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  • The development of novel detection method for multiple pharmacogene variations
  • The development of novel detection method for multiple pharmacogene variations

    Research: 2018/09/04


    Associate Professor Masahiro Hiratsuka, Assistant Professor Eiji Hishinuma, Professor Masayuki Yamamoto, and their colleagues developed a novel detection method by chromatographic printed-array strip for multiple pharmacogene variations, for example, CYP2C9, VKORC1 CYP4F2, DNA1555A>G. The assay results are obtained within 90 minutes.

    They did research using Japanese genome reference panel and immortalized lymphoblast from the Tohoku Medical Megabank Project, and published an article on Drug Metabolism and Pharmacokinetics.

    Please see below for more details on the article.

    Article information

    Title: Development and application of a rapid and sensitive genotyping method for pharmacogene variants using the single-stranded tag hybridization chromatographic printed-array strip (STH-PAS)

    Published journal: Drug Metabolism and Pharmacokinetics

    Authors: Masaki Kumondai, Akio Ito, Eiji Hishinuma, Aoi Kikuchi, Takahiro Saito, Masamitsu Takahashi, Chiharu Tsukada, Sakae Saito, Jun Yasuda, Masao Nagasaki, Naoko Minegishi, Masayuki Yamamoto, Akira Kaneko, Isao Teramoto, Masatsugu Kimura, Noriyasu Hirasawa, Masahiro Hiratsuka

    Available online: 22 August 2018

    https://doi.org/10.1016/j.dmpk.2018.08.003

     


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