Tohoku University Tohoku Medical Megabank Organization (Akira Uruno)
2022.08.12

1.   Kogure Mana, Nakamura Tomohiro, Tsuchiya Naho, et al. Consideration of the reference value and number of measurements of the urinary sodium-to-potassium ratio based on the prevalence of untreated home hypertension: TMM Cohort Study. Hypertension Research. 2022; 45 (5): 866-875. doi:10.1038/s41440-021-00843-7  
2.   Ohneda Kinuko, Hiratsuka Masahiro, Kawame Hiroshi, et al. A Pilot Study for Return of Individual Pharmacogenomic Results to Population-Based Cohort Study Participants. JMA Journal. 2022; 5 (2): . doi:10.31662/jmaj.2021-0156  
3.   Takase Masato, Nakamura Tomohiro, Nakaya Naoki, et al. Associations between the Combined Fat Mass Index and Fat-Free Mass Index with Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study. Journal of Atherosclerosis and Thrombosis. 2022; : 63523. doi:10.5551/jat.63523  
4.   Takase Masato, Nakamura Tomohiro, Hirata Takumi, et al. Association between fat mass index, fat‐free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community‐based Cohort Study. Journal of Diabetes Investigation. 2022; 13 (5): 858-867. doi:10.1111/jdi.13729  
5.   Sugawara Junichi, Ishikuro Mami, Obara Taku, et al. Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Journal of epidemiology. 2022; 32 (2): 69-79. doi:10.2188/jea.JE20200338  
6.   Kawame Hiroshi, Fukushima Akimune, Fuse Nobuo, et al. The return of individual genomic results to research participants: design and pilot study of Tohoku Medical Megabank Project. Journal of Human Genetics. 2022; 67 (1): 9-17. doi:10.1038/s10038-021-00952-8  
7.   Suzuki Norio, Iwamura Yuma, Nakai Taku, et al. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney International. 2022; 101 (1): 92-105. doi:10.1016/j.kint.2021.09.031  
8.   Fuse Nobuo, Sakurai Miyuki, Motoike Ikuko N., et al. Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan. Ophthalmology Science. 2022; 2 (1): 100113. doi:10.1016/j.xops.2022.100113  
9.   Yamada Mitsuhiro, Motoike Ikuko N., Kojima Kaname, et al. Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator. Communications Biology. 2021; 4 (1): 1288. doi:10.1038/s42003-021-02813-8  
10.   Uruno Akira, Saigusa Daisuke, Suzuki Takafumi, et al. Nrf2 plays a critical role in the metabolic response during and after spaceflight. Communications Biology. 2021; 4 (1): 1381. doi:10.1038/s42003-021-02904-6  
11.   Yumoto Akane, Kokubo Toshiaki, Izumi Ryutaro, et al. Novel method for evaluating the health condition of mice in space through a video downlink. Experimental Animals. 2021; 70 (2): 236-244. doi:10.1538/expanim.20-0102  
12.   Ogishima Soichi, Nagaie Satoshi, Mizuno Satoshi, et al. dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project. Human Genome Variation. 2021; 8 (1): 44. doi:10.1038/s41439-021-00175-5  
13.   Hirata Takumi, Kogure Mana, Tsuchiya Naho, et al. Impacts of the urinary sodium-to-potassium ratio, sleep efficiency, and conventional risk factors on home hypertension in a general Japanese population. Hypertension Research. 2021; 44 (7): 858-865. doi:10.1038/s41440-021-00628-y  
14.   Hozawa Atsushi, Tanno Kozo, Nakaya Naoki, et al. Study profile of the tohoku medical megabank community-based cohort study. Journal of Epidemiology. 2021; 31 (1): 65-76. doi:10.2188/jea.JE20190271  
