Tohoku University Tohoku Medical Megabank Organization (Masatsugu Orui)
2026.01.21

1.   Orui Masatsugu, Kogure Mana, Kotozaki Yuka, et al. Screening for Psychological Distress, Disaster-Related Experiences, and Newly Developed Mental Disorders among Residents Affected by the Great East Japan Earthquake: Implications for Suicide Prevention. JMA Journal. 2026; 9 (1): . doi:10.31662/jmaj.2025-0257  
2.   Ishikuro Mami, Fuse Nobuo, Obara Taku, et al. Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study. AJO International. 2025; 2 (1): 100088. doi:10.1016/j.ajoint.2024.100088  
3.   Kawaguchi Chikana, Ozawa Maki, Hidaka Takanori, et al. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Allergology International. 2025; 74 (2): 246-253. doi:10.1016/j.alit.2024.09.008  
4.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. BMJ Public Health. 2025; 3 (1): e001746. doi:10.1136/bmjph-2024-001746  
5.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. Cardiovascular Diabetology. 2025; 24 (1): 335. doi:10.1186/s12933-025-02849-8  
6.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; 89 (6): CJ-24-0780. doi:10.1253/circj.CJ-24-0780  
7.   Hatanaka Rieko, Nakaya Naoki, Tokioka Sayuri, et al. Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization. Circulation Reports. 2025; : CR-25-0263. doi:10.1253/circrep.CR-25-0263  
8.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. Clinical Kidney Journal. 2025; 18 (10): . doi:10.1093/ckj/sfaf275  
9.   Suzuki Satoko, Arita Ryutaro, Obara Taku, et al. Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study. Frontiers in Pharmacology. 2025; 16 : . doi:10.3389/fphar.2025.1562724  
10.   Shinoda Genki, Obara Taku, Takahashi Ippei, et al. Genome‐Wide Association Study of Cognitive Function in Population‐Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. Genes, Brain and Behavior. 2025; 24 (5): . doi:10.1111/gbb.70038  
11.   Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974  
12.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. Hypertension Research. 2025; 48 (10): 2606-2617. doi:10.1038/s41440-025-02314-9  
13.   Hatanaka Rieko, Nakaya Naoki, Kogure Mana, et al. Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study. Hypertension Research. 2025; : . doi:10.1038/s41440-025-02436-0  
14.   Obara Taku, Ishikuro Mami, Noda Aoi, et al. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International Journal of Epidemiology. 2025; 54 (5): . doi:10.1093/ije/dyaf148  
15.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy. JAMA Network Open. 2025; 8 (11): e2545719. doi:10.1001/jamanetworkopen.2025.45719  
16.   Mustakim, Ishikuro Mami, Kawaguchi Chikana, et al. Small for gestational age by grandmaternal smoking during pregnancy: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Developmental Origins of Health and Disease. 2025; 16 : e46. doi:10.1017/S2040174425100305  
17.   Sakakibara Koichi, Kawahara Tomoki, Nawa Nobutoshi, et al. Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study. Journal of Diabetes Investigation. 2025; 16 (10): 1900-1909. doi:10.1111/jdi.70101  
18.   Sawahashi Motoi, Kakuta Yoichi, Naito Takeo, et al. Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis. Journal of Gastroenterology. 2025; 60 (9): 1108-1117. doi:10.1007/s00535-025-02263-7  
19.   Kawahara Tomoki, Nawa Nobutoshi, Murakami Keiko, et al. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. Journal of Human Genetics. 2025; 70 (5): 265-273. doi:10.1038/s10038-025-01330-4  
20.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. Nutrition. 2025; 135 : 112739. doi:10.1016/j.nut.2025.112739  
21.   Fuse Nobuo, Anzawa Hayato, Sakurai Miyuki, et al. Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. Ophthalmology Science. 2025; 5 (5): 100821. doi:10.1016/j.xops.2025.100821  
22.   Morishita Kei, Obara Taku, Ishikawa Tomofumi, et al. Association of Quinolone Exposure in the First‐Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan. Pharmacoepidemiology and Drug Safety. 2025; 34 (9): . doi:10.1002/pds.70190  
23.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy. Pharmacoepidemiology and Drug Safety. 2025; 34 (11): . doi:10.1002/pds.70251  
24.   Ohseto Hisashi, Ishikuro Mami, Shinoda Genki, et al. The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women. Placenta. 2025; 172 : 100-103. doi:10.1016/j.placenta.2025.10.017  
25.   Orui Masatsugu, Ishikuro Mami, Obara Taku, et al. Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large‐scale community‐based cohort study. Psychiatry and Clinical Neurosciences Reports. 2025; 4 (2): . doi:10.1002/pcn5.70095  
26.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2025; 64 (5): 2591-2600. doi:10.1093/rheumatology/keae492  
27.   Ohseto Hisashi, Ishikuro Mami, Obara Taku, et al. Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. Scientific Reports. 2025; 15 (1): 13743. doi:10.1038/s41598-025-97291-x  
