| 1. | Hishinuma Eiji, Shigeta Shogo, Matsukawa Naomi, et al. Sequential Plasma Metabolome and Proteome Analyses to Develop a Novel Monitoring Strategy for Patients with Epithelial Ovarian Cancer: A Pilot Study. International Journal of Molecular Sciences. 2025; 26 (12): 5435. doi:10.3390/ijms26125435 | ||
| 2. | Tateishi Masaki, Goto Kota, Hishinuma Eiji, et al. Double prenylation of budding yeast Ykt6 regulates cell wall integrity and autophagy. Journal of Biological Chemistry. 2025; 301 (4): 108384. doi:10.1016/j.jbc.2025.108384 | ||
| 3. | Narita Daisuke, Hishinuma Eiji, Ebina-Shibuya Risa, et al. Histological and genetic features and therapeutic responses of lung cancers explored via the global analysis of their metabolome profile. Lung Cancer. 2025; 200 : 108082. doi:10.1016/j.lungcan.2025.108082 | ||
| 4. | Kodate Shun, Sato Mitsuharu, Hishinuma Eiji, et al. Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies. Scientific Reports. 2025; 15 (1): 17035. doi:10.1038/s41598-025-01634-7 | ||
| 5. | Yamazaki Shuki, Hishinuma Eiji, Suzuki Yuma, et al. Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals. Biochemical Pharmacology. 2024; 229 : 116515. doi:10.1016/j.bcp.2024.116515 | ||
| 6. | Akiyama Tomoyuki, Saigusa Daisuke, Inoue Takushi, et al. Exploration of urine metabolic biomarkers for new-onset, untreated pediatric epilepsy: A gas and liquid chromatography mass spectrometry-based metabolomics study. Brain and Development. 2024; 46 (4): 180-186. doi:10.1016/j.braindev.2023.12.004 | ||
| 7. | Shimizu Makiko, Makiguchi Miaki, Hishinuma Eiji, et al. Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources. Drug Metabolism and Pharmacokinetics. 2024; 55 : 100539. doi:10.1016/j.dmpk.2023.100539 | ||
| 8. | Kowalik Marta Anna, Taguchi Keiko, Serra Marina, et al. Metabolic reprogramming in Nrf2-driven proliferation of normal rat hepatocytes. Hepatology. 2024; 79 (4): 829-843. doi:10.1097/HEP.0000000000000568 | ||
| 9. | Sato Mitsuharu, Hishinuma Eiji, Matsukawa Naomi, et al. Dietary habits and plasma lipid concentrations in a general Japanese population. Metabolomics. 2024; 20 (2): 34. doi:10.1007/s11306-024-02087-1 | ||
| 10. | Tadaka Shu, Kawashima Junko, Hishinuma Eiji, et al. jMorp: Japanese Multi-Omics Reference Panel update report 2023. Nucleic Acids Research. 2024; 52 (D1): D622-D632. doi:10.1093/nar/gkad978 | ||
| 11. | Sakurai Miyuki, Motoike Ikuko N., Hishinuma Eiji, et al. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. Scientific Reports. 2024; 14 (1): 15681. doi:10.1038/s41598-024-66180-0 | ||
| 12. | Kumondai Masaki, Maekawa Masamitsu, Hishinuma Eiji, et al. Development of a Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analytical Method for Urinary Endogenous Substrates and Metabolites for Predicting Cytochrome P450 3A4 Activity. Biological and Pharmaceutical Bulletin. 2023; 46 (3): b22-00840. doi:10.1248/bpb.b22-00840 | ||
| 13. | Hishinuma Eiji, Shimada Muneaki, Matsukawa Naomi, et al. Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling. Cancer & Metabolism. 2023; 11 (1): 16. doi:10.1186/s40170-023-00317-z | ||
| 14. | Hishinuma Eiji, Narita Yoko, Rico Evelyn Marie Gutiérrez, et al. Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity. Drug Metabolism and Disposition. 2023; 51 (2): 165-173. doi:10.1124/dmd.122.001045 | ||
| 15. | Sato Yu, Hishinuma Eiji, Yamazaki Shuki, et al. Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω -Hydroxylation. Drug Metabolism and Disposition. 2023; 51 (12): 1561-1568. doi:10.1124/dmd.123.001389 | ||
