Tohoku University Tohoku Medical Megabank Organization (Eiichi N. Kodama)
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Hayashi Hironori, Hasegawa Kazuya, Saijo Erika, et al. Binding of a potential antibacterial drug, mangiferin, to serine hydroxymethyltransferase from Enterococcus faecium. Biochemical and Biophysical Research Communications. 2025; 743 : 151177. doi:10.1016/j.bbrc.2024.151177 |
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Akimoto Takafumi, Inaba Hiroshi, Ogishima Soichi, et al. Comparison of genotypes and phenotypes for von Willebrand factor gene variants using Japanese genome database. Blood Vessels, Thrombosis & Hemostasis. 2025; : 100070. doi:10.1016/j.bvth.2025.100070 |
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Tokioka Sayuri, Nakaya Naoki, Hatanaka Rieko, et al. Association Between Sodium- and Potassium-Related Urinary Markers and the Prevalence of Atrial Fibrillation. Circulation Journal. 2025; 89 (6): CJ-24-0780. doi:10.1253/circj.CJ-24-0780 |
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| 4. |
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Tokioka Sayuri, Takase Masato, Nakaya Naoki, et al. Sex difference in genetic risk in the prevalence of atrial fibrillation. Heart Rhythm. 2025; : . doi:10.1016/j.hrthm.2025.03.1974 |
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Takahara Aoi, Nakatsu Toru, Hirata Kazushige, et al. Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors. Journal of Medicinal Chemistry. 2025; 68 (3): 3123-3133. doi:10.1021/acs.jmedchem.4c02337 |
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Fuse Nobuo, Anzawa Hayato, Sakurai Miyuki, et al. Genome-Wide Association Study of Intraocular Pressure in Population-Based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study. Ophthalmology Science. 2025; 5 (5): 100821. doi:10.1016/j.xops.2025.100821 |
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Imai Haruka, Suzuki Jun, Mizuno Tomoki, et al. The effect of antibiotic prescription in non-critically ill hospitalized patients with COVID-19: A Japanese inpatient database study. PLOS ONE. 2025; 20 (3): e0318803. doi:10.1371/journal.pone.0318803 |
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Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic risk, lifestyle adherence, and risk of developing hyperuricaemia in a Japanese population. Rheumatology. 2025; 64 (5): 2591-2600. doi:10.1093/rheumatology/keae492 |
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Kobayashi Mika, Kobayashi Tomoko, Obara Taku, et al. Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder. The Tohoku Journal of Experimental Medicine. 2025; : 2025.J074. doi:10.1620/tjem.2025.J074 |
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Hayashi Hironori, Saijo Erika, Hirata Kazushige, et al. SHIN-2 exerts potent activity against VanA-type vancomycin-resistant Enterococcus faecium in vitro by stabilizing the active site loop of serine hydroxymethyltransferase. Archives of Biochemistry and Biophysics. 2024; 761 : 110160. doi:10.1016/j.abb.2024.110160 |
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Yoshida Yuki, Niimi Yushi, Fushihara Daichi, et al. 2′-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants. Bioorganic & Medicinal Chemistry. 2024; 110 : 117813. doi:10.1016/j.bmc.2024.117813 |
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| 12. |
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Noji Yoshiaki, Hatanaka Rieko, Nakaya Naoki, et al. Association of physiological factors with grip and leg extension strength: tohoku medical megabank community-based cohort study. BMC Public Health. 2024; 24 (1): 714. doi:10.1186/s12889-024-18244-z |
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Matsuda Kenichi, Niikura Shinya, Ichihara Rintaro, et al. Synthesis and Cytotoxicity of Cyclic Octapeptide Surugamides with Varied N-Acyl Moieties. Chemical and Pharmaceutical Bulletin. 2024; 72 (9): c24-00533. doi:10.1248/cpb.c24-00533 |
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| 14. |
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Takase Masato, Hirata Takumi, Nakaya Naoki, et al. Associations of combined genetic and lifestyle risks with hypertension and home hypertension. Hypertension Research. 2024; 47 (8): 2064-2074. doi:10.1038/s41440-024-01705-8 |
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| 15. |
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Takase Masato, Nakaya Naoki, Tanno Kozo, et al. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study. Hypertension Research. 2024; 47 (6): 1533-1545. doi:10.1038/s41440-024-01582-1 |
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| 16. |
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Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center. Hypertension Research. 2024; 47 (3): 586-597. doi:10.1038/s41440-023-01484-8 |
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| 17. |
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Himuro Hiromi, Kogure Mana, Nakaya Naoki, et al. The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study. Hypertension Research. 2024; 47 (11): 3025-3034. doi:10.1038/s41440-024-01827-z |
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Hirata Kazushige, Takahara Aoi, Suzuki Satoshi, et al. Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors. iScience. 2024; 27 (2): 108961. doi:10.1016/j.isci.2024.108961 |
