Tohoku University Tohoku Medical Megabank Organization (Hiroaki Tomita)
2022.05.17

1.   Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; : . https://www.jmaj.jp/detail.php?id=10.31662%2Fjmaj.2021-0156  
2.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2022; 67 (1): 9-17. doi:10.1038/s10038-021-00952-8  
3.   Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113  
4.   Murakami Keiko, Ishikuro Mami, Obara Taku, et al. Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Scientific Reports. 2022; 12 (1): 6400. doi:10.1038/s41598-022-09944-w  
5.   Ishikuro Mami, Noda Aoii, Murakami Keiko, et al. Families’ Health after the Great East Japan Earthquake: Findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Tohoku Journal of Experimental Medicine. 2022; 256 (2): 93-101. doi:10.1620/tjem.256.93  
6.   Komatsu Hiroshi, Ono Takashi, Onoguchi Goh, et al. Mediating effects of self-stigma and depression on the association between autistic symptoms and recovery in patients with schizophrenia-spectrum disorders: a cross-sectional study. BMC Psychiatry. 2021; 21 (1): 464. doi:10.1186/s12888-021-03472-z  
7.   Kotozaki Yuka, Tanno Kozo, Sakata Kiyomi, et al. Association between the social isolation and depressive symptoms after the great East Japan earthquake: findings from the baseline survey of the TMM CommCohort study. BMC Public Health. 2021; 21 (1): 925. doi:10.1186/s12889-021-10896-5  
8.   Kikuchi Saya, Kobayashi Natsuko, Watanabe Zen, et al. The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms. Depression and Anxiety. 2021; 38 (4): 422-430. doi:10.1002/da.23134  
9.   Akaishi Tetsuya, Suzuki Tomomi, Nemoto Harumi, et al. Five-Year Psychosocial Impact of Living in Postdisaster Prefabricated Temporary Housing. Disaster Medicine and Public Health Preparedness. 2021; : 1-9. doi:10.1017/dmp.2021.214  
10.   Komatsu Hiroshi, Takeuchi Hikaru, Ono Chiaki, et al. Association Between OLIG2 Gene SNP rs1059004 and Negative Self-Schema Constructing Trait Factors Underlying Susceptibility to Depression. Frontiers in Psychiatry. 2021; 12 : . doi:10.3389/fpsyt.2021.631475  
11.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
12.   Kikuchi Saya, Murakami Keiko, Obara Taku, et al. One-year trajectories of postpartum depressive symptoms and associated psychosocial factors: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Affective Disorders. 2021; 295 : 632-638. doi:10.1016/j.jad.2021.08.118  
13.   Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271  
14.   Kobayashi Natsuko, Nemoto Harumi, Seto Moe, et al. Experiences of perinatal women and public healthcare providers in a community affected by the great east Japan earthquake and tsunami: Concerns that must be considered for the mental healthcare of perinatal women in postdisaster settings. International Journal of Disaster Risk Reduction. 2020; 51 : 101767. doi:10.1016/j.ijdrr.2020.101767  
15.   Katayanagi Mitsuaki, Seto Moe, Nakaya Naoki, et al. Impact of the Great East Japan Earthquake on the Employment Status and Mental Health Conditions of Affected Coastal Communities. International Journal of Environmental Research and Public Health. 2020; 17 (21): 8130. doi:10.3390/ijerph17218130  
16.   Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169  
17.   Takahashi Yuta, Takeuchi Hikaru, Sakai Mai, et al. A single nucleotide polymorphism (−250 A/C) of the GFAP gene is associated with brain structures and cerebral blood flow. Psychiatry and Clinical Neurosciences. 2020; 74 (1): 49-55. doi:10.1111/pcn.12932  
18.   Komatsu Hiroshi, Takeuchi Hikaru, Kikuchi Yoshie, et al. Ethnicity-Dependent Effects of Schizophrenia Risk Variants of the OLIG2 Gene on OLIG2 Transcription and White Matter Integrity. Schizophrenia Bulletin. 2020; 46 (6): 1619-1628. doi:10.1093/schbul/sbaa049  
19.   Takahashi Yuta, Yoshizoe Kazuki, Ueki Masao, et al. Machine learning to reveal hidden risk combinations for the trajectory of posttraumatic stress disorder symptoms. Scientific Reports. 2020; 10 (1): 21726. doi:10.1038/s41598-020-78966-z  