28.   Ohseto Hisashi, Ishikuro Mami, Chen Geng, et al. Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. Scientific Reports. 2025; 15 (1): 18924. doi:10.1038/s41598-025-03652-x  
29.   Sutoh Yoichi, Hachiya Tsuyoshi, Otsuka-Yamasaki Yayoi, et al. Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study. The American Journal of Human Genetics. 2025; 112 (8): 1852-1863. doi:10.1016/j.ajhg.2025.06.015  
30.   Kawaguchi Chikana, Ishikuro Mami, Saito Ryota, et al. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. The Journal of Clinical Endocrinology & Metabolism. 2025; 110 (10): e3425-e3432. doi:10.1210/clinem/dgae825  
31.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Journal of Nutrition. 2025; 155 (5): 1498-1507. doi:10.1016/j.tjnut.2025.02.024  
32.   Khaing Phue Thet, Han Yin May Zin, Zaww Kyaw, et al. A Remote Access Qualitative Study Protocol to Investigate the Coping Strategies in the Mindset of the Affected Adults after the 2025 Myanmar Earthquake. The Tohoku Journal of Experimental Medicine. 2025; 267 (3): 2025.J130. doi:10.1620/tjem.2025.J130  
33.   Kobayashi Mika, Kobayashi Tomoko, Obara Taku, et al. Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J074. doi:10.1620/tjem.2025.J074  
34.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Acta Obstetricia et Gynecologica Scandinavica. 2024; 103 (6): 1192-1200. doi:10.1111/aogs.14820  
35.   Noji Yoshiaki, Hatanaka Rieko, Nakaya Naoki, et al. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. BMC Public Health. 2024; 24 (1): 714. doi:10.1186/s12889-024-18244-z  
36.   Takayama Jun, Makino Satoshi, Funayama Takamitsu, et al. A fine‐scale genetic map of the Japanese population. Clinical Genetics. 2024; 106 (3): 284-292. doi:10.1111/cge.14536  
37.   石黒 真美, 小原 拓, 黒田 真帆, et al. 東北メディカル・メガバンク計画三世代コホート調査:10年間の取り組みと周産期転帰のプロファイル. DOHaD研究. 2024; 12 (1): 11-17. doi:10.51067/dohad.12.1_11  
38.   Noda Aoi, Obara Taku, Matsuzaki Fumiko, et al. Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. Drugs - Real World Outcomes. 2024; 11 (2): 263-272. doi:10.1007/s40801-023-00411-0  
39.   Noda Aoi, Obara Taku, Shirota Matsuyuki, et al. Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. European Journal of Clinical Pharmacology. 2024; 80 (8): 1171-1180. doi:10.1007/s00228-024-03685-7  
40.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8  
41.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. Hypertension Research. 2024; 47 (11): 2989-3000. doi:10.1038/s41440-024-01790-9  
42.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; 47 (6): 1533-1545. doi:10.1038/s41440-024-01582-1  
43.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8  
44.   Himuro Hiromi, Kogure Mana, Nakaya Naoki, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension Research. 2024; 47 (11): 3025-3034. doi:10.1038/s41440-024-01827-z  
45.   Orui Masatsugu, Obara Taku, Ishikuro Mami. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. JMA Journal. 2024; 7 (3): 353-363. doi:10.31662/jmaj.2024-0043  
46.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906  
47.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; 31 (6): 64535. doi:10.5551/jat.64535  
48.   Takahashi Ippei, Obara Taku, Ishikuro Mami, et al. Prospective associations of screen time at age 2 with specific behavioral subscales at age 3: a cohort study. Journal of Public Health. 2024; 46 (4): 477-486. doi:10.1093/pubmed/fdae240  
49.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. The Use of Japanese Traditional (Kampo) Medicines Before and During Pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Pharmacoepidemiology and Drug Safety. 2024; 33 (10): . doi:10.1002/pds.70033  
50.   Takahashi Ippei, Obara Taku, Kikuchi Saya, et al. Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (3): . doi:10.1002/pcn5.226  
51.   Orui Masatsugu, Obara Taku, Ishikuro Mami, et al. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (4): . doi:10.1002/pcn5.70025  
52.   Sakurai Miyuki, Motoike Ikuko N., Hishinuma Eiji, et al. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. Scientific Reports. 2024; 14 (1): 15681. doi:10.1038/s41598-024-66180-0  
53.   Orui Masatsugu, Saeki Suzuka, Kozakai Yuki, et al. The Impact of the COVID-19 Pandemic on Suicide Rate Trends in the Tsunami-Disaster-Affected Area Following the Great East Japan Earthquake. Crisis. 2023; 44 (2): 93-99. doi:10.1027/0227-5910/a000832  
54.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
55.   Orui Masatsugu. Establishment of Training System to Cope with Mental Health and Social Issues in Disaster Recovery Public Housing After the Great East Japan Earthquake. Journal of Disaster Research. 2023; 18 (5): 485-491. doi:10.20965/jdr.2023.p0485  
56.   Orui Masatsugu. Disaster and Suicide Prevention Activities: A Literature Review Focused on Suicide-Related Outcomes. Journal of Suicidology. 2023; 18 (2): 518 - 528. doi:10.30126/JoS.202306_18(2).0004  
57.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Nutrition Journal. 2023; 23 (1): 268. doi:10.1186/s12884-023-05603-8