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Kodama Eiichi N, Taira Makiko, Kiyomoto Hideyasu. Urgent Notification Intervention of Home Blood Pressure in Cohort Studies of the Tohoku Medical Megabank Project. JMA Journal. 2024; 7 (3): 342-352. doi:10.31662/jmaj.2023-0215 |
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| 20. |
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Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Genetic Risk, Healthy Lifestyle Adherence, and Risk of Developing Diabetes in the Japanese Population. Journal of Atherosclerosis and Thrombosis. 2024; 31 (12): 64906. doi:10.5551/jat.64906 |
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| 21. |
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Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Relationships of Fat Mass Index and Fat-Free Mass Index with Low-Density Lipoprotein Cholesterol Levels in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2024; 31 (6): 64535. doi:10.5551/jat.64535 |
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| 22. |
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Takase Masato, Yamada Mitsuhiro, Nakamura Tomohiro, et al. Combined Fat Mass and Fat-free Mass Indices and Lung Function Among Japanese Population: The Tohoku Medical Megabank Community-based Cohort Study. Journal of Epidemiology. 2024; 34 (3): JE20220355. doi:10.2188/jea.JE20220355 |
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| 23. |
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Hozawa Atsushi, Nakaya Kumi, Nakaya Naoki, et al. Progress Report of the Tohoku Medical Megabank Community-based Cohort Study: Study Profile of the Repeated Center-based Survey During Second Period in Miyagi Prefecture. Journal of Epidemiology. 2024; 34 (9): JE20230241. doi:10.2188/jea.JE20230241 |
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Suzuki Tetsuya, Asai Yusuke, Tsuzuki Shinya, et al. Real-world effectiveness of full and booster mRNA vaccination for coronavirus disease 2019 against disease severity during the delta- and omicron-dominant phases: A propensity score-matched cohort study using the nationwide registry data in Japan. Journal of Microbiology, Immunology and Infection. 2024; 57 (1): 20-29. doi:10.1016/j.jmii.2023.12.002 |
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Suzuki Satoshi, Kuroda Mio, Aoki Keisuke, et al. Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion. RSC Chemical Biology. 2024; 5 (2): 131-140. doi:10.1039/D3CB00166K |
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Itoh Naoya, Akazawa Nana, Kawabata Takanori, et al. Improving diagnostic accuracy of blood culture-positive cases in a cancer center via an antimicrobial stewardship program and infectious disease consultations. Scientific Reports. 2024; 14 (1): 2869. doi:10.1038/s41598-024-53543-w |
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Hatanaka Rieko, Nakaya Naoki, Kogure Mana, et al. The risk of withdrawal from hypertension treatment in coastal areas after the Great East Japan Earthquake: the TMM CommCohort Study. Hypertension Research. 2023; 46 (12): 2718-2728. doi:10.1038/s41440-023-01454-0 |
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| 28. |
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Tokioka Sayuri, Nakaya Naoki, Nakaya Kumi, et al. Association of Central Blood Pressure and Carotid Intima Media Thickness with New-Onset Hypertension in People with High Normal Blood Pressure. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64151. doi:10.5551/jat.64151 |
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| 29. |
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Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (3): 63523. doi:10.5551/jat.63523 |
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| 30. |
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Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (10): 64039. doi:10.5551/jat.64039 |
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| 31. |
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Takase Masato, Nakaya Naoki, Nakamura Tomohiro, et al. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (12): 64425. doi:10.5551/jat.64425 |
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| 32. |
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Takase Masato, Yamada Mitsuhiro, Nakamura Tomohiro, et al. The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2023; 30 (8): 63826. doi:10.5551/jat.63826 |
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Iwasaki Yudai, Takei Yusuke, Yamada Mitsuhiro, et al. Circulating Extracellular Vesicle Levels in Patients with Coronavirus Disease 2019 Coagulopathy: A Prospective Cohort Study. Journal of Clinical Medicine. 2023; 12 (10): 3460. doi:10.3390/jcm12103460 |
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Takase Masato, Yamada Mitsuhiro, Nakamura Tomohiro, et al. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study. Journal of Hypertension. 2023; 41 (3): 443-452. doi:10.1097/HJH.0000000000003356 |
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Itoh Naoya, Kawabata Takanori, Akazawa Nana, et al. Reduction strategies for inpatient oral third-generation cephalosporins at a cancer center: An interrupted time-series analysis. PLOS ONE. 2023; 18 (2): e0281518. doi:10.1371/journal.pone.0281518 |
