Tohoku University Tohoku Medical Megabank Organization (Junichi Sugawara)
2021.09.17

1.   Uchida Yasuo, Higuchi Tomoya, Shirota Matsuyuki, et al. Identification and Validation of Combination Plasma Biomarker of Afamin, Fibronectin and Sex Hormone-Binding Globulin to Predict Pre-eclampsia. Biological and Pharmaceutical Bulletin. 2021; 44 (6): 804-815. doi:10.1248/bpb.b20-01043  
2.   Yonezawa Yudai, Ueno Fumihiko, Obara Taku, et al. Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan. British Journal of Nutrition. 2021; : 1-9. doi:10.1017/S0007114521002154  
3.   Usami Katsuki, Niimi Kanae, Matsuo Ayumi, et al. The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk. Cell Reports. 2021; 36 (10): 109655. doi:10.1016/j.celrep.2021.109655  
4.   Tanoue Kaou, Watanabe Zen, Nishigori Hidekazu, et al. The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake. Environmental Health and Preventive Medicine. 2021; 26 (1): 27. doi:10.1186/s12199-021-00944-2  
5.   Yonezawa Yudai, Obara Taku, Yamashita Takahiro, et al. Grain consumption before and during pregnancy and birth weight in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. European Journal of Clinical Nutrition. 2021; : . doi:10.1038/s41430-021-00939-w  
6.   Hirata Takumi, Kogure Mana, Tsuchiya Naho, et al. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. Hypertension Research. 2021; 44 (7): 858-865. doi:10.1038/s41440-021-00628-y  
7.   Kikuchi Saya, Murakami Keiko, Obara Taku, et al. One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Affective Disorders. 2021; 295 : 632-638. doi:10.1016/j.jad.2021.08.118  
8.   Ishikuro Mami, Obara Taku, Murakami Keiko, et al. Relation between disaster exposure, maternal characteristics, and obstetric outcomes: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Epidemiology. 2021; : JE20210052. doi:10.2188/jea.JE20210052  
9.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2021; : . doi:10.1038/s10038-021-00952-8  
10.   Yamauchi Takafumi, Ochi Daisuke, Matsukawa Naomi, et al. Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. Scientific Reports. 2021; 11 (1): 17777. doi:10.1038/s41598-021-97342-z  
11.   Okuda Hiroshi, Okamoto Koji, Abe Michiaki, et al. Genome-wide association study identifies new loci for albuminuria in the Japanese population. Clinical and Experimental Nephrology. 2020; 24 (8): 1-9. doi:10.1007/s10157-020-01884-x  
12.   Kogure Mana, Hirata Takumi, Nakaya Naoki, et al. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. Hypertension Research. 2020; 43 (1): 62-71. doi:10.1038/s41440-019-0335-2  
13.   Hirata Takumi, Nakamura Tomohiro, Kogure Mana, et al. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. Hypertension Research. 2020; 43 (1): 23-29. doi:10.1038/s41440-019-0329-0  
14.   Kobayashi Natsuko, Nemoto Harumi, Seto Moe, et al. Experiences of perinatal women and public healthcare providers in a community affected by the great east Japan earthquake and tsunami: Concerns that must be considered for the mental healthcare of perinatal women in postdisaster settings. International Journal of Disaster Risk Reduction. 2020; 51 : 101767. doi:10.1016/j.ijdrr.2020.101767  
15.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
16.   Itabashi Fumi, Hirata Takumi, Kogure Mana, et al. Combined associations of liver enzymes and obesity with diabetes mellitus prevalence: The Tohoku Medical Megabank Community-based Cohort Study. Journal of Epidemiology. 2020; : . doi:10.2188/jea.JE20200384  
17.   Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Epidemiology. 2020; : . doi:10.2188/jea.JE20200338  
18.   Shirota Matsuyuki, Saigusa Daisuke, Yamashita Riu, et al. Longitudinal plasma amino acid profiling with maternal genomic background throughout human pregnancy. Medical Mass Spectrometry. 2020; 4 (1): 36-49. doi:10.24508/mms.2020.06.001  
19.   Yonezawa Yudai, Obara Taku, Yamashita Takahiro, et al. Fruit and vegetable consumption before and during pregnancy and birth weight of new-borns in Japan: the Tohoku medical megabank project birth and three-generation cohort study. Nutrition Journal. 2020; 19 (1): 80. doi:10.1186/s12937-020-00595-z  
20.   Wagata Maiko, Ishikuro Mami, Obara Taku, et al. Low birth weight and abnormal pre-pregnancy body mass index were at higher risk for hypertensive disorders of pregnancy. Pregnancy Hypertension. 2020; 22 : 119-125. doi:10.1016/j.preghy.2020.08.001  
21.   Nishizawa Ayako, Kumada Kazuki, Tateno Keiko, et al. Analysis of HLA-G long-read genomic sequences in mother–offspring pairs with preeclampsia. Scientific Reports. 2020; 10 (1): 20027. doi:10.1038/s41598-020-77081-3  
22.   Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97  
