Tohoku University Tohoku Medical Megabank Organization (Keiko Taguchi)
2025.05.01

1.   ISHIDA Saeko, TAGUCHI Keiko, IIDA Ryuya, et al. Diverse Cre recombinase expression pattern in Albumin-Cre driver rats. Experimental Animals. 2025; : 24-0174. doi:10.1538/expanim.24-0174  
2.   Oshikiri Hiroyuki, Taguchi Keiko, Hirose Wataru, et al. Anticancer Effect of C19-Position Substituted Geldanamycin Derivatives Targeting NRF2-NQO1-activated Esophageal Squamous Cell Carcinoma. Molecular and Cellular Biology. 2025; 45 (2): 79-97. doi:10.1080/10985549.2024.2438817  
3.   Inose-Maruyama Atsushi, Irokawa Hayato, Takeda Kouki, et al. Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion. Cell Stress and Chaperones. 2024; 29 (3): 497-509. doi:10.1016/j.cstres.2024.05.003  
4.   Kowalik Marta Anna, Taguchi Keiko, Serra Marina, et al. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. Hepatology. 2024; 79 (4): 829-843. doi:10.1097/HEP.0000000000000568  
5.   Aoki Yu-ichi, Taguchi Keiko, Anzawa Hayato, et al. Whole blood transcriptome analysis for age- and gender-specific gene expression profiling in Japanese individuals. The Journal of Biochemistry. 2024; 175 (6): 611-627. doi:10.1093/jb/mvae008  
6.   Hirose Wataru, Horiuchi Makoto, Li Donghan, et al. Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium. Cellular and Molecular Gastroenterology and Hepatology. 2023; 15 (1): 153-178. doi:10.1016/j.jcmgh.2022.09.004  
7.   Shimizu Ritsuko, Hirano Ikuo, Hasegawa Atsushi, et al. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Communications Biology. 2023; 6 (1): 875. doi:10.1038/s42003-023-05251-w  
8.   Baird Liam, Taguchi Keiko, Zhang Anqi, et al. A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells. Redox Biology. 2023; 66 : 102845. doi:10.1016/j.redox.2023.102845  
9.   Edamitsu Tomohiro, Taguchi Keiko, Okuyama Ryuhei, Yamamoto Masayuki. AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis. Antioxidants. 2022; 11 (2): 227. doi:10.3390/antiox11020227  
10.   Hirose Wataru, Oshikiri Hiroyuki, Taguchi Keiko, Yamamoto Masayuki. The KEAP1-NRF2 System and Esophageal Cancer. Cancers. 2022; 14 (19): 4702. doi:10.3390/cancers14194702  
11.   Otsuki Akihito, Okamura Yasunobu, Ishida Noriko, et al. Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology. Communications Biology. 2022; 5 (1): 991. doi:10.1038/s42003-022-03953-1  
12.   Wakamori Shun, Taguchi Keiko, Nakayama Yuki, et al. Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening. Free Radical Biology and Medicine. 2022; 188 : 206-220. doi:10.1016/j.freeradbiomed.2022.06.239  
13.   Suzuki Norio, Iwamura Yuma, Nakai Taku, et al. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International. 2022; 101 (1): 92-105. doi:10.1016/j.kint.2021.09.031  
14.   Kuga Ayumi, Tsuchida Kouhei, Panda Harit, et al. The β -TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo. Molecular and Cellular Biology. 2022; 42 (7): 1-22. doi:10.1128/mcb.00563-21  
15.   Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6  
16.   Horiuchi Makoto, Taguchi Keiko, Hirose Wataru, et al. Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium. Molecular and Cellular Biology. 2021; 41 (2): 1-18. doi:10.1128/MCB.00536-20  
17.   Taguchi Keiko, Yamamoto Masayuki. The KEAP1–NRF2 System as a Molecular Target of Cancer Treatment. Cancers. 2020; 13 (1): 46. doi:10.3390/cancers13010046  
18.   Suzuki Takafumi, Uruno Akira, Yumoto Akane, et al. Nrf2 contributes to the weight gain of mice during space travel. Communications Biology. 2020; 3 (1): 496. doi:10.1038/s42003-020-01227-2  
19.   Yagishita Yoko, Fukutomi Toshiaki, Sugawara Akira, et al. Nrf2 Protects Pancreatic -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice. Diabetes. 2014; 63 (2): 605-618. doi:10.2337/db13-0909