Tohoku University Tohoku Medical Megabank Organization (Masatsugu Orui)
2026.03.19

1.   Hatanaka Rieko, Nakaya Naoki, Tokioka Sayuri, et al. Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization. Circulation Reports. 2026; 8 (3): CR-25-0263. doi:10.1253/circrep.CR-25-0263  
2.   Uematsu Ami, Orui Masatsugu, Ishikuro Mami, et al. Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study. Clinical and Experimental Pediatrics. 2026; 69 (1): 36-45. doi:10.3345/cep.2025.01165  
3.   Hayashi Saki, Kogure Mana, Chiba Ippei, et al. Association of subjective and objective physical activity with home hypertension. Hypertension Research. 2026; : . doi:10.1038/s41440-026-02587-8  
4.   Hatanaka Rieko, Nakaya Naoki, Kogure Mana, et al. Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study. Hypertension Research. 2026; 49 (2): 303-314. doi:10.1038/s41440-025-02436-0  
5.   Fujioka Shunsuke, Takada Naoko, Yoshida Sayaka, et al. Distribution of axial length in Japanese children and adolescents aged 4 to 19 years. Japanese Journal of Ophthalmology. 2026; : . doi:10.1007/s10384-026-01328-1  
6.   Orui Masatsugu, Kogure Mana, Kotozaki Yuka, et al. Screening for Psychological Distress, Disaster-Related Experiences, and Newly Developed Mental Disorders among Residents Affected by the Great East Japan Earthquake: Implications for Suicide Prevention. JMA Journal. 2026; 9 (1): . doi:10.31662/jmaj.2025-0257  
7.   Duan Changrong, Yu Zhiqian, Li Xue, et al. Sex differences in the risk of autistic-related traits in toddlers born to mothers with perinatal depression: Evidence from human cohort and mouse study. Molecular Psychiatry. 2026; : . doi:10.1038/s41380-026-03456-z  
8.   Iwasaki Chikashi, Nakaya Kumi, Yamada Mitsuhiro, et al. Age-related factors associated with preserved ratio impaired spirometry: The Tohoku medical Megabank project community-based cohort study. Respiratory Investigation. 2026; 64 (1): 101343. doi:10.1016/j.resinv.2025.101343  
9.   Ohseto Hisashi, Inoue Kosuke, Takahashi Ippei, et al. Genome-wide association study of social isolation in 63,497 Japanese individuals from the general population. Translational Psychiatry. 2026; : . doi:10.1038/s41398-026-03896-9  
10.   Ishikuro Mami, Fuse Nobuo, Obara Taku, et al. Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study. AJO International. 2025; 2 (1): 100088. doi:10.1016/j.ajoint.2024.100088  
11.   Kawaguchi Chikana, Ozawa Maki, Hidaka Takanori, et al. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Allergology International. 2025; 74 (2): 246-253. doi:10.1016/j.alit.2024.09.008  
12.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. BMJ Public Health. 2025; 3 (1): e001746. doi:10.1136/bmjph-2024-001746  
13.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. Cardiovascular Diabetology. 2025; 24 (1): 335. doi:10.1186/s12933-025-02849-8  
14.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; 89 (6): CJ-24-0780. doi:10.1253/circj.CJ-24-0780  
15.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. Clinical Kidney Journal. 2025; 18 (10): . doi:10.1093/ckj/sfaf275  
16.   Shinoda Genki, Obara Taku, Takahashi Ippei, et al. Genome‐Wide Association Study of Cognitive Function in Population‐Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. Genes, Brain and Behavior. 2025; 24 (5): . doi:10.1111/gbb.70038  
17.   Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974  
18.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. Hypertension Research. 2025; 48 (10): 2606-2617. doi:10.1038/s41440-025-02314-9  
19.   Obara Taku, Ishikuro Mami, Noda Aoi, et al. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International Journal of Epidemiology. 2025; 54 (5): . doi:10.1093/ije/dyaf148  
20.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy. JAMA Network Open. 2025; 8 (11): e2545719. doi:10.1001/jamanetworkopen.2025.45719  
