Tohoku University Tohoku Medical Megabank Organization (Genki Shinoda)
2026.02.20

1.   Takahashi Ippei, Obara Taku, Yamamoto Midori, et al. Bidirectional Associations of Screen Time with Externalizing and Internalizing Behaviors in Children: A Random Intercept Cross-Lagged Panel Model. American Journal of Epidemiology. 2026; : . doi:10.1093/aje/kwag023  
2.   Uematsu Ami, Orui Masatsugu, Ishikuro Mami, et al. Maternal sleep disorders during pregnancy and subsequent risk of allergic diseases in Japanese children: the TMM BirThree Cohort Study. Clinical and Experimental Pediatrics. 2026; 69 (1): 36-45. doi:10.3345/cep.2025.01165  
3.   Fujioka Shunsuke, Takada Naoko, Yoshida Sayaka, et al. Distribution of axial length in Japanese children and adolescents aged 4 to 19 years. Japanese Journal of Ophthalmology. 2026; : . doi:10.1007/s10384-026-01328-1  
4.   Orui Masatsugu, Kogure Mana, Kotozaki Yuka, et al. Screening for Psychological Distress, Disaster-Related Experiences, and Newly Developed Mental Disorders among Residents Affected by the Great East Japan Earthquake: Implications for Suicide Prevention. JMA Journal. 2026; 9 (1): . doi:10.31662/jmaj.2025-0257  
5.   Ishikuro Mami, Fuse Nobuo, Obara Taku, et al. Parental axial lengths and prenatal conditions related to child axial length: The TMM BirThree Cohort Study. AJO International. 2025; 2 (1): 100088. doi:10.1016/j.ajoint.2024.100088  
6.   Kawaguchi Chikana, Ozawa Maki, Hidaka Takanori, et al. Skin health survey on atopic dermatitis among Japanese children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Allergology International. 2025; 74 (2): 246-253. doi:10.1016/j.alit.2024.09.008  
7.   Suzuki Satoko, Arita Ryutaro, Obara Taku, et al. Association of first-trimester exposure to Kampo medicines containing Prunus persica kernel with preterm birth and major congenital malformations: a Japanese database study. Frontiers in Pharmacology. 2025; 16 : . doi:10.3389/fphar.2025.1562724  
8.   Shinoda Genki, Obara Taku, Takahashi Ippei, et al. Genome‐Wide Association Study of Cognitive Function in Population‐Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study. Genes, Brain and Behavior. 2025; 24 (5): . doi:10.1111/gbb.70038  
9.   Obara Taku, Ishikuro Mami, Noda Aoi, et al. Cohort Profile Update: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) 2023 update. International Journal of Epidemiology. 2025; 54 (5): . doi:10.1093/ije/dyaf148  
10.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Child Developmental Patterns by Age 4 Years Across Subtypes of Hypertensive Disorders of Pregnancy. JAMA Network Open. 2025; 8 (11): e2545719. doi:10.1001/jamanetworkopen.2025.45719  
11.   Mustakim, Ishikuro Mami, Kawaguchi Chikana, et al. Small for gestational age by grandmaternal smoking during pregnancy: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of Developmental Origins of Health and Disease. 2025; 16 : e46. doi:10.1017/S2040174425100305  
12.   Sakakibara Koichi, Kawahara Tomoki, Nawa Nobutoshi, et al. Household income modifies the association between social capital and gestational diabetes mellitus in Japan: Results from TMM BirThree Cohort Study. Journal of Diabetes Investigation. 2025; 16 (10): 1900-1909. doi:10.1111/jdi.70101  
13.   Kawahara Tomoki, Nawa Nobutoshi, Murakami Keiko, et al. Genetic effects on gestational diabetes mellitus and their interactions with environmental factors among Japanese women. Journal of Human Genetics. 2025; 70 (5): 265-273. doi:10.1038/s10038-025-01330-4  
14.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Exploring the association between human breast milk lipids and early adiposity rebound in children: A case-control study. Nutrition. 2025; 135 : 112739. doi:10.1016/j.nut.2025.112739  
15.   Takahashi Ippei, Shinoda Genki, Ueno Fumihiko, et al. Respiratory syncytial virus infection, non‐respiratory syncytial virus respiratory infections, and later wheezing. Pediatrics International. 2025; 67 (1): . doi:10.1111/ped.70050  
16.   Morishita Kei, Obara Taku, Ishikawa Tomofumi, et al. Association of Quinolone Exposure in the First‐Trimester of Pregnancy and the Risk of Major Congenital Malformations: A Health Administrative Database Study in Japan. Pharmacoepidemiology and Drug Safety. 2025; 34 (9): . doi:10.1002/pds.70190  
17.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. Perinatal Outcomes After the Use of Kampo Medicines Containing Ephedra During Pregnancy. Pharmacoepidemiology and Drug Safety. 2025; 34 (11): . doi:10.1002/pds.70251  
18.   Kunitoki Tadaharu, Sakai Takamasa, Ishikawa Tomofumi, et al. Risk of Major Congenital Malformations Associated With First‐Trimester Exposure to Topical Antifungal Medications: A Large Claims Database Study. Pharmacoepidemiology and Drug Safety. 2025; 34 (12): . doi:10.1002/pds.70274  