23.   Yamakage Shu, Oe Yuji, Sekimoto Akiyo, et al. Protease-activated receptor 2 contributes to placental development and fetal growth in mice. Thrombosis Research. 2020; 193 : 173-179. doi:10.1016/j.thromres.2020.06.039  
24.   Imaruoka Kenta, Oe Yuji, Fushima Tomofumi, et al. Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide. Biochemical and Biophysical Research Communications. 2019; 510 (4): 587-593. doi:10.1016/j.bbrc.2019.01.110  
25.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): e025939. doi:10.1136/bmjopen-2018-025939  
26.   Oe Yuji, Fushima Tomofumi, Sato Emiko, et al. Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury. Scientific Reports. 2019; 9 (1): 2986. doi:10.1038/s41598-019-39914-8  
27.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
28.   Mimori Takahiro, Yasuda Jun, Kuroki Yoko, et al. Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing. The Pharmacogenomics Journal. 2019; 19 (2): 136-146. doi:10.1038/s41397-017-0010-4  
29.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
30.   Ishikawa Tomofumi, Obara Taku, Nishigori Hidekazu, et al. Antihypertensives prescribed for pregnant women in Japan: Prevalence and timing determined from a database of health insurance claims. Pharmacoepidemiology and Drug Safety. 2018; 27 (12): 1325-1334. doi:10.1002/pds.4654  
31.   Yodsurang Varalee, Tang Yaqi, Takahashi Yukie, et al. Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13.1. PLOS ONE. 2018; 13 (12): e0209096. doi:10.1371/journal.pone.0209096  
32.   Sugawara Junichi, Iwama Noriyuki, Hoshiai Tetsuro, et al. Regional Birth Outcomes after the 2011 Great East Japan Earthquake and Tsunami in Miyagi Prefecture. Prehospital and Disaster Medicine. 2018; 33 (2): 215-219. doi:10.1017/S1049023X18000183  
33.   Nishigori Hidekazu, Nishigori Toshie, Sakurai Kasumi, et al. Pregnant Women’s Awareness of Social Capital in the Great East Japan Earthquake-Affected Areas of Miyagi Prefecture: The Japan Environment and Children’s Study. Disaster Medicine and Public Health Preparedness. 2017; 11 (3): 355-364. doi:10.1017/dmp.2016.150  
34.   Iwama Noriyuki, Metoki Hirohito, Ohkubo Takayoshi, et al. Maternal clinic and home blood pressure measurements during pregnancy and infant birth weight: the BOSHI study. Hypertension Research. 2016; 39 (3): 151-157. doi:10.1038/hr.2015.108  
35.   Watanabe Zen, Iwama Noriyuki, Nishigori Hidekazu, et al. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study. Journal of Affective Disorders. 2016; 190 : 341-348. doi:10.1016/j.jad.2015.10.024  
36.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
37.   Saigusa Daisuke, Okamura Yasunobu, Motoike Ikuko N., et al. Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLOS ONE. 2016; 11 (8): e0160555. doi:10.1371/journal.pone.0160555  
38.   Sugawara Junichi, Hoshiai Tetsuro, Sato Kazuyo, et al. Impact of the Great East Japan Earthquake on Regional Obstetrical Care in Miyagi Prefecture. Prehospital and Disaster Medicine. 2016; 31 (3): 255-258. doi:10.1017/S1049023X1600025X  
39.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
40.   Nishigori Hidekazu, Sasaki Michiho, Obara Taku, et al. Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan. Disaster medicine and public health preparedness. 2015; 9 (3): 307-12. doi:0.1017/dmp.2015.51  
41.   Tadakawa Mari, Sugawara Junichi, Saito Masatoshi, et al. Fertility and pregnancy outcomes following B-Lynch sutures for post-partum hemorrhage. Journal of Obstetrics and Gynaecology Research. 2015; 41 (4): 559-564. doi:10.1111/jog.12590  
42.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018  
43.   Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297  
44.   Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123  
45.   西本 光男, 湊 敬道, 高橋 聡太, et al. 経腟穿刺採卵から2か月後に卵巣膿瘍となった子宮内膜症合併不妊の1例. 岩手県立病院医学会雑誌. 2015; 55 (1): 35-39. http://jglobal.jst.go.jp/public/201502208333918994  
46.   Nishigori Hidekazu, Sugawara Junichi, Obara Taku, et al. Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake. Archives of Women's Mental Health. 2014; 17 (6): 579-581. doi:10.1007/s00737-014-0459-y  
47.   Suenaga Kaori, Kitahara Shuji, Suzuki Yasuhiro, et al. Role of the Vasohibin Family in the Regulation of Fetoplacental Vascularization and Syncytiotrophoblast Formation. PLoS ONE. 2014; 9 (9): e104728. doi:10.1371/journal.pone.0104728  
48.   黒澤 靖大, 濱田 裕貴, 菅原 準一. 【異常の早期発見 胎児心拍数モニタリングの読み方 医師との共通認識、冷静な判断につながる最新知識】 飛び込み分娩で救急搬送され、胎児心拍数異常から緊急帝王切開となった事例. 臨床助産ケア:スキルの強化. 2014; 6 (5): 31-38.  
49.   菅原 準一. 東北メディカル・メガバンク事業―次世代の医療モデルを実現するために―. 宮城県産婦人科医会誌. 2013; 120 : 6-9.  
50.   菅原 準一. 3.11 周産期医療に何が起こったか. 石川産科婦人科学会雑誌. 2013; 3 : 18-19.  
51.   菅原 準一. プライマリケアがお産を守る!大震災後の周産期医療と東北メディカル・メガバンク事業 災害時に母児を守る!その医療活動から見えてきたもの. 日本医事新報. 2013; 4637 : 25-29. http://www.jmedj.co.jp/article/detail.php?article_id=16019