Tohoku University Tohoku Medical Megabank Organization (Ippei Chiba)
2025.12.26

1.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Has the impact of cigarette smoking on mortality been underestimated by overlooking second-hand smoke? Tohoku medical megabank community-based cohort study. BMJ Public Health. 2025; 3 (1): e001746. doi:10.1136/bmjph-2024-001746  
2.   Nishimura Takayuki, Kunikata Hiroshi, Takada Naoko, et al. Exploring risk factors for axial length elongation: a population-based cohort study of 9195 eyes in Japan. British Journal of Ophthalmology. 2025; : bjo-2025-327213. doi:10.1136/bjo-2025-327213  
3.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study. Cardiovascular Diabetology. 2025; 24 (1): 335. doi:10.1186/s12933-025-02849-8  
4.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; 89 (6): CJ-24-0780. doi:10.1253/circj.CJ-24-0780  
5.   Hatanaka Rieko, Nakaya Naoki, Tokioka Sayuri, et al. Establishment of Ascertainment Methods for Cardiovascular Disease Onset in the Tohoku Medical Megabank Organization. Circulation Reports. 2025; : CR-25-0263. doi:10.1253/circrep.CR-25-0263  
6.   Takase Masato, Nakaya Naoki, Kogure Mana, et al. Effect of healthy lifestyle on renal dysfunction risk: interactions with genetic risk. Clinical Kidney Journal. 2025; 18 (10): . doi:10.1093/ckj/sfaf275  
7.   Nakaya Naoki, Nakajima Ryuto, Nakaya Kumi, et al. Physical, Mental, And Socioeconomic Factors That Promote Tsunami Evacuation: A Tohoku Medical Megabank Project. Disaster Medicine and Public Health Preparedness. 2025; 19 : e307. doi:10.1017/dmp.2025.10242  
8.   Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974  
9.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension. Hypertension Research. 2025; 48 (10): 2606-2617. doi:10.1038/s41440-025-02314-9  
10.   Hatanaka Rieko, Nakaya Naoki, Kogure Mana, et al. Population attributable fraction of all-cause mortality due to non-normal blood pressure: results from the 2013 to 2016 baseline survey of the TMM CommCohort Study. Hypertension Research. 2025; : . doi:10.1038/s41440-025-02436-0  
11.   Obara Taku, Ishikuro Mami, Noda Aoi, et al. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International Journal of Epidemiology. 2025; 54 (5): . doi:10.1093/ije/dyaf148  
12.   Nakaya Naoki, Nakaya Kumi, Kogure Mana, et al. Degree of housing damage caused by the Great East Japan Earthquake and all-cause mortality in the community-based cohort study of the Tohoku Medical Megabank Project. Journal of Epidemiology and Community Health. 2025; 79 (6): 451-458. doi:10.1136/jech-2024-223084  
13.   Nakaya Naoki, Nakaya Kumi, Sone Toshimasa, et al. Concordance of Cancer Screening Attendance Among Spouse Couples: A Cross‐Sectional Survey of the Tohoku Medical Megabank Project. Psycho-Oncology. 2025; 34 (5): . doi:10.1002/pon.70158  
14.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2025; 64 (5): 2591-2600. doi:10.1093/rheumatology/keae492  
15.   Chiba Ippei, Nakaya Naoki, Kogure Mana, et al. Associations between leisure time, non-leisure time physical activity, and kidney function in Japanese adults: a cross-sectional study. BMC Nephrology. 2024; 25 (1): 354. doi:10.1186/s12882-024-03813-6  
16.   Noji Yoshiaki, Hatanaka Rieko, Nakaya Naoki, et al. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. BMC Public Health. 2024; 24 (1): 714. doi:10.1186/s12889-024-18244-z  
17.   Akaishi Tetsuya, Nakaya Kumi, Nakaya Naoki, et al. Low Hemoglobin Level and Elevated Inflammatory Hematological Ratios Associated With Depression and Sleep Disturbance. Cureus. 2024; : . doi:10.7759/cureus.56621  
18.   Chiba Ippei, Nakaya Naoki, Kogure Mana, et al. Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community‐based cohort study. Geriatrics & Gerontology International. 2024; 24 (6): 509-516. doi:10.1111/ggi.14867  
19.   Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8  
20.   Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study. Hypertension Research. 2024; 47 (11): 2989-3000. doi:10.1038/s41440-024-01790-9  
21.   Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; 47 (6): 1533-1545. doi:10.1038/s41440-024-01582-1  
22.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8  
23.   Himuro Hiromi, Kogure Mana, Nakaya Naoki, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension Research. 2024; 47 (11): 3025-3034. doi:10.1038/s41440-024-01827-z  
24.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906  