21.   Mustakim, Ishikuro Mami, Kawaguchi Chikana, et al. Small for gestational age by grandmaternal smoking during pregnancy: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Developmental Origins of Health and Disease. 2025; 16 : e46. doi:10.1017/S2040174425100305  
22.   Sakakibara Koichi, Kawahara Tomoki, Nawa Nobutoshi, et al. Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study. Journal of Diabetes Investigation. 2025; 16 (10): 1900-1909. doi:10.1111/jdi.70101  
23.   Sawahashi Motoi, Kakuta Yoichi, Naito Takeo, et al. Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis. Journal of Gastroenterology. 2025; 60 (9): 1108-1117. doi:10.1007/s00535-025-02263-7  
24.   Kawahara Tomoki, Nawa Nobutoshi, Murakami Keiko, et al. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. Journal of Human Genetics. 2025; 70 (5): 265-273. doi:10.1038/s10038-025-01330-4  
25.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. Nutrition. 2025; 135 : 112739. doi:10.1016/j.nut.2025.112739  
26.   Fuse Nobuo, Anzawa Hayato, Sakurai Miyuki, et al. Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. Ophthalmology Science. 2025; 5 (5): 100821. doi:10.1016/j.xops.2025.100821  
27.   Morishita Kei, Obara Taku, Ishikawa Tomofumi, et al. Association of Quinolone Exposure in the First‐Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan. Pharmacoepidemiology and Drug Safety. 2025; 34 (9): . doi:10.1002/pds.70190  
28.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy. Pharmacoepidemiology and Drug Safety. 2025; 34 (11): . doi:10.1002/pds.70251  
29.   Kunitoki Tadaharu, Sakai Takamasa, Ishikawa Tomofumi, et al. Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study. Pharmacoepidemiology and Drug Safety. 2025; 34 (12): . doi:10.1002/pds.70274  
30.   Ohseto Hisashi, Ishikuro Mami, Shinoda Genki, et al. The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women. Placenta. 2025; 172 : 100-103. doi:10.1016/j.placenta.2025.10.017  
31.   Orui Masatsugu, Ishikuro Mami, Obara Taku, et al. Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large‐scale community‐based cohort study. Psychiatry and Clinical Neurosciences Reports. 2025; 4 (2): . doi:10.1002/pcn5.70095  
32.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2025; 64 (5): 2591-2600. doi:10.1093/rheumatology/keae492  
33.   Ohseto Hisashi, Ishikuro Mami, Obara Taku, et al. Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. Scientific Reports. 2025; 15 (1): 13743. doi:10.1038/s41598-025-97291-x  
34.   Ohseto Hisashi, Ishikuro Mami, Chen Geng, et al. Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. Scientific Reports. 2025; 15 (1): 18924. doi:10.1038/s41598-025-03652-x  
35.   Sutoh Yoichi, Hachiya Tsuyoshi, Otsuka-Yamasaki Yayoi, et al. Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study. The American Journal of Human Genetics. 2025; 112 (8): 1852-1863. doi:10.1016/j.ajhg.2025.06.015  
36.   Kawaguchi Chikana, Ishikuro Mami, Saito Ryota, et al. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. The Journal of Clinical Endocrinology & Metabolism. 2025; 110 (10): e3425-e3432. doi:10.1210/clinem/dgae825  
37.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Journal of Nutrition. 2025; 155 (5): 1498-1507. doi:10.1016/j.tjnut.2025.02.024  
38.   Khaing Phue Thet, Han Yin May Zin, Zaww Kyaw, et al. A Remote Access Qualitative Study Protocol to Investigate the Coping Strategies in the Mindset of the Affected Adults after the 2025 Myanmar Earthquake. The Tohoku Journal of Experimental Medicine. 2025; 267 (3): 2025.J130. doi:10.1620/tjem.2025.J130  
39.   Kobayashi Mika, Kobayashi Tomoko, Obara Taku, et al. Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J074. doi:10.1620/tjem.2025.J074  
