884-023-05919-5  
17.   Ohneda Kinuko, Hamanaka Yohei, Kawame Hiroshi, et al. Returning individual genomic results to population-based cohort study participants with BRCA1/2 pathogenic variants. Breast Cancer. 2023; 30 (1): 110-120. doi:10.1007/s12282-022-01404-7  
18.   Hirose Wataru, Horiuchi Makoto, Li Donghan, et al. Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium. Cellular and Molecular Gastroenterology and Hepatology. 2023; 15 (1): 153-178. doi:10.1016/j.jcmgh.2022.09.004  
19.   Shimizu Ritsuko, Hirano Ikuo, Hasegawa Atsushi, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Communications Biology. 2023; 6 (1): 875. doi:10.1038/s42003-023-05251-w  
20.   Tatara Yota, Yamazaki Hiromi, Katsuoka Fumiki, et al. Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment. Current Research in Translational Medicine. 2023; 71 (1): 103367. doi:10.1016/j.retram.2022.103367  
21.   Murakami Keiko, Kuriyama Shinichi, Hashimoto Hideki. Economic, cognitive, and social paths of education to health-related behaviors: evidence from a population-based study in Japan. Environmental Health and Preventive Medicine. 2023; 28 (1): 22-00178. doi:10.1265/ehpm.22-00178  
22.   Inoue-Yanagimachi Maki, Himori Noriko, Uchida Keiko, et al. Changes in glial cells and neurotrophic factors due to rotenone-induced oxidative stress in Nrf2 knockout mice. Experimental Eye Research. 2023; 226 : 109314. doi:10.1016/j.exer.2022.109314  
23.   Zhang Anqi, Suzuki Takafumi, Adachi Saki, et al. Nrf2 activation improves experimental rheumatoid arthritis. Free Radical Biology and Medicine. 2023; 207 : 279-295. doi:10.1016/j.freeradbiomed.2023.07.016  
24.   Kodama Naoki, Okada Hikaru, Hachisu Masakazu, et al. A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice. Frontiers in Nutrition. 2023; 10 : . doi:10.3389/fnut.2023.1081263  
25.   Li Xue, Ono Chiaki, Warita Noriko, et al. Comprehensive evaluation of machine learning algorithms for predicting sleep–wake conditions and differentiating between the wake conditions before and after sleep during pregnancy based on heart rate variability. Frontiers in Psychiatry. 2023; 14 : . doi:10.3389/fpsyt.2023.1104222  
26.   Watarai Gosuke, Suzuki Jun, Motoike Ikuko N, et al. Relationship between age‐related hearing loss and consumption of coffee and tea. Geriatrics & Gerontology International. 2023; 23 (6): 453-456. doi:10.1111/ggi.14589  
27.   Taira Makiko, Mugikura Shunji, Mori Naoko, et al. Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study: Rationale, Design, and Background. JMA Journal. 2023; 6 (3): 246-264. doi:10.31662/jmaj.2022-0220  
28.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
29.   Saito-Hakoda Akiko, Kikuchi Atsuo, Takahashi Tadahisa, et al. Familial Paget’s disease of bone with ocular manifestations and a novel TNFRSF11A duplication variant (72dup27). Journal of Bone and Mineral Metabolism. 2023; 41 (2): 193-202. doi:10.1007/s00774-022-01392-w  
30.   Sugawara Yuka, Kato Hideki, Nagasaki Masao, et al. CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome. Journal of Human Genetics. 2023; 68 (6): 427-430. doi:10.1038/s10038-023-01129-1  
31.   Sugawara Yuka, Hirakawa Yosuke, Nagasu Hajime, et al. Genome-wide association study of the risk of chronic kidney disease and kidney-related traits in the Japanese population: J-Kidney-Biobank. Journal of Human Genetics. 2023; 68 (2): 55-64. doi:10.1038/s10038-022-01094-1  
32.   Suzuki Takafumi, Takahashi Jun, Yamamoto Masayuki. Molecular Basis of the KEAP1-NRF2 Signaling Pathway. Molecules and Cells. 2023; 46 (3): 133-141. doi:10.14348/molcells.2023.0028  
33.   Sato Kota, Saigusa Daisuke, Kokubun Taiki, et al. Reduced glutathione level in the aqueous humor of patients with primary open-angle glaucoma and normal-tension glaucoma. npj Aging. 2023; 9 (1): 28. doi:10.1038/s41514-023-00124-2  
34.   Ono Chiaki T., Yu Zhiqian, Obara Taku, et al. Association between low levels of anti‐inflammatory cytokines during pregnancy and postpartum depression. Psychiatry and Clinical Neurosciences. 2023; 77 (8): 434-441. doi:10.1111/pcn.13566  
35.   Baird Liam, Yamamoto Masayuki. Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance. Redox Biology. 2023; 67 : 102904. doi:10.1016/j.redox.2023.102904  