| 16. | Makiguchi Miaki, Shimizu Makiko, Yokota Yuka, et al. Variants of Flavin-Containing Monooxygenase 3 Found in Subjects in an Updated Database of Genome Resources. Drug Metabolism and Disposition. 2023; 51 (7): 884-891. doi:10.1124/dmd.123.001310 | ||
| 17. | Miyoshi Keitaro, Hishinuma Eiji, Matsukawa Naomi, et al. Global Proteomics for Identifying the Alteration Pathway of Niemann–Pick Disease Type C Using Hepatic Cell Models. International Journal of Molecular Sciences. 2023; 24 (21): 15642. doi:10.3390/ijms242115642 | ||
| 18. | Hishinuma Eiji, Shimada Muneaki, Matsukawa Naomi, et al. Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics. Journal of Obstetrics and Gynaecology Research. 2023; 49 (8): 2109-2117. doi:10.1111/jog.15709 | ||
| 19. | Akiyama Mari, Akiyama Tomoyuki, Saigusa Daisuke, et al. Comprehensive study of metabolic changes induced by a ketogenic diet therapy using GC/MS- and LC/MS-based metabolomics. Seizure: European Journal of Epilepsy. 2023; 107 : 52-59. doi:10.1016/j.seizure.2023.03.014 | ||
| 20. | Shimizu Makiko, Hirose Nagisa, Kato Mao, et al. Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria. Drug Metabolism and Pharmacokinetics. 2022; 46 : 100465. doi:10.1016/j.dmpk.2022.100465 | ||
| 21. | Hishinuma Eiji, Narita Yoko, Obuchi Kai, et al. Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population. Frontiers in Pharmacology. 2022; 13 : . doi:10.3389/fphar.2022.930470 | ||
| 22. | Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; 5 (2): . doi:10.31662/jmaj.2021-0156 | ||
| 23. | Ganaha Akira, Hishinuma Eiji, Kaname Tadashi, et al. Rapid Genetic Diagnosis for Okinawan Patients with Enlarged Vestibular Aqueduct Using Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip. Journal of Clinical Medicine. 2022; 11 (4): 1099. doi:10.3390/jcm11041099 | ||
| 24. | Kato Koichi, Nakayoshi Tomoki, Nagura Ayuka, et al. Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations. Journal of Molecular Graphics and Modelling. 2022; 117 : 108288. doi:10.1016/j.jmgm.2022.108288 | ||
| 25. | Saigusa Daisuke, Honda Takeshi, Iwasaki Yuko, et al. Lipidomic and metabolic profiling of plasma and plasma-derived extracellular vesicles by UHPLC-MS/MS. Medical Mass Spectrometry. 2022; 6 (2): 126-137. doi:10.24508/mms.2020.06.001 | ||
| 26. | Nishiumi Shin, Izumi Yoshihiro, Hirayama Akiyoshi, et al. Comparative Evaluation of Plasma Metabolomic Data from Multiple Laboratories. Metabolites. 2022; 12 (2): 135. doi:10.3390/metabo12020135 | ||
| 27. | Siamoglou Stavroula, Koromina Maria, Hishinuma Eiji, et al. Identification and functional validation of novel pharmacogenomic variants using a next-generation sequencing-based approach for clinical pharmacogenomics. Pharmacological Research. 2022; 176 : 106087. doi:10.1016/j.phrs.2022.106087 | ||
| 28. | Liu Yexin, Uruno Akira, Saito Ritsumi, et al. Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice. Redox Biology. 2022; 58 : 102525. doi:10.1016/j.redox.2022.102525 | ||
| 29. | Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6 | ||
| 30. | Kumondai Masaki, Gutiérrez Rico Evelyn Marie, Hishinuma Eiji, et al. Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6 β -Hydroxylation. Drug Metabolism and Disposition. 2021; 49 (3): 212-220. doi:10.1124/dmd.120.000261 | ||
| 31. | Shimizu Makiko, Koibuchi Natsumi, Mizugaki Ami, et al. Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources. Drug Metabolism and Pharmacokinetics. 2021; 38 : 100387. doi:10.1016/j.dmpk.2021.100387 | ||
| 32. | Saigusa Daisuke, Matsukawa Naomi, Hishinuma Eiji, Koshiba Seizo. Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics. Drug Metabolism and Pharmacokinetics. 2021; 37 : 100373. doi:10.1016/j.dmpk.2020.11.008 | ||