15.   Sakurai-Yageta Mika, Kumada Kazuki, Gocho Chinatsu, et al. Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs. The Journal of Biochemistry. 2021; 170 (3): 399-410. doi:10.1093/jb/mvab060  
16.   Suzuki Takafumi, Uruno Akira, Yumoto Akane, et al. Nrf2 contributes to the weight gain of mice during space travel. Communications Biology. 2020; 3 (1): 496. doi:10.1038/s42003-020-01227-2  
17.   Kogure Mana, Hirata Takumi, Nakaya Naoki, et al. Multiple measurements of the urinary sodium-to-potassium ratio strongly related home hypertension: TMM Cohort Study. Hypertension Research. 2020; 43 (1): 62-71. doi:10.1038/s41440-019-0335-2  
18.   Hirata Takumi, Nakamura Tomohiro, Kogure Mana, et al. Reduced sleep efficiency, measured using an objective device, was related to an increased prevalence of home hypertension in Japanese adults. Hypertension Research. 2020; 43 (1): 23-29. doi:10.1038/s41440-019-0329-0  
19.   Uruno Akira, Matsumaru Daisuke, Ryoke Rie, et al. Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice. Molecular and Cellular Biology. 2020; 40 (6): . doi:10.1128/MCB.00467-19  
20.   Rashad Sherif, Saigusa Daisuke, Yamazaki Takahiro, et al. Metabolic basis of neuronal vulnerability to ischemia; an in vivo untargeted metabolomics approach. Scientific Reports. 2020; 10 (1): 6507. doi:10.1038/s41598-020-63483-w  
21.   Saigusa Daisuke, Saito Ritsumi, Kawamoto Komei, et al. Conductive Adhesive Film Expands the Utility of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. Analytical Chemistry. 2019; 91 (14): 8979-8986. doi:10.1021/acs.analchem.9b01159  
22.   Keleku-Lukwete Nadine, Suzuki Mikiko, Panda Harit, et al. Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood Advances. 2019; 3 (8): 1285-1297. doi:10.1182/bloodadvances.2018017574  
23.   Kurosawa Ryo, Satoh Kimio, Kikuchi Nobuhiro, et al. Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension: High-Throughput Screening of 5562 Compounds. Circulation Research. 2019; 125 (3): 309-327. doi:10.1161/CIRCRESAHA.119.315229  
24.   Yamaguchi-Kabata Yumi, Yasuda Jun, Uruno Akira, et al. Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals. Human Genetics. 2019; 138 (4): 389-409. doi:10.1007/s00439-019-01998-7  
25.   Fujishima Fumiyoshi, Katsushima Hiroki, Fukuhara Noriko, et al. Immunohistochemical pattern of c-MYC protein judged as “+/(weak)+/−” by a new notation correlates with MYC gene nontranslocation in large B-cell lymphoma. Human Pathology. 2019; 85 (3): 112-118. doi:10.1016/j.humpath.2018.10.025  
26.   Uranbileg Baasanjav, Ito Nobuko, Kurano Makoto, et al. Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model. Scientific Reports. 2019; 9 (1): 16578. doi:10.1038/s41598-019-52999-5  
27.   Rashad Sherif, Niizuma Kuniyasu, Saigusa Daisuke, et al. Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia. Neuroscience. 2018; 384 : 188-202. doi:10.1016/j.neuroscience.2018.05.015  
28.   Sato Kota, Saigusa Daisuke, Saito Ritsumi, et al. Metabolomic changes in the mouse retina after optic nerve injury. Scientific Reports. 2018; 8 (1): 11930. doi:10.1038/s41598-018-30464-z  
29.   Yagishita Yoko, Uruno Akira, Fukutomi Toshiaki, et al. Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress. Cell Reports. 2017; 18 (8): 2030-2044. doi:10.1016/j.celrep.2017.01.064  
30.   Yagishita Yoko, Fukutomi Toshiaki, Sugawara Akira, et al. Nrf2 Protects Pancreatic -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice. Diabetes. 2014; 63 (2): 605-618. doi:10.2337/db13-0909