36.   Hanyuda Akiko, Goto Atsushi, Katagiri Ryoko, et al. Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation. Scientific Reports. 2023; 13 (1): 7052. doi:10.1038/s41598-023-33966-7  
37.   Kobayashi Tomoko, Kobayashi Mika, Minegishi Naoko, et al. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2023; 259 (2): 2022.J103. doi:10.1620/tjem.2022.J103  
38.   Edamitsu Tomohiro, Taguchi Keiko, Okuyama Ryuhei, Yamamoto Masayuki. AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis. Antioxidants. 2022; 11 (2): 227. doi:10.3390/antiox11020227  
39.   Nakai Taku, Saigusa Daisuke, Iwamura Yuma, et al. Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration. Biochemical Pharmacology. 2022; 197 : 114939. doi:10.1016/j.bcp.2022.114939  
40.   Shimokawa Kazuro. A knowledge representation model for family relationship to three generation. Bioinformation. 2022; 18 (12): 1166-1172. doi:10.6026/973206300181166  
41.   Hirose Wataru, Oshikiri Hiroyuki, Taguchi Keiko, Yamamoto Masayuki. The KEAP1-NRF2 System and Esophageal Cancer. Cancers. 2022; 14 (19): 4702. doi:10.3390/cancers14194702  
42.   Satoh Hironori, Arai Yasuhito, Furukawa Eisaku, et al. Genomic landscape of chemical-induced lung tumors under Nrf2 different expression levels. Carcinogenesis. 2022; 43 (7): 613-623. doi:10.1093/carcin/bgac041  
43.   Otsuki Akihito, Okamura Yasunobu, Ishida Noriko, et al. Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology. Communications Biology. 2022; 5 (1): 991. doi:10.1038/s42003-022-03953-1  
44.   Hasegawa Atsushi, Hayasaka Yuki, Morita Masanobu, et al. Heterozygous variants in GATA2 contribute to DCML deficiency in mice by disrupting tandem protein binding. Communications Biology. 2022; 5 (1): 376. doi:10.1038/s42003-022-03316-w  
45.   Wakamori Shun, Taguchi Keiko, Nakayama Yuki, et al. Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening. Free Radical Biology and Medicine. 2022; 188 : 206-220. doi:10.1016/j.freeradbiomed.2022.06.239  
46.   Patel Shaili D., Anand Deepti, Motohashi Hozumi, et al. Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Frontiers in Cell and Developmental Biology. 2022; 10 : 206-220. doi:10.3389/fcell.2022.981893  
47.   Li Xue, Ono Chiaki, Warita Noriko, et al. Heart Rate Information-Based Machine Learning Prediction of Emotions Among Pregnant Women. Frontiers in Psychiatry. 2022; 12 : . doi:10.3389/fpsyt.2021.799029  
48.   Kanoni Stavroula, Graham Sarah E., Wang Yuxuan, et al. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biology. 2022; 23 (1): 268. doi:10.1186/s13059-022-02837-1  
49.   Shiga Naomi, Yamaguchi-Kabata Yumi, Igeta Saori, et al. Pathological variants in genes associated with disorders of sex development and central causes of hypogonadism in a whole-genome reference panel of 8380 Japanese individuals. Human Genome Variation. 2022; 9 (1): 34. doi:10.1038/s41439-022-00213-w  
50.   Zheng Jie, Zhang Yuemiao, Rasheed Humaira, et al. Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease. International Journal of Epidemiology. 2022; 50 (6): 1995-2010. doi:10.1093/ije/dyab203  
51.   Yu Zhiqian, Matsukawa Naomi, Saigusa Daisuke, et al. Plasma metabolic disturbances during pregnancy and postpartum in women with depression. iScience. 2022; 25 (12): 105666. doi:10.1016/j.isci.2022.105666  
52.   Baird Liam, Kensler Thomas W., Yamamoto Masayuki. Novel NRF2 ‐activated cancer treatments utilizing synthetic lethality. IUBMB Life. 2022; 74 (12): 1209-1231. doi:10.1002/iub.2680  
53.   Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; 5 (2): . doi:10.31662/jmaj.2021-0156  
54.   Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of epidemiology. 2022; 32 (2): 69-79. doi:10.2188/jea.JE20200338  
55.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2022; 67 (1): 9-17. doi:10.1038/s10038-021-00952-8  
56.   Suzuki Norio, Iwamura Yuma, Nakai Taku, et al. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International. 2022; 101 (1): 92-105. doi:10.1016/j.kint.2021.09.031  
57.   Katsuoka Fumiki, Otsuki Akihito, Hatanaka Nozomi, et al. Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer. Molecular and Cellular Biology. 2022; 42 (3): 1-18. doi:10.1128/mcb.00520-21  