25.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; 31 (6): 64535. doi:10.5551/jat.64535  
26.   Takase Masato, Yamada Mitsuhiro, Nakamura Tomohiro, et al. Combined Fat Mass and Fat-free Mass Indices and Lung Function Among Japanese Population: The Tohoku Medical Megabank Community-based Cohort Study. Journal of Epidemiology. 2024; 34 (3): JE20220355. doi:10.2188/jea.JE20220355  
27.   Hozawa Atsushi, Nakaya Kumi, Nakaya Naoki, et al. Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture. Journal of Epidemiology. 2024; 34 (9): JE20230241. doi:10.2188/jea.JE20230241  
28.   Nakaya Kumi, Nakaya Naoki, Kogure Mana, et al. Factors Associated With the Prevalence of Irritable Bowel Syndrome: The Miyagi Part of the Tohoku Medical Megabank Project Community-based Cohort Study. Journal of Neurogastroenterology and Motility. 2024; 30 (2): 208-219. doi:10.5056/jnm23090  
29.   Makino Keitaro, Raina Parminder, Griffith Lauren E., et al. Physical frailty and survival time after the onset of functional disability: Is there a sex difference?. Journal of the American Geriatrics Society. 2024; 72 (2): 399-409. doi:10.1111/jgs.18725  
30.   Orui Masatsugu, Obara Taku, Ishikuro Mami, et al. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (4): . doi:10.1002/pcn5.70025  
31.   Sato Shuichi, Imaeda Takao, Mugikura Shunji, et al. Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study. Scientific Reports. 2024; 14 (1): 19138. doi:10.1038/s41598-024-69726-4  
32.   Katayama Osamu, Lee Sangyoon, Bae Seongryu, et al. Differential effects of lifestyle activities on disability incidence based on neighborhood amenities. BMC Geriatrics. 2023; 23 (1): 483. doi:10.1186/s12877-023-04170-z  
33.   Chiba Ippei, Takahashi Masayoshi, Lee Sangyoon, et al. Association between COVID-19 emergency declarations and physical activity among community-dwelling older adults enrolled in a physical activity measurement program: Evidence from a retrospective observational study using the regression discontinuity desig. BMC Public Health. 2023; 23 (1): 998. doi:10.1186/s12889-023-15932-0  
34.   Hatanaka Rieko, Nakaya Naoki, Kogure Mana, et al. The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study. Hypertension Research. 2023; 46 (12): 2718-2728. doi:10.1038/s41440-023-01454-0  
35.   Sato Shuichi, Imaeda Takao, Mugikura Shunji, et al. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study. Journal of Alzheimer's Disease. 2023; 95 (4): 1469-1480. doi:10.3233/JAD-230318  
36.   Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64151. doi:10.5551/jat.64151  
37.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (10): 64039. doi:10.5551/jat.64039  
38.   Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425  
39.   Bae Seongryu, Shimada Hiroyuki, Lee Sangyoon, et al. Subjective Cognitive Decline and Frailty Trajectories and Influencing Factors in Japanese Community-Dwelling Older Adults: A Longitudinal Study. Journal of Clinical Medicine. 2023; 12 (18): 5803. doi:10.3390/jcm12185803  
40.   Takase Masato, Yamada Mitsuhiro, Nakamura Tomohiro, et al. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Hypertension. 2023; 41 (3): 443-452. doi:10.1097/HJH.0000000000003356  
41.   Seo Kanako, Takayanagi Naoto, Sudo Motoki, et al. Association between daily gait speed patterns and cognitive impairment in community-dwelling older adults. Scientific Reports. 2023; 13 (1): 2783. doi:10.1038/s41598-023-29805-4  
42.   Katayama Osamu, Lee Sangyoon, Bae Seongryu, et al. A simple algorithm to predict disability in community-dwelling older Japanese adults. Archives of Gerontology and Geriatrics. 2022; 103 : 104778. doi:10.1016/j.archger.2022.104778  
43.   Katayama Osamu, Lee Sangyoon, Bae Seongryu, et al. The association between social activity and physical frailty among community-dwelling older adults in Japan. BMC Geriatrics. 2022; 22 (1): 870. doi:10.1186/s12877-022-03563-w  
44.   Tomida Kouki, Lee Sangyoon, Bae Seongryu, et al. Association of Dual Sensory Impairment with Cognitive Decline in Older Adults. Dementia and Geriatric Cognitive Disorders. 2022; 51 (4): 322-330. doi:10.1159/000525820  
45.   Katayama Osamu, Lee Sangyoon, Bae Seongryu, et al. Differences in Subjective and Objective Cognitive Decline Outcomes Are Associated with Modifiable Protective Factors: A 4-Year Longitudinal Study. Journal of Clinical Medicine. 2022; 11 (24): 7441. doi:10.3390/jcm11247441