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Suzuki Tetsuya, Morioka Shinichiro, Yamamoto Kei, et al. Nasopharyngeal SARS-CoV-2 may not be dispersed by a high-flow nasal cannula. Scientific Reports. 2023; 13 (1): 2669. doi:10.1038/s41598-023-29740-4 |
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Kobayashi Tomoko, Kobayashi Mika, Minegishi Naoko, et al. Design and Progress of Child Health Assessments at Community Support Centers in the Birth and Three-Generation Cohort Study of the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2023; 259 (2): 2022.J103. doi:10.1620/tjem.2022.J103 |
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Sasano Mina, Hayashi Hironori, Kawaji Kumi, et al. Establishing an accurate and sensitive in vitro drug screening system for human adenovirus infection with human corneal cells. Virology. 2023; 581 : 34-38. doi:10.1016/j.virol.2023.02.005 |
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Makino Yuko, Oe Chihiro, Iwama Kazuya, et al. Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors. Communications Biology. 2022; 5 (1): 619. doi:10.1038/s42003-022-03555-x |
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Nomoto Hidetoshi, Asai Yusuke, Hayakawa Kayoko, et al. Impact of the COVID-19 pandemic on racial and ethnic minorities in Japan. Epidemiology and Infection. 2022; 150 : e202. doi:10.1017/S0950268822001674 |
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Morioka Shinichiro, Tan Ban Hock, Kikuchi Hiroe, et al. Factors Associated With Prolonged Psychological Distress Among Nurses and Physicians Engaged in COVID-19 Patient Care in Singapore and Japan. Frontiers in Psychiatry. 2022; 13 : . doi:10.3389/fpsyt.2022.781796 |
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Takahata Hanako, Onishi Kazunari, Nomoto Hidetoshi, et al. Surveillance and risk assessment of health screening for vaccine-preventable diseases among international students in Japan: A cross-sectional study in 2020. Human Vaccines & Immunotherapeutics. 2022; 18 (6): . doi:10.1080/21645515.2022.2136914 |
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Yajima Takehiro, Takahashi Hiroshi, Kimura Nozomu, et al. Comparison of sputum specimens and nasopharyngeal swab specimens for diagnosis of acute human metapneumovirus-related lower respiratory tract infections in adults. Journal of Clinical Virology. 2022; 154 : 105238. doi:10.1016/j.jcv.2022.105238 |
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Takase Masato, Nakamura Tomohiro, Hirata Takumi, et al. Association between fat mass index, fat‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study. Journal of Diabetes Investigation. 2022; 13 (5): 858-867. doi:10.1111/jdi.13729 |
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Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of epidemiology. 2022; 32 (2): 69-79. doi:10.2188/jea.JE20200338 |
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Oshima Kengo, Nakajima Chie, Hirata Kazushige, et al. Disseminated tuberculosis with paradoxical reactions caused by a Mycobacterium tuberculosis strain belonging to the Indo-Oceanic lineage: An imported case in Japan. Journal of Infection and Chemotherapy. 2022; 28 (7): 965-970. doi:10.1016/j.jiac.2022.02.008 |
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Itoh Naoya, Akazawa Nana, Ishikane Masahiro, et al. Lessons learned from an outbreak of COVID-19 in the head and neck surgery ward of a Japanese cancer center during the sixth wave by Omicron. Journal of Infection and Chemotherapy. 2022; 28 (12): 1610-1615. doi:10.1016/j.jiac.2022.08.010 |
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Ohata Yoshitsugu, Tomonaga Mitsunori, Watanabe Yasuo, et al. Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602. Journal of Virology. 2022; 96 (6): . doi:10.1128/jvi.01843-21 |
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Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113 |
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Iwamoto Noriko, Morisaki Naho, Uda Kazuhiro, et al. Change in use of pediatric oral antibiotics in Japan, pre‐ and post‐implementation of an antimicrobial resistance action plan. Pediatrics International. 2022; 64 (1): . doi:10.1111/ped.15197 |
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Itoh Naoya, Akazawa Nana, Kanawaku Eri, et al. Effects of infectious disease consultation and antimicrobial stewardship program at a Japanese cancer center: An interrupted time-series analysis. PLOS ONE. 2022; 17 (1): e0263095. doi:10.1371/journal.pone.0263095 |
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Sano Hirohito, Murakami Koji, Yokoyama Hisayuki, et al. COVID-19 in a Hairy Cell Leukemia Patient: A Rare Case Report. The Tohoku Journal of Experimental Medicine. 2022; 258 (1): 2022.J058. doi:10.1620/tjem.2022.J058 |
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Takase Masato, Nakamura Tomohiro, Tsuchiya Naho, et al. Association between the combined fat mass and fat-free mass index and hypertension: The Tohoku Medical Megabank Community-based Cohort Study. Clinical and Experimental Hypertension. 2021; 43 (7): 610-621. doi:10.1080/10641963.2021.1925681 |