58.   Kuga Ayumi, Tsuchida Kouhei, Panda Harit, et al. The β -TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo. Molecular and Cellular Biology. 2022; 42 (7): 1-22. doi:10.1128/mcb.00563-21  
59.   Sengoku Toru, Shiina Masaaki, Suzuki Kae, et al. Structural basis of transcription regulation by CNC family transcription factor, Nrf2. Nucleic Acids Research. 2022; 50 (21): 12543-12557. doi:10.1093/nar/gkac1102  
60.   Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113  
61.   Liu Yexin, Uruno Akira, Saito Ritsumi, et al. Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice. Redox Biology. 2022; 58 : 102525. doi:10.1016/j.redox.2022.102525  
62.   Ramdas Shweta, Judd Jonathan, Graham Sarah E., et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. The American Journal of Human Genetics. 2022; 109 (8): 1366-1387. doi:10.1016/j.ajhg.2022.06.012  
63.   Kittikulsuth Wararat, Nakano Daisuke, Kitada Kento, et al. Renal NG2-expressing cells have a macrophage-like phenotype and facilitate renal recovery after ischemic injury. American Journal of Physiology-Renal Physiology. 2021; 321 (2): F170-F178. doi:10.1152/ajprenal.00011.2021  
64.   Uchida Yasuo, Higuchi Tomoya, Shirota Matsuyuki, et al. Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia. Biological and Pharmaceutical Bulletin. 2021; 44 (6): 804-815. doi:10.1248/bpb.b20-01043  
65.   Yu Lei, Myers Greggory, Ku Chia-Jui, et al. An erythroid-to-myeloid cell fate conversion is elicited by LSD1 inactivation. Blood. 2021; 138 (18): 1691-1704. doi:10.1182/blood.2021011682  
66.   Suzuki Shiori, Goto Atsushi, Nakatochi Masahiro, et al. Body mass index and colorectal cancer risk: A Mendelian randomization study. Cancer Science. 2021; 112 (4): 1579-1588. doi:10.1111/cas.14824  
67.   von Scheidt Moritz, Zhao Yuqi, de Aguiar Vallim Thomas Q., et al. Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. 2021; 143 (18): 1809-1823. doi:10.1161/CIRCULATIONAHA.120.050186  
68.   Yamada Mitsuhiro, Motoike Ikuko N., Kojima Kaname, et al. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. Communications Biology. 2021; 4 (1): 1288. doi:10.1038/s42003-021-02813-8  
69.   Horie Yuta, Suzuki Takafumi, Inoue Jin, et al. Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism. Communications Biology. 2021; 4 (1): 576. doi:10.1038/s42003-021-02100-6  
70.   Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6  
71.   Miyauchi Kenichiro, Nakai Taku, Saito Sakae, et al. Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions. EBioMedicine. 2021; 64 : 103209. doi:10.1016/j.ebiom.2021.103209  
72.   Yumoto Akane, Kokubo Toshiaki, Izumi Ryutaro, et al. Novel method for evaluating the health condition of mice in space through a video downlink. Experimental Animals. 2021; 70 (2): 236-244. doi:10.1538/expanim.20-0102  
73.   Saito Sakae, Aoki Yuichi, Tamahara Toru, et al. Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project. Frontiers in Cellular and Infection Microbiology. 2021; 10 : . doi:10.3389/fcimb.2020.604596  
74.   Yamaguchi Ayami, Hirano Ikuo, Narusawa Shiho, et al. Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice. Genes to Cells. 2021; 26 (10): 782-797. doi:10.1111/gtc.12887  
75.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
76.   Nagaoka Shinichi, Yamaguchi-Kabata Yumi, Shiga Naomi, et al. Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal recessive bone dysplasia using a whole-genome reference panel of Japanese individuals. Human Genome Variation. 2021; 8 (1): 2. doi:10.1038/s41439-020-00133-7  
77.   Cvetko Filip, Caldwell Stuart T., Higgins Maureen, et al. Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry. 2021; 296 : 100169. doi:10.1074/jbc.RA120.016551  
78.   Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271  
79.   Shido Kosuke, Kojima Kaname, Shirota Matsuyuki, et al. GWAS Identified IL4R and the Major Histocompatibility Complex Region as the Associated Loci of Total Serum IgE Levels in 9,260 Japanese Individuals. Journal of Investigative Dermatology. 2021; 141 (11): 2749-2752. doi:10.1016/j.jid.2021.02.762  
80.   Saigusa Daisuke, Hishinuma Eiji, Matsukawa Naomi, et al. Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values. Metabolites. 2021; 11 (10): 652. doi:10.3390/metabo11100652  
