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  • Group of Microarray-based Genotyping Analysis
  • Group of Microarray-based Genotyping Analysis

    The Group of Microarray-Based Genotyping Analysis has the mission to construct microarray-based genotype database to support genome analysis of Japanese population.
    Tohoku Medical Megabank Organization (ToMMo) have collected biological specimens from participants of Tohoku Medical Megabank Project Cohort Studies. Among them, genomic sequences of thousands of individuals were analyzed precisely with next-generation sequencers, and SNV (Single Nucleotide Variant) panel, which consists of approximately 28 million SNVs, was constructed (latest version as of June 25, 2018; 3.5KJPNv2). Using the panel, full-custom genotyping microarray (Japonica Array) was developed. The Japonica Array contains about 660,000 Japanese-specific SNVs, and suits for genome analysis for Japanese population. By conducting genotype imputation of SNV data from Japonica Array with SNV panel, it is possible to estimate genotypes at higher density, comparable to whole genome sequencing. Accumulation of genotyping data from Japonica Array will facilitate establishment of an advanced medical system based on individual genome information.

    Mika Sakurai-Yageta, Associate Professor

    Group Leader
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    Gen Tamiya, Professor

    Deputy Group Leader
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