Tohoku University Tohoku Medical Megabank Organization (Daisuke Saigusa)
2019.09.13

1.   Saigusa Daisuke, Saito Ritsumi, Kawamoto Komei, et al. Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry. 2019; : acs.analchem.9b01159. doi:10.1021/acs.analchem.9b01159  
2.   Keleku-Lukwete Nadine, Suzuki Mikiko, Panda Harit, et al. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood advances. 2019; 3 (8): 1285-1297. doi:10.1182/bloodadvances.2018017574  
3.   Sugawara Junichi, Ochi Daisuke, Yamashita Riu, et al. Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy. BMJ Open. 2019; 9 (2): bmjopen-2018-025939. doi:10.1136/bmjopen-2018-025939  
4.   Kurosawa Ryo, Satoh Kimio, Kikuchi Nobuhiro, et al. Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds-. Circulation Research. 2019; : CIRCRESAHA.119.315229. doi:10.1161/CIRCRESAHA.119.315229  
5.   Sato Tomonori, Kawasaki Yoshihide, Maekawa Masamitsu, et al. Value of global metabolomics in association with diagnosis and clinicopathological factors of renal cell carcinoma. International journal of cancer. 2019; 145 (2): 484-493. doi:10.1002/ijc.32115  
6.   Dodo Mina, Kitamura Hiroshi, Shima Hiroki, et al. Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A. Journal of biochemistry. 2019; 165 (4): 323-334. doi:10.1093/jb/mvy108  
7.   Wang Jiao, Kano Kuniyuki, Saigusa Daisuke, Aoki Junken. Measurement of the Spatial Distribution of S1P in Small Quantities of Tissues: Development and Application of a Highly Sensitive LC-MS/MS Method Combined with Laser Microdissection. Mass spectrometry (Tokyo, Japan). 2019; 8 (1): A0072. doi:10.5702/massspectrometry.A0072  
8.   Kikuchi Koichi, Saigusa Daisuke, Kanemitsu Yoshitomi, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature Communications. 2019; 10 (1): 1835. doi:10.1038/s41467-019-09735-4  
9.   Yasuda Jun, Kinoshita Kengo, Katsuoka Fumiki, et al. Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare. The Journal of Biochemistry. 2019; 165 (2): 139-158. doi:10.1093/jb/mvy096  
10.   Mishima Eikan, Fukuda Shinji, Kanemitsu Yoshitomi, et al. Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model. American journal of physiology. Renal physiology. 2018; 315 (4): F824-F833. doi:10.1152/ajprenal.00314.2017  
11.   Watanabe Takashi, Saito Takahiro, Rico Evelyn Marie Gutiérrez, et al. Functional characterization of 40 CYP2B6 allelic variants by assessing efavirenz 8-hydroxylation. Biochemical Pharmacology. 2018; 156 : 420-430. doi:10.1016/j.bcp.2018.09.010  
12.   Uranbileg Baasanjav, Nishikawa Takeshi, Ikeda Hitoshi, et al. Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer. Clinical colorectal cancer. 2018; 17 (2): e171-e182. doi:10.1016/j.clcc.2017.11.004  
13.   Tachikawa Masanori, Sumiyoshiya Yuna, Saigusa Daisuke, et al. Liver Zonation Index of Drug Transporter and Metabolizing Enzyme Protein Expressions in Mouse Liver Acinus. Drug metabolism and disposition: the biological fate of chemicals. 2018; 46 (5): 610-618. doi:10.1124/dmd.117.079244  
14.   Saito Takahiro, Gutiérrez Rico Evelyn Marie, Kikuchi Aoi, et al. Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation. Drug Metabolism and Pharmacokinetics. 2018; 33 (6): 250-257. doi:10.1016/j.dmpk.2018.08.004  
15.   Saito Takahiro, Gutiérrez Rico Evelyn Marie, Kikuchi Aoi, et al. Functional characterization of 50 CYP2D6 allelic variants by assessing primaquine 5-hydroxylation. Drug metabolism and pharmacokinetics. 2018; 33 (6): 250-257. doi:10.1016/j.dmpk.2018.08.004  
16.   Koshiba Seizo, Motoike Ikuko, Saigusa Daisuke, et al. Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project. Genes to Cells. 2018; 23 (6): 406-417. doi:10.1111/gtc.12588  
17.   Saigusa Daisuke, Suzuki Norio, Matsumoto Yotaro, et al. Detection of novel metabolite for roxadustat doping by global metabolomics. Journal of biochemistry. 2018; 163 (6): e1. doi:10.1093/jb/mvy036  