81.   Horiuchi Makoto, Taguchi Keiko, Hirose Wataru, et al. Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium. Molecular and Cellular Biology. 2021; 41 (2): 1-18. doi:10.1128/MCB.00536-20  
82.   Zhang Anqi, Suzuki Takafumi, Adachi Saki, et al. Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction. Molecular and Cellular Biology. 2021; 41 (11): 1-22. doi:10.1128/MCB.00236-21  
83.   Otsuki Akihito, Okamura Yasunobu, Aoki Yuichi, et al. Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis. Molecular and Cellular Biology. 2021; 41 (2): 1-18. doi:10.1128/MCB.00472-20  
84.   Graham Sarah E., Clarke Shoa L., Wu Kuan-Han H., et al. The power of genetic diversity in genome-wide association studies of lipids. Nature. 2021; 600 (7890): 675-679. doi:10.1038/s41586-021-04064-3  
85.   Takayama Jun, Tadaka Shu, Yano Kenji, et al. Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference. Nature Communications. 2021; 12 (1): 226. doi:10.1038/s41467-020-20146-8  
86.   Gharahkhani Puya, Jorgenson Eric, Hysi Pirro, et al. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature Communications. 2021; 12 (1): 1258. doi:10.1038/s41467-020-20851-4  
87.   Sakaue Saori, Kanai Masahiro, Tanigawa Yosuke, et al. A cross-population atlas of genetic associations for 220 human phenotypes. Nature Genetics. 2021; 53 (10): 1415-1424. doi:10.1038/s41588-021-00931-x  
88.   Tadaka Shu, Hishinuma Eiji, Komaki Shohei, et al. jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population. Nucleic Acids Research. 2021; 49 (D1): D536-D544. doi:10.1093/nar/gkaa1034  
89.   Tokunaga Hideki, Iida Keita, Hozawa Atsushi, et al. Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2). PLOS ONE. 2021; 16 (1): e0236907. doi:10.1371/journal.pone.0236907  
90.   Shoji Masaki, Esumi Tomoyuki, Tanaka Narue, et al. Organic synthesis and anti-influenza A virus activity of cyclobakuchiols A, B, C, and D. PLOS ONE. 2021; 16 (3): e0248960. doi:10.1371/journal.pone.0248960  
91.   Nagayoshi Y., Chujo T., Hirata S., et al. Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. Science Advances. 2021; 7 (13): eabf3072. doi:10.1126/sciadv.abf3072  
92.   Yamauchi Takafumi, Ochi Daisuke, Matsukawa Naomi, et al. Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. Scientific Reports. 2021; 11 (1): 17777. doi:10.1038/s41598-021-97342-z  
93.   Sakurai-Yageta Mika, Kumada Kazuki, Gocho Chinatsu, et al. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs. The Journal of Biochemistry. 2021; 170 (3): 399-410. doi:10.1093/jb/mvab060  
94.   Hishinuma Eiji, Shimada Muneaki, Matsukawa Naomi, et al. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. Toxins. 2021; 13 (7): 461. doi:10.3390/toxins13070461  
95.   Yamaoka Ayaka, Suzuki Mikiko, Katayama Saori, et al. EVI1 and GATA2 misexpression induced by inv(3)(q21q26) contribute to megakaryocyte-lineage skewing and leukemogenesis. Blood Advances. 2020; 4 (8): 1722-1736. doi:10.1182/bloodadvances.2019000978  
96.   Hayashi Makiko, Kuga Ayumi, Suzuki Mikiko, et al. Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors. Cancer Research. 2020; 80 (16): 3331-3344. doi:10.1158/0008-5472.CAN-19-2888  
97.   Saigusa Daisuke, Motoike Ikuko N., Saito Sakae, et al. Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites. Cancer Science. 2020; 111 (2): 667-678. doi:10.1111/cas.14278  
98.   Yokose Takahiro, Kabe Yasuaki, Matsuda Atsushi, et al. O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer. Cancers. 2020; 12 (9): 2469. doi:10.3390/cancers12092469  
99.   Taguchi Keiko, Yamamoto Masayuki. The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment. Cancers. 2020; 13 (1): 46. doi:10.3390/cancers13010046  
100.   Afshinnekoo Ebrahim, Scott Ryan T., MacKay Matthew J., et al. Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. Cell. 2020; 183 (5): 1162-1184. doi:10.1016/j.cell.2020.10.050  
101.   Matsunaga Hiroshi, Ito Kaoru, Akiyama Masato, et al. Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease. Circulation: Genomic and Precision Medicine. 2020; 13 (3): . doi:10.1161/CIRCGEN.119.002670  
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