Tohoku University Tohoku Medical Megabank Organization (Masatsugu Orui)
2025.06.12

1.   Ishikuro Mami, Fuse Nobuo, Obara Taku, et al. Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study. AJO International. 2025; 2 (1): 100088. doi:10.1016/j.ajoint.2024.100088  
2.   Kawaguchi Chikana, Ozawa Maki, Hidaka Takanori, et al. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Allergology International. 2025; 74 (2): 246-253. doi:10.1016/j.alit.2024.09.008  
3.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. BMJ Public Health. 2025; 3 (1): e001746. doi:10.1136/bmjph-2024-001746  
4.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; 89 (6): CJ-24-0780. doi:10.1253/circj.CJ-24-0780  
5.   Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974  
6.   Sawahashi Motoi, Kakuta Yoichi, Naito Takeo, et al. Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis. Journal of Gastroenterology. 2025; : . doi:10.1007/s00535-025-02263-7  
7.   Kawahara Tomoki, Nawa Nobutoshi, Murakami Keiko, et al. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. Journal of Human Genetics. 2025; 70 (5): 265-273. doi:10.1038/s10038-025-01330-4  
8.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. Nutrition. 2025; 135 : 112739. doi:10.1016/j.nut.2025.112739  
9.   Fuse Nobuo, Anzawa Hayato, Sakurai Miyuki, et al. Genome-wide association study of intraocular pressure in population-based cohorts in Japan: The ToMMo Eye Study. Ophthalmology Science. 2025; : 100821. doi:10.1016/j.xops.2025.100821  
10.   Orui Masatsugu, Ishikuro Mami, Obara Taku, et al. Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large‐scale community‐based cohort study. Psychiatry and Clinical Neurosciences Reports. 2025; 4 (2): . doi:10.1002/pcn5.70095  
11.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2025; 64 (5): 2591-2600. doi:10.1093/rheumatology/keae492  
12.   Ohseto Hisashi, Ishikuro Mami, Obara Taku, et al. Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. Scientific Reports. 2025; 15 (1): 13743. doi:10.1038/s41598-025-97291-x  
13.   Ohseto Hisashi, Ishikuro Mami, Chen Geng, et al. Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. Scientific Reports. 2025; 15 (1): 18924. doi:10.1038/s41598-025-03652-x  
14.   Kawaguchi Chikana, Ishikuro Mami, Saito Ryota, et al. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. The Journal of Clinical Endocrinology & Metabolism. 2025; : . doi:10.1210/clinem/dgae825  
15.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Journal of Nutrition. 2025; 155 (5): 1498-1507. doi:10.1016/j.tjnut.2025.02.024  
16.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Acta Obstetricia et Gynecologica Scandinavica. 2024; 103 (6): 1192-1200. doi:10.1111/aogs.14820  
17.   Noji Yoshiaki, Hatanaka Rieko, Nakaya Naoki, et al. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. BMC Public Health. 2024; 24 (1): 714. doi:10.1186/s12889-024-18244-z  
18.   Takayama Jun, Makino Satoshi, Funayama Takamitsu, et al. A fine‐scale genetic map of the Japanese population. Clinical Genetics. 2024; 106 (3): 284-292. doi:10.1111/cge.14536  
19.   石黒 真美, 小原 拓, 黒田 真帆, et al. 東北メディカル・メガバンク計画三世代コホート調査:10年間の取り組みと周産期転帰のプロファイル. DOHaD研究. 2024; 12 (1): 11-17. doi:10.51067/dohad.12.1_11  
20.   Noda Aoi, Obara Taku, Matsuzaki Fumiko, et al. Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. Drugs - Real World Outcomes. 2024; 11 (2): 263-272. doi:10.1007/s40801-023-00411-0  
21.   Noda Aoi, Obara Taku, Shirota Matsuyuki, et al. Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. European Journal of Clinical Pharmacology. 2024; 80 (8): 1171-1180. doi:10.1007/s00228-024-03685-7  
22.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8  
23.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. Hypertension Research. 2024; 47 (11): 2989-3000. doi:10.1038/s41440-024-01790-9  
24.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; 47 (6): 1533-1545. doi:10.1038/s41440-024-01582-1  
25.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8  
26.   Himuro Hiromi, Kogure Mana, Nakaya Naoki, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension Research. 2024; 47 (11): 3025-3034. doi:10.1038/s41440-024-01827-z  
27.   Orui Masatsugu, Obara Taku, Ishikuro Mami. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. JMA Journal. 2024; 7 (3): 353-363. doi:10.31662/jmaj.2024-0043  
28.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906  
29.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; 31 (6): 64535. doi:10.5551/jat.64535  
30.   Takahashi Ippei, Obara Taku, Ishikuro Mami, et al. Prospective associations of screen time at age 2 with specific behavioral subscales at age 3: a cohort study. Journal of Public Health. 2024; 46 (4): 477-486. doi:10.1093/pubmed/fdae240  
31.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. The Use of Japanese Traditional (Kampo) Medicines Before and During Pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Pharmacoepidemiology and Drug Safety. 2024; 33 (10): . doi:10.1002/pds.70033  
32.   Takahashi Ippei, Obara Taku, Kikuchi Saya, et al. Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (3): . doi:10.1002/pcn5.226  
33.   Orui Masatsugu, Obara Taku, Ishikuro Mami, et al. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (4): . doi:10.1002/pcn5.70025  
34.   Sakurai Miyuki, Motoike Ikuko N., Hishinuma Eiji, et al. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. Scientific Reports. 2024; 14 (1): 15681. doi:10.1038/s41598-024-66180-0  
35.   Orui Masatsugu, Saeki Suzuka, Kozakai Yuki, et al. The Impact of the COVID-19 Pandemic on Suicide Rate Trends in the Tsunami-Disaster-Affected Area Following the Great East Japan Earthquake. Crisis. 2023; 44 (2): 93-99. doi:10.1027/0227-5910/a000832  
36.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
37.   Orui Masatsugu. Establishment of Training System to Cope with Mental Health and Social Issues in Disaster Recovery Public Housing After the Great East Japan Earthquake. Journal of Disaster Research. 2023; 18 (5): 485-491. doi:10.20965/jdr.2023.p0485  
38.   Orui Masatsugu. Disaster and Suicide Prevention Activities: A Literature Review Focused on Suicide-Related Outcomes. Journal of Suicidology. 2023; 18 (2): 518 - 528. doi:10.30126/JoS.202306_18(2).0004  
39.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Association between frequency of breakfast intake before and during pregnancy and developmental delays in children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Nutrition Journal. 2023; 22 (1): 66. doi:10.1186/s12937-023-00901-5