19.   Ohseto Hisashi, Ishikuro Mami, Shinoda Genki, et al. The relationship between preeclampsia subtypes and birth weight to placental weight ratio: Insights from a study of 17,709 pregnant Japanese women. Placenta. 2025; 172 : 100-103. doi:10.1016/j.placenta.2025.10.017  
20.   Orui Masatsugu, Ishikuro Mami, Obara Taku, et al. Longitudinal association between the duration of eye gaze fixation on social information and specific symptoms of neurodevelopmental disorders in children: A large‐scale community‐based cohort study. Psychiatry and Clinical Neurosciences Reports. 2025; 4 (2): . doi:10.1002/pcn5.70095  
21.   Ohseto Hisashi, Ishikuro Mami, Obara Taku, et al. Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study. Scientific Reports. 2025; 15 (1): 13743. doi:10.1038/s41598-025-97291-x  
22.   Ohseto Hisashi, Ishikuro Mami, Chen Geng, et al. Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. Scientific Reports. 2025; 15 (1): 18924. doi:10.1038/s41598-025-03652-x  
23.   Kawaguchi Chikana, Ishikuro Mami, Saito Ryota, et al. Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children. The Journal of Clinical Endocrinology & Metabolism. 2025; 110 (10): e3425-e3432. doi:10.1210/clinem/dgae825  
24.   Sawane Kento, Takahashi Ippei, Ishikuro Mami, et al. Association Between Human Milk Oligosaccharides and Early Adiposity Rebound in Children: A Case–Control Study of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. The Journal of Nutrition. 2025; 155 (5): 1498-1507. doi:10.1016/j.tjnut.2025.02.024  
25.   Shinoda Genki, Matsuzaki Fumiko, Ueno Fumihiko, et al. Impact of Telework on Health and Lifestyle Changes During the COVID-19 Pandemic in Japan. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J014. doi:10.1620/tjem.2025.J014  
26.   Chen Geng, Ishikuro Mami, Ohseto Hisashi, et al. Hypertensive disorders of pregnancy, neonatal outcomes and offspring developmental delay in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Acta Obstetricia et Gynecologica Scandinavica. 2024; 103 (6): 1192-1200. doi:10.1111/aogs.14820  
27.   石黒 真美, 小原 拓, 黒田 真帆, et al. 東北メディカル・メガバンク計画三世代コホート調査:10年間の取り組みと周産期転帰のプロファイル. DOHaD研究. 2024; 12 (1): 11-17. doi:10.51067/dohad.12.1_11  
28.   Noda Aoi, Obara Taku, Matsuzaki Fumiko, et al. Risk of Major Congenital Malformations Associated with the Use of Japanese Traditional (Kampo) Medicine Containing Ephedra During the First Trimester of Pregnancy. Drugs - Real World Outcomes. 2024; 11 (2): 263-272. doi:10.1007/s40801-023-00411-0  
29.   Noda Aoi, Obara Taku, Shirota Matsuyuki, et al. Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. European Journal of Clinical Pharmacology. 2024; 80 (8): 1171-1180. doi:10.1007/s00228-024-03685-7  
30.   Orui Masatsugu, Obara Taku, Ishikuro Mami. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. JMA Journal. 2024; 7 (3): 353-363. doi:10.31662/jmaj.2024-0043  
31.   Takahashi Ippei, Obara Taku, Ishikuro Mami, et al. Prospective associations of screen time at age 2 with specific behavioral subscales at age 3: a cohort study. Journal of Public Health. 2024; 46 (4): 477-486. doi:10.1093/pubmed/fdae240  
32.   Noda Aoi, Arita Ryutaro, Obara Taku, et al. The Use of Japanese Traditional (Kampo) Medicines Before and During Pregnancy in Japan: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Pharmacoepidemiology and Drug Safety. 2024; 33 (10): . doi:10.1002/pds.70033  
33.   Takahashi Ippei, Obara Taku, Kikuchi Saya, et al. Combination of taking neuropsychiatric medications and psychological distress in pregnant women, with behavioral problems in children at 2 years of age: The Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (3): . doi:10.1002/pcn5.226  
34.   Orui Masatsugu, Obara Taku, Ishikuro Mami, et al. Evaluation of depression at 6 and 12 months postpartum by examining depressive symptoms and self‐harm ideation during the early postpartum period: Tohoku Medical Megabank Project Birth and Three‐Generation Cohort Study. Psychiatry and Clinical Neurosciences Reports. 2024; 3 (4): . doi:10.1002/pcn5.70025  
35.   Shinoda Genki, Nagaoka Yudai, Ueno Fumihiko, et al. Association between being Overweight in Young Childhood and during School Age and Puberty. Children. 2023; 10 (5): 909. doi:10.3390/children10050909  
36.   Takahashi Ippei, Obara Taku, Ishikuro Mami, et al. Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years. JAMA Pediatrics. 2023; 177 (10): 1039. doi:10.1001/jamapediatrics.2023.3057  
37.   Aizawa Misato, Murakami Keiko, Takahashi Ippei, et al. Association between frequency of breakfast intake before and during pregnancy and infant birth weight: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Nutrition Journal. 2023; 23 (1): 268. doi:10.1186/s12884-023-05603-8