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Yamada Mitsuhiro, Motoike Ikuko N., Kojima Kaname, et al. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. Communications Biology. 2021; 4 (1): 1288. doi:10.1038/s42003-021-02813-8 |
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Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271 |
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Hattori Shin-ichiro, Higashi-Kuwata Nobuyo, Hayashi Hironori, et al. A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Communications. 2021; 12 (1): 668. doi:10.1038/s41467-021-20900-6 |
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Oe Chihiro, Hayashi Hironori, Hirata Kazushige, et al. Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related Proteins. ACS Infectious Diseases. 2020; 6 (6): 1490-1500. doi:10.1021/acsinfecdis.9b00305 |
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Saito Sho, Hayakawa Kayoko, Tsuzuki Shinya, et al. A Matched Case-Case-Control Study of the Impact of Clinical Outcomes and Risk Factors of Patients with IMP-Type Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae in Japan. Antimicrobial Agents and Chemotherapy. 2020; 65 (3): 251-257. doi:10.1128/AAC.01483-20 |
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Nakagawara Kohsuke, Hayashi Hironori, Kawaji Kumi, et al. Application of human lymphoid cells for the evaluation of antivirals against human adenovirus type 19: Zalcitabine has superior activity compared to cidofovir. Antiviral Chemistry and Chemotherapy. 2020; 28 : 204020662092131. doi:10.1177/2040206620921319 |
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Kuriyama Shinichi, Metoki Hirohito, Kikuya Masahiro, et al. Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective. International Journal of Epidemiology. 2020; 49 (1): 18-19m. doi:10.1093/ije/dyz169 |
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Tsukada Kento, Shinki Shono, Kaneko Akiho, et al. Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones. Nature Communications. 2020; 11 (1): 1830. doi:10.1038/s41467-020-15664-4 |
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Oikawa Yoshitsugu, Izumi Rumiko, Koide Masashi, et al. Mitochondrial dysfunction underlying sporadic inclusion body myositis is ameliorated by the mitochondrial homing drug MA-5. PLOS ONE. 2020; 15 (12): e0231064. doi:10.1371/journal.pone.0231064 |
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Tsuboi Akito, Matsui Hiroyuki, Shiraishi Naru, et al. Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project. The Tohoku Journal of Experimental Medicine. 2020; 251 (2): 97-115. doi:10.1620/tjem.251.97 |
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Siarot Lowela, Chutiwitoonchai Nopporn, Sato Hirotaka, et al. Identification of human immunodeficiency virus type-1 Gag-TSG101 interaction inhibitors by high-throughput screening. Biochemical and Biophysical Research Communications. 2018; 503 (4): 2970-2976. doi:10.1016/j.bbrc.2018.08.079 |
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Kikuchi Haruhisa, Kawai Kosuke, Nakashiro Yota, et al. Construction of a Meroterpenoid‐Like Compounds Library Based on Diversity‐Enhanced Extracts. Chemistry – A European Journal. 2018; 25 (4): chem.201805417. doi:10.1002/chem.201805417 |
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Watanabe Masahiro, Hashimoto Koichi, Abe Yusaku, et al. A Novel Peptide Derived from the Fusion Protein Heptad Repeat Inhibits Replication of Subacute Sclerosing Panencephalitis Virus In Vitro and In Vivo. PLOS ONE. 2016; 11 (9): e0162823. doi:10.1371/journal.pone.0162823 |
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Salie Zhe Li, Kirby Karen A., Michailidis Eleftherios, et al. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA). Proceedings of the National Academy of Sciences. 2016; 113 (33): 9274-9279. doi:10.1073/pnas.1605223113 |
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Miyamoto Fusako, Kawaji Kumi, Oishi Shinya, et al. Anti-HIV-1 activity determined by β-galactosidase activity in the multinuclear activation of an indicator assay is comparable with that by a conventional focus counting method. Antiviral Chemistry and Chemotherapy. 2015; 24 (2): 77-82. doi:10.1177/2040206615614164 |
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Asai Teigo, Tsukada Kento, Ise Satomi, et al. Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides. Nature Chemistry. 2015; 7 (9): 737-743. doi:10.1038/nchem.2308 |
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Hachiya Atsuko, Reeve Aaron B, Marchand Bruno, et al. Evaluation of Combinations of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine with Clinically Used Antiretroviral Drugs. Antimicrobial Agents and Chemotherapy. 2013; 57 (9): 4554-4558. doi:10.1128/AAC.00283-13 |
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Shimane Kazuki, Kawaji Kumi, Miyamoto Fusako, et al. HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains. Antimicrobial Agents and Chemotherapy. 2013; 57 (8): 4035-4038. doi:10.1128/AAC.00237-13 |
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Maeda Kenji, Desai Darshan V, Aoki Manabu, et al. Delayed emergence of HIV-1 variants resistant to 4’-ethynyl-2-fluoro-2’-deoxyadenosine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-986001. Antiviral Therapy. 2013; 19 (2): 179-189. doi:10.3851/IMP2697 |
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