Tohoku University Tohoku Medical Megabank Organization (Masahiro Hiratsuka)
2020.09.30

1.   Gutiérrez Rico Evelyn Marie, Kikuchi Aoi, Saito Takahiro, et al. CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity. Drug Metabolism and Pharmacokinetics. 2020; 35 (1): 89-101. doi:10.1016/j.dmpk.2019.07.003  
2.   Hishinuma Eiji, Gutiérrez Rico Evelyn, Hiratsuka Masahiro. In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase. Journal of Clinical Medicine. 2020; 9 (8): 2342. doi:10.3390/jcm9082342  
3.   Kumondai Masaki, Hishinuma Eiji, Gutiérrez Rico Evelyn Marie, et al. Heterologous expression of high-activity cytochrome P450 in mammalian cells. Scientific Reports. 2020; 10 (1): 14193. doi:10.1038/s41598-020-71035-5  
4.   Shimizu Makiko, Yoda Hiromi, Nakakuki Komei, et al. Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database. Drug Metabolism and Pharmacokinetics. 2019; 34 (5): 334-339. doi:10.1016/j.dmpk.2019.06.001  
5.   Watanabe Takashi, Saito Takahiro, Rico Evelyn Marie Gutiérrez, et al. Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation. Biochemical Pharmacology. 2018; 156 : 420-430. doi:10.1016/j.bcp.2018.09.010  
6.   Hishinuma Eiji, Narita Yoko, Saito Sakae, et al. Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals. Drug Metabolism and Disposition. 2018; 46 (8): 1083-1090. doi:10.1124/dmd.118.081737  
7.   Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003  
8.   Saito Takahiro, Gutiérrez Rico Evelyn Marie, Kikuchi Aoi, et al. Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation. Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 250-257. doi:10.1016/j.dmpk.2018.08.004  
9.   Kumondai Masaki, Hosono Hiroki, Maekawa Masamitsu, et al. Functional characterization of 9 CYP2A13 allelic variants by assessment of nicotine C -oxidation and coumarin 7-hydroxylation. Drug Metabolism and Pharmacokinetics. 2018; 33 (1): 82-89. doi:10.1016/j.dmpk.2017.11.004  
10.   Saito Takahiro, Kikuchi Aoi, Kaneko Akira, et al. Rapid and sensitive multiplex single-tube nested PCR for the identification of five human Plasmodium species. Parasitology International. 2018; 67 (3): 277-283. doi:10.1016/j.parint.2018.01.005  
11.   Hishinuma Eiji, Akai Fumika, Narita Yoko, et al. Functional characterization of 21 allelic variants of dihydropyrimidinase. Biochemical Pharmacology. 2017; 143 : 118-128. doi:10.1016/j.bcp.2017.06.121  
12.   Saito T, Honda M, Takahashi M, et al. Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid omega-hydroxylation. Drug Metab Pharmacokinet. 2015; 30 (1): 119-122. doi:10.1016/j.dmpk.2014.09.001