20.   Utsumi Yusuke, Nemoto Harumi, Nakaya Naoki, et al. The Impact of Health Consciousness on the Association Between Walking Durations and Mental Health Conditions After a Disaster: a Cross-Sectional Study. Sports Medicine - Open. 2020; 6 (1): 30. doi:10.1186/s40798-020-00259-6  
21.   Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97  
22.   Takahashi Yuta, Ueki Masao, Yamada Makoto, et al. Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection. Translational Psychiatry. 2020; 10 (1): 157. doi:10.1038/s41398-020-0831-9  
23.   Takahashi Yuta, Ueki Masao, Tamiya Gen, et al. Machine learning for effectively avoiding overfitting is a crucial strategy for the genetic prediction of polygenic psychiatric phenotypes. Translational Psychiatry. 2020; 10 (1): 294. doi:10.1038/s41398-020-00957-5  
24.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Prefabricated Temporary Housing and Eczema or Respiratory Symptoms in Schoolchildren after the Great East Japan Earthquake: The ToMMo Child Health Study. Disaster Medicine and Public Health Preparedness. 2019; 13 (5-6): 905-911. doi:10.1017/dmp.2019.8  
25.   Nishiyama Takeshi, Nakatochi Masahiro, Goto Atsushi, et al. Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population. Sleep. 2019; 42 (6): . doi:10.1093/sleep/zsz046  
26.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
27.   Narita Akira, Nakaya Naoki, Nakamura Tomohiro, et al. [Association between mild physical injury and psychological distress: Shichigahama Health Promotion Project]. [Nihon koshu eisei zasshi] Japanese journal of public health. 2018; 65 (4): 157-163. doi:10.11236/jph.65.4_157  
28.   Kuniyoshi Yasutaka, Kikuya Masahiro, Miyashita Masako, et al. Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study. Allergology International. 2018; 67 (4): 481-486. doi:10.1016/j.alit.2018.02.009  
29.   Nakaya Naoki, Nemoto Harumi, Yi Carine, et al. Effect of tsunami drill experience on evacuation behavior after the onset of the Great East Japan Earthquake. International Journal of Disaster Risk Reduction. 2018; 28 : 206-213. doi:10.1016/j.ijdrr.2018.02.037  
30.   Sakai Mai, Takeuchi Hikaru, Yu Zhiqian, et al. Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain. Psychiatry and Clinical Neurosciences. 2018; 72 (6): 409-422. doi:10.1111/pcn.12649  
31.   Ishikuro Mami, Obara Taku, Osanai Tamae, et al. Strategic Methods for Recruiting Grandparents: The Tohoku Medical Megabank Birth and Three-Generation Cohort Study. The Tohoku Journal of Experimental Medicine. 2018; 246 (2): 97-105. doi:10.1620/tjem.246.97  
32.   Yu Zhiqian, Fukushima Hotaka, Ono Chiaki, et al. Microglial production of TNF-alpha is a key element of sustained fear memory. Brain, Behavior, and Immunity. 2017; 59 : 313-321. doi:10.1016/j.bbi.2016.08.011  
33.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Psychological Distress and the Risk of Withdrawing From Hypertension Treatment After an Earthquake Disaster. Disaster Medicine and Public Health Preparedness. 2017; 11 (2): 179-182. doi:10.1017/dmp.2016.102  
34.   Tsuchiya Naho, Nakaya Naoki, Nakamura Tomohiro, et al. Impact of social capital on psychological distress and interaction with house destruction and displacement after the Great East Japan Earthquake of 2011. Psychiatry and Clinical Neurosciences. 2017; 71 (1): 52-60. doi:10.1111/pcn.12467  
35.   Sakai Mai, Takahashi Yuta, Yu Zhiqian, Tomita Hiroaki. Microglial Gene Expression Alterations in the Brains of Patients with Psychiatric Disorders. Advances in Neuroimmune Biology. 2016; 6 (2): 83-93. doi:10.3233/NIB-160110  
36.   Takahashi Yuta, Yu Zhiqian, Sakai Mai, Tomita Hiroaki. Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders. Frontiers in Cellular Neuroscience. 2016; 10 : . doi:10.3389/fncel.2016.00144  
37.   Kuriyama Shinichi, Yaegashi Nobuo, Nagami Fuji, et al. The Tohoku Medical Megabank Project: Design and Mission. Journal of Epidemiology. 2016; 26 (9): 493-511. doi:10.2188/jea.JE20150268  