| 33. | Isaka Yuichi, Nishio Shin-ya, Hishinuma Eiji, et al. Improvement of a Rapid and Highly Sensitive Method for the Diagnosis of the Mitochondrial m.1555A>G Mutation Based on a Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip. Genetic Testing and Molecular Biomarkers. 2021; 25 (1): 79-83. doi:10.1089/gtmb.2020.0105 | ||
| 34. | Fukunaga Koya, Hishinuma Eiji, Hiratsuka Masahiro, et al. Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population. Journal of Human Genetics. 2021; 66 (2): 139-149. doi:10.1038/s10038-020-0815-x | ||
| 35. | Kumondai Masaki, Ito Akio, Gutiérrez Rico Evelyn Marie, et al. Functional Assessment of 12 Rare Allelic CYP2C9 Variants Identified in a Population of 4773 Japanese Individuals. Journal of Personalized Medicine. 2021; 11 (2): 94. doi:10.3390/jpm11020094 | ||
| 36. | Kumondai Masaki, Gutiérrez Rico Evelyn, Hishinuma Eiji, et al. Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-Deethylation. Journal of Personalized Medicine. 2021; 11 (8): 690. doi:10.3390/jpm11080690 | ||
| 37. | Saigusa Daisuke, Hishinuma Eiji, Matsukawa Naomi, et al. Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values. Metabolites. 2021; 11 (10): 652. doi:10.3390/metabo11100652 | ||
| 38. | Tadaka Shu, Hishinuma Eiji, Komaki Shohei, et al. jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population. Nucleic Acids Research. 2021; 49 (D1): D536-D544. doi:10.1093/nar/gkaa1034 | ||
| 39. | Hishinuma Eiji, Shimada Muneaki, Matsukawa Naomi, et al. Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer. Toxins. 2021; 13 (7): 461. doi:10.3390/toxins13070461 | ||
| 40. | Gutiérrez Rico Evelyn Marie, Kikuchi Aoi, Saito Takahiro, et al. CYP2D6 genotyping analysis and functional characterization of novel allelic variants in a Ni-Vanuatu and Kenyan population by assessing dextromethorphan O-demethylation activity. Drug Metabolism and Pharmacokinetics. 2020; 35 (1): 89-101. doi:10.1016/j.dmpk.2019.07.003 | ||
| 41. | Hishinuma Eiji, Gutiérrez Rico Evelyn, Hiratsuka Masahiro. In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase. Journal of Clinical Medicine. 2020; 9 (8): 2342. doi:10.3390/jcm9082342 | ||
| 42. | Baird Liam, Suzuki Takafumi, Takahashi Yushi, et al. Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2. Molecular and Cellular Biology. 2020; 40 (22): . doi:10.1128/MCB.00377-20 | ||
| 43. | Kumondai Masaki, Hishinuma Eiji, Gutiérrez Rico Evelyn Marie, et al. Heterologous expression of high-activity cytochrome P450 in mammalian cells. Scientific Reports. 2020; 10 (1): 14193. doi:10.1038/s41598-020-71035-5 | ||
| 44. | Shimizu Makiko, Yoda Hiromi, Nakakuki Komei, et al. Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database. Drug Metabolism and Pharmacokinetics. 2019; 34 (5): 334-339. doi:10.1016/j.dmpk.2019.06.001 | ||
| 45. | Watanabe Takashi, Saito Takahiro, Rico Evelyn Marie Gutiérrez, et al. Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation. Biochemical Pharmacology. 2018; 156 : 420-430. doi:10.1016/j.bcp.2018.09.010 | ||
| 46. | Hishinuma Eiji, Narita Yoko, Saito Sakae, et al. Functional Characterization of 21 Allelic Variants of Dihydropyrimidine Dehydrogenase Identified in 1070 Japanese Individuals. Drug Metabolism and Disposition. 2018; 46 (8): 1083-1090. doi:10.1124/dmd.118.081737 | ||
| 47. | Kumondai Masaki, Ito Akio, Hishinuma Eiji, et al. Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS). Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 258-263. doi:10.1016/j.dmpk.2018.08.003 |