18.   Saigusa Daisuke, Suzuki Norio, Matsumoto Yotaro, et al. Detection of novel metabolite for Roxadustat doping by global metabolomics. Journal of biochemistry. 2018; : . doi:10.1093/jb/mvy028  
19.   Yamaguchi-Kabata Yumi, Yasuda Jun, Tanabe Osamu, et al. Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals. Journal of Human Genetics. 2018; 63 (2): 213-230. doi:10.1038/s10038-017-0347-1  
20.   Tadaka Shu, Saigusa Daisuke, Motoike Ikuko N., et al. jMorp: Japanese Multi Omics Reference Panel. Nucleic Acids Research. 2018; 46 (D1): D551-D557. doi:10.1093/nar/gkx978  
21.   Tadaka Shu, Saigusa Daisuke, Motoike Ikuko N, et al. jMorp: Japanese Multi Omics Reference Panel. Nucleic acids research. 2018; 46 (D1): D551-D557. doi:10.1093/nar/gkx978  
22.   Sato Kota, Saigusa Daisuke, Saito Ritsumi, et al. Metabolomic changes in the mouse retina after optic nerve injury. Scientific Reports. 2018; 8 (1): 11930. doi:10.1038/s41598-018-30464-z  
23.   Sato Kota, Saigusa Daisuke, Saito Ritsumi, et al. Metabolomic changes in the mouse retina after optic nerve injury. Scientific reports. 2018; 8 (1): 11930. doi:10.1038/s41598-018-30464-z  
24.   Takahashi Nobuyuki, Li Feng, Fushima Tomofumi, et al. Vitamin B3 Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth. The Tohoku journal of experimental medicine. 2018; 244 (3): 243-248. doi:10.1620/tjem.244.243  
25.   Takahashi Nobuyuki, Li Feng, Fushima Tomofumi, et al. Vitamin B3 Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth. The Tohoku journal of experimental medicine. 2018; 244 (3): 243-248. doi:10.1620/tjem.244.243  
26.   Mishima Eikan, Fukuda Shinji, Kanemitsu Yoshitomi, et al. Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model. American Journal of Physiology-Renal Physiology. 2017; 315 (4): F824-F833. doi:10.1152/ajprenal.00314.2017  
27.   Yagishita Yoko, Uruno Akira, Fukutomi Toshiaki, et al. Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress. Cell reports. 2017; 18 (8): 2030-2044. doi:10.1016/j.celrep.2017.01.064  
28.   Kanemitsu Yoshitomi, Asaji Kei, Matsumoto Yotaro, et al. Simultaneous quantitative analysis of uremic toxins by LC–MS/MS with a reversed-phase/cation-exchange/anion-exchange tri-modal mixed-mode column. Journal of Chromatography B. 2017; 1068-1069 : 1-8. doi:10.1016/j.jchromb.2017.10.009  
29.   Yokoro Miyuki, Nakayama Yosuke, Yamagishi Sho-ichi, et al. Asymmetric Dimethylarginine Contributes to the Impaired Response to Erythropoietin in CKD-Anemia. Journal of the American Society of Nephrology. 2017; 28 (9): 2670-2680. doi:10.1681/ASN.2016111184  
30.   Nezu Masahiro, Souma Tomokazu, Yu Lei, et al. Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression. Kidney International. 2017; 91 (2): 387-401. doi:10.1016/j.kint.2016.08.023  
31.   Shima Hisato, Sasaki Kensuke, Suzuki Takehiro, et al. A novel indole compound MA-35 attenuates renal fibrosis by inhibiting both TNF-α and TGF-β1 pathways. Scientific Reports. 2017; 7 (1): 1884. doi:10.1038/s41598-017-01702-7  
32.   Kanoh Naoki, Mano Kosuke, Saigusa Daisuke, et al. Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate. Bioorganic & Medicinal Chemistry Letters. 2016; 26 (23): 5770-5772. doi:10.1016/j.bmcl.2016.10.046  
33.   Satoh H., Moriguchi T., Saigusa D., et al. NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. Cancer Research. 2016; 76 (10): 3088-3096. doi:10.1158/0008-5472.CAN-15-1584  
34.   Sato Emiko, Tsunokuni Yukako, Fushima Tomofumi, et al. OS 08-06 METABOLOMIC ANALYSIS OF A MOUSE MODEL OF PREECLAMPSIA INDUCED BY OVERPRODUCING sFlt-1. Journal of hypertension. 2016; 34 Suppl 1 : e69. doi:10.1097/01.hjh.0000500031.24401.46  