38.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Unemployment risk among individuals undergoing medical treatment for chronic diseases. Occupational Medicine. 2016; 66 (2): 143-149. doi:10.1093/occmed/kqv159  
39.   Yoshida Hirokazu, Kobayashi Natsuko, Honda Nami, et al. Post-traumatic growth of children affected by the Great East Japan Earthquake and their attitudes to memorial services and media coverage. Psychiatry and Clinical Neurosciences. 2016; 70 (5): 193-201. doi:10.1111/pcn.12379  
40.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. Prospect of future housing and risk of psychological distress at 1 year after an earthquake disaster. Psychiatry and Clinical Neurosciences. 2016; 70 (4): 182-189. doi:10.1111/pcn.12377  
41.   Nakaya Naoki, Narita Akira, Tsuchiya Naho, et al. Partners’ Ongoing Treatment for Chronic Disease and the Risk of Psychological Distress after the Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2016; 239 (4): 307-314. doi:10.1620/tjem.239.307  
42.   Lebowitz Adam, Tsai Athena Yi-Jung, Forester Brent P, et al. Possibilities for a Composite Approach: Summary of the Disaster Gerontology Panel at the International College of Geriatric Psychoneuropharmacology Annual Meeting (ICGP-2014). Disaster Medicine and Public Health Preparedness. 2015; 9 (5): 478-479. doi:10.1017/dmp.2015.87  
43.   Nakaya Naoki, Nakamura Tomohiro, Tsuchiya Naho, et al. The Association Between Medical Treatment of Physical Diseases and Psychological Distress After the Great East Japan Earthquake: The Shichigahama Health Promotion Project. Disaster Medicine and Public Health Preparedness. 2015; 9 (4): 374-381. doi:10.1017/dmp.2015.52  
44.   Takeuchi Hikaru, Tomita Hiroaki, Taki Yasuyuki, et al. The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences. Frontiers in Psychology. 2015; 6 : . doi:10.3389/fpsyg.2015.00912  
45.   Yu Zhiqian, Ono Chiaki, Aiba Setsuya, et al. Therapeutic concentration of lithium stimulates complement C3 production in dendritic cells and microglia via GSK-3 inhibition. Glia. 2015; 63 (2): 257-270. doi:10.1002/glia.22749  
46.   Nagasaki Masao, Yasuda Jun, Katsuoka Fumiki, et al. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals. Nature Communications. 2015; 6 (1): 8018. doi:10.1038/ncomms9018  
47.   Takeuchi Hikaru, Tomita Hiroaki, Taki Yasuyuki, et al. Cognitive and neural correlates of the 5-repeat allele of the dopamine D4 receptor gene in a population lacking the 7-repeat allele. NeuroImage. 2015; 110 : 124-135. doi:10.1016/j.neuroimage.2015.01.053  
48.   Moriya Yuki, Kasahara Yoshiyuki, Hall F. Scott, et al. Sex differences in the effects of adolescent social deprivation on alcohol consumption in μ-opioid receptor knockout mice. Psychopharmacology. 2015; 232 (8): 1471-1482. doi:10.1007/s00213-014-3784-y  
49.   Miyashita Masako, Kikuya Masahiro, Yamanaka Chizuru, et al. Eczema and Asthma Symptoms among Schoolchildren in Coastal and Inland Areas after the 2011 Great East Japan Earthquake: The ToMMo Child Health Study. The Tohoku Journal of Experimental Medicine. 2015; 237 (4): 297-305. doi:10.1620/tjem.237.297  
50.   Kikuya Masahiro, Miyashita Masako, Yamanaka Chizuru, et al. Protocol and Research Perspectives of the ToMMo Child Health Study after the 2011 Great East Japan Earthquake. The Tohoku Journal of Experimental Medicine. 2015; 236 (2): 123-130. doi:10.1620/tjem.236.123  
51.   Ono Chiaki, Yu Zhiqian, Kasahara Yoshiyuki, et al. Fluorescently Activated Cell Sorting Followed by Microarray Profiling of Helper T Cell Subtypes from Human Peripheral Blood. PLoS ONE. 2014; 9 (11): e111405. doi:10.1371/journal.pone.0111405  
52.   富田 博秋. 東日本大震災から4年目を控えて感じること. 精神医学. 2014; 56 (12): pp. 994----995. http://medicalfinder.jp/doi/abs/10.11477/mf.1405204062  
53.   富田 博秋. 災害精神医学に関する研究の課題. 精神神経学雑誌. 2014; : 116: 231--237, 2014. https://journal.jspn.or.jp/Disp?style=abst&vol=116&year=2014&mag=0&number=3&start=231