40.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Acta Obstetricia et Gynecologica Scandinavica. 2024; 103 (6): 1192-1200. doi:10.1111/aogs.14820  
41.   Noji Yoshiaki, Hatanaka Rieko, Nakaya Naoki, et al. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. BMC Public Health. 2024; 24 (1): 714. doi:10.1186/s12889-024-18244-z  
42.   Takayama Jun, Makino Satoshi, Funayama Takamitsu, et al. A fine‐scale genetic map of the Japanese population. Clinical Genetics. 2024; 106 (3): 284-292. doi:10.1111/cge.14536  
43.   石黒 真美, 小原 拓, 黒田 真帆, et al. 東北メディカル・メガバンク計画三世代コホート調査:10年間の取り組みと周産期転帰のプロファイル. DOHaD研究. 2024; 12 (1): 11-17. doi:10.51067/dohad.12.1_11  
44.   Noda Aoi, Obara Taku, Matsuzaki Fumiko, et al. Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. Drugs - Real World Outcomes. 2024; 11 (2): 263-272. doi:10.1007/s40801-023-00411-0  
45.   Noda Aoi, Obara Taku, Shirota Matsuyuki, et al. Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. European Journal of Clinical Pharmacology. 2024; 80 (8): 1171-1180. doi:10.1007/s00228-024-03685-7  
46.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8  
47.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. Hypertension Research. 2024; 47 (11): 2989-3000. doi:10.1038/s41440-024-01790-9  
48.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; 47 (6): 1533-1545. doi:10.1038/s41440-024-01582-1  
49.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8  
50.   Himuro Hiromi, Kogure Mana, Nakaya Naoki, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension Research. 2024; 47 (11): 3025-3034. doi:10.1038/s41440-024-01827-z  
51.   Orui Masatsugu, Obara Taku, Ishikuro Mami. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. JMA Journal. 2024; 7 (3): 353-363. doi:10.31662/jmaj.2024-0043  
52.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906  
53.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; 31 (6): 64535. doi:10.5551/jat.64535  
54.   Takahashi Ippei, Obara Taku, Ishikuro Mami, et al. Prospective associations of screen time at age 2 with specific behavioral subscales at age 3: a cohort study. Journal of Public Health. 2024; 46 (4): 477-486. doi:10.1093/pubmed/fdae240  
55.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. The Use of Japanese Traditional (Kampo) Medicines Before and During Pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Pharmacoepidemiology and Drug Safety. 2024; 33 (10): . doi:10.1002/pds.70033  
56.   Takahashi Ippei, Obara Taku, Kikuchi Saya, et al. Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (3): . doi:10.1002/pcn5.226  
57.   Orui Masatsugu, Obara Taku, Ishikuro Mami, et al. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (4): . doi:10.1002/pcn5.70025  
58.   Sakurai Miyuki, Motoike Ikuko N., Hishinuma Eiji, et al. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. Scientific Reports. 2024; 14 (1): 15681. doi:10.1038/s41598-024-66180-0  
59.   Orui Masatsugu, Saeki Suzuka, Kozakai Yuki, et al. The Impact of the COVID-19 Pandemic on Suicide Rate Trends in the Tsunami-Disaster-Affected Area Following the Great East Japan Earthquake. Crisis. 2023; 44 (2): 93-99. doi:10.1027/0227-5910/a000832  
60.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
61.   Orui Masatsugu. Establishment of Training System to Cope with Mental Health and Social Issues in Disaster Recovery Public Housing After the Great East Japan Earthquake. Journal of Disaster Research. 2023; 18 (5): 485-491. doi:10.20965/jdr.2023.p0485  
62.   Orui Masatsugu. Disaster and Suicide Prevention Activities: A Literature Review Focused on Suicide-Related Outcomes. Journal of Suicidology. 2023; 18 (2): 518 - 528. doi:10.30126/JoS.202306_18(2).0004  
63.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Nutrition Journal. 2023; 23 (1): 268. doi:10.1186/s12884-023-05603-8