35.   Suzuki T., Yamaguchi H., Kikusato M., et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. Journal of the American Society of Nephrology. 2016; 27 (7): 1925-1932. doi:10.1681/ASN.2015060623  
36.   Maekawa Masamitsu, Omura Kaoru, Sekiguchi Shoutaro, et al. Identification of Two Sulfated Cholesterol Metabolites Found in the Urine of a Patient with Niemann-Pick Disease Type C as Novel Candidate Diagnostic Markers. Mass spectrometry (Tokyo, Japan). 2016; 5 (2): S0053. doi:10.5702/massspectrometry.S0053  
37.   Saigusa Daisuke, Okamura Yasunobu, Motoike Ikuko N., et al. Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery. PLOS ONE. 2016; 11 (8): e0160555. doi:10.1371/journal.pone.0160555  
38.   Uranbileg Baasanjav, Ikeda Hitoshi, Kurano Makoto, et al. Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. PLOS ONE. 2016; 11 (2): e0149462. doi:10.1371/journal.pone.0149462  
39.   Li Feng, Fushima Tomofumi, Oyanagi Gen, et al. Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia. Proceedings of the National Academy of Sciences. 2016; 113 (47): 13450-13455. doi:10.1073/pnas.1614947113  
40.   Sato Emiko, Mori Takefumi, Mishima Eikan, et al. Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease. Scientific Reports. 2016; 6 (1): 36618. doi:10.1038/srep36618  
41.   Sato Masaya, Ikeda Hitoshi, Uranbileg Baasanjav, et al. Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human. Scientific reports. 2016; 6 : 32119. doi:10.1038/srep32119  
42.   Koshiba Seizo, Motoike Ikuko, Kojima Kaname, et al. The structural origin of metabolic quantitative diversity. Scientific Reports. 2016; 6 (1): 31463. doi:10.1038/srep31463  
43.   Iwamori Saki, Sato Emiko, Saigusa Daisuke, et al. A novel and sensitive assay for heme oxygenase activity. American Journal of Physiology-Renal Physiology. 2015; 309 (7): F667-F671. doi:10.1152/ajprenal.00210.2015  
44.   Takahashi Tomohiro, Saigusa Daisuke, Takeda Chihiro, et al. Determination of Sphingolipids by LC-MS/MS. Bioactive Lipid Mediators. 2015; : 357-370. doi:10.1007/978-4-431-55669-5_26  
45.   Saito T, Honda M, Takahashi M, et al. Functional characterization of 10 CYP4A11 allelic variants to evaluate the effect of genotype on arachidonic acid omega-hydroxylation. Drug Metab Pharmacokinet. 2015; 30 (1): 119-122. doi:10.1016/j.dmpk.2014.09.001  
46.   Suzuki Takehiro, Yamaguchi Hiroaki, Kikusato Motoi, et al. Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases. The Tohoku Journal of Experimental Medicine. 2015; 236 (3): 225-232. doi:10.1620/tjem.236.225  
47.   Nakanaga Keita, Hama Kotaro, Kano Kuniyuki, et al. Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. Journal of Biochemistry. 2014; 155 (4): 235-241. doi:10.1093/jb/mvt114  
48.   Okudaira Michiyo, Inoue Asuka, Shuto Akira, et al. Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS. Journal of Lipid Research. 2014; 55 (10): 2178-2192. doi:10.1194/jlr.D048439  
49.   Mishima Eikan, Inoue Chisako, Saigusa Daisuke, et al. Conformational change in transfer RNA is an early indicator of acute cellular damage. Journal of the American Society of Nephrology : JASN. 2014; 25 (10): 2316-26. doi:10.1681/ASN.2013091001  
50.   Saigusa Daisuke, Okudaira Michiyo, Wang Jiao, et al. Simultaneous Quantification of Sphingolipids in Small Quantities of Liver by LC-MS/MS. Mass Spectrometry. 2014; 3 (Special_Issue_3): S0046-S0046. doi:10.5702/massspectrometry.S0046  
51.   Mullen William, Saigusa Daisuke, Abe Takaaki, et al. Proteomics and Metabolomics as Tools to Unravel Novel Culprits and Mechanisms of Uremic Toxicity: Instrument or Hype?. Seminars in Nephrology. 2014; 34 (2): 180-190. doi:10.1016/j.semnephrol.2014.02.009  
52.   Nakamura Atsushi, Ebina-Shibuya Risa, Itoh-Nakadai Ari, et al. Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The Journal of experimental medicine. 2013; 210 (11): 2191-204. doi:10.1084/jem.20130028